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| 1 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 2 | High-throughput characterization methods for lithium batteries显示文摘The development of high-performance lithium ion batteries requires the discovery of new materials and the optimization of key components.By contrast with traditional one-by-one method,high-throughput method can synthesize and characterize a large number of compositionally varying samples,which is able to accelerate the pace of discovery,development and optimization process of materials.Because of rapid progress in thin film and automatic control technologies,thousands of compounds with different compositions could be synthesized rapidly right now,even in a single experiment.However,the lack of rapid or combinatorial characterization technologies to match with high-throughput synthesis methods,limit the application of high-throughput technology.Here,we review a series of representative highthroughput characterization methods used in lithium batteries,including high-throughput structural and electrochemical characterization methods and rapid measuring technologies based on synchrotron light sources. | Yingchun Lyu Yali Liu Tao Cheng Bingkun Guo | 2017 | Journal of Materiomics2017，3，3： | 6 |
| 3 | Chokeberry(Aronia melanocarpa)as a new functional food relationship with health:an overview显示文摘As a consumer product,black chokeberry(Aronia melanocarpa)is diffi cult to consume due to its pungent taste.It is mainly used in various food industries to produce a variety of juices,preserves,extracts,fruit teas and nutritional supplements.Traditionally,Potawatomi Native Americans used black chokeberry to treat colds,coughs and fever.It has been found to contain numerous active ingredients.Currently,there are many health and medical products that contain black chokeberry.The purpose of this review is to understand the nutritional benefi ts of black chokeberry and to explore its benefi cial effects on biological systems in vitro,thereby emphasizing its therapeutic prospects. | Yiwen Zhang Yingchun Zhao Xinglong Liu Xueyan Chen Chuanbo Ding Ling Dong Jinping Zhang Shuwen Sun Qiteng Ding Sadia Khatoom Zhiqiang Cheng Wencong Liu Liqian Shen Fengyan Xiao | 2021 | Journal of Future Foods2021，1，2： | 3 |
| 4 | Ultrafine microstructure development in laser polishing of selective laser melted Ti alloy显示文摘1.Introduction Titanium(Ti)alloys have been widely used in aerospace[1],biomedical industries[2],marine and offshore[3],due to their high yield strength,low density,good biocompatibility and outstanding corrosion resistance[4-6].Compared with traditional material processing methods,such as forging[7],stamping[8]and casting[9],additive manufacturing(AM)has attracted much attention to produce complex components close to their final prototypes with the formation of an ultrafine eutectoid microstructure caused by high cooling rates under multiple thermal cycles[2]. | Yuhang Li Xu Cheng Yingchun Guan | 2021 | Journal of Materials Science & Technology2021，，24： | 3 |
| 5 | Metamodel-Based Multi-Objective Reliable Optimization for Front Structure of Electric Vehicle显示文摘In this paper,a multi-objective reliable optimization(MORO)procedure for the front body of an electric vehicle is proposed and compared with determinate multi-objective optimization(DMOO).The energy absorption and peak crash force of the simplified vehicle model under the full-lap frontal impact condition are used as the design objectives,with the weighted sum of the basic frequency,the first-order torsional and bending frequencies of the full-size vehicle model,and the weight of the front body taken as the constraints.The thicknesses of nine components on the front body are defined as design variables,and their geometric tolerances determine the uncertainty factor.The most accurate metamodel using the polynomial response surface,kriging,and a radial basis function is selected to model four design criteria during optimization,allowing the efficiency improvement to be computed.Monte Carlo simulations are adopted to handle the probability constraints,and multi-objective particle swarm optimization is employed as the solver.The MORO results indicate reliability levels of R=100%,demonstrating the significant enhancement in reliability of the front body over that given by DMOO,and reliable design schemes and proposals are provided for further study. | Fengling Gao Shan Ren Cheng Lin Yingchun Bai Wenwei Wang | 2018 | Automotive Innovation2018，1，2： | 2 |
| 6 | Ultraefficient thermoacoustic conversion through a split ring resonator显示文摘Microwaves,which have a∼10-cm wavelength,can penetrate deeper into tissue than photons,heralding exciting deep tissue applications such as modulation or imaging via the thermoacoustic effect.Thermoacoustic conversion efficiency is however very low,even with an exogenous contrast agent.We break this low-conversion limit,using a split ring resonator to effectively collect and confine the microwaves into a submillimeter hot spot for ultrasound emission and achieve a conversion efficiency over 2000 times higher than other reported thermoacoustic contrast agents.Importantly,the frequency of emitted ultrasound can be precisely tuned and multiplexed by modulation of the microwave pulses.Such performance is inaccessible by a piezoelectric-based transducer or a photoacoustic emitter and,therefore,split ring resonators open up new opportunities to study the frequency response of cells in ultrasonic biomodulation.For applications in deep tissue localization,a split ring resonator can be used as a wireless,battery-free ultrasound beacon placed under a breast phantom. | Lu Lan Yueming Li Tiffany Yang-Tran Ying Jiang Yingchun Cao Ji-Xin Cheng | 2020 | Advanced Photonics2020，2，3： | 1 |
| 7 | Preparation of Bio-polyols by Liquefaction of Hardwood Residue and Their Application in the Modification of Polyurethane Foams显示文摘Hardwood residue(HR),a byproduct of paper industry,was liquefied by using polyethylene glycol 400(PEG400) and ethylene carbonate(EC) as the liquefaction solvents,and concentrated sulfuric acid as the catalyst to produce bio-polyols(HRLP),which were used to synthesize polyurethane(PU) foams.The effects of conditions on the properties of HRLP and modified PU foams were investigated and the mechanism of biomass liquefaction was discussed.The optimum conditions of liquefaction were obtained as follows: reaction temperature of 160 °C,reaction time of 60 min,ratio of PEG400/EC of 8:2(w/w),and ratio of liquid/solid of 5:1(w/w).The characterization of HRLP modified PU foams suggested that HRLP could partially replace the petroleum polyols to synthesize PU foams.With the increase of the replacement percentage of HRLP,the apparent density and compressive strength of the foams increased firstly,and then decreased.Meanwhile,the thermal stability was improved slightly. | 鹿现哲 WANG Yingchun ZHANG Yizhuan CHENG Xiansu 于岩 靳艳巧 | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，4： | 1 |
| 8 | A new π-conjugated star-shaped polymer comprising of full fluorene units: An efficient blue emitter without reduction of color purity undergoing an annealing显示文摘 | Shijie Ren Jiangong Cheng Danli Zeng Wenqing Zhu Jing Sun Junping Du Erjian Xu Hongliang Zhong Yingchun Liu Qiang Fang | 2008 | Synthetic Metals2008，，1： | 1 |
| 9 | Doping monolayer graphene with single atom substitutions显示文摘 | Wang Hongtao Wang Qingxiao Cheng Yingchun | 2012 | Nano Letters2012，12，1： | 1 |
| 10 | Dynamic landscape mapping of humoral immunity to SARS-CoY-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 patients显示文摘A comprehensive analysis of the humoral immune response to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is essential in understanding COVID-19 pathogenesis and developing antibody-based diagnostics and therapy.In this work,we performed a longitudinal analysis of antibody responses to SARS-CoV-2 proteins in 104 serum samples from 49 critical COVID-19 patients using a peptide-based SARS-CoV-2 proteome microarray.Our data show that the binding epitopes of IgM and IgG antibodies differ across SARS-CoV-2 proteins and even within the same protein. | Linlin Cheng Xiaomei Zhang Yu Chen Dan Wang Dong Zhang Songxin Yan Hongye Wang Meng Xiao Te Liang Haolong Li Meng Xu Xin Hou jiayu Dai Xian Wu Mingyuan Li Minya Lu Dong Wu Ran Tian Jing Zhao Yan Zhang Wei Cao Jinglan Wang Xiaowei Yan Xiang Zhou Zhengyin Liu Yingchun Xu Fuchu He Yongzhe Li Xiaobo Yu Shuyang Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 11 | Evaluation of Mechanical Properties of Cross-Laminated Timber with Different Lay-ups Using Japanese Larch显示文摘Japanese larch is one of the main plantation tree species in China.A lack of engineered wood products made by Japanese larch,however,limits its application in wood stnuctures.In this study,based on optimum process parameters,such as pressure(12 MPa),adhesive spread rate(200 g/m^(2))and adhesive(one-component polyurethane),the mechanical properties of Japanese larch-made cross-laminated timber(CLT)with different lay-ups were evaluated by means of the static method.Results of this study showed that variations in lay-ups significantly affected the mechanical properties of CLT.The strength and modulus of bending and parallel compression for CLT increased with the thickness of lumber,while that of bending,parallel compression and rolling shear all decreased with the number of layers.Thickness,layup orientation and the number of layers all had an impact on the strength of CLT.Failure modes obtained from numerical simulation were basically the same as those of experimental tests.There was also strong alignment between theoretical value and test value for effective bending stifness and shear stifness.Thus,the shear analogy method can be used to predict the mechanical properties of CLT effectively.This study proved great potential in using Japanese larch wood for manufacturing CLT due to its good mechanical properties. | Yingchun Gong Fenglu Liu Zhaopeng Tian Guofang Wu Haiqing Ren Cheng Guan | 2019 | Journal of Renewable Materials2019，7，10： | 1 |
| 12 | Simultaneous Reduction of Aldehyde Group to Hydroxymethyl Group in Palladium-catalyzed Suzuki Cross-coupling Reaction显示文摘 | WANG Yingchun LI Xiuying LI Yajun PAN Yingming CHENG Keguang WANG Hengshan | 2014 | Chemical Research in Chinese Universities2014，30，4： | 1 |
| 13 | Efficient solar cells based on cosensitizing porphyrin dyes containing a wrapped donor, a wrapped π-framework and a substituted benzothiadiazole unit显示文摘Three new porphyrin dyes XW45-XW47 have been synthesized employing a dialkoxy-wrapped phenothiazine donor, a tetraalkoxy-wrapped porphyrin π-framework, a benzothiadiazole(BTD)-based auxiliary acceptor, and an anchoring benzoic acid group. On the basis of our previously reported dye XW36, XW45 was synthesized by introducing a BTD unit to broaden the absorption spectrum, further introducing a hexyl-substituent into the BTD unit afforded XW46, and an additional fluorine atom was introduced to the carboxyphenyl acceptor to afford XW47. As expected, the BTD unit obviously broadens and red-shifts the absorption threshold of XW45-XW47 to ca.750 nm. Dye-sensitized solar cells(DSSCs) were fabricated based on a cobalt electrolyte using chenodeoxycholic acid(CDCA) as the coadsorbent. Under full sun illumination, XW45 exhibits an efficiency of 9.73%, which is slightly lower than that of 10.19% obtained for the reference dye SM315. By contrast, XW46 and XW47 show higher efficiencies than SM315 owing to the improved anti-aggregation ability associated with the hexyl group on the BTD unit and better ICT effect induced by the fluorine atom on the carboxyphenyl unit. Thus, XW47 exhibits the highest efficiency of 10.41% among the porphyrin dyes. Furthermore, PT-C6 was used as the cosensitizer to improve the light harvesting ability and efficiencies of the cells due to its broad absorption within 350–560 nm. Thus, high efficiencies of 10.32%, 11.38% and 10.90% were achieved for the cosensitized solar cells based on XW45–XW47, respectively, owing to the obviously enhanced photocurrent density(JSC). In addition, under 30% full sun illumination, XW46+PT-C6 exhibits a high efficiency of 13.08%. These results give an effective method for building high performance DSSCs through the cosensitization of porphyrin dyes containing a wrapped donor, a wrapped porphyrin framework and a properly substituted auxiliary benzothiadiazole unit. | Yunyue Lu Yingchun Cheng Chengjie Li Jiaxin Luo Weiqiang Tang Shuangliang Zhao Qingyun Liu Yongshu Xie | 2019 | Science China Chemistry2019，62，8： | 1 |
| 14 | Illiquidity ,Trans-action Cost, And Optimal Holding Period for Real Estate:Theo- ryand application 显示文摘 | Ping Cheng Zhenguo Lin Yingchun Liu | 2010 | Journal of Housing Economics2010，19，2： | 1 |
| 15 | Gastrochilus wolongensis(Orchidaceae):a new species from Sichuan,China,based on molecular and morphological data显示文摘Gastrochilus wolongensis(Orchidaceae),a new orchid species from Sichuan Province,Southwest China,is described and illustrated.It morphologically resembles G.sinensis,but differs markedly from the latter in having black-purple stripes(vs.purplish-red spots)on the adaxial side of the petals and sepals,a reniform epichile densely covered with long papillate hairs(vs.sparsely pubescent)with purplish-red spots(vs.unspotted),and outside the sac of the hypochile with purplish-red stripes(vs.purplish-red spotted).The molecular phylogenetic analysis based on nuclear ribosome internal transcribed spacer(nrITS)and four chloroplast DNA fragments(matK,psbA-trnH,psbM-trnD,and trnL-F)of 36 Gastrochilus species showed that G.wolongensis was closely related to G.ciliaris and G.formosanus. | Junyi Zhang Yuehong Cheng Min Liao Senlong Jin Chunmao Qu Yingchun Tan Anđelka Plenković-Moraj Bo Xu | 2022 | Ecosystem Health and Sustainability2022，8，1： | 0 |
| 16 | A bi-functional strategy involving surface coating and subsurface gradient co-doping for enhanced cycle stability of LiCoO_(2) at 4.6 V显示文摘Layered LiCoO_(2)(LCO)acts as a dominant cathode material for lithium-ion batteries(LIBs)in 3C products because of its high compacted density and volumetric energy density.Although improving the high cutoff voltage is an effective strategy to increase its capacity,such behavior would trigger rapid capacity decay due to the surface or/and structure degradation.Herein,we propose a bi-functional surface strategy involving constructing a robust spinel-like phase coating layer with great integrity and compatibility to LiCoO_(2) and modulating crystal lattice by anion and cation gradient co-doping at the subsurface.As a result,the modified LiCoO_(2)(AFM-LCO)shows a capacity retention of 80.9%after 500 cycles between 3.0and 4.6 V.The Al,F,Mg enriched spinel-like phase coating layer serves as a robust physical barrier to effectively inhibit the undesired side reactions between the electrolyte and the cathode.Meanwhile,the Al,F,Mg gradient co-doping significantly enhances the surficial structure stability,suppresses Co dissolution and oxygen release,providing a stable path for Li-ions mobility all through the long-term cycles.Thus,the surface bi-functional strategy is an effective method to synergistically improve the electrochemical performances of LCO at a high cut-off voltage of 4.6 V. | Yun He Xiaoliang Ding Tao Cheng Hongyu Cheng Meng Liu Zhijie Feng Yijia Huang Menghan Ge Yingchun Lyu Bingkun Guo | 2023 | Journal of Energy Chemistry2023，，2： | 0 |
| 17 | Assessment of Ankylosing Spondylitis Based on the Theory of Yin and Yang in Traditional Chinese Medicine显示文摘The theory of yin and yang in Chinese medicine signifies everything and can be used to divide everything in the world.The diagnosis and assessment of ankylosing spondylitis in Western medicine can also be divided by yin and yang.The current technologies used in Western medicine for detecting ankylosing spondylitis is summarized,divided,and reasoned with the philosophical views of yin and yang in traditional Chinese medicine. | Yuan Cheng Jichao Yin Xinglv Hu Penggang Xu Yingchun Liu Chengxiang Lei | 2021 | Journal of Clinical and Nursing Research2021，5，5： | 0 |
| 18 | Effect of vortex dynamics and instability characteristics on the induced drag of trailing vortices显示文摘In this paper, trailing vortices generated by three wingtip configurations, namely the M6wing and the M6 wing with a blended or split winglet, are experimentally investigated using the Stereo Particle Image Velocimetry(SPIV) technology. Then, linear stability analysis is performed to investigate instability characteristics. Three corresponding trailing vortex patterns, including the isolated trailing vortex without wake(pattern v) and with wake(pattern v-w), co-rotating vortex pair(pattern v-v), are observed in experiments. The strength of trailing vortices, characterized by circulation, is reduced after installing winglets as expected, and the strength of pattern v-v can be further suppressed compared with pattern v-w. Moreover, instability characteristics, such as the eigenvalue spectrum and perturbation mode, are distinctive among these three vortex patterns.The distribution of eigenvalue spectrums indicates that pattern v and pattern v-w are temporally“marginally stable”, while pattern v-v is temporally “unstable.” The primary perturbation mode of pattern v and pattern v-w is the m =-1 helical mode, while |m|>1 for the case of pattern v-v.The effect of vortex dynamics and instability characteristics can be concluded in two aspects.Firstly, the value of induced drag is polluted by about 3% from vortex wandering since vortex wandering affects the tangential velocity and streamwise vorticity of trailing vortices. Secondly, the growth rate and penetration depth perturbation mode affect trailing vortex evolution and further affect induced drag. Specifically, the larger the growth rate and penetration depth are, the more turbulence injects inside the vortex core, thus leading to a quicker and more intense attenuation of trailing vortex, as well as a smaller induced drag. This finding can guide us to manipulate the induced drag in flow control. | Zepeng CHENG Shiyan ZHANG Yang XIANG Chun SHAO Miao ZHANG Hong LIU Yingchun CHEN | 2022 | Chinese Journal of Aeronautics2022，35，9： | 0 |
| 19 | Confinement of Fe atoms between MoS_(2) interlayers drives phase transition for improved reactivity in Fenton-like reactions显示文摘Phase manipulation of MoS_(2) from thermodynamically stable 2H phase to the unstable but more reactive 1T phase represents a crucial strategy for improving the reactivity in many reactions.The widely adopted wet chemistry approach uses intercalating entities especially alkali metal ions to achieve the phase transition;however,these entities are normally inert for the target reaction.Here,we describe the first use of iron atoms for the intercalation of 2H-MoS_(2) layers,driving the partial transition from 2H to 1T phase.Interestingly,in the peroxymonosulfate(PMS)-based Fenton-like reactions,the interlayered confinement of Fe atoms not only activates the inert basal plane,but also adds more reactive Fe sites for the formation of metal-PMS complex as primary reactive species for pollutant removal.In the degradation of a model pollutant carbamazepine(CBZ),the Fe-intercalated MoS_(2) exhibits a first order rate constant 13.3 times higher than 2H-MoS_(2).This strategy is a new direction for manipulating the phase composition and boosting the catalytic reactivity of MoS_(2)-based catalysts in various scenarios,including environmental remediation and energy applications. | Yibing Sun Yu Zhou Hongchao Li Chuan Wang Xuan Zhang Qian Ma Yingchun Cheng Jieshu Qian Bingcai Pan | 2024 | Nano Research2024，17，3： | 0 |
| 20 | Nontraditional manufacturing technique——Nano machining technique based on SPM显示文摘Nano machining based on SPM is a novel, nontraditional advanced manufacturing technique. There are three main machining methods based on SPM, i.e.single atom manipulation, surface modification using physical or chemical actions and mechanical scratching. The current development of this technique is summarized. Based on the analysis of mechanical scratching mechanism, a 5 μm micro inflation hole is fabricated on the surface of inertial confinement fusion (ICF) target. The processing technique is optimized. The machining properties of brittle material, single crystal Ge, are investigated. A micro machining system combining SPM and a high accuracy stage is developed. Some 2D and 3D microstructures are fabricated using the system. This method has broad applications in the field of nano machining. | DONG Shen YAN Yongda SUN Tao LIANG Yingchun CHENG Kai | 2004 | Science China(Physics,Mechanics & Astronomy)2004，47，z1： | 0 |
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