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| 1 | Ownership and firm innovation in a transition economy: Evidence from China显示文摘 | Suk Bong Choi Soo Hee Lee Christopher Williams | 2011 | Research Policy2011，，3： | 3 |
| 2 | SLC26A4 mutation testing for hearing loss associated with enlargement of the vestibular aqueduct显示文摘Pendred syndrome(PS) is characterized by autosomal recessive inheritance of goiter associated with a defect of iodide organification, hearing loss, enlargement of the vestibular aqueduct(EVA), and mutations of the SLC26A4 gene. However, not all EVA patients have PSor SLC26A4 mutations. Two mutant alleles of SLC26A4 are detected in 1/4 of North American or European EVA populations, one mutant allele is detected in another 1/4 of patient populations, and no mutations are detected in the other 1/2. The presence of two mutant alleles of SLC26A4 is associated with abnormal iodide organification, increased thyroid gland volume, increased severity of hearing loss, and bilateral EVA. The presence of a single mutant allele of SLC26A4 is associated with normal iodide organification, normal thyroid gland volume, less severe hearing loss and either bilateral or unilateral EVA. When other underlying correlations are accounted for, the presence of a cochlear malformation or the size of EVA does not have an effect on hearing thresholds. This is consistent with observations of an Slc26a4 mutant mouse model of EVA in which hearing loss is independent of endolymphatic hydrops or inner ear malformations. Segregation analyses of EVA in families suggest that the patients carrying one mutant allele of SLC26A4 have a second, undetected mutant allele of SLC26A4, and the probability of a sibling having EVA is consistent with its segregation as an autosomal recessive trait. Patients without any mutations are an etiologically heterogeneous group in which siblings have a lower probability of having EVA. SLC26A4 mutation testing can provide prognostic information to guide clinical surveillance and management, as well as the probability of EVA affecting a sibling. | Taku Ito Julie Muskett Parna Chattaraj Byung Yoon Choi Kyu Yup Lee Christopher K Zalewski Kelly A King Xiangming Li Philine Wangemann Thomas Shawker Carmen C Brewer Seth L Alper Andrew J Griffith | 2013 | World Journal of Otorhinolaryngology2013，3，2： | 2 |
| 3 | Acupuncture for the treatment of cancer pain: a systematic review of randomised clinical trials显示文摘 | Tae-Young Choi Myeong Lee Tae-Hun Kim Christopher Zaslawski Edzard Ernst | 2012 | Supportive Care in Cancer2012，，： | 2 |
| 4 | Ownership and firm innovation in a transition economy: Evidence from China显示文摘 | Suk Bong Choi Soo Hee Lee Christopher Williams | 2011 | Research Policy2011，，3： | 2 |
| 5 | Effect of CO 2 gasification reaction on char particle combustion in oxy-fuel conditions显示文摘 | Daehee Kim Sangmin Choi Christopher R. Shaddix Manfred Geier | 2014 | Fuel2014，，： | 2 |
| 6 | Ownership and firm innovation in a transition economy: Evidence from China显示文摘 | Suk Bong Choi Soo Hee Lee Christopher Williams | 2011 | Research Policy2011，，3： | 1 |
| 7 | Oxidation-Specific Epitopes Are Danger-Associated Molecular Patterns Recognized by Pattern Recognition Receptors of Innate Immunity显示文摘 | Yury I. Miller Soo-Ho Choi Philipp Wiesner Longhou Fang Richard Harkewicz Karsten Hartvigsen Agnès Boullier Ayelet Gonen Cody J. Diehl Xuchu Que Erica Montano Peter X. Shaw Sotirios Tsimikas Christoph J. Binder Joseph L. Witztum | 2011 | Circulation Research2011，，2： | 1 |
| 8 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 9 | Impact of conditioning regimen on peripheral blood hematopoietic cell transplant显示文摘AIM To investigate infused hematopoietic cell doses and their interaction with conditioning regimen intensity +/-total body irradiation(TBI) on outcomes after peripheral blood hematopoietic cell transplant(PBHCT).METHODS Our retrospective cohort included 247 patients receiving a first, T-replete, human leukocyte antigen-matched allogeneic PBHCT and treated between 2001 and2012. Correlations were calculated using the Pearson product-moment correlation coefficient. Overall survival and progression free survival curves were generated using the Kaplan-Meier method and compared using the log-rank test.RESULTS Neutrophil engraftment was significantly faster after reduced intensity TBI based conditioning [reduced intensity conditioning(RIC) + TBI] and > 4 × 10~6 CD34+cells/kg infused. A higher total nucleated cell dose led to a higher incidence of grade II-IV acute graft-versus-host disease in the myeloablative + TBI regimen group(P = 0.03), but no significant difference in grade III-IV graft-versus-host disease. A higher total nucleated cell dose was also associated with increased incidence of moderate/severe chronic graft-versus-host disease, regardless ofconditioning regimen. Overall and progression-free survival were significantly better in patients with a RIC + TBI regimen and total nucleated cell dose > 8 ×10~8/kg(3 years, overall survival: 70% vs 38%, P = 0.02, 3 years, progression free survival: 64% vs 38%, P = 0.02).CONCLUSION TBI and conditioning intensity may alter the relationship between infused cell doses and outcomes after PBHCT. Immune cell subsets may predict improved survival after unmanipulated PBHCT. | Michael Burns Anurag K Singh Carrie C Hoefer Yali Zhang Paul K Wallace George L Chen Alexis Platek Timothy B Winslow Austin J Iovoli Christopher Choi Maureen Ross Philip L McCarthy Theresa Hahn | 2019 | World Journal of Clinical Oncology2019，10，2： | 1 |
| 10 | Paclitaxel Interrupts TGF-β1 Signaling Between Gallbladder Epithelial Cells and Myofibroblasts显示文摘 | Ho-Soon Choi Christopher E. Savard Jae-Woon Choi Rahul Kuver Sum P. Lee | 2007 | Journal of Surgical Research2007，，2： | 1 |
| 11 | Light Duty Gasoline Vehicle Emission Factors at High Transient and Constant Speeds for Short Road Segments显示文摘 | Choi Hyung-Wook Christopher Frey H | 2009 | Transportation Research Part D Transport and Environment2009，14，8： | 1 |
| 12 | Fruit maturity, controlled atmosphere delays and storage temperature affect fruit quality and incidence of storage disorders of ‘Fuji’ apples显示文摘 | Hun-Joong Kweon In-Kyu Kang Mok-Jong Kim Jinwook Lee Yong-Sun Moon Cheol Choi Dong Geun Choi Christopher B. Watkins | 2013 | Scientia Horticulturae2013，，： | 1 |
| 13 | Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: Implications for Th17-mediated inflammation in auto-immunity显示文摘 | Chun Kwok Wong Lydia Choi Wan Lit Lai Shan Tam Edmund Kwok Ming Li Purple Tsz Yan Wong Christopher Wai Kei Lam | 2008 | Clinical Immunology2008，，3： | 1 |
| 14 | Efficacy and Safety of Regorafenib in Patients With Metastatic and/or Unresectable GI Stromal Tumor After Failure of Imatinib and Sunitinib: A Multicenter Phase II Trial显示文摘 | Suzanne George Qian Wang Michael C. Heinrich Christopher L. Corless Meijun Zhu James E. Butrynski Jeffrey A. Morgan Andrew J. Wagner Edwin Choy William D. Tap Jeffrey T. Yap Annick D. Van den Abbeele Judith B. Manola Sarah M. Solomon Jonathan A. Fletcher | 2012 | Journal of Clinical Oncology2012，，19： | 1 |
| 15 | Evidence that collaboration between HIF-1α and Notch-1 promotes neuronal cell death in ischemic stroke显示文摘 | Yi-Lin Cheng Jong-Sung Park Silvia Manzanero Yuri Choi Sang-Ha Baik Eitan Okun Mathias Gelderblom David Yang-Wei Fann Tim Magnus Bradley S. Launikonis Mark P. Mattson Christopher G. Sobey Dong-Gyu Jo Thiruma V. Arumugam | 2014 | Neurobiology of Disease2014，，： | 1 |
| 16 | Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism显示文摘 | Stephan J. Sanders A. Gulhan Ercan-Sencicek Vanessa Hus Rui Luo Michael T. Murtha Daniel Moreno-De-Luca Su H. Chu Michael P. Moreau Abha R. Gupta Susanne A. Thomson Christopher E. Mason Kaya Bilguvar Patricia B.S. Celestino-Soper Murim Choi Emily L. Crawf | 2011 | Neuron2011，，5： | 1 |
| 17 | Ownership and Firm Innovation in a Transition Economy: Evidence from China 显示文摘 | Suk Bong Choi Soo Hee Lee Christopher Williams | 2011 | Research Policy2011，3，40： | 1 |
| 18 | Genomic analysis of sleep deprivation reveals translational regulation in the hippocampus显示文摘 | Christopher G Vecsey Lucia Peixoto Jennifer H Choi | | 0，，20： | 1 |
| 19 | Source Tracking of Microbial Intrusion in Water Systems Using Artificial Neural Networks显示文摘 | Minyoung Kim Christopher Y Choi Charles P Gerbac | 2008 | Water Research2008，42，： | 1 |
| 20 | Hospital Nurse Staffing: Choice of Measure Matters显示文摘 | Beatrice J. Kalisch Christopher R. Friese Seung Hee Choi Monica Rochman | 2011 | Medical Care2011，，： | 1 |
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