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| 1 | Vitamin B12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection显示文摘Missense mutations in Leucine-Rich Repeat Kinase 2(LRRK2)cause the majority of familial and some sporadic forms of Parkinson’s disease(PD).The hyperactivity of LRRK2 kinase induced by the pathogenic mutations underlies neurotoxicity,promoting the development of LRRK2 kinase inhibitors as therapeutics.Many potent and specific small-molecule LRRK2 inhibitors have been reported with promise.However,nearly all inhibitors are ATP competitive—some with unwanted side effects and unclear clinical outcome—alternative types of LRRK2 inhibitors are lacking.Herein we identify 5′-deoxyadenosylcobalamin(AdoCbl),a physiological form of the essential micronutrient vitamin B12 as a mixed-type allosteric inhibitor of LRRK2 kinase activity.Multiple assays show that AdoCbl directly binds LRRK2,leading to the alterations of protein conformation and ATP binding in LRRK2.STD-NMR analysis of a LRRK2 homologous kinase reveals the contact sites in AdoCbl that interface with the kinase domain.Furthermore,we provide evidence that AdoCbl modulates LRRK2 activity through disrupting LRRK2 dimerization.Treatment with AdoCbl inhibits LRRK2 kinase activity in cultured cells and brain tissue,and prevents neurotoxicity in cultured primary rodent neurons as well as in transgenic C.elegans and D.melanogaster expressing LRRK2 disease variants.Finally,AdoCbl alleviates deficits in dopamine release sustainability caused by LRRK2 disease variants in mouse models.Our study uncovers vitamin B12 as a novel class of LRRK2 kinase modulator with a distinct mechanism,which can be harnessed to develop new LRRK2-based PD therapeutics in the future. | Adam Schaffner Xianting Li Yacob Gomez-Llorente Emmanouela Leandrou Anna Memou Nicolina Clemente Chen Yao Farinaz Afsari Lianteng Zhi Nina Pan Keita Morohashi Xiaoluan Hua Ming-Ming Zhou Chunyu Wang Hui Zhang Shu G.Chen Christopher J.Elliott Hardy Rideout Iban Ubarretxena-Belandia Zhenyu Yue | 2019 | Cell Research2019，29，4： | 7 |
| 2 | Application of chemical vapor-deposited monolayer ReSe2 in the electrocatalytic hydrogen evolution reaction显示文摘 | Shaolong Jiang Zhepeng Zhang Na Zhang Yahuan Huan Yue Gong Mengxing Sun Jianping Shi Chunyu Xie Pengfei Yang Qiyi Fang He Li Lianming Tong Dan Xie Lin Gu Porun Liu Yanfeng Zhang | 2018 | Nano Research2018，11，4： | 6 |
| 3 | Dissecting human embryonic skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses显示文摘Human skeletal stem cells(SSCs)have been discovered in fetal and adult long bones.However,the spatiotemporal ontogeny of human embryonic SSCs during early skeletogenesis remains elusive.Here we map the transcriptional landscape of human limb buds and embryonic long bones at single-cell resolution to address this fundamental question.We found remarkable heterogeneity within human limb bud mesenchyme and epithelium,and aligned them along the proximal-distal and anterior-posterior axes using known marker genes.Osteo-chondrogenic progenitors first appeared in the core limb bud mesenchyme,which give rise to multiple populations of stem/progenitor cells in embryonic long bones undergoing endochondral ossification.Importantly,a perichondrial embryonic skeletal stem/progenitor cell(eSSPC)subset was identified,which could self-renew and generate the osteochondral lineage cells,but not adipocytes or hematopoietic stroma.eSSPCs are marked by the adhesion molecule CADM1 and highly enriched with FOXP1/2 transcriptional network.Interestingly,neural crest-derived cells with similar phenotypic markers and transcriptional networks were also found in the sagittal suture of human embryonic calvaria.Taken together,this study revealed the cellular heterogeneity and lineage hierarchy during human embryonic skeletogenesis,and identified distinct skeletal stem/progenitor cells that orchestrate endochondral and intramembranous ossification. | Jian He Jing Yan Jianfang Wang Liangyu Zhao Qian Xin Yang Zeng Yuxi Sun Han Zhang Zhijie Bai Zongcheng Li Yanli Ni Yandong Gong Yunqiao Li Han He Zhilei Bian Yu Lan Chunyu Ma Lihong Bian Heng Zhu Bing Liu Rui Yue | 2021 | Cell Research2021，31，7： | 5 |
| 4 | A review on SRAM-based computing in-memory:Circuits,functions,and applications显示文摘Artificial intelligence(AI)processes data-centric applications with minimal effort.However,it poses new challenges to system design in terms of computational speed and energy efficiency.The traditional von Neumann architecture cannot meet the requirements of heavily datacentric applications due to the separation of computation and storage.The emergence of computing inmemory(CIM)is significant in circumventing the von Neumann bottleneck.A commercialized memory architecture,static random-access memory(SRAM),is fast and robust,consumes less power,and is compatible with state-of-the-art technology.This study investigates the research progress of SRAM-based CIM technology in three levels:circuit,function,and application.It also outlines the problems,challenges,and prospects of SRAM-based CIM macros. | Zhiting Lin Zhongzhen Tong Jin Zhang Fangming Wang Tian Xu Yue Zhao Xiulong Wu Chunyu Peng Wenjuan Lu Qiang Zhao Junning Chen | 2022 | Journal of Semiconductors2022，43，3： | 2 |
| 5 | Enhanced perovskite electronic properties via A-site cation engineering显示文摘Organic-inorganic halide perovskites have emerged as excellent candidates for low-cost photovoltaics and optoelectronics.While the predominant recent trend in designing perovskites for efficient and stable solar cells has been to mix different A-site cations,the role of A-site cations is still limited to tune the lattice and bandgap of perovskites.Herein we compare the optoelectronic properties of acetamidinum(Ace)and guanidinium(Gua)mixed methylammonium lead iodide perovskites and shed a light on the hidden role of A-site cation on the carrier mobility of mixed-cation lead iodide perovskites.The cations do not affect the bandgap of the perovskites since the orbitals from Ace and Gua do not contribute to the band edges of the material.However,the mobility of the Ace mixed perovskite is significantly enhanced to be an order of magnitude higher than that of the pristine perovskite.We apply the Ace mixed perovskite in hole-conductor-free printable mesoscopic perovskite solar cells and obtain a stabilized PCE of over 18%(certified 17.7%),which is the highest certified efficiency so far. | Xufeng Xiao Yanmeng Chu Chunyu Zhang Zhihui Zhang Zexiong Qiu Cheng Qiu Huaixing Wang Anyi Mei Yaoguang Rong Gengzhao Xu Yue Hu Hongwei Han | 2021 | Fundamental Research2021，1，4： | 2 |
| 6 | Evaluating alternative hypotheses behind biodiversity and multifunctionality relationships in the forests of Northeastern China显示文摘Background:The importance of biodiversity in maintaining multiple ecosystem functions has been widely accepted.However,the specific mechanisms affecting biodiversity and ecosystem multifunctionality(BEMF)relationships in forests are largely unknown.This is particularly evident for the macroscale of a large forested landscape.Methods:Based on 412 one-tenth hectare field plots distributed over forested areas across northeastern China,we evaluated three alternative hypotheses explaining the relationships between BEMF,namely:niche complementarity,mass ratio,and vegetation quantity effect.We used Rao's quadratic entropy and community weighted mean trait values to quantify forest“biodiversity”.These two variables represent two complementary aspects of functional properties,which are in line with niche complementary and mass ratio effects,respectively.Results:Ecosystem multifunctionality was negatively associated with the community weighted mean values of acquisitive traits(a proxy of mass ratio effect).Rao's quadratic entropy(a proxy of niche complementarity)had no relationship with ecosystem multifunctionality.Higher stand biomass greatly increased ecosystem multifunctionality,which is in line with the vegetation quantity effect.Our results confirm that in the temperate forests of northeastern China,the relationship of BEMF was primarily affected by vegetation quantity,followed by mass ratio effects.Conclusions:The results of this study contribute to a better understanding of the main drivers of ecosystem multifunctionality in forest ecosystems.The results of this study provide additional evidence to support the vegetation quantity and mass ratio hypotheses in forest ecosystems. | Qingmin Yue Minhui Hao Yan Geng Xuerui Wang Klaus von Gadow Chunyu Zhang Xiuhai Zhao Lushuang Gao | 2022 | Forest Ecosystems2022，9，3： | 1 |
| 7 | Synergistic effects between sulfurized W-DLC coating and MoDTC lubricating additive for improvement of tribological performance显示文摘 | Wen Yue Chunyue Liu Zhiqiang Fu Chengbiao Wang Haipeng Huang Jiajun Liu | 2013 | Tribology International2013，，： | 1 |
| 8 | SAR image denoising in nonsubsampled eontourlet transform domain based on maximum a posteriori and non-local constraint 显示文摘 | YUE Chunyu JIANG Wanshou | 2013 | Remote Sens Lett2013，4，3： | 1 |
| 9 | Laser ablation of copper and aluminium in air显示文摘 | Yueyuan Xia Liangmo Mei Chunyu Tan Xiangdong Liu Qingpu Wang Shubin Yue | 1991 | Applied Physics A Solids and Surfaces1991，，6： | 1 |
| 10 | High phosphorylated cyclin-dependent kinase 2 expressionindicates poor prognosis of luminal androgen receptortriple-negative breast cancer显示文摘Triple-negative breast cancer(TNBC)is a highly aggressive breast cancer subtype characterized by a lack of estrogen receptorα(ER)and progesterone receptor(PR)expression and the absence of HER2 overexpression or amplification. | Zining Jin Qingfu Zhang Chunyu Wang Shengli Wang Lin Lin Renlong Zou Ge Sun Kai Zeng Baosheng Zhou Yuxin Tong Bo Chen Yue Zhao | 2022 | Acta Biochimica et Biophysica Sinica2022，54，7： | 1 |
| 11 | A homozygous frameshift mutation in ADAD2 causes male infertility with spermatogenic impairments显示文摘Male infertility is a complex reproductive disorder that impedes a huge number of couples from having children naturally in the world(Agarwal et al.,2021).As an important pathogenic factor of male infertility,spermatogenic impairments are mainly characterized by impaired male gamete production,reduced sperm quality,or function(Tournaye et al.,2017).Spermatogenesis is a delicate and complex biological process that requires the collaboration of a large number of proteins performing different biological functions(Liu et al.,2021). | Shixiong Tian Ziqi Wang Liting Liu Yiling Zhou Yue Lv Dongdong Tang Jiaxiong Wang Jing Jiang Huan Wu Shuyan Tang Guanxiong Wang Hao Geng Fangbiao Tao Hongbin Liu Xiaojin He Feng Zhang Jinsong Li Li Jin Tao Huang Chunyu Liu Yunxia Cao | 2023 | Journal of Genetics and Genomics2023，50，4： | 0 |
| 12 | Air Pollution Health Impact Monitoring and Health Risk Assessment Technology and Its Application-China,2006-2019显示文摘Air pollution is a significant risk factor contributing to the burden of disease in China.Health risk assessment and management are important to reduce the impact of air pollution on public health.To help formulate standardized health risk assessment techniques,a series of studies were conducted from 2006 to 2019.Through systematic review,study of molecular mechanisms,epidemiological investigation,and health effect monitoring,the overall project established a monitoring and evaluation indicator system,a comprehensive information platform,software for automatic data cleaning,and standardized health risk assessment techniques.Technical specifications have been issued by the National Health Commission for promoting health risk assessments across China.This paper introduces the project,the research approach,its main research accomplishments,innovations,and public health significance,and describes directions for further research. | Jingxiu Han Dongqun Xu Donggang Xu Xu Yang Qin Wang Mingqing Chen Wenrong Xia Weiwei Xing Chunyu Xu Yue Liu Junrui Chang Wenliang Fu Shuxin Hao Na Li Xiaoyan Dong Yunpu Li Congshen Meng Jingyi Liu | 2022 | China CDC weekly2022，4，26： | 0 |
| 13 | Binary encoding-inspired generation of vector vortex beams显示文摘Vortex and vector terahertz(THz)beams with inhomogeneous polarization states have become a considerable hot topic in the last decade due to their important roles in multiplexed wireless data transmission.However,the technical instruments to form and evaluate such beams are rather limited,as they are mainly collected in the visible range.The emergence of coded metasurfaces has reinvigorated the design of functional devices with multiple degrees of freedom.Here,we demonstrate a versatile design inspired by a binary encoding approach for generating off-axis vectorial THz beams on all-silicon metasurfaces.Experimentally,simultaneous manipulation of the encoding method within the orthogonal circularly polarized(CP)channel provides strong support for developing versatility in vector THz beams,including the generation of arbitrary polarization profiles and the directional emission of multiplexed vector vortex beams(VVBs)with specified polarization states.The introduction of the latitudinal polarization control factor guarantees that continuously rotating or independently designed vector polarization profiles can be obtained on a pre-defined focal plane.Subsequently,a universal parametric theoretical model is developed to analyze the evolutionary trend of off-axis VVB in detail.Notably,the proposed monolayer vector metasurface bypasses the requirement of multiple cascaded optical elements,further inducing the advancement of ultra-thin vector THz sources,and also facilitating the generation of vector fields with tailored polarization distributions in 3D space. | Hui Li Chenglong Zheng Jingyu Liu Hang Xu Chunyu Song Fan Yang Jitao Li Zhen Yue Wei Shi Yating Zhang Yan Zhang Jianquan Yao | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，5： | 0 |
| 14 | Adenosine cyclic phosphate with ultrasonic-assisted pectinase extraction alleviated allergic reactions in RBL-2H3 through inhibiting the influx of intracellular Ca^(2+)显示文摘Jujube contains abundant cyclic adenosine monophosphate(cAMP)and the ultrasonic-assisted pectinase extraction(UAPE)conditions for obtaining the maximum cAMP yield from jujube were optimized.Orthogonal array design was applied to evaluate the effects of 4 variables by UAPE on cAMP yield.The results showed that the optimal cAMP yield(783.0μg/g)was derived at ratio of liquid to solid 5 mL/g,ratio of pectinase to raw material 1.5%,time 60 min and temperature 40℃.Moreover,the effect of cAMP on the anti-allergic function of action induced by immunoglobulin E(IgE)and its meschanism was investigated through establishing the sensitized cell model in rat basophilic leukemia(RBL-2 H3)cells using dinitrophenylated(DNP)-bovine serum albumin(BSA)-IgE.The results showed that cAMP interfered with sensitized cells,effectively inhibited the occurrence of basophil degranulation in dose dependence,and significantly reduced the activity ofβ-hexosamindase(β-hex),at the optimal concentration of 50μg/mL.The level of anti-inflammatory factor interleukin-10(IL-10)was promoted and the content of pro-inflammatory factor tumor necrosis factor-α(TNF-α)was suppressed by cAMP.In addition,influx of intracellular Ca^(2+) was repressed effectively.Our results demonstrate that jujube cAMP regulated the cytokine balance in the allergy pathway through blocking the influx of extracellular Ca^(2+),with the prevention of allergy symptoms. | Qiao Bai Xiaoping Feng Yu Wang Chunyu Wu Ye Liu Jiao Sun Tianli Yue Fangyu Long | 2023 | Food Science and Human Wellness2023，12，3： | 0 |
| 15 | Response Mechanism of Water Ecosystem under the Influence of Urbanization: A Case Study of the Connection Zone between Shenyang and Fushun显示文摘Taking the connection zone between Shenyang and Fushun as an example,urbanization indicator system was established from the aspects of population,economy,space and society,and the comprehensive evaluation indicator system of water ecological environment was also established from the aspects of water ecological environmental pressure,state and response. Based on the evaluation of comprehensive level of urbanization and the comprehensive quality of water ecological environment,their changing trends during 2000-2014 were analyzed,and the response model between them was established. The composite index of urbanization in the connection zone between Shenyang and Fushun always increased from 2000 to 2014,and urbanization developed rapidly after 2004. The comprehensive quality of water ecological environment decreased firstly and then increased during 2000-2014. The response relationship between urbanization comprehensive index and water ecological comprehensive index during 2000-2014 could be expressed by a cubic curve. | Zhang Runjie Gu Chunyu Zuo Shiwen Qi Yue Tong Lili Fu Baorong | 2018 | Meteorological and Environmental Research2018，9，5： | 0 |
| 16 | Effect of Metformin on Lactate Metabolism in Normal Hepatocytes under High Glucose Stress in Vitro显示文摘To study the effect of metformin on lactate metabolism in hepatocytes in vitro under high glucose stress.Method:LO2 hepatocytes was cultured in vitro,hepatocytes were randomly divided into blank control group,25 mmol/L glucose solution,27 mmol/L glucose solution,29 mmol/L glucose solution,31 mmol/L glucose solution,33 mmol/L glucose solution,35 mmol/L glucose solution treatment group,after determining the optimal concentration as 31 mmol/L,use 30 mmol/L metformin solution,and then divided into blank control group,normal hepatocytes+the optimal concentration of glucose solution,normal hepatocytes+metformin solution,normal hepatocytes+.The optimal concentration of glucose solution normal hepatocytes+metformin solution,calculate the number of hepatocytes on cell count plate respectively in the 12 h,24 h,48 h,and use the lactic acid kit to determine the lactic acid value of the cell culture medium of normal liver cells+optimal concentration glucose solution and normal liver cells+optimal concentration glucose solution+metformin solution at 12 h,24 h,and 48 h,respectively.Results:There was no significant change in the lactic acid concentration but significant increase in the number of surviving hepatocytes in the high-glycemic control group compared with that in the high-glycemic control group without metformin.Conclusions:Metformin has no significant effect on lactic acid metabolism of hepatocytes under high glucose stress in vitro,and has a protective effect on hepatocytes under high glucose stress.Based on this,it is preliminarily believed that metformin is not the direct factor leading to diabetic lactic acidosis. | Jianhao Wu Qinnan Zhang Yubiao Yang Chunyue Wang Xindi Yue Zhilu Li Pingping Yan | 2021 | Journal of Advances in Medicine Science2021，4，2： | 0 |
| 17 | Infuence of Liquid Film Characteristics on Hot Cracking Initiation in Al–Cu Alloys at the End of Solidifcation显示文摘In this study,Al–4Cu alloy specimens with spherical grains and liquid flms were obtained by isothermal reheating treatment.The hot cracking of the solidifcation process was determined using a modifed constrained rod casting experimental apparatus,and the efect of liquid flm characteristics at the end of solidifcation on hot cracking initiation of Al–4Cu alloys was systematically investigated by combining molecular dynamics simulations and other methods.With the extension of soaking time,the liquid fraction(liquid flm fraction at the end of solidifcation)and grain shape factor increased with higher isothermal reheating temperatures.Additionally,the widened flling channel decreased the hot cracking initiation temperature and the critical hot cracking shrinkage stress was found to increase,thus reducing the hot cracking severity in Al–4Cu alloys.Molecular dynamics simulations revealed that with the extension of soaking time,the composition of the liquid flm changed at diferent isothermal reheating temperatures,but the short-range structure and atomic ordering of the liquid flm remained the same.The activity of the liquid flm increased in equilibrium,leading to a decrease in viscosity and an increase in fuidity,which contributed to the flling behaviour.After isothermal reheating at 640℃for 60 min,the liquid fraction reached the maximum,and the viscosity of the liquid flm was the minimum.In addition,almost no hot cracks were found. | Ming Su Xiaoguang Yuan Chunyu Yue Wentao Zheng Yuxiang Wang Jian Kang | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，1： | 0 |
| 18 | Transcriptome Analysis and Morphological Changes in Response to Waterlogging in Iris pseudacorus显示文摘Iris pseudacorus is a widely cultivated and studied ornamental plant with a large biomass,strong adaptability and extensive management.Moreover,it has the ability to decontaminate and enrich heavy metals.However,few studies have been conducted on its submergence tolerance with little known about the molecular response of I.pseudacorus to flooding.Morphologically,I.pseudacorus had strong adaptability to waterlogging,the aerenchyma was gradually enlarged and adventitious roots developed between 0 and 14 d.The transcriptome data showed that the differentially expressed genes counts in plants flooded for 2 h,4 h,12 h and 24 h compared with the unflooded controls were 3555,9439,10734,and 4997,respectively.For GO term entries enriched by different genes,many biological processes,cell components and molecular processes in the I.pseudacorus roots were affected by flooding stress.Pathways enrichment analysis showed DEGs involved in hormone signal transduction pathways,glucose metabolism,glycolysis,and fermentation.The quantitative real-time PCR analysis of DEGs was basically consistent with the trend of transcriptome data,indicating reliability of the transcriptome data.The transcriptome analysis showed that formation of aerenchyma and adventitious roots was mainly induced by IAA(auxin)and accompanied by other hormone signals.Energy production was the primary coping mechanism of I.pseudacorus when aerenchyma was not sufficiently enlarged under water flooding.These results laid a foundation for further study on the mechanism of submerging-tolerance of I.pseudacorus and other aquatic plants. | Xiaofang Yu Linjie Yue Qing Wu Liu Yang Chunyu Fan Zhiwen Wang Jiani Hu | 2022 | Phyton-International Journal of Experimental Botany2022，91，10： | 0 |
| 19 | A Hot Cracking Initiation Criterion Based on Solidification Liquid Film Characteristic and Microstructure显示文摘Herein,a hot cracking initiation criterion based on the characteristics of solidification liquid film and the microstructure was proposed,which integrated both the mechanical and non-mechanical factors during solidification.The criterion also took the effect of the shrinkage volume of the solid-liquid two-phase in the mushy zone,the flow behavior of the liquid film and the microstructure on the feeding behavior into account.Meanwhile,the effect factors of hot cracking initiation such as alloy composition,microstructure,mold design and process condition were included in this criterion,and it could quantitatively calculate whether hot cracks occurred under a certain state or not during solidification.The criterion was utilized to predict whether hot cracks occurred in Al-4.0 wt%Cu alloy in different initial solidification states or not,which was consistent with the experimental results and verified its reliability.According to the criterion expression,Vfeeding*was related with five effect factors includingη,ΔP*,l*,r*and n,in which r*and n were in positive correlation with Vfeeding*whileη,ΔP*and l*were in negative correlation with that,which provided a good instructive significance for mold design,process optimization and composition and microstructure regulation of alloys and simultaneously further enriched the mechanism and influencing factors of hot cracking initiation.Furthermore,a multiscale simulation method for calculating the characteristic parameters of hot tearing behavior during solidification was also provided in this study. | Ming Su Wentao Zheng Chunyu Yue Bowen Zheng Xiaojiao Zuo Mengyuan He Xiaoguang Yuan | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，11： | 0 |
| 20 | Dt1 inhibits SWEET-mediated sucrose transport to regulate photoperiod-dependent seed weight in soybean显示文摘Soybean is a photoperiod-sensitive short-day crop whose reproductive period and yield are markedly affected by day-length changes.Seed weight is one of the key traits determining the soybean yield;how-ever,the prominent genes that control the final seed weight of soybean and the mechanisms underlying the photoperiod's effect on this trait remain poorly understood.In this study,we identify SwW19 as a major locus controlling soybean seed weight by QTL mapping and determine Dt1,an orthologous gene of Arabidopsis TFL1 that is known to govern the soybean growth habit,as the causal gene of the SW19 locus.We showed that Dt1 is highly expressed in developing seeds and regulates photoperiod-dependent seed weight in soybean.Further analyses revealed that the Dt1 protein physically interacts with the sucrose transporter GmSWEET10a to negatively regulate the import of sucrose from seed coat to the embryo,thus modulating seed weight under long days.However,Dt1 does not function in seed development under short days due to its very low expression.Importantly,we discovered a novel natural allelic variant of Dt1(H4 haplotype)that decouples its pleiotropic effects on seed size and growth habit;i.e.,this variant remains functional in seed development but fails to regulate the stem growth habit of soybean.Collectively,our findings provide new insights into how soybean seed development responds to photoperiod at different latitudes,offering an ideal genetic component for improving soybean's yield by manipulating its seed weightandgrowth habit. | Xiaoming Li Zhonghui Chen Haiyang Li Lin Yue Cuirong Tan Hongjie Liu Yilong Hu Yuhua Yang Xiani Yao Lingping Kong Xiang Huangi Bin Yu Chunyu Zhang Yuefeng Guan Baohui Liu Fanjiang Kong Xingliang Hou | 2024 | Molecular Plant2024，17，3： | 0 |
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