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| 1 | 多器官床旁即时超声在新型冠状病毒肺炎中的应用:国际专家共识显示文摘新型冠状病毒肺炎(简称新冠肺炎,COVID-19)自首次报道以来,已造成全球超一亿人感染,给各国的公共卫生体系造成了巨大威胁。新冠肺炎的临床表现以呼吸系统体征和症状为主,80%的患者症状轻微,约5%为危重症患者,常表现为急性呼吸窘迫综合征(ARDS)。前期,由于缺乏相关研究,面对日益紧迫的临床困境,医务人员不得不借鉴采取一些经验性措施以应对疫情。 | 王臻(译) Arif Hussain Gabriele Via Lawrence Melniker Alberto Goffi Guido Tavazzi Luca Neri Tomas Villen Richard Hoppmann Francesco Mojoli Vicki Noble Laurent Zieleskiewicz Pablo Blanco Irene W.Y.Ma Mahathar Abd.Wahab Abdulmohsen Alsaawi Majid AI Salamah Martin Balik Diego Barca Karim Bendjelid Belaid Bouhemad Pablo Bravo-Figueroa Raoul Breitkreutz Juan Calderon Jim Connolly Roberto Copetti Francesco Corradi Anthony J.Dean AndréDenault Deepak Govil Carmela Graci Young-Rock Ha Laura Hurtado Toru Kameda Michael Lanspa Christian B Laursen Francis Lee Rachel Liu Massimiliano Meineri Miguel Montorfano Peiman Nazerian Bret P.Nelson Aleksandar N.Neskovic Ramon Nogue Adi Osman JoséPazeli Elmo Pereira-Junior Tomislav Petrovic Emanuele Pivetta Jan Poelaert Susanna Price Gregor Prosen Shalim Rodriguez Philippe Rola Colin Royse Yale Tung Chen Mike Wells Adrian Wong Wang Xiaoting Wang Zhen Yaseen Arabi | 2021 | 中国呼吸与危重监护杂志2021，20，2： | 5 |
| 2 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 3 | Cabozantinib in Progressive Medullary Thyroid Cancer显示文摘 | Rossella Elisei Martin J. Schlumberger Stefan P. Müller Patrick Sch?ffski Marcia S. Brose Manisha H. Shah Lisa Licitra Barbara Jarzab Viktor Medvedev Michael C. Kreissl Bruno Niederle Ezra E.W. Cohen Lori J. Wirth Haythem Ali Colin Hessel Yifah Yaron Doug | 2013 | Journal of Clinical Oncology2013，，29： | 3 |
| 4 | The New Revised Classification of Acute Pancreatitis 2012显示文摘 | Michael G. Sarr Peter A. Banks Thomas L. Bollen Christos Dervenis Hein G. Gooszen Colin D. Johnson Gregory G. Tsiotos Santhi Swaroop Vege | 2013 | Surgical Clinics of North America2013，，3： | 3 |
| 5 | Pharmacological Activation of Liver X Receptors Promotes Reverse Cholesterol Transport In Vivo显示文摘 | Snehal U. Naik Xun Wang Jaqueline S. Da Silva Michael Jaye Colin H. Macphee Muredach P. Reilly Jeffrey T. Billheimer George H. Rothblat Daniel J. Rader | 2006 | Circulation2006，，： | 2 |
| 6 | A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study显示文摘 | Michael J. Proctor David S. Morrison Dinesh Talwar Steven M. Balmer Colin D. Fletcher Denis St.J. O’Reilly Alan K. Foulis Paul G. Horgan Donald C. McMillan | 2011 | European Journal of Cancer2011，，17： | 2 |
| 7 | Hemorheological abnormalities in lipoprotein lipase deficient mice with severe hypertriglyceridemia显示文摘 | Tieqiang Zhao Jun Guo Hui Li Wei Huang Xunde Xian Colin J.D. Ross Michael R. Hayden Zongyao Wen George Liu | 2006 | Biochemical and Biophysical Research Communications2006，，4： | 2 |
| 8 | Early Goal-Directed Sedation Versus Standard Sedation in Mechanically Ventilated Critically Ill Patients: A Pilot Study*显示文摘 | Yahya Shehabi Rinaldo Bellomo Michael C. Reade Michael Bailey Frances Bass Belinda Howe Colin McArthur Lynne Murray Ian M. Seppelt Steve Webb Leonie Weisbrodt | 2013 | Critical Care Medicine2013，，： | 2 |
| 9 | A modified silver staining protocol for visualization of proteins compatible with matrix‐assisted laser desorption/ionization and electrospray ionization‐ mass spectrometry显示文摘 | Jun X.Yan RobinWait TomBerkelman Rachel A.Harry Jules A.Westbrook Colin H.Wheeler Michael J.Dunn | 2000 | ELECTROPHORESIS2000，，17： | 2 |
| 10 | 船只排放物对欧洲空气质量及酸性沉降造成的影响显示文摘一个名为'STOCHEM'的三维拉氏化学传输模型被用于描述2000年气候条件下国际海运活动产生的SO_2、NO_x、VOCs和CO排放造成的欧洲大西洋沿岸区域性酸性沉降和臭氧空气质量影响的状况。该模型得出的从西南海域到不列颠群岛和布列塔尼水域国际海运活动产生的硫沉降总量高达200mg/m^2·a。夏季国际海运活动对表层臭氧浓度的影响在爱尔兰、布列塔尼和葡萄牙高达约6ppb。在欧洲,海运活动产生的排放物是一种对酸性沉降和臭氧空气质量造成影响的外部因素,并且如果要在将来达到严格的沉降及空气质量目标,就需要采取一系列控制措施。 | Richard G.Derwent David S.Stevenson Ruth M.Doherty William J.Collins Michael G.Sanderson Colin E.Johnson Janusz Cofala Reinhard Mechler Markus Amann Frank J.Dentener 许天虎 | 2005 | AMBIO-人类环境杂志2005，34，1： | 2 |
| 11 | The insulin receptor changes conformation in unforeseen ways on ligand binding:sharpening the picture of insulin receptor activation显示文摘 | Ward Colin W Menting John G Lawrence Michael C | 2013 | Bioessays2013，35，11： | 1 |
| 12 | Intramuscular Administration of AAV1-Lipoprotein LipaseS447X Lowers Triglycerides in Lipoprotein Lipase–Deficient Patients显示文摘 | Erik S. Stroes Melchior C. Nierman Janneke J. Meulenberg Remco Franssen Jaap Twisk C Pieter Henny Mario M. Maas Aeilko H. Zwinderman Colin Ross Eleonora Aronica Katherine A. High Marcel M. Levi Michael R. Hayden John J. Kastelein Jan Albert Kuivenhoven | 2008 | Arteriosclerosis Thrombosis and Vascular Biology2008，，12： | 1 |
| 13 | Mycotoxin analysis: An update显示文摘 | Rudolf Krska Patricia Schubert-Ullrich Alexandra Molinelli Michael Sulyok Susan MacDonald Colin Crews | 2008 | Food Additives & Contaminants: Part A2008，，2： | 1 |
| 14 | Femtosecond laser cataract surgery: technology and clinical practice显示文摘 | Timothy V Roberts Michael Lawless Colin CK Chan Mark Jacobs David Ng Shveta J Bali Chris Hodge Gerard Sutton | 2012 | Clinical & Experimental Ophthalmology2012，，2： | 1 |
| 15 | The Crystal Structure of a Truncated ErbB2 Ectodomain Reveals an Active Conformation, Poised to Interact with Other ErbB Receptors显示文摘 | Thomas P.J. Garrett Neil M. McKern Meizhen Lou Thomas C. Elleman Timothy E. Adams George O. Lovrecz Michael Kofler Robert N. Jorissen Edouard C. Nice Antony W. Burgess Colin W. Ward | 2003 | Molecular Cell2003，，2： | 1 |
| 16 | Production of Serum Immunoglubulins and T Cell Antigen Binding Molecules Specific for Cow'Milk Antigen in adults Intolerant to Cow 'milk显示文摘 | Colin H Georgy M Michael J | 1998 | Clin Immunol Immunopathol1998，89，2： | 1 |
| 17 | Softwaretransactional memory:why is it only a research toy 显示文摘 | Calin Cascava Blundell Colin Maged Michael | 2008 | CACM2008，51，11： | 1 |
| 18 | Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammationinduced secondary injury after CNS trauma 显示文摘 | Michael TF Catherine D Colin K | 1999 | J Neurosci1999，19，19： | 1 |
| 19 | CARD15 gene mutations and risk for early surgery in pediatric-onset Crohn’s disease显示文摘 | Subra Kugathasan Nicole Collins Karen Maresso Raymond G. Hoffmann Michael Stephens Steven L. Werlin Colin Rudolph Ulrich Broeckel | 2004 | Clinical Gastroenterology and Hepatology2004，，11： | 1 |
| 20 | Sensitive detection of HIV-1 resistance to Zidovudine and impact on treatment outcomes in low-to middle-income countries显示文摘Background:Thymidine analogs,namely AZT(Zidovudine or Retrovir^(TM))and d4T(Stavudine or Zerit^(TM))are antiretroviral drugs still employed in over 75%of first line combination antiretroviral therapy(cART)in Kampala,Uganda despite aversion to prescribing these drugs for cART in high income countries due in part to adverse events.For this study,we explored how the continued use of these thymidine analogs in cART could impact emergence of drug resistance and impact on future treatment success in Uganda,a low-income country.Methods:We examined the drug resistance genotypes by Sanger sequencing of 262 HIV-infected patients failing a first line combined antiretroviral treatment containing either AZT or d4T,which represents approximately 5%of the patients at the Joint Clinical Research Center receiving a AZT or d4T containing treatment.Next generation sequencing(DEEPGEN^(TM)HIV)and multiplex oligonucleotide ligation assays(AfriPOLA)were then performed on a subset of patient samples to detect low frequency drug resistant mutations.CD4 cell counts,viral RNA loads,and treatment changes were analyzed in a cohort of treatment success and failures.Results:Over 80%of patients failing first line AZT/d4T-containing cART had predicted drug resistance to 3TC(Lamivudine)and non-nucleoside RT inhibitors(NNRTIs)in the treatment regimen but only 45%had resistance AZT/d4T associated resistance mutations(TAMs).TAMs were however detected at low frequency within the patients HIV quasispecies(1-20%)in 21 of 34 individuals who were failing first-line AZT-containing cART and lacked TAMs by Sanger.Due to lack of TAMs by Sanger,AZT was typically maintained in second-line therapies and these patients had a low frequency of subsequent virologic success.Conclusions:Our findings suggest that continued use of AZT and d4T in first-line treatment in low-to-middle income countries may lead to misdiagnosis of HIV-1 drug resistance and possibly enhance a succession of second-and third-line treatment failures. | Richard M.Gibson Gabrielle Nickel Michael Crawford Fred Kyeyune Colin Venner Immaculate Nankya Eva Nabulime Emmanuel Ndashimye Art F.Y.Poon Robert A.Salata Cissy Kityo Peter Mugyenyi Miguel E.Quinones-Mateu Eric J.Arts | 2017 | Infectious Diseases of Poverty2017，6，1： | 1 |
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