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| 1 | Management of primary ciliary dyskinesia/Kartagener's syndrome in infertile male patients and current progress in defining the underlying genetic mechanism显示文摘Kartagener 的症候群(KS ) 是为主要睫的运动障碍(PCD ) 的约 50% 盒子的正染色体的后退的基因疾病财务。当它被许多复杂并发症伴随, PCD/KS 严重地影响病人生活的质量。为 PCD/KS 的治疗学的途径试图提高预防,便于快速的权威的诊断,避免错误诊断,维持活跃治疗,控制感染并且推迟损害的发展。在男病人,精子毛虫可以显示出缺陷在或完成转动的能力的缺席,它最终导致男不孕。帮助繁殖技术将当然有益于如此的病人。为有完全无法移动的精子的 PCD/KS 病人, intracytoplasmic 精子注射可能很重要、甚至不可缺少。就被识别的 PCD/KS 危险性基因和变化的数字而言,更广泛的基因屏蔽在有这些疾病的病人是不可缺少的。而且,进这些疾病的潜在的分子的机制的进一步的研究被要求。在这评论,我们在这疾病的各种各样的方面上总结可得到的信息以便描出治疗学的目的更清楚地,并且与 PCD/KS-associated 不孕为病人作为治疗的一个工具澄清帮助繁殖技术的功效。 | Yan-Wei Sha Lu Ding Ping Li | 2014 | Asian Journal of Andrology2014，16，1： | 16 |
| 2 | Genetic diversity of Tricholoma matsutake in Yunnan Province显示文摘To investigate the genetic diversity of Tricholoma matsutake,we studied ITS and IGS1 sequences and PCR polymorphism of a retrotransposon in 56 fruit bodies collected from 13 counties of 9 regions in Yunnan Province. We found one and three haplotypes based on ITS and IGS1 sequences,respectively. Moreover,there was no significant difference in PCR polymorphism of the retrotransposon among different populations. Compared with Jilin Province(China) and Japanese populations,although Yun-nan was highly homogenous to Japanese populations,low genetic diversity of T. matsutake in Yunnan did not support the view that this species originated from Yunnan. | SHA Tao ZHANG HanBo DING HuaSun LI ZongJu CHENG LiZhong ZHAO ZhiWei ZHANG YaPing | 2007 | Chinese Science Bulletin2007，52，9： | 8 |
| 3 | Nodeless pairing in superconducting copper-oxide monolayer films on BieSreCaCueO8+δ显示文摘 | Yong Zhong Yang Wang Sha Han Yan-Feng Lv Wen-Lin Wang Ding Zhang Hao Ding Yi-Min Zhang Lili Wang Ke He Ruidan Zhong John A. Schneeloch Gen-Da Gu Can-Li Song Xu-Cun Ma Qi-Kun Xue | 2016 | Science Bulletin2016，61，16： | 8 |
| 4 | Orthogonal design to sift the optimal parameter of Neiguan acupuncture for cerebral infarction显示文摘The individual difference and non-repeatability in acupuncture have not only restricted the development of acupuncture,but have also affected the specificity of acupoints.The present study used instruments to control needle depth,lifting and thrusting frequency,and the duration of acupuncture.Effects of the quantified acupuncture were observed at Neiguan(PC6)with different stimulation parameters.A frequency of 1,2,or 3 Hz and duration of 5,60,or 180 seconds were used to observe cerebral blood flow and ratio of infarct volume recovery.Results showed that stimulation at Neiguan with a frequency of 1 Hz and long duration of 180 seconds or 2/3 Hz and long duration of 5/60seconds significantly increased cerebral blood flow and decreased the ratio of infarct volume.Interactions between frequency and duration play a critical role in quantified acupuncture therapy. | Yanan Zhang Sha Yang Xiaonong Fan Shu Wang Nina He Lingxin Li Ding Luo Xuemin Shi | 2013 | Neural Regeneration Research2013，8，28： | 7 |
| 5 | A fully automatic registration approach based on contour and SIFT for HJ-1 images显示文摘To achieve a fully automatic registration between HJ-1 CCD images and HJ-1 infrared images is a difficult task as it must deal with the varying illuminations and resolutions of the images,different perspectives,and the local deformations within the images.In this paper,aimed at those registration issues,a fully automatic registration approach based on contour and SIFT is proposed.The registration technique performs a pre-registration process using contour feature matching algorithm that decides the overlapping region between a reference image and an input image.Once the coarse regions are obtained,it performs a fine registration process based on SIFT detector and a local adaptive matching strategy.In the fine registration process,image blocking theory is used,which not only speeds up the features extraction and matching,but also makes the matching point pairs distributed uniformly in images,and further improves the accuracy of input image rectification.Experiments with visible images and infrared images from HJ-1A/B demonstrate the efficiency and the accuracy of the proposed technique for multisource remote sensing images registration. | NI XiLiang CAO ChunXiang DING Lin JIANG Tao ZHANG Hao JIA HuiCong LI GuangHe ZHAO Jian CHEN Wei JI Wei XU Min GAO MengXu ZHENG Sheng TIAN Rong LIU Cheng LI Sha | 2012 | Science China Earth Sciences2012，55，10： | 5 |
| 6 | Genome sequences of five Sitopsis species of Aegilops and the origin of polyploid wheat B subgenome显示文摘Common wheat(Triticum aestivum,BBAADD)is a major staple food crop worldwide.The diploid progenitors of the A and D subgenomes have been unequivocally identified;that of B,however,remains ambiguous and controversial but is suspected to be related to species of Aegilops,section Sitopsis.Here,we report the assembly of chromosome-level genome sequences of all five Sitopsis species,namely Aegilops bicornis,Ae.longissima,Ae.searsii,Ae.sharonensis,and Ae.speltoides,as well as the partial assembly of the Amblyopyrum muticum(synonym Aegilops mutica)genome for phylogenetic analysis.Our results reveal that the donor of the common wheat B subgenome is a distinct,and most probably extinct,diploid species that diverged from an ancestral progenitor of the B lineage to which the still extant Ae.speltoides and Am.muticum belong.In addition,we identified interspecific genetic introgressions throughout the evolution of the Triticum/Aegilops species complex.The five Sitopsis species have various assembled genome sizes(4.11-5.89 Gb)with high proportions of repetitive sequences(85.99%-89.81%);nonetheless,they retain high collinearity with other genomes or subgenomes of species in the Triticum/Aegilops complex.Differences in genome size were primarily due to independent post-speciation amplification of transposons.We also identified a set of Sitopsis genes pertinent to important agronomic traits that can be harnessed for wheat breeding.These newly assembled genome resources provide a new roadmap for evolutionary and genetic studies of the Triticum/Aegilops complex,as well as for wheat improvement. | Lin-Feng Li Zhi-Bin Zhang Zhen-Hui Wang Ning Li Yan Sha Xin-Feng Wang Ning Ding Yang Li Jing Zhao Ying Wu Lei Gong Fabrizio Mafessoni Avraham A.Levy Bao Liu | 2022 | Molecular Plant2022，15，3： | 5 |
| 7 | Genetic factors contributing to human primary ciliary dyskinesia and male infertility显示文摘主要睫的运动障碍(PCD ) 是源于正常睫的功能的损失的正染色体后退的混乱。症状包括新生的呼吸悲痛,长期的窦炎, bronchiectasis,地点 inversus,和不孕。然而,仅仅 15 联系 PCD 的基因被识别了迄今为止引起男不孕。由于 PCD 的基因异质,全面分子的基因测试没被认为照顾的标准。这里,我们在与与男不孕联系的 PCD 有关的基因因素的鉴定上提供进步的更改,总结内在的分子的机制,并且讨论这些调查结果的临床的含意。这块地里的进一步的研究将为男不孕影响诊断策略,使临床医生能向病人提供通知基因建议,并且帮助为开发直接指向的个性化的药采用治疗的最好的功课。 | Zhi-Yong Ji Yan-Wei Sha Lu Ding Ping Li | 2017 | Asian Journal of Andrology2017，19，5： | 5 |
| 8 | The role of pineal microRNA-325 in regulating circadian rhythms after neonatal hypoxic-ischemic brain damage显示文摘Circadian rhythm disorder is a common,but often neglected,consequence of neonatal hypoxic-ischemic brain damage(HIBD).However,the underlying molecular mechanisms remain largely unknown.We previously showed that,in a rat model of HIBD,up-regulation of microRNA-325(miR-325)in the pineal gland is responsible for the suppression of Aanat,a key enzyme involved in melatonin synthesis and circadian rhythm regulation.To better understand the mechanism by which miR-325 affects circadian rhythms in neonates with HIBD,we compared clinical samples from neonates with HIBD and samples from healthy neonates recruited from the First Affiliated Hospital of Soochow University(Dushuhu Branch)in 2019.We found that circulating miR-325 levels correlated positively with the severity of sleep and circadian rhythm disorders in neonates with HIBD.Furthermore,a luciferase reporter gene assay revealed that LIM homeobox 3(LHX3)is a novel downstream target of miR-325.In addition,in miR-325 knock-down mice,the transcription factor LHX3 exhibited an miR-325-dependent circadian pattern of expression in the pineal gland.We established a neonatal mouse model of HIBD by performing doublelayer ligation of the left common carotid artery and exposing the pups to a low-oxygen environment for 2 hours.Lhx3 mRNA expression was significantly down-regulated in these mice and partially rescued in miR-325 knockout mice subjected to the same conditions.Finally,we showed that improvement in circadian rhythm-related behaviors in animals with HIBD was dependent on both miR-325 and LHX3.Taken together,our findings suggest that the miR-325-LHX3 axis is responsible for regulating circadian rhythms and provide novel insights into the identification of potential therapeutic targets for circadian rhythm disorders in patients with neonatal HIBD.The clinical trial was approved by Institutional Review Board of Children’s Hospital of Soochow University(approval No.2015028)on July 20,2015.Animal experiments were approved by Animal Care and Use Committee,School of Medicine,Soochow University,China(approval No.XD-2016-1)on January 15,2016. | Ning Sha Hua-Wei Wang Bin Sun Min Gong Po Miao Xiao-Lu Jiang Xiao-Feng Yang Mei Li Li-Xiao Xu Chen-Xi Feng Yuan-Yuan Yang Jie Zhang Wen-Jing Zhu Yuan-Yuan Gao Xing Feng Xin Ding | 2021 | Neural Regeneration Research2021，16，10： | 4 |
| 9 | Effects of long-term fertilization on oxidizable organic carbon fractions on the Loess Plateau,China显示文摘The effects of long-term fertilization on pools of soil organic carbon(SOC)have been well studied,but limited information is available on the oxidizable organic carbon(OOC)fractions,especially for the Loess Plateau in China.We evaluated the effects of a 15-year fertilization on the OOC fractions(F1,F2,F3 and F4)in the 0–20 and 20–40 cm soil layers in flat farmland under nine treatments(N(nitrogen,urea),P(phosphorus,monocalcium phosphate),M(organic fertilizer,composted sheep manure),N+P(NP),M+N(MN),M+P(MP),M+N+P(MNP),CK(control,no fertilizer)and bare land(BL,no crops or fertilizer)).SOC content increased more markedly in the treatment containing manure than in those with inorganic fertilizers alone.F1,F2,F4 and F3 accounted for 47%,27%,18% and 8% of total organic carbon,respectively.F1 was a more sensitive index than the other C fractions in the sensitivity index(SI)analysis.F1 and F2 were highly correlated with total nitrogen(TN)and available nitrogen(AN),F3 was negatively correlated with p H and F4 was correlated with TN.A cluster analysis showed that the treatments containing manure formed one group,and the other treatments formed another group,which indicated the different effects of fertilization on soil properties.Long-term fertilization with inorganic fertilizer increased the F4 fraction while manure fertilizer not only increased labile fractions(F1)in a short time,but also increased passive fraction(F4)over a longer term.The mixed fertilizer mainly affected F3 fraction.The study demonstrated that manure fertilizer was recommended to use in the farmland on the Loess Plateau for the long-term sustainability of agriculture. | DING Shaonan XUE Sha LIU Guobin | 2016 | Journal of Arid Land2016，8，4： | 4 |
| 10 | First successful pregnancy outcome after intracytoplasmic sperm injection with short-tailed sperm from an infertile Han Chinese man显示文摘 | Yan-Wei Sha Qing Zhang Lu Ding Ping Li | 2017 | Asian Journal of Andrology2017，19，5： | 3 |
| 11 | Preparation of New Cementitious System using Fly Ash and Dehydrated Autoclaved Aerated Concrete显示文摘We experimentally studied the interaction between pozzolanic material(fly ash) and dehydrated autoclaved aerated concrete(DAAC). The DAAC powder was obtained by grinding aerated concrete waste to particles fi ner than 75μm and was then heated to temperatures up to 900 ℃. New cementitious material was prepared by proportioning fly ash and DAAC, named as AF. X-ray diffraction(XRD) was employed to identify the crystalline phases of DAAC before and after rehydration. The hydration process of AF was analyzed by the heat of hydration and non-evaporable water content(Wn). The experimental results show that the highest reactivity of DAAC can be obtained by calcining the powder at 700 ℃ and the dehydrated products are mainly β-C2 S and CaO. The cumulative heat of hydration and Wn was found to be strongly dependent on the replacement level of fl y ash, increasing the replacement level of fl y ash lowered them in AF. The strength contribution rates on pozzolanic effect of fl y ash in AF are always negative, showing a contrary tendency of that of cement-fl y ash system. | 水中和 LU Jianxin TIAN Sufang SHEN Peiliang DING Sha | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，4： | 3 |
| 12 | Enhancement of strength-ductility balance of heavy Ti and Al alloyed FeCoNiCr high-entropy alloys via boron doping显示文摘As one of the most effective mechanisms,precipitation-hardening is widely used to strengthen high-entropy alloys.Yet,heavy precipitation-hardened high-entropy alloys usually exhibit serious embrittlement.How to effectively achieve ultra-high strength and maintain reliable ductility remains a challenge.Here,we report a study of doping extremely little boron to meet this target.We found that adding of 30 ppm boron into the heavy Ti and Al alloyed FCC FeCoNiCr high-entropy,(FeCoNiCr)_(88) Ti_(6) Al_(6) HEA(at.%)which is strengthened mainly by both coarse BCC-based(Ni,Co)_(2) TiAl Heusler and fine L12-type FCC-based(Ni,Co)_(3) TiAl precipitates and shows ultrahigh strength but poor ductility,could significantly change the original microstructure and consequently improve mechanical performance,owing to the well-known effect of boron on reducing the energy of grain boundaries.The boron addition can(1)eliminate microcavities formed at Heusler precipitate-matrix interfaces;(2)suppress the formation and segregation of coarse BCC Heusler precipitates;(3)promote the formation of L12 nanoparticles.This changes of microstructure substantially improve the tensile ductility more than by~86%and retain comparable or even better ultimate tensile strength.These findings may provide a simple and costless solution to produce heavy precipitation-strengthened HEAs with ultrahigh strength and prevent accidental brittleness. | Yongliang Qi Tinghui Cao Hongxiang Zong Yake Wu Lin He Xiangdong Ding Feng Jiang Shenbao Jin Gang Sha Jun Sun | 2021 | Journal of Materials Science & Technology2021，，16： | 2 |
| 13 | Taking the pulse of COVID-19:a spatiotemporal perspective显示文摘The sudden outbreak of the Coronavirus disease(COVID-19)swept across the world in early 2020,triggering the lockdowns of several billion people across many countries,including China,Spain,India,the U.K.,Italy,France,Germany,Brazil,Russia,and the U.S.The transmission of the virus accelerated rapidly with the most confirmed cases in the U.S.,India,Russia,and Brazil.In response to this national and global emergency,the NSF Spatiotemporal Innovation Center brought together a taskforce of international researchers and assembled implementation strategies to rapidly respond to this crisis,for supporting research,saving lives,and protecting the health of global citizens.This perspective paper presents our collective view on the global health emergency and our effort in collecting,analyzing,and sharing relevant data on global policy and government responses,human mobility,environmental impact,socioeconomical impact;in developing research capabilities and mitigation measures with global scientists,promoting collaborative research on outbreak dynamics,and reflecting on the dynamic responses from human societies. | Chaowei Yang Dexuan Sha Qian Liu Yun Li Hai Lan Weihe Wendy Guan Tao Hu Zhenlong Li Zhiran Zhang John Hoot Thompson Zifu Wang David Wong Shiyang Ruan Manzhu Yu Douglas Richardson Luyao Zhang Ruizhi Hou You Zhoua Cheng Zhong Yifei Tian Fayez Beaini Kyla Carte Colin Flynn Wei Liu Dieter Pfoser Shuming Bao Mei Li Haoyuan Zhang Chunbo Liu Jie Jiang Shihong Du Liang Zhao Mingyue Lu Lin Li Huan Zhou Andrew Ding | 2020 | International Journal of Digital Earth2020，13，10： | 2 |
| 14 | Globozoospermic infertility associated with balanced DPY19L2 translocation/gene deletion at the chromosomal breakpoint显示文摘 | Yan-Wei Sha Li-Bin Mei Liang-Kai Zheng Rui-Hua Tian Lu Ding Zhi-Yong Ji Qing Zhang Ping Li | 2018 | Asian Journal of Andrology2018，20，2： | 2 |
| 15 | Positioning taxonomic research for the future显示文摘Why do taxonomists matter? The work of taxonomists is often understated if not completely misunderstood. Without taxonomists, organisms cannot be accurately identified, neither can these organisms be given universally accepted names, and reliably positioned in the phylogenetic tree of life. Thanks to the work of taxonomists over the last 269 years since Carl Linnaeus established the binomial system, we can now measure the health and wealth of our biodiversity in a refined, science-based inventory prescribed by stringent nomenclatural rules. | Deyuan Hong Wenying Zhuang Min Zhu Keping Ma Xiaoquan Wang Dawei Huang Yalin Zhang Guodong Ren Wenjun Bu Wanzhi Cai Dong Ren Ding Yang Aiping Liang Fengyan Bai Runzhi Zhang Fumin Lei Shuqiang Li Hongzhi Kong Lei Cai Yucheng Dai Chaodong Zhu Qisen Yang Jun Chen Zhongli Sha Jianping Jiang Jing Che Donghui Wu Jiatang Li Qiang Wang Xinli Wei Ming Bai Xingyue Liu Xuexin Chen Gexia Qiao | 2022 | Zoological Systematics2022，47，3： | 2 |
| 16 | Platinum-crosslinking polymeric nanoparticle for synergetic chemoradiotherapy of nasopharyngeal carcinoma显示文摘Despite extensive use of radiotherapy in nasopharyngeal carcinoma(NPC)treatment because of its high radiosensitivity,there have been huge challenges in further improving therapeutic effect,meanwhile obviously reducing radiation damage.To this end,synergistic chemoradiotherapy has emerged as a potential strategy for highly effective NPC therapy.Here,we developed RGD-targeted platinum-based nanoparticles(RGD-PtNPs,denoted as RPNs)to achieve targeted chemoradiotherapy for NPC.Such nanoparticles consist of an RGD-conjugated shell and a cis-platinum(CDDP)crosslinking core.Taking advantage of RGD,the RPNs may effectively accumulate in tumor,penetrate into tumor tissues and be taken by cancer cells,giving rise to a high delivery efficiency of CDDP.When they are fully enriched in tumor sites,the CDDP loaded RPNs can act as radiotherapy sensitizer and chemotherapy agents.By means of X-ray-promoted tumor cell uptake of nanoparticle and CDDP-induced cell cycle arrest in radiation-sensitive G2/M phases,RPNs may offer remarkable therapeutic outcome in the synergistic chemoradiotherapy for NPC. | Yuxun Ding Xiaohui Xiao Lingli Zeng Qiuping Shang Wei Jiang Sha Xiong Xiaohui Duan Jun Shen Ruibing Wang Jinshan Guo Yue Pan | 2021 | Bioactive Materials2021，6，12： | 1 |
| 17 | Band-gap-tailored random laser显示文摘A band-gap-tailored random laser with a wide tunable range and low threshold through infrared radiation is demonstrated. When fluorescent dyes are doped into the liquid crystal and heavily doped chiral agent system,we demonstrate a wavelength tuning random laser instead of a side-band laser, which is caused by the combined effect of multi-scattering of liquid crystal(LC) and band-gap control. Through rotating the infrared absorbing material on the side of the LC cell, an adjustable range for random lasing of 80 nm by infrared light irradiation was observed. | HONGBO Lu JIAN XING CHENG WEI JIANGYING XIA JUNQING SHA YUNSHENG DING GUOBING ZHANG KANG XIE LONGZHEN QIU ZHIJIA Hu | 2018 | Photonics Research2018，6，5： | 1 |
| 18 | Evolutionary pattern of rDNA following polyploidy in Leymus (Triticeae:Poaceae)显示文摘 | Fan X Liu J Sha L N Sun G L Hu Z Q Zeng J Kang H Y Zhang H Q Wang Y Wang X L Zhang L Ding C B Yang R W Zheng Y L Zhou Y H | 2014 | Mo- lecular Phylogenetics and Evolution2014，77，： | 1 |
| 19 | Humanin peptides block calcium influx of rat hippocampal neurons by altering flbrogenesis of Abeta(1-40) 显示文摘 | Zou P Ding Y Sha Y | 2003 | Peptides2003，24，： | 1 |
| 20 | A minimally invasive anterior approach to reduction and screw fixation of coronoid fractures显示文摘 | Kang LQ Ding ZQ Sha M | 2010 | J Hand Surg Eur Vol2010，35，3： | 1 |
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