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| 1 | Carbonate-salt-based composite materials for medium- and high-temperature thermal energy storage显示文摘This paper discusses composite materials based on inorganic salts for medium- and high-temperature thermal energy storage application.The composites consist of a phase change material(PCM),a ceramic material,and a high thermal conductivity material.The ceramic material forms a microstructural skeleton for encapsulation of the PCM and structural stability of the composites;the high thermal conductivity material enhances the overall thermal conductivity of the composites.Using a eutectic salt of lithium and sodium carbonates as the PCM,magnesium oxide as the ceramic skeleton,and either graphite flakes or carbon nanotubes as the thermal conductivity enhancer,we produced composites with good physical and chemical stability and high thermal conductivity.We found that the wettability of the molten salt on the ceramic and carbon materials significantly affects the microstructure of the composites. | Zhiwei Ge Feng Ye Hui Cao Guanghui Leng Yue Qin Yulong Ding | 2014 | Particuology2014，12，4： | 19 |
| 2 | OsVPS9A Functions Cooperatively with OsRAB5A to Regulate Post-Golgi Dense Vesicle-Mediated Storage Protein Trafficking to the Protein Storage Vacuole in Rice Endosperm Cells显示文摘在米饭内乳房间, glutelins 作为 proglutelins 在不平的 endoplasmic 蜂窝胃上被综合并且被排序到称为蛋白质身体 II (PBII ) 的 theprotein 存储液泡(PSV ) ,在他们被变换成成熟形式的地方。稠密的泡(DV ) 调停了在大米种子的 proglutelins 的 trafficking 被建议了,但是这个过程的 post-Golgi 控制是 largelyunknown。DV 是否能与 PSV 直接熔化,是争论的另一件事。在这研究,我们建议规章的 mechanismunderlying 调停 DV, post-Golgi proglutelin trafficking 到 PBII (PSV ) 。gpa2, OsVPS9A 的 loss-of-function 异种,编码 OsRAB5A 的 GEF,积累了 uncleaved proglutelins。Proglutelins 对到沿着在 DV 形式的房间墙的 apoplast 的 paramural bodiesand 指向 mis,它在 PBII 尺寸导致了伴随物减小。Previouslyreported gpa1,在 OsRab5a 变异,有类似的显型,当时两倍异种加重了的 gpa1gpa2 条件。另外, OsVPS9A 在 vitro 并且在 vivo 与 OsRAB5A 交往了。我们断定 OsVPS9A 和 OsRAB5A 可以一起工作并且在调停 DV 的 post-Golgi proglutelintrafficking 起一个规章的作用到 PBII (PSV ) 。DV 可能直接熔化到 PBII (PSV ) 交付货物的证据也是 presented.Key 词: | Feng Liu Yulong Ren Yihua Wang Cheng Peng Kunneng Zhou Jia Lv Xiuping Guo Xin Zhang Jianmin wan Yiqun Bao | 2013 | Molecular Plant2013，6，6： | 16 |
| 3 | Wnt and BMP signaling crosstalk in regulating dental stem cells:Implications in dental tissue engineering显示文摘Tooth is a complex hard tissue organ and consists of multiple cell types that are regulated by important signaling pathways such as Wnt and BMP signaling.Serious injuries and/or loss of tooth or periodontal tissues may significantly impact aesthetic appearance,essential oral functions and the quality of life.Regenerative dentistry holds great promise in treating oral/dental disorders.The past decade has witnessed a rapid expansion of our understanding of the biological features of dental stem cells,along with the signaling mechanisms governing stem cell self-renewal and differentiation.In this review,we first summarize the biological characteristics of seven types of dental stem cells,including dental pulp stem cells,stem cells from apical papilla,stem cells from human exfoliated deciduous teeth,dental follicle precursor cells,periodontal ligament stem cells,alveolar bone-derived mesenchymal stem cells(MSCs),and MSCs from gingiva.We then focus on how these stem cells are regulated by bone morphogenetic protein(BMP)and/or Wnt signaling by examining the interplays between these pathways.Lastly,we analyze the current status of dental tissue engineering strategies that utilize oral/dental stem cells by harnessing the interplays between BMP and Wnt pathways.We also highlight the challenges that must be addressed before the dental stem cells may reach any clinical applications.Thus,we can expect to witness significant progresses to be made in regenerative dentistry in the coming decade. | Fugui Zhang Jinlin Song Hongmei Zhang Enyi Huang Dongzhe Song Viktor Tollemar Jing Wang Jinhua Wang Maryam Mohammed Qiang Wei Jiaming Fan Junyi Liao Yulong Zou Feng Liu Xue Hu Xiangyang Qu Liqun Chen Xinyi Yu Hue H.Luu Michael J.Lee Tong-Chuan He Ping Ji | 2016 | Genes & Diseases2016，3，4： | 16 |
| 4 | Multi-walled carbon nanotubes added to Na_2CO_3/MgO composites for thermal energy storage显示文摘Na_2CO_3/MgO composites with added multi-walled carbon nanotubes(MWCNTs) were prepared and tested as phase change materials(PCMs) for thermal energy storage.Na_2CO_3/MgO composite PCMs were prepared and their chemical compatibility and thermal stability were studied.MWCNTs introduced with Na_2CO_3/MgO composite PCMs were also investigated and scanning electron microscopy(SEM) characterization was used to demonstrate the uniform dispersion of MWCNTs in Na2C03/MgO composite PCMs.The composites with added MWCNTs still display good thermal stability with mass losses lower than 5%.Introducing MWCNTs into composite Na_2CO_3/MgO PCMs by material formation/calcination significantly enhances the thermal conductivity of the composite PCMs.The thermal conductivity of the composite PCMs was found to increase with an increase in the weight fraction of the added MWCNTs and an increase in the testing temperature.This study may present a promising way to prepare high temperature phase change materials with superior properties such as improved thermal stability. | Feng Ye Zhiwei Ge Yulong Ding Jun Yang | 2014 | Particuology2014，12，4： | 13 |
| 5 | Meningeal lymphatic vessels regulate brain tumor drainage and immunity显示文摘Recent studies have shown that meningeal lymphatic vessels(MLVs),which are located both dorsally and basally beneath the skull,provide a route for draining macromolecules and trafficking immune cells from the central nervous system(CNS)into cervical lymph nodes(CLNs),and thus represent a potential therapeutic target for treating neurodegenerative and neuroinflammatory diseases.However,the roles of MLVs in brain tumor drainage and immunity remain unexplored.Here we show that dorsal MLVs undergo extensive remodeling in mice with intracranial gliomas or metastatic melanomas.RNA-seq analysis of MLV endothelial cells revealed changes in the gene sets involved in lymphatic remodeling,fluid drainage,as well as inflammatory and immunological responses.Disruption of dorsal MLVs alone impaired intratumor fluid drainage and the dissemination of brain tumor cells to deep CLNs(dCLNs).Notably,the dendritic cell(DC)trafficking from intracranial tumor tissues to dCLNs decreased in mice with defective dorsal MLVs,and increased in mice with enhanced dorsal meningeal lymphangiogenesis.Strikingly,disruption of dorsal MLVs alone,without affecting basal MLVs or nasal LVs,significantly reduced the efficacy of combined anti-PD-1/CTLA-4 checkpoint therapy in striatal tumor models.Furthermore,mice bearing tumors overexpressing VEGF-C displayed a better response to anti-PD-1/CTLA-4 combination therapy,and this was abolished by CCL21/CCR7 blockade,suggesting that VEGF-C potentiates checkpoint therapy via the CCL21/CCR7 pathway.Together,the results of our study not only demonstrate the functional aspects of MLVs as classic lymphatic vasculature,but also highlight that they are essential in generating an efficient immune response against brain tumors. | Xueting Hu Qiuping Deng Lu Ma Qingqing Li Yidong Chen Yuhan Liao Fan Zhou Chen Zhang Linlin Shao Jun Feng Tubao He Weihai Ning Yan Kong Yingqing Huo Aibin He Bing Liu Jingjing Zhang Ralf Adams Yulong He Fuchou Tang Xiuwu Bian Jincai Luo | 2020 | Cell Research2020，30，3： | 11 |
| 6 | Noxious invasive Eupatorium adenophorum may be a moving target:Implications of the finding of a native natural enemy,Dorylus orientalis显示文摘Eupatorium adenophorum is a noxious invasive weed that is distributed throughout subtropical areas worldwide.Enemy release may be at least one of the reasons underlying its success as an invader.In this study,we observed damage to the epidermis,cortex,phloem,cambium,and xylem tissues of roots and stems around the root collar of E.adenophorum growing in an experimental field in Yunnan Province,southwest China.The damage was caused by Dorylus orientalis,a polyphagous ant feeding on the weed and resulted in the death of the plants by interrupting nutrient exchange between shoots and roots.This ant showed selectivity for the invader to some extent.The finding of D.orientalis and other native enemies indicate that E.adenophorum may gradually naturalize in introduced landscapes.In addition,this ant may have potential for use as a biocontrol agent against the invader. | NIU YanFen FENG YuLong XIE JianLei LUO FuCheng | 2010 | Chinese Science Bulletin2010，55，33： | 10 |
| 7 | Glutamate and aspartate alleviate testicular/epididymal oxidative stress by supporting antioxidant enzymes and immune defense systems in boars显示文摘Several potential oxidative agents have damaging effects on mammalian reproductive systems.This study was conducted to investigate the effects of glutamate(Glu)and aspartate(Asp)supplementation on antioxidant enzymes and immune defense systems in the outer scrotum of boars injected with H2O2.A total of 24 healthy boars were randomly divided into 4 treatment groups:control(basal diet,saline-treated),H2O2(basal diet,H2O2-challenged outer scrotum(1 m L kg^–1 BW)),Glu(basal diet+2%Glu,H2O2-challenged),and Asp(basal diet+2%Asp,H2O2-challenged).Our results showed that both Glu and Asp supplementation improved testicular morphology and decreased the genital index in the H2O2-treated boars.Glu and Asp administration increased the antioxidant enzyme activities and affected the testicular inflammatory cytokine secretion but had no effect on sex hormone levels.Furthermore,the m RNA expression of CAT,Cu Zn SOD,and GPx4 was altered in the testes and epididymis of boars treated with Asp and Glu.Glu and Asp supplementation also modulated the expression of TGF-β1,IL-10,TNF-α,IL-6 and IL-1βin the testis and epididymis.These results indicate that dietary Glu and Asp supplementation might enhance antioxidant capacity and regulate the secretion and expression of inflammatory cytokines to protect the testes and epididymis of boars against oxidative stress. | Wenjie Tang Jian Wu Shunshun Jin Liuqin He Qinlu Lin Feijun Luo Xingguo He Yanzhong Feng Binsheng He Pingping Bing Tiejun Li Yulong Yin | 2020 | Science China(Life Sciences)2020，63，1： | 9 |
| 8 | Highly expressed BMP9/GDF2 in postnatal mouse liver and lungs may account for its pleiotropic effects on stem cell differentiation,angiogenesis,tumor growth and metabolism显示文摘Bone morphogenetic protein 9(BMP9)(or GDF2)was originally identified from fetal mouse liver cDNA libraries.Emerging evidence indicates BMP9 exerts diverse and pleiotropic functions during postnatal development and in maintaining tissue homeostasis.However,the expression landscape of BMP9 signaling during development and/or in adult tissues remains to be analyzed.Here,we conducted a comprehensive analysis of the expression landscape of BMP9 and its signaling mediators in postnatal mice.By analyzing mouse ENCODE transcriptome datasets we found Bmp9 was highly expressed in the liver and detectable in embryonic brain,adult lungs and adult placenta.We next conducted a comprehensive qPCR analysis of RNAs isolated from major mouse tissues/organs at various ages.We found that Bmp9 was highly expressed in the liver and lung tissues of young adult mice,but decreased in older mice.Interestingly,Bmp9 was only expressed at low to modest levels in developing bones.BMP9-associated TGFβ/BMPR type I receptor Alk1 was highly expressed in the adult lungs.Furthermore,the feedback inhibitor Smads Smad6 and Smad7 were widely expressed in mouse postnatal tissues.However,the BMP signaling antagonist noggin was highly expressed in fat and heart in the older age groups,as well as in kidney,liver and lungs in a biphasic fashion.Thus,our findings indicate that the circulating BMP9 produced in liver and lungs may account for its pleiotropic effects on postnatal tissues/organs although possible roles of BMP9 signaling in liver and lungs remain to be fully understood. | Wei Liu Zhongliang Deng Zongyue Zeng Jiaming Fan Yixiao Feng Xi Wang Daigui Cao Bo Zhang Lijuan Yang Bin Liu Mikhail Pakvasa William Wagstaff Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Huiming Ding Yongtao Zhang Changchun Niu Rex C.Haydon Hue H.Luu Jennifer Moriatis Wolf Michael J.Lee Wei Huang Tong-Chuan He Yulong Zou | 2020 | Genes & Diseases2020，7，2： | 9 |
| 9 | Inductance calculation for 3D microsolenoids with single-layer coils显示文摘Three-dimensional(3D) single-layer microcoils have always been a key element for electromagnetic systems;but they lack an easy and accurate method to calculate the inductance value for their complex 3D micro-structures. This paper employed a curve-fitting process to obtain the associated equation for the inductance value and geometric parameters based on the simulation results. The correction factors regarding helical pitch and wire diameter were reviewed,which are used for compensation in the Nagaoka formula. The simulation process numerically simulated the performance of the 3D microcoils using a FEM electro-magnetic-coupled analysis method. Comparison of the simulated inductance value and the Nagaoka formula was undertaken,which shows that the helical pitch and wire diameter contribute a main role in the calculation error. The derived formula was expressed in a concise form to precisely calculate the inductance value of 3D microsolenoids with single-layer coils. | LIU Keyin YANG Qing CHEN Feng ZHAO Yulong MENG Xiangwei SHAN Chao LI Yanyang | 2014 | Instrumentation2014，1，2： | 6 |
| 10 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 11 | Effects of Exogenous Trehalose on the Metabolism of Sugar and Abscisic Acid in Tomato Seedlings Under Salt Stress显示文摘Salt stress a ects the growth and development of plants, which results in a decrease in crop quality and yield. In this study, we used tomato seedlings treated with salt and trehalose as experimental materials and analyzed them using the technique for order preference by similarity to ideal solution analysis to select the optimal trehalose concentration for treatment. We also determined the contents of sugar and abscisic acid (ABA) and detected the expression of genes involved in the metabolism of sugar and ABA by quantitative real-time PCR. Results showed that the optimal trehalose concentration was 2 mmol/L for tomato seedlings under salt stress. Exogenous trehalose decreased the starch content and increased the soluble sugar con- tent by a ecting the expression of genes related to the metabolism of starch and soluble sugar. Exogenous trehalose altered the accumulation and distribution of sugar by inducing the upregulation of sugar transporter genes. Furthermore, trehalose increased the ABA content to induce salt stress response by regulating the expression of genes related to the synthesis and metabolism of ABA. In conclusion, trehalose can e ectively alleviate salt stress and enhance salt tolerance of tomato. These ndings provide a novel perspective and a better resource to investigate the salt tolerance mechanism and a new method for alleviating salt stress in tomato. | Yanchun Feng Xiuyu Chen Yulong He Xiaohong Kou Zhaohui Xue | 2019 | Transactions of Tianjin University2019，25，5： | 4 |
| 12 | Three Tiaobu Feishen therapies protect human alveolar epithelial cells against cigarette smoking and tumor necrosis factor-mlear factor-kappa B pathwayα-induced inflamation by nuc显示文摘OBJECTIVE: To investigate the efficacy of Tiaobu Feishen formulae(TBFS), including Bufei Jianpi formula(BJF), Bufei Yishen formula(BYF), and Yiqi Zishen formula(YZF), on inflammatory response, protease-anti-protease imbalance and collagen deposition in rats.METHODS: In present work, we used an in vitro model of cigarette smoking extract(CSE)-and tumor necrosis factor-α(TNF-α)-induced A549 cellsto examine the efficacy of BJF, BYF and YZF on the production of inflammatory cytokines, including TNF-α and interleukin(IL)-8, IL-6, matrix metalloproteinases(MMP)-9, and IL-10 in CSE or TNF-ls. And their related transcripα-induced A549 celtion factors and signaling pathway were also analyzed.RESULTS: The results showed that BJF, BYF and YZF could significantly decrease the expression levels of the pro-inflammatory cytokines induced by CSE or TNF-α. Furthermore, BJF, BYF and YZF could suppress CSE-or TNF-α-induced activation of nuclear factor-kappa B(NF-κB) transcription factors and its corresponding pathways. Taken together, these data implied that BJF, BYF and YZF effectively inhibited CSE-or TNF-α-induced inflammatory response in alveolar epithelial cell, which was due to their inhibition effect on NF-κB pathways.CONCLUSION: Our findings suggest that the Tiaobu Feishen therapies may protect human alveolar epithelial cells against cigarette smoking and TNF-α-induced inflammation. NF-κB pathway may involve in the actions. | Chen Yulong Wu Yaosong Li Jiansheng Feng Suxiang Hao Lili Liu Xuefang Zheng Wanchun Dong Haoran Qin Yanqin Yin Sugai Zhao Peng | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 4 |
| 13 | Synthesis and Characterization of Disodium Hydrogen Phosphate Dodecahydrate-Lauric-Palmitic Acid Used for Indoor Energy Storage Floor Units显示文摘Organic and inorganic phase change materials(PCMs) are considered potential materials for thermal energy storage(TES) with different phase change characteristics. In this study, a novel organic-inorganic composite phase change material(PCM) called disodium hydrogen phosphate dodecahydrate-lauric-palmitic acid(D-LA-PACM) was prepared. Expanded graphite(EG) was selected as the support material, and the novel organic-inorganic form-stable PCM called D-LA-PAPCM/EG was prepared using the vacuum adsorption method. Differential scanning calorimetry, Fourier transform infrared spectroscopy, X-ray diffraction, leakage testing, melting and solidification cycle testing, thermal conductivity testing, scanning electron microscopy observation of the micromorphology, and other characterization methods were used to study the microstructure and morphology, thermal physical parameters, thermal conductivity, stability of the PCMs, and the comprehensive material properties of D-LA-PAPCM under the composite action of EG. Results indicated that the melting and freezing temperatures and latent heats of D-LA-PAPCM/EG were measured to be 31.6℃ and 34.3℃ and 142.9 and 142.8 J/g, respectively. Although some of the lauric-palmitic acid(LA-PA) and disodium hydrogen phosphate dodecahydrate(DHPD) separated in the multiple porous structures of EG after 1000 cycles, they could still absorb and release latent heats independently, with D-LA-PAPCM/EG still exhibiting good thermal stability. The thermal conductivity of D-LA-PAPCM/EG was 1.361 W/(m·K). Therefore, the material and thermal properties of the prepared D-LA-PAPCM/EG indicate that it could be well used as a feasible material for energy-saving phase change floor units in indoor TES systems. | XU Qian AKKURT Nevzat ZOU Zhenwei LIU Yang FENG Junxiao YU Chuqiao DING Chong XIONG Yaxuan ZHOU Jingzhi ZANG Yong DING Yulong | 2020 | Journal of Thermal Science2020，29，2： | 4 |
| 14 | New insights into eutrophication management:Importance of temperature and water residence time显示文摘Eutrophication and harmful cyanobacterial blooms threaten water resources all over the world.There is a great controversy about controlling only phosphorus or controlling both nitrogen and phosphorus in the management of lake eutrophication.The primary argument against the dual nutrients control of eutrophication is that nitrogen fixation can compensate the nitrogen deficits.Thus,it is of great necessary to study the factors that can significantly affect the nitrogen fixation.Due to the difference of climate and human influence,the water quality of different lakes(such as water temperature,N:P ratio and water residence time)is also quite different.Numerous studies have reported that the low N:P ratio can intensify the nitrogen fixation capacities.However,the effects of temperature and water residence time on the nitrogen fixation remain unclear.Thus,30 shallows freshwater lakes in the eastern plain of China were selected to measure dissolved N_(2) and Ar concentrations through N_(2):Ar method using a membrane inlet mass spectrometer to quantify the nitrogen fixation capacities and investigate whether the temperature and water residence time have a great impact on nitrogen fixation.The results have shown that the short lake water residence time can severely inhibit the nitrogen fixation capacities through inhibiting the growth of nitrogenfixing cyanobacteria,changing the N:P ratio and resuspending the solids from sediments.Similarly,lakes with low water temperature also have a low nitrogen fixation capacity,suggesting that controlling nitrogen in such lakes is feasible if the growth of cyanobacteria is limited by nitrogen. | Feng Zhao Xu Zhan Hai Xu Guangwei Zhu Wei Zou Mengyuan Zhu Lijuan Kang Yulong Guo Xingchen Zhao Zicong Wang Wei Tang | 2022 | Journal of Environmental Sciences2022，34，1： | 2 |
| 15 | Effects of T-S wave amplitude on the control of boundary layer transition by streaks显示文摘The effects of streaks on boundary layer transition depend on the initial amplitude of T-S waves introduced to excite the transition. This problem was studied in a flat-plate boundary layer in water tunnel by using hydrogen bubble method. Three T-S wave initial amplitudes were tested. The results show that both narrow and wide-spacing streaks depress the transition excited by T-S waves with lower initial amplitude. However, when transition is excited by T-S waves of higher initial amplitude, the narrow-spacing streaks depress the transition, while the wide-spacing streaks promote the transition. Further the underlying mechanisms were also analyzed. | Hui Guo Yulong Feng Haiwen Wang Ziteng Liu | 2013 | Theoretical & Applied Mechanics Letters2013，3，4： | 2 |
| 16 | Chicory polysaccharides alleviate high-fat diet-induced non-alcoholic fatty liver disease via alteration of lipid metabolism-and inflammation-related gene expression显示文摘Administration of chicory polysaccharides(CP) can modify lipid metabolism, improve dyslipidemia, and reduce liver inflammation, all of which may help alleviate non-alcoholic fatty liver disease(NAFLD). However, the underlying mechanisms remain unclear. This study aimed to gain further understanding of the potential molecular mechanisms that mediate the protective effects of CP against NAFLD via transcriptomic and metabolomic analyses. Hepatic RNA-sequencing analysis demonstrated that long-term intake of CP restored expression of lipid metabolism-related genes Xbp1, Insig2, and Cth in NAFLD rats, thereby inhibiting de novo lipogenesis. Moreover, CP consumption restored expression levels of genes involved in pro-inflammatory responses, such as Irf1. In addition, metabolic data confirmed that CP treatment increased levels of L-palmitoylcarnitine and hexadecanoyl-Co A, implying that CP administration can promote hepatic fatty acid β-oxidation. The present results demonstrate the underlying mechanisms of CP in high-fat dietinduced NAFLD rats and suggest that CP treatment might provide a dietary therapeutic tool for the treatment of NAFLD in humans. | Shengjie Li Yulong Wu Haitao Jiang Feng Zhou Ailing Ben Renlei Wang Chun Hua | 2022 | Food Science and Human Wellness2022，11，4： | 2 |
| 17 | Influence of oxygen content on the microstructure and mechanical properties of cold rolled Ti-32.5Nb-6.8Zr-2.7Sn-x O alloys after aging treatment显示文摘The influence of oxygen(O) content on the microstructure and mechanical properties of cold rolled Ti-32.5 Nb-6.8 Zr-2.7 Sn-xO(TNZS-xO; x = 0,0.3.0.6; mass%) alloys after aging at temperature range from 350 to 600℃ for 24 h was investigated. Results showed that the cold rolled TNZS-xO alloys possess single βphase. During the aging process, O could not only effectively suppress the precipitation of ω phase but also retard the formation and decomposition of a phase. In addition, the corresponding temperatures of the maximal volume fraction of α phase precipitation and the(α+β)/β transus temperatures of the TNZS-xO alloys were all increased with the increasing of O content. For mechanical properties, it was found that the strength and Young's modulus of the TNZS-xO alloys increased owing to the ω phase and/or a phase precipitation and decreased owing to the a phase decomposition. However, the elongation showed the opposite change tendency with the above mentioned strength. The mechanical properties of TNZS-xO alloys can be controlled over a wide range by subjecting to aging treatment and/or changing their 0 content. When aged at or below 450 ℃,the TNZS-xO alloys exhibit great potential to become a series of new candidates for biomedical applications since they possess high strength(870-1460 MPa), low Young's modulus(45.1-75.6 GPa), high strength-to-modulus ratio(0.018-0.02) and appropriate elongation(7.2%-14.9%), which are superior to those of Ti-6 Al-4 V alloy and suitable for the use as bio-implant materials. | Chunbo Lan Feng Chen Huijuan Chen Yulong Wu Xiangwei Wu | 2018 | Journal of Materials Science & Technology2018，34，11： | 2 |
| 18 | Recent diagnostic developments at the 100 kJ-level laser facility in China显示文摘A 100 kJ-level laser facility has been designed to study inertial confinement fusion physics in China.This facility incorporates various diagnostic techniques,including optical,x-ray imaging,x-ray spectrum,and fusion product diagnostics,as well as general diagnostics assistance systems and central control and data acquisition systems.This paper describes recent developments in diagnostics at the facility. | Feng Wang Shaoen Jiang Yongkun Ding Shenye Liu Jiamin Yang Sanwei Li Tianxuan Huang Zhurong Cao Zhenghua Yang Xin Hu Wenyong Miao Jiyan Zhang Zhebin Wang Guohong Yang Rongqing Yi Qi Tang Longyu Kuang Zhichao Li Dong Yang Yulong Li Xiaoshi Peng Kuan Ren Baohan Zhang | 2020 | Matter and Radiation at Extremes2020，5，3： | 2 |
| 19 | Epidemiological features of four human plague cases in the Inner Mongolia Autonomous Region, China in 2019显示文摘This study aims to investigate cases of human plague in the Inner Mongolia Autonomous Region (IMAR), China, and to inform the development of plague prevention and control strategies. On 12th of November 2019, two herdsmen from Sunitezuo Banner, Xilingol League were diagnosed with pneumonic plague in Beijing, China. On November 16th, one resident of Xianghuang Banner, Xilingol League was diagnosed with bubonic plague in Huade County Hospital, Ulanqab, China. On 27th of November, one resident of Siziwang Banner was diagnosed with bubonic plague. In total, 78 close contacts were monitored over a period, but none of them developed symptoms. Plague outbreaks in animals had been reported in Sunitezuo Banner, Xianghuang Banner, and Siziwang Banner in 2019. Two of the four cases were related (husband and wife), but not the other two. All the cases may be associated with contact with rodents (hare) or infected fleas. The cases highlight the importance of early identification of plague cases in humans in order to stop further infection. This demonstrates the value of monitoring and ongoing vigilance on endemic diseases, the importance of updating medical training and raising public awareness about infectious diseases that even have not been observed over decades. | Feng Yilan Fan Mengguang Gao Yulong Li Jianyun Zhang Dayu Wang Shuyi Wang Wenrui | 2020 | Biosafety and Health2020，2，1： | 2 |
| 20 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
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