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| 1 | Characteristics of Caragana korshinskii and Hippophae rhamnoides stemflow and their significance in soil moisture enhancement in Loess Plateau, China显示文摘Stemflow of xerophytic shrubs represents a significant component of water replenishment to the soil-root system and influences water utilization of plant roots at the stand scale,especially in water-scarce semi-arid ecosystems.The stemflow of two semi-arid shrubs(Caragana korshinskii and Hippophae rhamnoides)and its effect on soil moisture enhancement were evaluated during the growing season of 2011 in the semi-arid loess region of China.The results indicated that stemflow averaged 12.3%and 8.4%of the bulk precipitation for C.korshinskii and H.rhamnoides,respectively.Individual stemflow increased in a linear function with increasing rainfall depth.The relationship between funneling ratios and rainfall suggested that there existed a rainfall depth threshold of 11 mm for both C.korshinskii and H.rhamnoides.Averaged funneling ratios were 156.6±57.1 and49.5±30.8 for C.korshinskii and H.rhamnoides,respectively,indicating that the canopy architecture of the two shrubs was an effective funnel to channel stemflow to the root area,and C.korshinskii showed a greater potential to use stemflow water in the semi-arid conditions.For individual rainfall events,the wetting front depths were approximately 2 times deeper in the rooting zone around the stems than in the bare area outside canopy for both C.korshinskii and H.rhamnoides.Correspondingly,soil water content was also significantly higher in the root area around the shrub stem than in the area outside the shrub canopy.This confirms that shrub stemflow conserved in the deep soil layers may be an available moisture source for plant growth under semi-arid conditions. | ShengQi JIAN ChuanYan ZHAO ShuMin FANG Kai YU | 2014 | Journal of Arid Land2014，6，1： | 6 |
| 2 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 3 | Imine-Linked Covalent Organic Framework on Surface for Biosensor显示文摘Imine-linked covalent organic framework on amino functionalized silicon substrate was constructed via a step-wise reaction between 1,3,5-benzenetricarboxaldehyde and 1,4-diaminobenzene.The obtained material was used as biosensor for bovine serum albumin(BSA)adsorption and probe DNA immobilization,which extended the application of covalent organic frameworks(COFs)to a new field. | Peiyuan Wang Mengmeng Kang Shumin Sun Qiang Liu Zhihong Zhang Shaoming Fang | 2014 | Chinese Journal of Chemistry2014，32，9： | 3 |
| 4 | SRSF1 plays a critical role in invariant natural killer T cell development and function显示文摘Invariant natural killer T(iNKT)cells are highly conserved innate-like T lymphocytes that originate from CD4^(+)CD8^(+)double-positive(DP)thymocytes.Here,we report that serine/arginine splicing factor 1(SRSF1)intrinsically regulates iNKT cell development by directly targeting Myb and balancing the abundance of short and long isoforms.Conditional ablation of SRSF1 in DP cells led to a substantially diminished iNKT cell pool due to defects in proliferation,survival,and TCRαrearrangement.The transition from stage 0 to stage 1 of iNKT cells was substantially blocked,and the iNKT2 subset was notably diminished in SRSF1-deficient mice.SRSF1 deficiency resulted in aberrant expression of a series of regulators that are tightly correlated with iNKT cell development and iNKT2 differentiation,including Myb,PLZF,Gata3,ICOS,and CD5.In particular,we found that SRSF1 directly binds and regulates pre-mRNA alternative splicing of Myb and that the expression of the short isoform of Myb is substantially reduced in SRSF1-deficient DP and iNKT cells.Strikingly,ectopic expression of the Myb short isoform partially rectified the defects caused by ablation of SRSF1.Furthermore,we confirmed that the SRSF1-deficient mice exhibited resistance to acute liver injury uponα-GalCer and Con A induction.Our findings thus uncovered a previously unknown role of SRSF1 as an essential post-transcriptional regulator in iNKT cell development and functional differentiation,providing new clinical insights into iNKT-correlated disease. | Jingjing Liu Menghao You Yingpeng Yao Ce Ji Zhao Wang Fang Wang Di Wang Zhihong Qi Guotao Yu Zhen Sun Wenhui Guo Juanjuan Liu Shumin Li Yipeng Jin Tianyan Zhao Hai-Hui Xue Yuanchao Xue Shuyang Yu | 2021 | Cellular & Molecular Immunology2021，18，11： | 3 |
| 5 | Atmospheric Response to Mesoscale Ocean Eddies over the South China Sea显示文摘The South China Sea(SCS) is an eddy-active area. Composite analyses based on 438 mesoscale ocean eddies during 2000–2012 revealed the status of the atmospheric boundary layer is influenced remarkably by such eddies. The results showed cold-core cyclonic(warm-core anticyclonic) eddies tend to cool(warm) the overlying atmosphere and cause surface winds to decelerate(accelerate). More than 5% of the total variance of turbulent heat fluxes, surface wind speed and evaporation rate are induced by mesoscale eddies. Furthermore, mesoscale eddies locally affect the columnar water vapor, cloud liquid water, and rain rate. Dynamical analyses indicated that both variations of atmospheric boundary layer stability and sea level pressure are responsible for atmospheric anomalies over mesoscale eddies. To reveal further details about the mechanisms of atmospheric responses to mesoscale eddies, atmospheric manifestations over a pair of cold and warm eddies in the southwestern SCS were simulated. Eddy-induced heat flux anomalies lead to changes in atmospheric stability. Thus, anomalous turbulence kinetic energy and friction velocity arise over the eddy dipole, which reduce(enhance) the vertical momentum transport over the cold(warm) eddy, resulting in the decrease(increase) of sea surface wind. Diagnoses of the model's momentum balance suggested that wind speed anomalies directly over the eddy dipole are dominated by vertical mixing terms within the atmospheric boundary layer, while wind anomalies on the edges of eddies are produced by atmospheric pressure gradient forces and atmospheric horizontal advection terms. | Haoya LIU Weibiao LI Shumin CHEN Rong FANG Zhuo LI | 2018 | Advances in Atmospheric Sciences2018，35，9： | 2 |
| 6 | Association of PDE4D and IL-1 gene polymorphism with ischemic stroke in a Han Chinese population显示文摘 | Nan Li Zhiyi He Jialiang Xu Fang Liu Shumin Deng Hui Zhang | 2009 | Brain Research Bulletin2009，，1： | 1 |
| 7 | Oxygen permeation and electrical transport of Gd1-x PrxBaCo2O5+δ debse membranes显示文摘 | Yang Chunli Wu Xiusheng Fang Shumin | 2009 | Mater Lett2009，63，12： | 1 |
| 8 | Gentianine protects hippocampal neurons in a rat model of recurrent febrile convulsion显示文摘Gentianine has been shown to have a protective effect on hippocampal CA1 neurons in rats subjected to recurrent febrile convulsion(FC).The present study sought to explore the possible mechanism of gentianine by intraperitoneally injecting gentianine into rats with warm water-induced FC.The results revealed that neuronal organelle injury was slightly ameliorated in the hippocampal CA1 region.The level of glutamate was decreased,but the level of γ-aminobutyric acid was increased,as detected by ninhydrin staining.In addition,glutamate acid decarboxylase expression in hippocampal CA1 was increased,as determined by immunohistochemistry.The results demonstrated that gentianine can ameliorate FC-induced neuronal injury by enhancing glutamate acid decarboxylase activity,decreasing glutamate levels and increasing γ-aminobutyric acid levels. | Xuewei Liu Shumin Liu Na Wang Fang Lu Min Cao | 2011 | Neural Regeneration Research2011，6，15： | 1 |
| 9 | Variations in High-frequency Oscillations of Tropical Cyclones over the Western North Pacific显示文摘Variations in the high-frequency oscillations of tropical cyclones(TCs) over the western North Pacific(WNP) are studied in numerical model simulations. Power spectrum analysis of maximum wind speeds at 10 m(MWS_(10)) from an ensemble of15 simulated TCs shows that oscillations are significant for all TCs. The magnitudes of oscillations in MWS_(10) are similar in the WNP and South China Sea(SCS); however, the mean of the averaged significant periods in the SCS(1.93 h) is shorter than that in the open water of the WNP(2.83 h). The shorter period in the SCS is examined through an ensemble of simulations,and a case simulation as well as a sensitivity experiment in which the continent is replaced by ocean for Typhoon Hagupit(2008). The analysis of the convergence efficiency within the boundary layer suggests that the shorter periods in the SCS are possibly due to the stronger terrain effect, which intensifies convergence through greater friction. The enhanced convergence strengthens the disturbance of the gradient and thermal wind balances, and then contributes to the shorter oscillation periods in the SCS. | Shumin CHEN Weibiao LI Zhiping WEN Mingsen ZHOU Youyu LU Yu-Kun QIAN Haoya LIU Rong FANG | 2018 | Advances in Atmospheric Sciences2018，35，4： | 1 |
| 10 | A Comparative Study of Supervised Learning as Applied to Acronym Expansion in Clinical Repo 显示文摘 | Mou Shumin Wei Junping Liu Fang Wan Xiuzhi Cao Aimei Liu Yajun Wang Jia Chen Liang Liu Do | 2008 | Sichuan2008，，11： | 1 |
| 11 | A Comparative Study of Supervised Learning as Applied to Acronym Expansion in Clinical Repo显示文摘 | Mou Shumin Wei Junping Liu Fang | 2008 | Sichuan2008，，11： | 1 |
| 12 | Effects of different vegetation restoration on soil water storage and water balance in the Chinese Loess Plateau 显示文摘 | Jian Shengqi Zhao Chuanyan Fang Shumin | 2015 | Agricultural and Forest Meteorology2015，206，1： | 1 |
| 13 | in newly-diagnosed type 2 diabete spathogenesis and syndrome characteristics of tra- ditional Chinese medicine 显示文摘 | Mou Shumin Wei Junping Liu Fang | 2008 | Sichuan2008，，11： | 1 |
| 14 | Continuous wave operation of GaAsBi microdisk lasers at room temperature with large wavelengths ranging from 1.27 to 1.41 μm显示文摘Submicron-meter size GaAsBi disk resonators were fabricated with the GaAsBi/GaAs single-quantum-well(QW)-structure grown by molecular beam epitaxy. The GaAsBi/GaAs QW revealed very broad photoluminescence signals in the wavelength range of 1100–1400 nm at 300 K. The 750 nm diameter and 220 nm thick disk resonators were optically pumped and exhibited lasing characteristics with continuous wave operation at room temperature.To our knowledge, it is the first demonstration of a lasing wavelength longer than 1.3 μm with a maximum value of 1.4 μm in a GaAsBi/GaAs material system. The lasing wavelength spans about 130 nm by adjusting the disk diameter, covering almost the entire O band. The ultrasmall GaAsBi disk lasers may have great potential for highly dense on-chip integration with large tunability in the O band. | Xiu Liu Lijuan Wang Xuan Fang Taojie Zhou Guohong Xiang Boyuan Xiang Xueqing Chen Suikong Hark Hao Liang Shumin Wang Zhaoyu Zhang | 2019 | Photonics Research2019，7，5： | 1 |
| 15 | Function Analyses of Geographic Information System on Rural Distribution Network显示文摘With the actuality and characteristic and requirement of rural power enterprise distribution network management, this article introduced the function of geographic information system on the framework of distribution network, in order to develop rural distribution network. | FANG Junlong FAN Yongcun ZHANG Chunmei GU Shumin | 2006 | Journal of Northeast Agricultural University(English Edition)2006，13，2： | 0 |
| 16 | The influence of dihydropyridines calcium antagonists on 5-HT-induced intracellular calcium signal显示文摘Confocal laser scanning microscopy (CLSM) was applied to detect the intracellular [Ca2+] variety of fluorescent intension, with Fluo-3/AM fluorescence loaded in SFSMC. The results show that 10 μmol/L Lacidipine can reduce the frequence which 10 μmol/L 5-HT induced [Ca2+] spark in SFSMC of calcium over loading to 50%, and amplitude to 50% or so. We can draw a conclusion that dihydropyridines cal-cium antagonists lacidipine can antagonize the release of intracellular [Ca2+] which 5-HT-induced in dose dependent manner. | WANG ShuMin GUAN HuaShi FANG Yi MA Ping SUN JianZi LIU LiHong | 2007 | Science China Chemistry2007，50，4： | 0 |
| 17 | Interface stress around a nanosized spherical inhomogeneity under asymmetric dynamic loads显示文摘In the design and optimization of nanocomposites,the surface/interface stress arising at the inhomogeneity-matrix boundary plays an important role in determining the strength of structures.In this paper,the effect of surface/interface stress on the dynamic stress around a spherical inhomogeneity subjected to asymmetric dynamic loads is investigated.The surface/interface stress effects are taken into account by introducing Gurtin-Murdoch surface/interface elasticity model.The analytical solutions to displacement potentials are expressed by spherical wave function and associated Legendre function.The dynamic stress concentration factors around the spherical nano-inhomogeneity are illustrated and analyzed.The effects of the incident wave number,and the material properties of the interface and inhomogeneity on the dynamic stress around the inhomogeneity are examined. | FANG XueQian LIU JinXi ZHANG LeLe DUAN ShuMin | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，10： | 0 |
| 18 | A case of Gitelman syndrome with homozygous SLC12A3 deletion presenting with epilepsy显示文摘Background Gitelman syndrome(GS)is a rare autosomal recessive hereditary renal tubular disorder characterized by hypokalemia,metabolic alkalosis,hypomagnesemia,and hypocalciuria.Case presentation We report a rare case of GS with homozygous loss of SLC12A3 presenting with epilepsy.The patient was a 21-year-old female who sought medical attention for seizures.Her condition primarily manifested as epilepsy,diarrhea,and weakness of limbs.Through genetic analysis,we confirmed the diagnosis of this case and formulated a comprehensive approach for its management.Conclusions This case report extends the clinical symptoms of GS and provides a complete family of GS as a reference for subsequent studies. | Ying Wang Wenting Huang Jia Li Shumin Mao Wenqiang Fang Huiqin Xu | 2023 | Acta Epileptologica2023，6，4： | 0 |
| 19 | Neuroprotective effect of Eleutheroside B on 1-methyl-4-phenylpyridinium ion-induced apoptosis in PC12 cells显示文摘Apoptosis and viability of PC12 cells following 1-methyl-4-phenylpyridinium ion (MPP+)-induced injury were monitored by flow cytometry, following Annexin V-propidium iodide double labeling, and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, respectively. The release of lactate dehydrogenase, superoxide dismutase activity and levels of malondialdehyde were determined by UV spectrophotometry. The changes in mitochondrial membrane potential and the intracellular concentration of calcium were determined by flow cytometry, and the activity of caspase-3 was monitored by western blot. According to cell viability and apoptosis studies, MPP+-induced apoptosis in PC12 cells was inhibited in the presence of 10 μg/mL of Eleutheroside B. Our results indicate that the neuroprotective effect of Eleutheroside B, following MPP+-induced apoptosis in PC12 cells, involves increasing the anti-oxidative stress capacity of cells, maintaining the high-energy state of mitochondrial membrane potential, reducing intracellular calcium concentration and inhibiting caspase-3 activity. | Fang Lu Yang Dong Laijun Deng Shumin Liu Shihui Zhou Lifeng An Bo Tang | 2011 | Neural Regeneration Research2011，6，18： | 0 |
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