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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | LJbiquitin--Proteasome System in ABA Signaling: From Perception to Action显示文摘由 ubiquitination 的蛋白质 translational 以后修正(PTM ) 在工厂生长,开发,和压力回答的许多方面期间被观察了。ubiquitin-proteasome 系统精确调整植物激素由影响蛋白质活动,本地化,汇编,和相互作用能力发信号。Abscisic 酸(骆驼毛的织物) 是主要植物激素,并且在正常或强调的生长条件下面在植物起重要作用。表明小径的骆驼毛的织物由磷酸酶, kinases,抄写因素,和膜离子隧道组成。多重骆驼毛的织物发信号变换器被 ubiquitination 受到规定,这被报导了。特别地,最近的研究识别了 E3 ligases 的不同类型调停在不同房间分隔空间的骆驼毛的织物受体的 ubiquitination。这评论由发生在血浆膜的 monoubiquitination 或 polyubiquitination 集中于这些部件的调整, endomembranes,并且从 cytosol 到原子核;这暗示存在后退并且被 ubiquitination 在骆驼毛的织物发信号调整的 trafficking 过程。很多单个单位的 E3 ligases,多子单元 E3 ligases 的部件, E2s,和涉及骆驼毛的织物信号规定的 26S proteasome 的特定的子单元被讨论。把在 ABA 小径的 ubiquitination 的精确功能可以帮助我们在发信号 ubiquitination 和 PTM 的另外的类型调整的另外的植物激素理解关键因素。 | Feifei Yu Yaorong Wu Qi Xie | 2016 | Molecular Plant2016，9，1： | 18 |
| 3 | ESCRT-I Component VPS23A Affects ABA Signaling by Recognizing ABA Receptors for Endosomal Degradation显示文摘受体在过去的十年在植物科学成为了很重要的进展之一的 PYR/PYL/RCAR-type abscisic 酸(骆驼毛的织物) 的最近的发现。在哺乳动物,排序的 endosomal 充当一条重要小径到 downregulate 受体的不同类型,而是它在植物荷尔蒙发信号的角色糟糕被理解。这里,我们报导那 ubiquitin 象 E2 一样蛋白质, VPS23A,是 ESCRT-I 的一个关键部件,否定地调整骆驼毛的织物发信号。VPS23A 与 PYR/PYL/RCAR-type 骆驼毛的织物受体和提高的 VPS23A 的混乱有 epistatic 关系在在骆驼毛的织物处理下面表明小径的 ABA 的关键 kinase OST1 的活动。而且, VPS23A 与 PYR1/PYLs 交往,连接 K63 的 diubiquitin,和 PYL4 在 vivo 拥有连接 K63 的 ubiquitinated 修正。进一步的分析表明 VPS23A 影响 PYR1 和 PYL4 的稳定性的 subcellular 本地化。一起拿,我们的结果建议 VPS23A 经由调停液泡的降级影响 PYR1/PYL4,提供两个的先进理解在植物荷尔蒙发信号的骆驼毛的织物受体和 ESCRT 的周转。 | Feifei Yu Lijuan Lou Miaomiao Tian Qingliang Li Yanglin Ding Xiaoqiang Cao Yaorong Wu Borja Belda-Palazon Pedro L. Rodriguez Shuhua Yang Qi Xie | 2016 | Molecular Plant2016，9，12： | 17 |
| 4 | Allele-defined genome reveals biallelic differentiation during cassava evolution显示文摘Dear Editor,Generation of heterozygous genomes by hybridization between or within species can help maintain plant diversity and serve as a potential source of new species(Baek et al.,2018).Moreover,genomic heterozygosity is associated with genomic coadaptation,developmental stability,and heterosis.Accurate definition of alleles in haplotypes is necessary to precisely characterize allelic variation controlling agriculturally important traits(Shi et al.,2019).Currently,most released genomes have mosaic assembly of haplotypes due to random selection or collapse of alleles during genome assembly(Shi et al.,2019),which masked allelic variation and functional differentiation of divergent alleles in heterozygous species. | Wei Hu Changmian Ji Haitao shi Zhe Liang Zehong Ding Jianqiu Ye Wenjun Ou Gang Zhou Weiwei Tie Yan Yan Jinghao Yang Xiaoying Yang Yunxie Wei Zhiqiang Jin Jianghui Xie Ming Peng Wenquan Wang Anping Guo Biyu Xu Jianchun Guo Songbi Chen Liming Ma Mingcheng Wang Yang Zhou Xiaolong Li Ruoxi Li Siyi Guo Xinhui Xiao Zhongqing Wan Feifei An Jie Zhang Qingyun Leng Yin Li Ray Ming Kaimian Li | 2021 | Molecular Plant2021，14，6： | 8 |
| 5 | Accuracy Analysis of Low Altitude Photogrammetry with Wide-angle Camera显示文摘Firstly,the relationship between the accuracy of low altitude aerial photogrammetry and the field angle of camera is made by a quantitative analysis from the theory.The conclusion that the low altitude photogrammetry should use wide-angle camera as much as possible is done.Then,the limitation of the single lens camera to expand field angle and the combined wide-angle camera existing on the market not suitable for light load of low altitude UAV(Unmanned Aerial Vehicle)due to excessive weight are pointed out.The characteristics of combined wide-angle low altitude light camera with self-calibration and self-stabilization developed by the author are described,especially the principle of self-calibration for the combination of static error and dynamic error.Based on the practice of large scale mapping,a technical procedure in aerial photography by taking with wide-angle camera and large overlap simultaneously for improving the accuracy of low altitude photogrammetry is proposed.The typical engineering produced data is used to verity the above theoretical analysis.A technical route for increasing accuracy of low altitude photogrammetry with combined wide-angle camera is expounded. | Zongjian LIN Feifei XIE Guozhong SU | 2018 | Journal of Geodesy and Geoinformation Science2018，1，1： | 5 |
| 6 | ESCRT-I Component VPS23A Sustains Salt Tolerance by Strengthening the SOS Module in Arabidopsis显示文摘The Salt-Overly-Sensitive(SOS)signaling module,comprising the sodium-transport protein SOS1 and the regulatory proteins SOS2 and SOS3,is well known as the central salt excretion system,which helps protect plants against salt stress.Here we report that VPS23A,a component of the ESCRT(endosomal sorting complex required for transport),plays an essential role in the function of the SOS module in conferring plant salt tolerance.VPS23A enhances the interaction of SOS2 and SOS3.In the presence of salt stress,VPS23A positively regulates the redistribution of SOS2 to the plasma membrane,which then activates the antiporter activity of SOS1 to reduce Na+accumulation in plant cells.Genetic evidence demonstrated that plant salt tolerance achieved by the overexpression of SOS2 and SOS3 dependeds on VPS23A.Taken together,our results revealed that VPS23A is a crucial regulator of the SOS module and affects the localization of SOS2 to the cell membrane.Moreover,the strong salt tolerance of Arabidopsis seedlings conferred by the engineered membrane-bound SOS2 revealed the significance of SOS2 sorting to the cell membrane in achieving its function,providing a potential strategy for crop salt tolerance engineering. | Lijuan Lou Feifei Yu Miaomiao Tian Guangchao Liu Yaorong Wu Yujiao Wu Ran Xia Jose M.Pardo Yan Guo Qi Xie | 2020 | Molecular Plant2020，13，8： | 5 |
| 7 | ESCRT-I Component VPS23A Is Targeted by E3 Ubiquitin Ligase XBAT35 for Proteasome-Mediated Degradation in Modulating ABA Signaling显示文摘A myriad of abiotic stress responses in plants are controlled by abscisic acid(ABA)signaling.ABA receptors can be degraded by both the 26S proteasome pathway and vacuolar degradation pathway after processing via the endosomal sorting complex required for transport(ESCRT)proteins.Despite being essential for ABA signaling,the upstream regulators of ESCRTs remain unknown.Here,we report that the ESCRT-I component VPS23A is an unstable protein that is degraded via the ubiquitin-proteasome system(UPS).The UEV domain of VPS23A physically interacts with the two PSAP motifs of XBAT35,an E3 ubiquitin ligase,and this interaction results in the deposition of K48 polyubiquitin chains on VPS23A,marking it for degradation by 26S proteasomes.We showed that XBAT35 in plants is a positive regulator of ABA responses that acts via the VPS23A/PYL4 complex,specifically by accelerating VPS23A turnover and thereby increasing accumulation of the ABA receptor PYL4.This work deciphers how an ESCRT component is regulated in plants and deepens our understanding of plant stress responses by illustrating a mechanism whereby crosstalk between the UPS and endosome-vacuole-mediated degradation pathways controls ABA signaling. | Feifei Yu Xiaoqiang Cao Guangchao Liu Qian Wang Ran Xia Xiangyun Zhang Qi Xie | 2020 | Molecular Plant2020，13，11： | 4 |
| 8 | Synthesis and Photocatalytic Activity of Ti-pillared Bentonite显示文摘支柱 Ti 的火山灰成胶状黏土成功地用那能导致 TiO_2 支柱的转变从的一个修改方法被准备了对在低温度(150 deg C ) 的锐钛矿阶段非结晶。=1.94 nm 由支柱 Ti 的火山灰成胶状黏土获得了的 d_(001 ) 的价值比相应未加工的泥土(1.56 nm ) 的大。由于形成的大量 Ti 支柱,支柱 theTi 的火山灰成胶状黏土在吸附玫瑰精 B (RB ) 显示出一个优秀能力。photocatalyticactivity 和运动方程被在紫外照耀下面分解 RB 答案调查。支柱 Ti 的火山灰成胶状黏土显示出超级相片,这被发现为 RB 答案的降级的催化活动与未经治疗的火山灰成胶状黏土和纯 TiO_2 相比,并且 RB 答案的降级的运动方程是一个 1.5 颂诗方程。 | TANG Jianwen WU Pingxiao ZHENG Shaoyan LIU Yun WANG Feifei XIE Xianfa | 2006 | Acta Geologica Sinica(English Edition)2006，80，2： | 3 |
| 9 | Modeling of 3-D Air Traffic Complexity Based on Route Structure Constraints显示文摘It is an important issue to assess traffic situation complexity for air traffic management.There is a lack of systematic review of the existing air traffic complexity assessment methods,and there is no consideration of the role of airspace and traffic coordination mechanism.A new 3-D airspace complexity measurement method is proposed based on route structure constraints to evaluate the air traffic complexity objectively.Firstly,the model of the impact on horizontal and vertical direction for“aircraft pair”is established based on the route guidance.After that,the coupled complexity model for 3-D airspace is given according to the modification on the model in terms of flight standardization.Finally,the global model of the airspace traffic complexity is established.It is proved by the experimental data from the actual operation in airspace that the proposed model can reflect the space coupling situation and complexity of aircraft.At the same time,it can precisely describe the actual operation of civil aviation in China. | XIE Hua WU Zhe CHEN Feifei CHEN Haiyan | 2019 | Transactions of Nanjing University of Aeronautics and Astronautics2019，36，2： | 2 |
| 10 | 3D-assembled microneedle ion sensor-based wearable system for the transdermal monitoring of physiological ion fluctuations显示文摘Monitoring human health is of considerable significance in biomedicine.In particular,the ion concentrations in blood are important reference indicators related to many diseases.Microneedle array-based sensors have enabled promising breakthroughs in continuous health monitoring due to their minimally invasive nature.In this study,we developed a microneedle sensing-array integrated system to continuously detect subcutaneous ions to monitor human health status in real time based on a fabrication strategy for assembling planar microneedle sheets to form 3D microneedle arrays.The limitations of preparing 3D microneedle structures with multiple electrode channels were addressed by assembling planar microneedle sheets fabricated via laser micromachining;the challenges of modifying closely spaced microneedle tips into different functionalized types of electrodes were avoided.The microneedle sensing system was sufficiently sensitive for detecting real-time changes in Ca^(2+),K^(+),and Na^(+) concentrations,and it exhibited good detection performance.The in vivo results showed that the ion-sensing microneedle array successfully monitored the fluctuations in Ca^(2+),k^(+),and Na^(+) in the interstitial fluids of rats in real time.By using an integrated circuit design,we constructed the proposed microneedle sensor into a wearable integrated monitoring system.The integrated system could potentially provide information feedback for diseases related to physiological ion changes. | Xinshuo Huang Shantao Zheng Baoming Liang Mengyi He Feifei Wu Jingbo Yang Hui-jiuan Chen Xi Xie | 2023 | Microsystems & Nanoengineering2023，9，2： | 2 |
| 11 | Creation of fragrant sorghum by CRISPR/Cas9显示文摘Sorghum,the fifth largest cereal crop,has high value as a staple food and raw material for liquor and vinegar brewing.Due to its high biomass and quality,it is also used as the second most planted silage resource.No fragrant sorghums are currently on the market.Through CRISPR/Cas9-mediated knockout of Sb BADH2,we obtained sorghum lines with extraordinary aromatic smell in both seeds and leaves.Animal feeding experiments showed that fragrant sorghum leaves were attractable.We believe this advantage will produce great value in the sorghum market for both grain and whole biomass forage. | Dan Zhang Sanyuan Tang Peng Xie Dekai Yang Yaorong Wu Shujing Cheng Kai Du Peiyong Xin Jinfang Chu Feifei Yu Qi Xie | 2022 | Journal of Integrative Plant Biology2022，64，5： | 1 |
| 12 | Negative regulation of abscisic acid signaling by the Brassica oleracea ABI1 ortholog显示文摘 | Feifei Yuan Mengyao Wang Hongmei Hao Yanfeng Zhang Huixian Zhao Aiguang Guo Hong Xu Xiaona Zhou Chang Gen Xie | 2013 | Biochemical and Biophysical Research Communications (-)2013，，3： | 1 |
| 13 | Using pectin to separate talc and molybdenite through the surface modification with Cu^(2+):Applications and mechanism显示文摘Organic depressants have low selectivity in separating molybdenite and talc because their metal sites lack activity for organics chemisorption.In this study,surface modification by copper sulfate was used to induce the differential adsorption of pectin onto molybdenite and talc surfaces for enhanced flotation separation.Contact-angle experiments,scanning electron microscopy,adsorption measurements,timeof-flight secondary-ion mass spectrometry,and X-ray photoelectron spectroscopy analyses were conducted to reveal the interaction mechanism.Results illustrated that molybdenite and talc could not be separated using pectin alone,while molybdenite was selectively depressed after surface modification by copper sulfate and this effect was strengthened under alkaline conditions.Metal sites(Mg,Si and Mo)of talc and molybdenite themselves were unable to react with pectin,whereas Cu+would deposit and further function as active site for pectin chemisorption after surface modification.However,the quantity of deposited Cu sites dropped on talc surface and increased on molybdenite surface with increased pH,and the Mo atoms of molybdenite crystal were activated to take part in pectin chemisorption.Therefore,more pectin was adhered on molybdenite surface,which imparted molybdenite stronger wettability.Herein,surface-modification through metal ions can enable the differential adsorption of organic depressants and enhance the flotation separation of minerals. | Changtao Wang Qilin Zhai Runqing Liu Meirong Wu Wei Sun Nianwen Jing Feifei Xie | 2023 | International Journal of Mining Science and Technology2023，33，3： | 1 |
| 14 | Inhibition effect of procyanidins from lotus seedpod on mouse B16 melanoma in vivo and in vitro显示文摘 | Yuqing Duan Haihui Zhang Feifei Xu Bijun Xie Xianwen Yang Yong Wang Yongsheng Yan | 2010 | Food Chemistry2010，，1： | 1 |
| 15 | Reversal of cardiomyopathy in patients with congestive heart failure secondary to tachycardia显示文摘 | Zhao Donghua Peng Jian Xiao Zhongbo Zhang Feifei Peng Xinhui Yang Hao Liu Fuqiang Li Yan Xie Yong Huang Xinfu Meng Surong Wu Muli Xu Dingli | 2013 | Journal of Interventional Cardiac Electrophysiology2013，，： | 1 |
| 16 | Off/On Fluorescent Chemosensors for Organotin Halides Based on Binuclear Ruthenium Complexes显示文摘 | Yufen Niu Feifei Han Qian Zhang Tingwan Xie Liu Lu Shunhua Li Haiping Xia | 2013 | Angew Chem Int Ed2013，，21： | 1 |
| 17 | High Dynamic Range Compression and Detail Enhancement of Infrared Images in the Gradient Domain 显示文摘 | ZHANG Feifei XIE Wei MA Guorui | 2014 | Infrared Physics & Technology2014，67，11： | 1 |
| 18 | Molecular characterization of an ABA insensitive 5 orthologue in Brassica oleracea显示文摘 | Xiaona Zhou Feifei Yuan Mengyao Wang Aiguang Guo Yanfeng Zhang Chang Gen Xie | 2012 | Biochemical and Biophysical Research Communications2012，，： | 1 |
| 19 | Structural and photovoltaic properties of highly ordered ZnFe 2 O 4 nanotube arrays fabricated by a facile sol–gel template method显示文摘 | Feifei Liu Xinyong Li Qidong Zhao Yang Hou Xie Quan Guohua Chen | 2009 | Acta Materialia2009，，9： | 1 |
| 20 | Establishment and characterization of a new cell culture system for hepatitis B virus replication and infection显示文摘Hepatitis B virus(HBV)is a primary cause of chronic liver diseases in humans.HBV infection exhibits strict host and tissue tropism.HBV core promoter(Cp)drives transcription of pregenomic RNA(pg RNA)and plays a key role in the viral life cycle.Hepatocyte nuclear factor 4α(HNF4α)acts as a major transcriptional factor that stimulates Cp.In this work,we reported that BEL7404 cell line displayed a high efficiency of DNA transfection and high levels of HBV antigen expression after transfection of HBV replicons without prominent viral replication.The introduction of exogenous HNF4αand human sodium taurocholate cotransporting polypeptide(h NTCP)expression into BEL7404made it permissive for HBV replication and susceptible to HBV infection.BEL7404-derived cell lines with induced HBV permissiveness and susceptibility were constructed by stable co-transfection of h NTCP and Tet-inducible HNF4αfollowed by limiting dilution cloning.HBV replication in such cells was sensitive to inhibition by nucleotide analog tenofovir,while the infection was inhibited by HBV entry inhibitors.This cell culture system provides a new and additional tool for the study of HBV replication and infection as well as the characterization of antiviral agents. | Yingying Song Shuyu Shou Huimin Guo Zixiang Gao Nannan Liu Yang Yang Feifei Wang Qiang Deng Jing Liu Youhua Xie | 2022 | Virologica Sinica2022，37，4： | 1 |
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