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| 1 | Accumulation of soil organic carbon during natural restoration of desertified grassland in China's Horqin Sandy Land显示文摘China's Horqin Sandy Land,a formerly lush grassland,has experienced extensive desertification that caused considerable carbon(C) losses from the plant-soil system.Natural restoration through grazing exclusion is a widely suggested option to sequester C and to restore degraded land.In a desertified grassland,we investigated the C accumulation in the total and light fractions of the soil organic matter from 2005 to 2013 during natural restoration.To a depth of 20 cm,the light fraction organic carbon(LFOC) storage increased by 221 g C/m2(84%) and the total soil organic carbon(SOC) storage increased by 435 g C/m2(55%).The light fraction dry matter content represented a small proportion of the total soil mass(ranging from 0.74% in 2005 to 1.39% in 2013),but the proportion of total SOC storage accounted for by LFOC was remarkable(ranging from 33% to 40%).The C sequestration averaged 28 g C/(m2·a) for LFOC and 54 g C/(m2·a) for total SOC.The total SOC was strongly and significantly positively linearly related to the light fraction dry matter content and the proportions of fine sand and silt+clay.The light fraction organic matter played a major role in total SOC sequestration.Our results suggest that grazing exclusion can restore desertified grassland and has a high potential for sequestering SOC in the semiarid Horqin Sandy Land. | YuQiang LI XueYong ZHAO FengXia ZHANG Tala AWADA ShaoKun WANG HaLin ZHAO TongHui ZHANG YuLin LI | 2015 | Journal of Arid Land2015，7，3： | 21 |
| 2 | NARROW AND ROLLED LEAF 2 regulates leaf shape,male fertility, and seed size in rice显示文摘Grain yield in rice(Oryza sativa L.) is closely related to leaf and flower development. Coordinative regulation of leaf, pollen, and seed development in rice as a critical biological and agricultural question should be addressed. Here we identified two allelic rice mutants with narrow and semirolled leaves, named narrow and rolled leaf 2-1(nrl2-1) and nrl2-2. Map-based molecular cloning revealed that NRL2 encodes a novel protein with unknown biochemical function. The mutation of NRL2 caused pleiotropic effects, including a reduction in the number of longitudinal veins, defective abaxial sclerenchymatous cell differentiation, abnormal tapetum degeneration and microspore development, and the formation of more slender seeds compared with the wild type(WT). The NRL2 protein interacted with Rolling-leaf(RL14),causing the leaves of the nrl2 mutants to have a highercellulose content and lower lignin content than the WT, which may have been related to sclerenchymatous cell differentiation and tapetum degeneration. Thus, this gene is an essential developmental regulator controlling fundamental cellular and developmental processes, serving as a potential breeding target for high-yielding rice cultivars. | Shuangshuang Zhao Lei Zhao Fengxia Liu Yongzhen Wu Zuofeng Zhu Chuanqing Sun Lubin Tan | 2016 | Journal of Integrative Plant Biology2016，58，12： | 19 |
| 3 | Natural Variations at TIG1 Encoding a TCP Tran scription Factor Contribute to Plant Architecture Domestication in Rice显示文摘The modification of plant architecture is a crucial target in rice domestication and modern genetic improvement.Although several genes regulating rice plant architecture have been characterized,the molecular mechanisms underlying rice plant architecture domestication remain largely unclear.Here we show that the inclined tiller growth in wild rice is controlled by a single dominant gene,TILLER INCLINED GROWTH 1 (T/Gf),which is located on chromosome 8 and encodes a TCP transcriptional activator.TIG1 is primarily expressed in the adaxial side of the tiller base,promotes cell elongation,and enlarges the tiller angle in wild rice.Variations in the TIG1 promoter of indica cultivars {tig1 allele) resulted in decreased expression of TIG1 in the adaxial side of tiller base and reduced cell length and tiller angle,leading to the transition from inclined tiller growth in wild rice to erect tiller growth during rice domestication.TIG1 positively regulates the expression of EXP A3,EXPB5,and SAUR39 to promote cell elongation and increase the tiller angle.Selective sweep analysis revealed that the tig1 allele was selected in indica cultivars by human beings.The cloning and characterization of TIG1 supports a new scenario of plant architecture evolution in rice. | Weifeng Zhang Lubin Tan Hongying Sun Xinhui Zhao Fengxia Liu Hongwei Cai Yongcai Fu Xianyou Sun Ping Gu Zuofeng Zhu Chuanqing Sun | 2019 | Molecular Plant2019，12，8： | 13 |
| 4 | Recently duplicated sesterterpene(C25) gene clusters in Arabidopsis thaliana modulate root microbiota显示文摘Land plants co-speciate with a diversity of continually expanding plant specialized metabolites(PSMs) and root microbial communities(microbiota).Homeostatic interactions between plants and root microbiota are essential for plant survival in natural environments.A growing appreciation of microbiota for plant health is fuelling rapid advances in genetic mechanisms of controlling microbiota by host plants.PSMs have long been proposed to mediate plant and single microbe interactions.However,the effects of PSMs,especially those evolutionarily new PSMs,on root microbiota at community level remain to be elucidated.Here,we discovered sesterterpenes in Arabidopsis thaliana,produced by recently duplicated prenyltransferase-terpene synthase(PT-TPS) gene clusters,with neo-functionalization.A single-residue substitution played a critical role in the acquisition of sesterterpene synthase(sesterTPS) activity in Brassicaceae plants.Moreover,we found that the absence of two root-specific sesterterpenoids,with similar chemical structure,significantly affected root microbiota assembly in similar patterns.Our results not only demonstrate the sensitivity of plant microbiota to PSMs but also establish a complete framework of host plants to control root microbiota composition through evolutionarily dynamic PSMs. | Qingwen Chen Ting Jiang Yong-Xin Liu Haili Liu Tao Zhao Zhixi Liu Xiangchao Gan Asis Hallab Xuemei Wang Juan He Yihua Ma Fengxia Zhang Tao Jin M. Eric Schranz Yong Wang Yang Bai Guodong Wang | 2019 | Science China(Life Sciences)2019，62，7： | 11 |
| 5 | Flanking sequence determination and event-specific detection of genetically modified wheat B73-6-1显示文摘以便建立一个特定的鉴定方法因为遗传上修改了(美国通用汽车公司) 小麦,外长在外长的碎片和美国通用汽车公司小麦 B73-6-1 的 recombinant 染色体之间插入 DNA 和 flanking 顺序成功地借助于常规聚合酶链反应(PCR ) 被获得并且热不对称交叉(尾巴)-PCR 策略。最新获得的外长的碎片包括标记 uidA,除草剂抵抗的酒吧, ubiquitin 倡导者,和 high-molecular-weight 面筋子单元盖住象转变 plasmid 那样的转变基因和相应功能的基因的全身的顺序。flanking 顺序在之间插入高揭示的 DNA 有 Triticum turgidum 的类似基因(GenBank:AY494981.1 ) 。为美国通用汽车公司小麦 B73-6-1 的一个特定的 PCR 察觉方法根据根据 flanking 顺序设计的教材被建立。这个特定的 PCR 方法被美国通用汽车公司小麦,美国通用汽车公司玉米,美国通用汽车公司大豆,美国通用汽车公司米饭,和非美国通用汽车公司小麦验证。明确地放大的目标乐队仅仅在美国通用汽车公司小麦 B73-6-1 被观察。这个方法具有为美国通用汽车公司小麦 B73-6-1 的鉴定的高特性,高重制度,快速的鉴定,和优秀精确性。 | Junyi Xu Jijuan Cao Dongmei Cao Tongtong Zhao Xin Huang Piqiao Zhang Fengxia Luan | 2013 | Acta Biochimica et Biophysica Sinica2013，45，5： | 4 |
| 6 | Epidemiological characteristics and temporal-spatial analysis of overseas imported dengue fever cases in outbreak provinces of China, 2005–2019显示文摘Background Overseas imported dengue fever is an important factor in local outbreaks of this disease in the mainland of China.To better prevent and control such local outbreaks,the epidemiological characteristics and temporal-spatial distribution of overseas imported dengue fever cases in provincial-level administrative divisions(PLADs)where dengue fever is outbreak in the mainland of China were explored.Methods Using the Chinese National Notifiable Infectious Disease Reporting Information System(CNNDS),we identified overseas imported dengue fever cases in dengue fever outbreak areas in the mainland of China from 2005 to 2019 to draw the epidemic curve and population characteristic distribution of overseas imported cases in each PLAD.Based on spatial autocorrelation analysis of ArcGIS 10.5 and temporal-spatial scanning analysis of SaTScan 9.5,we analyzed the temporal-spatial distribution of overseas imported dengue fever in dengue fever outbreak areas in the mainland of China.Results A total of 11,407 imported cases,mainly from Southeast Asia,were recorded from 2005 to 2019 in these 13 PLADs.Of which 62.1%were imported into Yunnan and Guangdong Provinces.Among the imported cases,there were more males than females,mainly from the 21–50 age group.The hot spots were concentrated in parts of Yunnan,Guangdong and Fujian Provinces.We found the cluster of infected areas were expanding northward.Conclusions Based on the analysis of overseas imported dengue cases in 13 PLADs of the mainland of China from 2005 to 2019,we obtained the epidemiological characteristics and spatial distribution of imported dengue cases.Border controls need to pay attention to key population sectors,such as 21–50 years old men and education of key populations on dengue prevention.There is a need to improve the awareness of the prevention and control of imported cases in border areas.At the same time,northern regions cannot relax their vigilance. | Xinchang Lun Yiguan Wang Chunchun Zhao Haixia Wu Caiying Zhu Delong Ma Mingfang Xu Jun Wang Qiyong Liu Lei Xu Fengxia Meng | 2022 | Infectious Diseases of Poverty2022，11，1： | 3 |
| 7 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 8 | Facile synthesis of colloidal nitrogen-doped titanium carbide sheets with enhanced electrochemical performance显示文摘Heteroatom nitrogen doping in two-dimensional transition metal carbides,known as MXenes,has been considered as a promising strategy for modulating their electronic structure and electrochemical reactivity.While hightemperature annealing in the presence of a nitrogen source has been one popular method to introduce nitrogen,annealing exfoliated multilayered MXenes typically brings about incomplete delamination and the treatment of delaminated monolayer MXenes often leads to irreversible restacking.Here,starting from the typical carbide precursor,we developed an aqueous colloid containing monolayered nitrogen-doped titanium carbide sheets with excellent dispersity and stability.This achievement is critically dependent on the retaining of the hydrophilic surface of host layers during annealing treatment.The successful realization of nitrogen doping into individual MXene monolayers resulted in enhanced electrical conductivity and redox reactivity,for which the sample exhibited excellent capacitive electrochemical performance(586 F/g at a scan rate of 5mV/s)and cycling stability(capacitance retention of 96.2%after 104 cycles at 5 A/g).This paper presents a feasible and simple strategy for designing nitrogen-doped MXenes colloid,the realization of which promises its facile uses in liquid phase engineering techniques toward versatile applications. | Tianlun Qiu Guohui Li Yuanlong Shao Kun Jiang Fangfang Zhao Fengxia Geng | 2020 | Carbon Energy2020，2，4： | 2 |
| 9 | Defective arginine metabolism impairs mitochondrial homeostasis in Caenorhabditis elegans显示文摘Arginine catabolism involves enzyme-dependent reactions in both mitochondria and the cytosol,defects in which may lead to hyperargininemia,a devastating developmental disorder.It is largely unknown if defective arginine catabolism has any effects on mitochondria.Here we report that normal arginine catabolism is essential for mitochondrial homeostasis in Caenorhabditis elegans.Mutations of the arginase gene argn-1 lead to abnormal mitochondrial enlargement and reduced adenosine triphosphate(ATP)production in C elegans hypodermal cells.ARGN-1 localizes to mitochondria and its loss causes arginine accumulation,which disrupts mitochondrial dynamics.Heterologous expression of human ARGl or ARG2 rescued the mitochondrial defects of argn-1 mutants.Importantly,genetic inactivation of the mitochondrial basic amino acid transporter SLC-25A29 or the mitochondrial glutamate transporter SLC-25A18.1 fully suppressed the mitochondrial defects caused by argn-1 mutations.These findings suggest that mitochondrial damage probably contributes to the pathogenesis of hyperargininemia and provide clues for developing therapeutic treatments for hyperargininemia. | Ruofeng Tang Xin Wang Junxiang Zhou Fengxia Zhang Shan Zhao Qiwen Gan Liyuan Zhao Fengyang Wang Qian Zhang Jie Zhang Guodong Wang Chonglin Yang | 2020 | Journal of Genetics and Genomics2020，47，3： | 2 |
| 10 | A novel recombinant DNA vaccine encodingMycobacterium tuberculosis ESAT-6 and FL protects againstMycobacterium tuberculosis challenge in mice显示文摘Mycobacterium tuberculosis 6-kDa early secretory antigenic target(ESAT-6)is a dominant target antigen for cell-mediated immunity in the early phase of tuberculosis.The fms-like tyrosine kinase 3 ligand(FL)that induces potent immune response has been used as an adjuvant in vaccine development.In this study,a new recombinant plasmid(pIRES-epitope-peptides-FL)encoding three T cell epitopes of ESAT-6 and FL was constructed,and the immunogenicity of the DNA vaccine was assessed in C57BL/6 mice immunized with the plasmid DNA vaccine.Additionally,a strategy of intramuscular injection with the DNA vaccine(prime)and intranasal administration of the epitope peptides(boost)was employed to induce higher immune reaction of the mice.The results showed that mice vaccinated with the recombinant plasmid DNA vaccine and boosted with the peptides not only increased the levels of Th1 cytokines(IFN-γand IL-12),the number of IFN-γ+T cells and activities of cytotoxic T lymphocytes as well as IgG,but also enhanced protection against Mycobacterium tuberculosis challenge.In conclusion,these data indicate that the novel recombinant pIRES-epitope-peptides-FL plasmid is a useful DNA vaccine for preventing Mycobacterium tuberculosis infection. | Qingtao Jiang Jing Zhang Xia Chen Mei Xia Yanlai Lu Wen Qiu Ganzhu Feng Dan Zhao Yan Li Fengxia He Guangyong Peng Yingwei Wang | 2013 | The Journal of Biomedical Research2013，27，5： | 2 |
| 11 | Lipase-catalysed acidolysis of lard with caprylic acid to produce structured lipid显示文摘 | ZHAO Haizhen LU Zhaoxin LU Fengxia | 2006 | Inter- national Journal of Food Science and Technology2006，41，9： | 1 |
| 12 | Synthesis and characterisation of galactosyl glycerol by β-galactosidase catalysed reverse hydrolysis of galactose and glycerol显示文摘 | Wei Wei Danping Qi Hai-zhen Zhao Zhao-xin Lu Fengxia Lv Xiaomei Bie | 2013 | Food Chemistry2013，，3： | 1 |
| 13 | Opti- mized enzymatic synthesis of ascorbyl esters from lard using Novozym 435 inco - solventmixtures 显示文摘 | ZHAO Haizhen ZHANG Yu LU Fengxia | 2011 | J MolCatal B Enzym2011，69，3： | 1 |
| 14 | Improvement of precision for pendulous integrating gyro accelerometer via adaptive internal model control显示文摘An adaptive internal mode control is proposed to eliminate effectively periodic disturbance with uncertain frequency caused by input error angle of PIGA (Pendulous Integrating Gyro Accelerometer). An adaptive algorithm with periodic disturbance frequency identification on line is applied and the internal model controller parameters are adjusted to eliminate disturbance. Then the convergence of this algorithm and the stability of the system are proved by the averaging method. Simulation results verify the proposed scheme can eliminate periodic disturbance and improve the test precision for PIGA effectively. | Xu Fengxia Xia Gang Zeng Ming Sun Baoku Zhao Xuezeng | 2007 | Journal of Systems Engineering and Electronics2007，18，4： | 1 |
| 15 | Lipase-catalysed acidolysis of lard with caprylic acid to produce structured lipid显示文摘 | ZHAO Haizhen LU Zhaoxin LU Fengxia | | 0，，： | 1 |
| 16 | Proteomic analysis of berry-sizing effect of GAa on seedless Vitis vinifera L 显示文摘 | Wang Zeng Zhao Fengxia Zhao Xiao | 2012 | Proteomics2012，12，1： | 1 |
| 17 | Metabonomics study of liver cancer based on ultra performance liquid chromatography coupled to mass spectrometry with HILIC and RPLC separations显示文摘 | Jing Chen Wenzhao Wang Shen Lv Peiyuan Yin Xinjie Zhao Xin Lu Fengxia Zhang Guowang Xu | 2009 | Analytica Chimica Acta2009，，1： | 1 |
| 18 | Treadmill exercise promotes angiogenesis in the ischemic penumbra of rat brains through caveolin-1/VEGF signaling pathways显示文摘 | Yong Gao Yun Zhao Jingzi Pan Liu Yang Tingting Huang Xiaomin Feng Chao Li Shujing Liang Dingfu Zhou Chan Liu Fengxia Tu Cai Tao Xiang Chen | 2014 | Brain Research2014，，： | 1 |
| 19 | Sublytic C5b-9 triggers glomerular mesangial cell apoptosis in rat Thy-1 nephritis via Gadd45 activation mediated by Egr-1 and p300-dependent ATF3 acetylation显示文摘The apoptosis of glomerular mesangial cells(GMCs)is considered to be an important contributor to the initiation and development of rat Thy-1 nephritis(Thy-1N)and is accompanied by sublytic C5b-9 deposition.However,the mechanism by which sublytic C5b-9 triggers GMC apoptosis has not been elucidated.In this study,functional and histological examinations were performed on GMCs treated with sublytic C5b-9(in vitro)and renal tissues of Thy-1N rats(in vivo).The in vitro studies found that sublytic C5b-9 could trigger GMC apoptosis through upregulating Egr-1,ATF3,and Gadd45 expression.Egr-1-mediated post-transcriptional modulation of ATF3,Egr-1/ATF3-enhanced Gadd45 promoter activity,and p300-mediated ATF3 acetylation were all involved in GMC apoptosis.More importantly,the effective binding elements for Egr-1 and ATF3 to Gadd45β/γpromoters and the ATF3 acetylation site were identified.In vivo,silencing renal p300,Egr-1,ATF3,and Gadd45β/γsignificantly decreased GMC apoptosis,secondary GMC proliferation,and urinary protein secretion in Thy-1N rats.Together,these findings implicate that sublytic C5b-9-induced activation of Egr-1/p300–ATF3/Gadd45 axis plays a critical role in GMC apoptosis in Thy-1N rats. | Fengxia He Mengya Zhou Tianyi Yu Dan Zhao Jing Zhang Wen Qiu Yanlai Lu Yu Liu Lulu Wang Yingwei Wang | 2016 | Journal of Molecular Cell Biology2016，8，6： | 1 |
| 20 | Application of Grading of Recommendations Assessment, Development, and Evaluation (GRADE) to the guideline development for clinical practice with acupuncture and moxibustion显示文摘 | Hong Zhao Fengxia Liang Yigong Fang Baoyan Liu | 2017 | Frontiers of Medicine2017，11，4： | 1 |
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