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| 1 | Fields of applications,diagnostic yields and findings of OMOM capsule endoscopy in 2400 Chinese patients显示文摘AIM:To retrospectively analyze the fields of application,diagnostic yields and findings of OMOM capsule endoscopy in Chinese patients.METHODS:A database including 2400 Chinese patients who received OMOM capsule endoscopy in 27 endoscopy centers in China was retrieved from the Jianshan Science and Technology Ltd.OMOM capsule endoscopy database.The patient's age,gender,fields of application,the potentially relevant findings,pyloric transit time(PTT),small bowel transit time(SBTT),and complete small-bowel examination rate(CSER) were recorded and analyzed.RESULTS:Two thousand four hundred patients aged 9-91 years(mean,49 years),of whom 1510 were males(62.9%),underwent 2400 OMOM capsule endoscopy procedures.One thousand two hundred and thirty two(51.3%) were referred with obscure gastrointestinal bleeding(OGIB),642(26.8%) with abdominal pain,and 223(9.3%) with chronic diarrhea.The overall diagnostic yield was 47.7%(1144/2400).The diagnostic yield of OMOM capsule endoscopy in OGIB subgroup was much higher than in the non-OGIB subgroup(62.4% vs 32.1%,P<0.001).The most common findings of the small bowel in Chinese patients with OGIB were arteriovenous malformation(28.1%) and tumors(18.9%).There was no significant difference in the diagnostic yield between the male and female patients with OGIB.However,the diagnostic yield in patients aged more than 60 was higher than in patients aged less than 60(69.8% vs 58.9%,P<0.001).The median PTT was 41 min(range:1-544 min) and the mean SBTT was 247.2 ± 88.9 min.The overall CSER was 86.8%.CONCLUSION:The OMOM capsule endoscopy is a valuable tool for small bowel evaluation with good overall diagnostic yield and CSER. | Liao, Zhuan Gao, Rui Li, Feng Xu, Can Zhou, Yi Wang, Jin-Shan Li, Zhao-Shen | 2010 | World Journal of Gastroenterology2010，16，21： | 35 |
| 2 | Assessing environmental factors associated with regional schistosomiasis prevalence in Anhui Province,Peoples’Republic of China using a geographical detector method显示文摘Background:Schistosomiasis is a water-borne disease caused by trematode worms belonging to genus Schistosoma,which is prevalent most of the developing world.Transmission of the disease is usually associated with multiple biological characteristics and social factors but also factors can play a role.Few studies have assessed the exact and interactive influence of each factor promoting schistosomiasis transmission.Methods:We used a series of different detectors(i.e.,specific detector,risk detector,ecological detector and interaction detector)to evaluate separate and interactive effects of the environmental factors on schistosomiasis prevalence.Specifically,(i)specific detector quantifies the impact of a risk factor on an observed spatial disease pattern,which were ranked statistically by a value of Power of Determinate(PD)calculation;(ii)risk detector detects high risk areas of a disease on the condition that the study area is stratified by a potential risk factor;(iii)ecological detector explores whether a risk factor is more significant than another in controlling the spatial pattern of a disease;(iv)interaction detector probes whether two risk factors when taken together weaken or enhance one another,or whether they are independent in developing a disease.Infection data of schistosomiasis based on conventional surveys were obtained at the county level from the health authorities in Anhui Province,China and used in combination with information from Chinese weather stations and internationally available environmental data.Results:The specific detector identified various factors of potential importance as follows:Proximity to Yangtze River(0.322)>Land cover(0.285)>sunshine hours(0.256)>population density(0.109)>altitude(0.090)>the normalized different vegetation index(NDVI)(0.077)>land surface temperature at daytime(LST_(day))(0.007).The risk detector indicated that areas of schistosomiasis high risk were located within a buffer distance of 50 km from Yangtze River.The ecological detector disclosed that the factors investigated have significantly different effects.The interaction detector revealed that interaction between the factors enhanced their main effects in most cases.Conclusion:Proximity to Yangtze River had the strongest effect on schistosomiasis prevalence followed by land cover and sunshine hours,while the remaining factors had only weak influence.Interaction between factors played an even more important role in influencing schistosomiasis prevalence than each factor on its own.High risk regions influenced by strong interactions need to be targeted for disease control intervention. | Yi Hu Congcong Xia Shizhu Li Michael PWard Can Luo Fenghua Gao Qizhi Wang Shiqing Zhang Zhijie Zhang | 2017 | Infectious Diseases of Poverty2017，6，1： | 9 |
| 3 | Studies and advances on joint source-channel encoding/decoding techniques in flow media communications显示文摘Joint source-channel coding/decoding (JSCC/JSCD) techniques in flow media communications have become a state-of-the-art and one of the challenging research subjects in the spatial communication area. They have great application prospective and deep impact in various manned space flights, satellite missions, mobile radio communications and deep-space explorations. In the last few years, there have been influential achievements in JSCC/JSCD studies. This paper aims at an introduction to the basic principles of joint source-channel optimal design. A general summarization and classification for various existing JSCC/JSCD methods is addressed. Also presented is a JSCD scheme based on variable-length coding, capable of providing reliable resolutions for flow media data transmission in spatial communications. | TU GuoFang LIU JianJun ZHANG Can GAO ShaoShuai LI ShiDong | 2010 | Science China(Information Sciences)2010，53，1： | 8 |
| 4 | A Pilot Study of Quantitative Loop-mediated Isothermal Amplification-guided Target Therapies for Hospital-acquired Pneumonia显示文摘 | Fang Wang Ran Li Ying Shang Can Wang Guo-Qing Wang DeXun Zhou Dong-Hong Yang Wen Xi Ke-QiangWang Jing Bao Yu Kang Zhan-Cheng Gao | 2016 | Chinese Medical Journal2016，，2： | 5 |
| 5 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 6 | Quercetin attenuates the progression of monocrotaline-induced pulmonary hypertension in rats显示文摘Pulmonary arterial hypertension (PAH) is a progressive disease associated with increased constriction and remodeling of the pulmonary vasculature.Quercetin is a natural flavonoid and has a variety of pharmacological effects including improvement of endothelial cell function.However,its pharmacological effects on pulmonary hypertension have been rarely reported.We sought to observe the protective effect of quercetin in rats with monocrotaline induced PAH.We divided 30 male Sprague-Dawley rats randomly into three groups with ten rats in each group:the monocrotaline group,the quercetin group and the control group.We found that,compared with the controls,the mean pulmonary artery pressure (mPAP) and the right ventricular hypertrophy index in the monocrotaline group were significantly higher (P < 0.01).Quercetin caused a significant reduction both in the mPAP and right ventricular hypertrophy index compared with the monocrotaline group (P < 0.01) while no difference was found between the quercetin group and the control group (P > 0.05).Monocrotaline induced a marked increase in the wall thickness (WT) in small and mid-sized pulmonary arteries compared with the controls (P < 0.01).Monocrotaline also induced a marked increase in the wall area (WA) in small [(56.38±6.65)% in monocrotaline vs.(19.80±4.63)% in control] and mid-sized [(43.71±5.38)% in monocrotaline vs.(14.24±3.66)% in control] pulmonary arteries (P < 0.01).Quercetin treatment markedly reduced monocrotaline induced increase in both WT and WA (P < 0.01),which,however,still remained significantly elevated compared with those of the controls (P < 0.01).Furthermore,compared with controls,proliferating cell nuclear antigen (PCNA) expression in the pulmonary artery tissues was markedly increased by monocrotaline [(45.59±1.27) in monocrotaline vs.(9.64±0.69) in controls],which was significantly attenuated by quercetin.Our animal experiment indicated that quercetin could have protective effects on monocrotaline-induced PAH. | Hanhua Gao Can Chen Shi'an Huang Bo Li | 2012 | The Journal of Biomedical Research2012，26，2： | 4 |
| 7 | Hypoxia/oxidative stress alters the pharmacokinetics of CPU86017-RS through mitochondrial dysfunction and NADPH oxidase activation显示文摘 | Jie GAO Xuan-sheng DING Yu-mao ZHANG De-zai DAI Mei LIU Can ZHANG Yin DA | 2013 | Acta Pharmacologica Sinica2013，34，12： | 4 |
| 8 | Physical activity guidelines for Chinese children and adolescents:The next essential step显示文摘1.Introduction Because of the joint efforts of Active Healthy Kids Global Alliance,the results from the Global Matrix 2.0,involving 38countries,provide a timely insight into physical activity(PA)in children and adolescents worldwide.1All the 38 countries,including China,published a report card on 9 PA indicators.1,2Surprisingly,92%of the countries had average grades of C or | Jincheng Xu Can Gao | 2018 | Journal of Sport and Health Science2018，7，1： | 4 |
| 9 | Indications and detection, completion, and retention rates of small-bowel capsule endoscopy: a systematic review显示文摘 | Zhuan Liao Rui Gao Can Xu Zhao-Shen Li | 2010 | Gastrointestinal Endoscopy2010，，2： | 4 |
| 10 | Experiment and Numerical Simulation of Free Water Jet by a Central-body Nozzle显示文摘The recent research about cavitation jet mainly focuses on the organ-pipe nozzle and triangular nozzle.The research content mainly includes the optimized design about the structure of nozzles,the observation and flow analysis about the cavitation jet in the water,and the theory of rock attacked by the cavitation jet,while the energy characteristic of the free jet is not studied yet.In China,the research about the central-body nozzle is almost empty.For the purpose of studying the energy characteristic and the structure of free water jet discharged from central-body nozzle,an experiment with phase Doppler particle anemometry(PDPA) technology is carried out to measure the free water jet flow,which is produced by a central-body nozzle under the jet pressure of 15 MPa.While five sections with different axial distances from the nozzle outlet are selected for data process and analysis,the axial and radial velocity and the droplets of the particle size are studied.Meanwhile,numerical calculation of corresponding flow field is conducted by using volume of fluid(VOF) multiphase model,and the jet flow feature is discussed.The experimental and calculating results show that the axial velocity of high speed jet flow dissipates slowly in the air,and the core area and diffused area are discovered.The diameter of droplet in the core area is small,and jet energy is concentrated,while in the diffusion area,water is mingled with ambient air and radial velocity is relatively large.Obvious low-pressure area exists behind the central body and potential cavitation may occur in that area.The proposed research reveals the energy characteristic of free jet discharged from central-body nozzle,provides the theoretical basis for preestimating erosion feature of the central-body nozzle and also the theoretical foundation for revealing the mechanism of erosion. | YANG Minguan ZHANG Feng KANG Can GAO Bo | 2010 | Chinese Journal of Mechanical Engineering2010，23，6： | 3 |
| 11 | Optical fiber SPR biosensor complying with a 3D composite hyperbolic metamaterial and a graphene film显示文摘In the present study, an optical fiber surface plasmon resonance(SPR) biosensor was developed for measuring time-and concentration-dependent DNA hybridization kinetics. Its design complies with a 3D Au∕Al2O3 multilayer composite hyperbolic metamaterial(HMM), a graphene film, and a D-shaped plastic optical fiber.According to the numerical simulation and the experimental demonstration, the SPR peak of the designed biosensor can be effectively altered in the range of visible to near-infrared by varying the HMM structure. The sensitivity of the appliance was shown to achieve a value of up to 4461 nm/RIU, allowing its applicability for bulk refractive index sensing. Furthermore, a biosensor designed in this work displayed high-resolution capability(ranging from 10 pM to 100 nM), good linearity, and high repeatability along with a detection limit down to 10 pM, thus suggesting a vast potential for medical diagnostics and clinical applications. | Can Li Jinjuan Gao Muhammad Shafi Runcheng Liu Zhipeng Zha Dejun Feng Mei Liu Xuejian Du Weiwei Yue Shouzhen Jiang | 2021 | Photonics Research2021，9，3： | 3 |
| 12 | Identifi cation of national priority areas for adaptation to climate change in China显示文摘The problem of global warming has been identif ied as the f irst in the list of the top ten environmental prob-lems in the world.As climate change will seriously affect the social and natural world that people live in,so it may lay serious repercussions on economic progress,social improvement,and sustainable development.International bodies everywhere and many of the countries' governments are responding urgently to this call.In recent years,climate change has affected different regions in China in different ways.In its national agenda,the Chinese government should address the problem of climate change and its negative impact on socio-economic development.In this endeavor the nation should introduce policies which will help its people and economy to adapt to these effects and changes.Priorityf ields of adaptation to climate change are the sensitive areas or departments which are more vulnerable to the negative influences of climate change.The negative impacts of climate change in some parts of China are considered to be very serious indeed as they affect the whole economy and community.As a result,priority should be given to these more affected regions for the limited state f inancing.This paper def ines adaptation and discusses the basic principles and programs in the identif ication of national priority areas where adaptation should be exercised.Based on the past studies,four priority areas in China are identif ied,namely,disaster prevention and mitigation,water resources,agriculture,and ecosystem.An analysis on the identifi cation procedures,and the reasons and tasks involved are given for each. | Jiang Dongmei Wang Can Gao Fei Zhang Mengheng | 2008 | Ecological Economy2008，4，4： | 3 |
| 13 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 14 | Joint source channel VL coding/decoding for deep space communication networks based on a space trellis显示文摘This paper presents joint source channel variable length (VL) coding/decoding based on a space trellis.Through constructing a joint decoding plane trellis,better decoding performance can be achieved than by using the bit-level decoding algorithm.However,the plane trellis is complicated,which results in high decoding complexity for decoding VL turbo codes.To solve this problem,we construct a space trellis and design a low-complexity joint decoding algorithm with a variable length symbol-a posteriori probability (VLS-APP) algorithm in resource constrained deep space communication networks.Simulation results show that the proposed approach reduces the decoding complexity by 10% compared with the plane trellis,and the gain of Eb/N0 is about 0.2 dB at SER=10-4.Furthermore,it provides substantial error protection for variable-length encoded image data. | WU WeiRen TU Juan TU GuoFang GAO ShaoShuai ZHANG Can | 2011 | Science China(Information Sciences)2011，54，9： | 2 |
| 15 | 振兴中国足球:公共健康的机遇与挑战(英文)显示文摘Dear editor,In 2015,a national reform plan was implemented by the central government that covers not only professional clubs and leagues but also campus and grassroots football,to develop football(soccer)in China.1According to the plan of | Jincheng Xu Can Gao Jiexiu Zhao | 2016 | Journal of Sport and Health Science2016，5，2： | 2 |
| 16 | Effects of frustration on explosive synchronization显示文摘In this study, we consider the emergence of explosive synchronization in scale-free networks by con-sidering the Kuramoto model of coupled phase oscillators. The natural frequencies of oscillators areassumed to be correlated with their degrees and frustration is included in the system. This assumptioncan enhance or delay the explosive transition to synchronization. Interestingly, a de-synchronizationphenomenon occurs and the type of phase transition is also changed. Furthermore, we provide an ana-lytical treatment based on a star graph, which resembles that obtained in scale-free networks. Finally,a self-consistent approach is implemented to study the de-synchronization regime. Our findings haveimportant implications for controlling synchronization in complex networks because frustration is acontrollable parameter in experiments and a discontinuous abrupt phase transition is always dangerousin engineering in the real world. | Xia Huang Jian Gao Yu-Ting Sun Zhi-Gang Zheng Can Xu | 2016 | Frontiers of physics2016，11，6： | 2 |
| 17 | In-situ generation and global property profiling of metal nanoclusters by ultraviolet laser dissociation-mass spectrometry显示文摘Metal nanoclusters are promising nanomaterials with unique properties, but only a few ones with specific numbers of metal atoms can be obtained and studied up to now. In this study, we establish a new paradigm of in-situ generation and global study of metal nanoclusters with different sizes, constitutions, and charge states, including both accurate constitution characterization and global activity profiling. The complex mixtures of metal nanoclusters are produced by employing single-pulsed 193-nm laser dissociation of monolayer-protected cluster(MPC) precursors within a high-resolution mass spectrometry(HRMS). More than400 types of bare gold nanoclusters including novel multiply charged(2+ and 3+), S-/P-doped, and silver alloy ones can be efficiently generated and accurately characterized. A distinct size(1 to 142 atoms)-and charge(1+ to 3+)-hierarchy reactivity is clearly observed for the first time. This global cluster study might greatly promote the developments and applications of novel metal nanoclusters. | Zheyi Liu Zhaoxian Qin Chaonan Cui Zhixun Luo Bing Yang You Jiang Can Lai Zhipeng Wang Xiaolei Wang Xiang Fang Gao Li Fangjun Wang Chunlei Xiao Xueming Yang | 2022 | Science China Chemistry2022，65，6： | 2 |
| 18 | Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization显示文摘Tumor-associated macrophages(TAMs),one of the dominating constituents of tumor microenvironment,are important contributors to cancer progression and treatment resistance.Therefore,regulation of TAMs polarization from M2 phenotype towards M1 phenotype has emerged as a new strategy for tumor immunotherapy.Herein,we successfully initiated antitumor immunotherapy by inhibiting TAMs M2 polarization via autophagy intervention with polyethylene glycol-conjugated gold nanoparticles(PEG-Au NPs).PEG-Au NPs suppressed TAMs M2 polarization in both in vitro and in vivo models,elicited antitumor immunotherapy and inhibited subcutaneous tumor growth in mice.As demonstrated by the m RFP-GFP-LC3 assay and analyzing the autophagy-related proteins(LC3,beclin1 and P62),PEGAu NPs induced autophagic flux inhibition in TAMs,which is attributed to the PEG-Au NPs induced lysosome alkalization and membrane permeabilization.Besides,TAMs were prone to polarize towards M2phenotype following autophagy activation,whereas inhibition of autophagic flux could reduce the M2polarization of TAMs.Our results revealed a mechanism underlying PEG-Au NPs induced antitumor immunotherapy,where PEG-Au NPs reduce TAMs M2 polarization via induction of lysosome dysfunction and autophagic flux inhibition.This study elucidated the biological effects of nanomaterials on TAMs polarization and provided insight into harnessing the intrinsic immunomodulation capacity of nanomaterials for effective cancer treatment. | Siyue Zhang Fangyuan Xie Kaichun Li He Zhang You Yin Yuan Yu Guangzhao Lu Shihao Zhang Yan Wei Ke Xu Yan Wu Hong Jin Lan Xiao Leilei Bao Can Xu Yulin Li Ying Lu Jie Gao | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 2 |
| 19 | Indications and detection, completion, and retention rates of small-bowel capsule endoscopy: a systematic review显示文摘 | Zhuan Liao Rui Gao Can Xu Zhao-Shen Li | 2010 | Gastrointestinal Endoscopy2010，，2： | 2 |
| 20 | HYDROGEN TRANSFER IN CATALYTIC CRACKING显示文摘Hydrogen transfer is an important secondary reaction of catalytic cracking reactions, which affects product yield distribution and product quality. It is an exothermic reaction with low activation energy around 43.3 kJ/mol. Catalyst properties and operation parameters in catalytic cracking greatly influence the hydrogen transfer reaction. Satisfactory results are expected through careful selection of proper catalysts and operation conditions.Fluid catalytic cracking (FCC) is one of the major refining processes for converting vacuum distillates and residues into gas, high octane gasoline and diesel fuels over solid acidic catalysts. Cracking catalyst promotes cracking reactions, the reaction mechanism can be explained by carbonium ion theory [1] . Hydrogen transfer is a bimolecular reaction which requires two adjacent acid sites, where hydrogen usually transfers from a heavier hydrocarbon molecule to a lighter alkene molecule, the latter desorbs as an isoalkane molecule, and the former that donates hydrogen becomes more aromatic and finally coke [2] . Hydrogen transfer activity has long been recognized as relating to the acid site density of the catalyst. Thus the alkene content and composition of cracked naphtha and of product gas are expected to be adjusted by hydrogen transfer reaction occurred in FCC process. In this study, many factors affecting hydrogen transfer reaction, such as different kinds of zeolite catalysts used, reaction temperature, reaction time and coke deposit, were investigated. It will be helpful for the refiners to control proper extent of hydrogen transfer reaction in FCC process operation to adapt to different purposes and various options, such as maximizing gasoline yield, maximizing or minimizing olefins in gasoline, maximizing or minimizing gas olefins or iso olefins in product etc.. | GAO Yong can, ZHANG Jiu shun (Research Institute of Petroleum Processing, Beijing 100083, China) | 2001 | 石油学报(石油加工)2001，17，1： | 2 |
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