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| 1 | Size Distributions of Aerosol Sulfates and Nitrates in Beijing during the 2008 Olympic Games: Impacts of Pollution Control Measures and Regional Transport显示文摘为 2008 个奥运会,激烈的控制措施在二氧化物(SO2 ) ,氮氧化物(没有 x ) 和处理穷人的问题的另外的污染物质通风的硫的工业、城市的排出物上被实现在北京的质量。在微粒硫酸盐和硝酸盐集中以及他们的尺寸分布上调查 SO2 和没有 x 减小的效果,分离尺寸的喷雾器样品在照原尺寸的控制前后在北京在城市、顺风的农村地点用微孔的一致存款 impactors (MOUDI ) 被收集。在采样时期期间,在城市、农村的地点的好粒子(PM1.8 ) 的集体集中分别地是 94.0 和 85.9 g m3。超过 90% 硫酸盐和 60% 硝酸盐形成了同样好的粒子。得益于有益的气象学的条件和来源控制,硫酸盐在奥林匹克期间在相当低的集中并且首先在冷凝作用模式被观察。控制措施的效果独立被分析让北风和南方的 air-mass-dominated 天说明任何偏爱。在控制措施被实现以后,当在北方的空气群众占优势时,下午,硫酸盐,和硝酸盐显著地被减少,与在更大的粒子的减小的一个更高的百分比。在控制措施被实现以后,微滴模式粒子,在控制被实现以前,统治了硫酸盐和硝酸盐,显著地在集体集中被减少。但当弄脏的南方的空气群众占优势时,本地来源控制在北京测量,有效地没从北方中国平原由于庞大的地区性的贡献减少周围的硫酸盐集中。 | WANG Xinfeng WANG Tao Ravi Kant PATHAK Mattias HALLQUIST GAO Xiaomeit NIE Wei XUE Likun GAO Jian GAO Rui ZHANG Qingzhu WANG Wenxing WANG Shulan CHAI Fahe CHEN Yizhen | 2013 | Advances in Atmospheric Sciences2013，30，2： | 8 |
| 2 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 3 | Electrosorption behavior of cations with carbon nanotubes and carbon nanofibres composite film electrodes显示文摘 | Yang Gao Likun Pan HaiBo Li Yanping Zhang Zhejuan Zhang Yiwei Chen Zhuo Sun | 2008 | Thin Solid Films2008，，5： | 2 |
| 4 | Electrosorption of anions with carbon nanotube and nanofibre composite film electrodes显示文摘 | Likun Pan Xinzheng Wang Yang Gao Yanping Zhang Yiwei Chen Zhuo Sun | 2008 | Desalination2008，，1： | 2 |
| 5 | miR-24-3p promotes colon cancer progression by targeting ING1显示文摘Dear Editor,Activation or upregulation of oncogenes and/or loss of function or downregulation of tumour suppressors are central to the processes involved in the transformation from normal colonic mucosa to malignant tumours.Inhibitor of growth 1(ING1)has been functionally linked to cell cycle arrest,apoptosis and chromatin remodelling. | Zhiying Gao Likun Zhou Shiyu Hua Huan Wu Laizhi Luo Libo Li Shuping Wang Yanqing Liu Zhen Zhou Xi Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 6 | The effect of collagen hydrogels on chondrocyte behaviors through restricting the contraction of cell/hydrogel constructs显示文摘Collagen is a promising material for tissue engineering,but the poor mechanical properties of collagen hydrogels,which tend to cause contraction under the action of cellular activity,make its application challengeable.In this study,the amino group of type I collagen(Col I)was modified with methacrylic anhydride(MA)and the photo-crosslinkable methacrylate anhydride modified type I collagen(CM)with three different degrees of substitution(DS)was prepared.The physical properties of CM and Col I hydrogels were tested,including micromorphology,mechanical properties and degradation properties.The results showed that the storage modulus and degradation rate of hydrogels could be adjusted by changing the DS of CM.In vitro,chondrocytes were seeded into these four groups of hydrogels and subjected to fluorescein diacetate/propidium iodide(FDA/PI)staining,cell counting kit-8(CCK-8)test,histological staining and cartilage-related gene expression analysis.In vivo,these hydrogels encapsulating chondrocytes were implanted subcutaneously into nude mice,then histological staining and sulfated glycosaminoglycan(sGAG)/DNA assays were performed.The results demonstrated that contraction of hydrogels affected behaviors of chondrocytes,and CM hydrogels with suitable DS could resist contraction of hydrogels and promote the secretion of cartilage-specific matrix in vitro and in vivo. | Longpeng Dong Qingli Liu Yongli Gao Hengxing Jia Wenling Dai Likun Guo Hongsong Fan Yujiang Fan Xingdong Zhang | 2021 | Regenerative Biomaterials2021，8，4： | 2 |
| 7 | Preparation and Characterization of Ag_2S/PMMA Nanocomposites by Microemulsion显示文摘Ag_2S nanoparticles in polymethyl methacrylate(PMMA) are prepared in n-heptane/sodium bis(2-ethylhexyl)sulfosuccinate/water microemulsions.The Ag_2S nanoparticles dispersed in the polymer are characterized by FT-IR spectrum,UV-Vis absorption spectroscopy,transmission electron microscopy(TEM),and X-ray powder diffraction(XRD).The FT-IR spectrum shows that the composite has the characteristic bands of nano-Ag_2S and pure PMMA.The TEM photograph of the sample shows that the Ag_2S nanoparticles are elliptical.The phase structure of the composite is characterized by XRD,which reveals that Ag_2S particles are formed.The UV-Vis absorption recorded at various times indicates an initial rapid formation of the nanoparticles and the quantum confinement effect of Ag_2S nanoparticles. | Yuzhen Li Lizhen Gao Wenjun Chen Weike Zhang Lili Gao Yanqing Yang Likun Shang Meilu Wang | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，1： | 1 |
| 8 | Study on scandium separation from rare earth ore in Yunnan Province 显示文摘 | Zhang Zonghua Zhang Guifang Gao Likun | 2005 | Journal of Rare Earths2005，23，3： | 1 |
| 9 | Synthesis of photo-reactive poly(vinyl alcohol)and construction of scaffold-free cartilage like pellets in vitro显示文摘Photo-reactive poly(vinyl alcohol)(PRPVA)was synthesized by introduction of phenyl azido groups into poly(vinyl alcohol)(PVA)and applied for surface modification.PRPVA was grafted onto cell culture plate surface homogeneously or in a micropattern.Human mesenchymal stem cells(hMSCs)cultured on cell culture plate surface and PVA-modified surface showed different behaviors.Cells adhered and spread well on cell culture plate surface,while they did not adhere on PVA-grafted surface at all.When hMSCs were cultured on PVA-micropatterned surface,they formed a cell micropattern.Cells formed pellets after cultured on PVA homogeneously modified surface in chondrogenic induction medium for 2 weeks.The pellets were positively stained by hematoxylin/eosin,safranin-O/fast green and toluidin blue,and they were also stained brown by Type II collagen and proteoglycan immunohistological staining.Real-time PCR analysis was conducted to investigate the expression of colI,colII,colX,aggrecan and sox9 mRNA.Results of gene expression were in agreement with those of histological and immunohistological observations.These results indicated that hMSCs cultured on PVA-modified surface performed chondrogenic differentiation,and it was possible to construct scaffold-free cartilage like pellets with PVA-modified surface in vitro. | Bao Li Yongli Gao Likun Guo Yujiang Fan Naoki Kawazoe Hongsong Fan Xingdong Zhang Guoping Chen | 2018 | Regenerative Biomaterials2018，5，3： | 1 |
| 10 | 靶向肾癌中的E3连接酶接头蛋白SPOP的小分子抑制剂显示文摘近年来肾癌发病率上升幅度在恶性肿瘤中排名第一。临床治疗表明,肾癌对放疗和化疗均不敏感,以索拉非尼和舒尼替尼为代表的靶向抗肿瘤药物是晚期肾癌的一线治疗药物,但对转移性肾癌的疗效十分有限,并且容易产生耐药。因此,发现并确证治疗肾癌特异性药物作用新靶标是一项十分紧迫并意义重大的任务。 | Zhong-Qiang Guo Tong Zheng Baoen Chen Cheng Luo Sisheng Ouyang Shouzhe Gong Jiafei Li Liu-Liang Mao Fulin Lian Yong Yang Yue Huang Li Li Jing Lu Bidong Zhang Luming Zhou Hong Ding Zhiwei Gao Liqun Zhou Guoqiang Li Ran Zhou Ke Chen Jingqiu Liu Yi Wen Likun Gong Yuwen Ke Shang-Dong Yang Xiao-Bo Qiu Naixia Zhang Jin Ren Dafang Zhong 杨财广 刘江 蒋华良 | 2017 | 科学新闻2017，19，4： | 1 |
| 11 | Size-resolved aerosol ionic composition and secondary formation at Mount Heng in South Central China显示文摘理解解决尺寸的喷雾器在南方华中在上面的边界层影响第二等的喷雾器形成的离子的作文和因素,分离尺寸的喷雾器样品在在山 Heng ( 1269 m asl )的顶点的春天 2009 用微孔的一致存款 impactor ( MOUDI )被收集,由 13 个无机、器官的水溶性的离子的随后的实验室分析列在后面。在 non-dust-storm 时期期间,普通下午 < 潜水艇 class= “ a-plus-plus ” > 1.8 集中是 41.8 g?? | Xinfeng WANG Wenxing WANG Likun XUE Xiaomei GAO Wei NIE Yangchun YU Yang ZHOU Lingxiao YANG Qingzhu ZHANG Tao WANG | 2013 | Frontiers of Environmental Science & Engineering2013，7，6： | 1 |
| 12 | Semi-continuous measurement of water-soluble ions in PM 2.5 in Jinan, China: Temporal variations and source apportionments显示文摘 | Xiaomei Gao Lingxiao Yang Shuhui Cheng Rui Gao Yang Zhou Likun Xue Youping Shou Jing Wang Xinfeng Wang Wei Nie Pengju Xu Wenxing Wang | 2011 | Atmospheric Environment2011，，33： | 1 |
| 13 | In situ fabrication of 2D SnS2 nanosheets as a new electron transport layer for perovskite solar cells显示文摘To promote commercialization of perovskite solar cells (PSCs), low-temperatureprocessed electron transport layer (ETL) with high carrier mobility still needs tobe further developed. Here, we reported two-dimensional (2D) tin disulfide(SnS2) nanosheets as ETL in PSCs for the first time. The morphologies of the 2DSnS2 material can be easy controlled by the in situ synthesized method on theconductive fluorine-doped fin oxide (FTO) substrate. We achieved a championpower conversion efficiency (PCE) of 13.63%, with the short-circuit currentdensity (Jsc) of 23.70 mA/cm2 open-circuit voltage (Voc) of 0.95 V, and fill factor(FF) of 0.61. The high Jsc of PSCs results from effective electron collection ofthe 2D SnS2 nanosheets from perovskite layer and fast electron transport tothe FTO. The low Voc and FF are the results of the lower conduction band of 2DSnS2 (4.23 eV) than that of TiO2 (4.0 eV). These results demonstrate that 2Dmaterial is a promising candidate for ETL in PSCs. | Erling Zhao Liguo Gao Shuzhang Yang Likun Wang Junmei Cao Tingli Ma | 2018 | Nano Research2018，11，11： | 1 |
| 14 | Formation of secondary organic carbon and long-range transport of carbonaceous aerosols at Mount Heng in South China显示文摘 | Shengzhen Zhou Zhe Wang Rui Gao Likun Xue Chao Yuan Tao Wang Xiaomei Gao Xinfeng Wang Wei Nie Zheng Xu Qingzhu Zhang Wenxing Wang | 2012 | Atmospheric Environment2012，，： | 1 |
| 15 | Electrosorption of anions with carbon nanotube and nanofibre composite film electrodes显示文摘 | PAN Likun WANG Xinzheng GAO Yang | 2009 | Desalination2009，244，123： | 1 |
| 16 | Electrosorptive desalination by carbon nanotubes and nanofibres electrodes and ion-exchange membranes显示文摘 | Haibo Li Yang Gao Likun Pan Yanping Zhang Yiwei Chen Zhuo Sun | 2008 | Water Research2008，，20： | 1 |
| 17 | Formation of secondary organic carbon and cloud impact on carbonaceous aerosols at Mount Tai, North China显示文摘 | Zhe Wang Tao Wang Jia Guo Rui Gao Likun Xue Jiamin Zhang Yang Zhou Xuehua Zhou Qingzhu Zhang Wenxing Wang | 2011 | Atmospheric Environment2011，，： | 1 |
| 18 | Electrosorptive desalination by carbon nanotubes and nanofibres elec- trodes and ion-exchange membranes 显示文摘 | Li Haibo Gao Yang Pan Likun | 2008 | Water Re- search2008，42，： | 1 |
| 19 | Let There Be Light显示文摘THE express train of the Chinese economy can only keep going when its fuel tank is full. Like any part of the world, China depends heavily on electricity. In China’s case its power supply comes primarily from coal-burning power stations. With a tremendous trove of the flammable black rock, Shanxi Province in north China is traditionally the locomotive of the nation’s power industry. During an inspection of the province in July 2005, President Hu Jintao commented: 'As a major coal producer, Shanxi should take advantage of its | GAO YAN LI LIKUN | 2008 | China Today2008，57，3： | 0 |
| 20 | Detector development at the Back-n white neutron source显示文摘Purpose Back-n is a white neutron beamline at China spallation neutron source,which was established in the year of 2018.It is a powerful facility for nuclear data measurement,neutron detector calibration,and radiation effect research.Method A series of detectors were built for different experiments,including beam monitoring,beam profile measurement,neutron induced secondaries(fission fragments,light charged particles and gamma)cross section measurement,and neutron resonance radiography,etc.A common digitization electronics and a cluster-based DAQ were developed for these detector systems.Most detectors have been employed at Back-n and serviced for experiments from the beginning of the beamline running.Results and conclusion As an overview of detectors of Back-n,the details of the detector design and the experiment performing are described in this paper.Some developing systems,e.g.,MTPC and B-MCP,are also included. | Fan Ruirui Li Qiang Bao Jie Li Yang Liu Rong Jiang Wei Ren Jie Zhang Qiwei Cao Ping Gu Minhao Ren Zhizhou Yi Han Tang Jingyu An Qi Bai Haofan Bai Jiangbo Chen Qiping Chen Yonghao Chen Zhen Cui Zengqi Fan Anchuan Feng Changqing Feng Fanzhen Gao Keqing Han Changcai Han Zijie He Guozhu He Yongcheng Hong Yang Hu Yiwei Huang Hanxiong Jia Weihua Jiang Haoyu Jiang Zhijie Jin Zhengyao Kang Ling Li Bo Li Chao Li Gong Li Jiawen Li Xiao Liu Jie Liu Shubin Luan Guangyuan Ning Changjun Qi Binbin Ruan Xichao Song Zhaohui Sun Kang Tan Zhixin Tang Shengda Wang Pengcheng Wang Zhaohui Wen Zhongwei Wu Xiaoguang Wu Xuan Xie Likun Yang Yiwei Yu Yongji Zhang Guohui Zhang Linhao Zhang Mohan Zhang Xianpeng Zhang Yuliang Zhang Yue Zhang Zhiyong Zhao Maoyuan Zhou Luping Zhou Zhihao Zhu Kejun The CSNS Back-n Collaboration | 2023 | Radiation Detection Technology and Methods2023，7，2： | 0 |
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