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| 1 | A Rare Allele of GS2 Enhances Grain Size anc Grain Yield in Rice显示文摘谷物尺寸决定谷物重量并且影响谷物质量。调整谷物尺寸的几主要量的特点 loci (QTL ) 被克隆;然而,我们调整米饭谷物的尺寸的内在的机制的理解仍然保持碎片。这里,我们报导克隆和主导的 QTL 的描述,染色体 2 上的谷物尺寸(GS2 ) 编码调整生长的因素 4,一个 transcriptional 管理者。GS2 本地化到原子核并且可以充当抄写使活跃之物。影响 microRNA 的有约束力的地点的 GS2 的一个稀罕变化, OsmiR396c,原因提高了 GS2/OsGRF4 的表示。GS2 表示的增加导致更大的房间和房间的增加的数字,它因此提高谷物重量和产量。进米饭栽培变种的 GS2/OsGRF4 的这稀罕等位基因的介绍能显著地提高谷物重量和增加谷物产量,用在引起产量很高的米饭变化的可能的应用。 | Jiang Hu Yuexing Wang Yunxia Fang Longjun Zeng Jie Xu Haiping Yu Zhenyuan Shi Jiangjie Pan Dong Zhang Shujing Kang Li Zhu Guojun Dong Longbiao Guo Dali Zeng Guangheng Zhang Lihong Xie Guosheng Xiong Jiayang Li Qian Qian | 2015 | Molecular Plant2015，8，10： | 57 |
| 2 | Combined obeticholic acid and apoptosis inhibitor treatment alleviates liver fibrosis显示文摘Obeticholic acid(OCA), the first FXR-targeting drug, has been claimed effective in the therapy of liver fibrosis. However, recent clinical trials indicated that OCA might not be effective against liver fibrosis, possibly due to the lower dosage to reduce the incidence of the side-effect of pruritus. Here we propose a combinatory therapeutic strategy of OCA and apoptosis inhibitor for combating against liver fibrosis. CCl4-injured mice, D-galactosamine/LPS(GalN/LPS)-treated mice and cycloheximide/TNFα(CHX/TNFα)-treated HepG2 cells were employed to assess the effects of OCA, or together with IDN-6556, an apoptosis inhibitor. OCA treatment significantly inhibited hepatic stellate cell(HSC)activation/proliferation and prevented fibrosis. Elevated bile acid(BA) levels and hepatocyte apoptosis triggered the activation and proliferation of HSCs. OCA treatment reduced BA levels but could not inhibit hepatocellular apoptosis. An enhanced anti-fibrotic effect was observed when OCA was co-administrated with IDN-6556. Our study demonstrated that OCA inhibits HSCs activation/proliferation partially by regulating BA homeostasis and thereby inhibiting activation of HSCs. The findings in this study suggest that combined use of apoptosis inhibitor and OCA at lower dosage represents a novel therapeutic strategy for liver fibrosis. | Jiyu Zhou Ningning Huang Yitong Guo Shuang Cui Chaoliang Ge Qingxian He Xiaojie Pan Guangji Wang Hong Wang Haiping Hao | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 13 |
| 3 | The pleiotropic ABNORMAL FLOWER AND DWARF1 affects plant height, floral development and grain yield in rice显示文摘Moderate plant height and successful establishment of reproductive organs play pivotal roles in rice grain production. The molecular mechanism that controls the two aspects remains unclear in rice. In the present study,we characterized a rice gene, ABNORMAL FLOWER AND DWARF1(AFD1) that determined plant height, floral development and grain yield. The afd1 mutant showed variable defects including the dwarfism, long panicle, low seed setting and reduced grain yield. In addition, abnormal floral organs were also observed in the afd1 mutant including slender and thick hulls, and hull-like lodicules.AFD1 encoded a DUF640 domain protein and was expressed in all tested tissues and organs. Subcellular localization showed AFD1-green fluorescent fusion protein(GFP) was localized in the nucleus. Meantime, our results suggested that AFD1 regulated the expression of cell division and expansion related genes. | Deyong Ren Yuchun Rao Liwen Wu Qiankun Xu Zizhuang Li Haiping Yu Yu Zhang Yujia Leng Jiang Hu Li Zhu Zhenyu Gao Guojun Dong Guangheng Zhang Longbiao Guo Dali Zeng Qian Qian | 2016 | Journal of Integrative Plant Biology2016，58，6： | 4 |
| 4 | Physiological levels of ATP negatively regulate proteasome function显示文摘由 ubiquitin-proteasome 系统的细胞内部的蛋白质降级是 ATP 依赖者,和最佳的 ATP 集中激活 proteasome 在 vitro 的功能是 ~ 100 渭 M。细胞内部的 ATP 层次在在这个范围以内的水平通常在低 millimolar 范围,而是 ATP 被显示在 vitro 禁止 proteasome peptidase 活动。这里,我们报导支持在生理的层次的细胞内部的 ATP 双向地调整的一个假设的新证据 26S proteasome 在房间的解朊的功能。首先,我们证实 ATP 在 vitro 在 26S proteasome 上施加了双向规定,与最佳的 ATP 集中(在 50 和 100 渭 M 之间) 刺激 proteasome 像糜蛋白酶的活动。第二,我们发现操作细胞内部的 ATP 层次也在有教养的房间在 proteasome 特定的蛋白质底层的层次导致了双向变化。最后,测量增加提高的细胞内部的 ATP,当减少的细胞内部的 ATP 稀释了导致房间死亡的 proteasome 抑制的能力时。这些数据强烈建议在生理的集中范围以内的内长的 ATP 能在 proteasome 活动施加否定影响,允许房间到很快,在应力下面的 ATP 减小上的 upregulate proteasome 活动调节。 | Hongbiao Huang Xiaoyan Zhang Shujue Li Ningning Liu Wen Elan Emily McDowell Ping Zhou Canguo Zhao Haiping Guo Change Zhang Changshan Yang Guangmei Wen Xiaoxian Dong Li Lu Ningfang Ma Weihua Dong Q Ping Dou Xuejun Wang Jinbao Liu | 2010 | Cell Research2010，20，12： | 4 |
| 5 | Leveraging proficiency and preference for online Karaoke recommendation显示文摘Recently,many online Karaoke(KTV)platforms have been released,where music lovers sing songs on these platforms.In the meantime,the system automatically evaluates user proficiency according to their singing behavior.Recommending approximate songs to users can initialize singers5 participation and improve users,loyalty to these platforms.However,this is not an easy task due to the unique characteristics of these platforms.First,since users may be not achieving high scores evaluated by the system on their favorite songs,how to balance user preferences with user proficiency on singing for song recommendation is still open.Second,the sparsity of the user-song interaction behavior may greatly impact the recommendation task.To solve the above two challenges,in this paper,we propose an informationfused song recommendation model by considering the unique characteristics of the singing data.Specifically,we first devise a pseudo-rating matrix by combing users’singing behavior and the system evaluations,thus users'preferences and proficiency are leveraged.Then we mitigate the data sparsity problem by fusing users*and songs'rich information in the matrix factorization process of the pseudo-rating matrix.Finally,extensive experimental results on a real-world dataset show the effectiveness of our proposed model. | Ming HE Hao GUO Guangyi LV Le WU Yong GE Enhong CHEN Haiping MA | 2020 | Frontiers of Computer Science2020，14，2： | 3 |
| 6 | A survey on chemical and microbiological composition of kurut, naturally fermented yak milk from Qinghai in China显示文摘 | Heping Zhang Jie Xu Junguo Wang Menghebilige Tiansong Sun Haiping Li Mingruo Guo | 2007 | Food Control2007，，6： | 3 |
| 7 | Identification and characterization of Mini1, a gene regulating rice shoot development显示文摘The aerial parts of higher plants are generated from the shoot apical meristem(SAM). In this study, we isolated a small rice(Oryza sativa L.) mutant that showed premature termination of shoot development and was named mini rice 1(mini1). The mutant was first isolated from a japonica cultivar Zhonghua11(ZH11) subjected to ethyl methanesulfonate(EMS)treatment. With bulked segregant analysis(BSA) and map-based cloning method, Mini1 gene was finally fine-mapped to an interval of 48.6 kb on chromosome 9. Sequence analyses revealed a single base substitution from G to A was found in the region, which resulted in an amino acid change from Gly to Asp.The candidate gene Os09g0363900 was predicted to encode a putative adhesion of calyx edges protein ACE(putative HOTHEAD precursor) and genetic complementation experiment confirmed the identity of Mini1. Os09g0363900 contains glucose-methanol-choline(GMC) oxidoreductase and NAD(P)-binding Rossmann-like domain, and exhibits high similarity to Arabidopsis HOTHEAD(HTH). Expression analysis indicated Mini1 was highly expressed in young shoots but lowly in roots and the expression level of most genes involved in auxin biosynthesis and signal transduction were reduced in mutant.We conclude that Mini1 plays an important role in maintaining SAM activity and promoting shoot development in rice. | Yunxia Fang Jiang Hu Jie Xu Haiping Yu Zhenyuan Shi Guosheng Xiong Li Zhu Dali Zeng Guangheng Zhang Zhenyu Gao Guojun Dong Meixian Yan Longbiao Guo Yonghong Wang Qian Qian | 2015 | Journal of Integrative Plant Biology2015，57，2： | 3 |
| 8 | Neutron response functions and detection efficiency of a spherical proton recoil proportional counter显示文摘The neutron response function and detection efficiency of a spherical proton recoil proportional counter (SP) play key roles in precise measurement of neutron spectra of the interior materials.In this paper,the response functions and detection efficiency of three SPs developed at CAEP are simulated by Geant4.The simulated spectra are compared with pulse-height spectra measured at 0.165,0.575,1.4,and 14.1 MeV of incident neutrons.And the calculated detector efficiencies agree within 5%with the data obtained by neutron activation. | Wang Xinhua He Tie Guo Haiping An Li Zhen Pu Mou Yunfeng Yang Jian | 2010 | Nuclear Science and Techniques2010，21，6： | 2 |
| 9 | Analysis of Abnormal Characteristics of Regional Crustal Deformation before the Menyuan MS6.4 Earthquake by GPS Continuous Data显示文摘In order to study the characteristics of crustal deformation around the epicenter before the 2016 M_S6. 4 Menyuan earthquake,the GPS continuous stations of the period from 2010 to 2016 were selected according to the observation data of the tectonic environment monitoring network in Chinese Mainland. The deformation characteristics of the crust before the earthquake were discussed through inter-station baseline time series analysis and the strain time series analysis in the epicentral region. The results show that a trend turn of the baseline movement state around the epicenter region occurred after 2014,and the movement after 2014 reflects an obvious decreasing trend of compressional deformation.During this period,the stress field energy was in a certain accumulation state. Since the beginning of 2014,the EW-component linear strain and surface strain rate weakened gradually before the earthquake. It shows that there was an obvious deformation deficit at the epicentral area in the past two years,which indicates that the region accumulated a high degree of strain energy before the earthquake. Therefore,there was a significant background change in the area before the earthquake. The results of the study can provide basic research data for understanding the seismogenic process and mechanism of this earthquake. | Ma Haiping Feng Jiangang Guo Peng Shi Xuelu | 2017 | Earthquake Research in China2017，31，2： | 2 |
| 10 | Asymmetrical free diffusion with orientation-dependence of molecules in finite timescales显示文摘Using molecular dynamics simulations, we show that free diffusion of a nanoscale particle (molecule) with asymmetric structure critically depends on the orientation in a finite timescale of picoseconds to nanoseconds. In a timescale of ~100 ps, there are ~10% more possibilities for the particle moving along the initial orientation than moving opposite to the orientation; and the diffusion distances of the particle reach ~1 nm. We find that the key to this observation is the orientation-dependence of the damping force to the moving of the nanoscale particle and a finite time is required to regulate the particle orientation. This finding extends the work of Einstein to nano-world beyond random Brownian motion, thus will have a critical role in the understanding of the nanoscale world. | SHENG Nan TU YuSong GUO Pan WAN RongZheng FANG HaiPing | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，6： | 2 |
| 11 | Efficacy of ICIs on patients with oncogene-driven non-small cell lung cancer:a retrospective study显示文摘Aim:The objective of our study was to assess the efficacy of immune checkpoint inhibitors(ICIs)on patients with non-small-cell lung cancer(NSCLC)harboring oncogenic alterations.Methods:We retrospectively enrolled patients with advanced non-squamous NSCLC who were treated with anti-PD-1-based monotherapy or combined immunotherapy.Major characteristics including PD-L1 expression,treatment,and survival were analyzed.Results:In total,309 non-squamous NSCLC patients with a median age of 61 years(range 20-88 years)including 70.9%male were retrospectively enrolled.The molecular alterations involved epidermal growth factor receptor(EGFR)(n=81),V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS)(n=31),anaplastic lymphoma kinase(ALK)(n=1),human epidermal growth factor receptor 2(HER2)(n=12),V-raf murine sarcoma viral oncogene homolog(BRAF)(n=2),rearranged during transfection(n=4),and c-ros oncogene 1(ROS1)(n=3).In the EGFR subset,the ORR was 30.9%(n=81)and PFS was significantly shorter than WT group(median PFS:5.7 months vs.7.1 months;P=0.0061).In subgroup analyses,ICI combined therapy was significantly correlated with a longer PFS compared with ICI monotherapy(median PFS:7.7 months vs.4.7 months;P=0.0112).In KRAS patients,ORR was 51.6%(n=31).No significant difference was found in subgroup analyses.The ORR and PFS were 16.7%(n=12)and 28.6%(n=7),7.8 months and 9.0 months for HER2 and EGFR Exon20 insertion patients,respectively.Three ROS1 patients were enrolled with a PFS of 16.0,34.2,and 45.0 months individually,and one ALK patient with PFS of 4.4 months was identified.No response was found in two BRAF patients.Conclusion:ICI-based combination therapy can bring benefit to patients with EGFR-mutant NSCLC.ICI-based combination therapy could be considered for patients with ROS1 rearrangement,HER2 mutation and EGFR Exon20 insertion NSCLC. | Xiaojin Guo He Du Jiayu Li Menghang Yang Anweng Xiong Haiping Zhang Fengying Wu | 2022 | Cancer Drug Resistance2022，5，1： | 2 |
| 12 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 13 | Combination of eddy current and heat treatment for crack healing and mechanical-property improvement in magnesium alloy tube显示文摘The continuous eddy current pulse treatment(ECPT)combined with heat treatment was employed to heal the microcracks in spin formed Mg alloy tubes and improve their mechanical properties in this study.The results show that all the microcracks in different tube specimens were almost healed after different continuous ECPT schemes up to 15 cycles.The schemes with less cooling intervals exhibited better healing effect and increased the strength and elongation of Mg alloy tubes more obviously.After aging treatment,the strength improvement of the specimens with ECPT was more remarkable than that of the specimens without ECPT,and the elongation decrease of the specimens with ECPT was less evident than that of specimens without ECPT due to the segregation of RE elements on the crack surface.Besides,after solution treatment,the strength reduction and ductility improvement of the specimens with ECPT were more pronounced than that of the specimens without ECPT owing to the notable decrease of dislocation density of the specimens with ECPT.Both narrowed cracks induced by ECPT and the segregation of precipitates in the vicinity of microcrack surface during aging treatment contributed to the maximum strength in the as-spun specimens with ECPT followed by aging treatment. | Wenchen Xu Chuan Yang Haiping Yu Xueze Jin Guojing Yang Debin Shan Bin Guo | 2021 | Journal of Magnesium and Alloys2021，9，5： | 1 |
| 14 | Homoclinic orbits for nonlinear difference equations containing both advance and retardation显示文摘 | Yu Jianshe Shi Haiping Guo Zhiming | 2009 | J Math Anal App12009，352，2： | 1 |
| 15 | Surface strengthening of Ti 3 SiC 2 through magnetron sputtering Cu and subsequent annealing显示文摘 | Haiping Guo Jie Zhang Fangzhi Li Yi Liu Jinjie Yin Yanchun Zhou | 2008 | Journal of the European Ceramic Society2008，，10： | 1 |
| 16 | Study on ionosphere change over Shandong based from SDCORS in 2012显示文摘Temporal and spatial variation of ionosphere can influence our daily communication activities.By solving the one-year global positioning system(GPS) data of Shandong Continuous Operational Reference System(SDCORS) in 2012,we modeled the single-layer spherical harmonic model of vertical total electron content(TEC) over Shandong Province,China,and analyzed the time series of TEC in 2012.The ionosphere over Shandong in 2012 was in the peak year of solar activity.The ionospheric model over Shandong was calibrated and verified using data of the Center for Orbit Determination in Europe(CODE)and the Crustal Movement Observation Network of China(CMONOC),respectively.The ionosphere is greatly influenced by latitude and solar activity and has the phenomenon of Winter anomaly and semiannual anomaly as well as the session change,diurnal variation,monthly change and seasonal variations.So we can grasp the regularity of temporal and spatial distribution of ionosphere over Shandong,China. | Jinyun Guo Zhenghua Dong Zhimin Liu Jijun Mao Haiping Zhang | 2017 | Geodesy and Geodynamics2017，8，4： | 1 |
| 17 | Enhanced adsorptive removal of naphthalene intermediates from aqueous solution by introducing reed straw into sewage sludge-based activated carbon显示文摘 | Lin Gu Huaqing Guo Pin Zhou Nanwen Zhu Daofang Zhang Haiping Yuan Ziyang Lou | 2014 | Environmental Science and Pollution Research2014，，3： | 1 |
| 18 | A survey on chemical and microbiological composition of kurut, naturally fermented yak milk from Qinghai in China显示文摘 | Heping Zhang Jie Xu Junguo Wang Menghebilige Tiansong Sun Haiping Li Mingruo Guo | 2007 | Food Control2007，，6： | 1 |
| 19 | Dysregulations of UDP-glucuronosyltransferases in rats with valproic acid and high fat diet induced fatty liver显示文摘 | Lifang Zhang Xiaoman Chu Hong Wang Hao Xie Cen Guo Lijuan Cao Xueyan Zhou Guangji Wang Haiping Hao | 2013 | European Journal of Pharmacology . 2013 (1-3)2013，，1： | 1 |
| 20 | Phage display selection of peptides that inhibit metastasis ability of gastric cancer cells with high liver-metastatic potential显示文摘 | Shengjuan Hu Xinning Guo Huahong Xie Yulei Du Yanglin Pan Yongquan Shi Jun Wang Liu Hong Shuang Han Dongtao Zhang Dawei Huang Kedong Zhang Feihu Bai Haiping Jiang Huihong Zhai Yongzhan Nie Kaichun Wu Daiming Fan | 2006 | Biochemical and Biophysical Research Communications2006，，4： | 1 |
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