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| 1 | A natural variation in Ribonuclease H-like gene underlies Rht8 to confer“Green Revolution”trait in wheat显示文摘Dear Editor,Introduction of gibberellin(GA)-insensitive Reduced height(Rht)genes,Rht-B1b and Rht-D1b,has resulted in the“Green Revolution”in modern wheat cultivars(Triticum aestivum)that has skyrocketed wheat grain yields worldwide since the 1960s(Peng et al.,1999;Velde et al.,2021).However,Rht-B1b/D1b also reduce coleoptiles,which is undesired in dryland regions where deep planting is essential for seedling establishment(Rebetzke et al.,1999,Rebetzke et al.,2001;Ellis et al.,2004). | Lingling Chai Mingming Xin Chaoqun Dong Zhaoyan Chen Huijie Zhai Junhong Zhuang Xuejiao Cheng Naijiao Wang Jia Geng Xiaobo Wang Ruolin Bian Yingyin Yao Weilong Guo Zhaorong Hu Huiru Peng Guihua Bai Qixin Sun Zhenqi Su Jie Liu Zhongfu Ni | 2022 | Molecular Plant2022，15，3： | 8 |
| 2 | cDNA cloning, expression and antibacterial activity of lysozyme C in the blue shrimp (Litopenaeus stylirostris)显示文摘The gene coding for lysozyme in blue shrimp (Litopenaeus stylirostris) was cloned, sequenced and expressed in pET-32a vector. The deduced amino acid sequence of F. merguiensi lysozyme showed 37–93% similarity with the mouse, human, chicken, and tiger prawn counterparts. The lysozyme was purified to homogeneity and observed as a band of approximately 15 kDa in 15% SDS–PAGE. Semiquantitative RT-PCR analysis demonstrated that mRNA transcripts of lysozyme could be mainly detected in the tissues of haemocytes, gill, gonad and the lymphoid organ of unchallenged shrimps, whereas the expression of lysozyme transcripts was increased in all the tested tissues after the heat-killed Vibrio alginolyticus challenge. The temporal expression of lysozyme mRNA in haemolymph challenged by Micrococcus luteus and V. alginolyticus was both up-regulated and reached the maximum level at 8 and 16 h post-stimulation, respectively, and then dropped back to the original level. Bacteriolytic activity of the lysozyme against different bacterial cultures was determined by the solid phase and turbidimetric assays. The results demonstrated that the lysozyme we obtained was not only against Grampositive and Gram-negative bacteria but also against shrimp pathogens V. alginolyticus and V. parahemolyticus. In addition, the study of the inhibition mechanism revealed that the antibacterial activity of the lysozyme was a result of the bactericidal effect. | Weijun Mai Chaoqun Hu | 2009 | Progress in Natural Science:Materials International2009，19，7： | 5 |
| 3 | Non-equilibrium Plasma Assisted Combustion of Low Heating Value Fuels显示文摘This paper describes the effects of non-equilibrium air plasma generated by a dielectric barrier discharge (DBD) on the combustion of low heating value fuels. The experimental results indicate that addition of a very small amount of energy to the air flow in the form of DBD significantly improves the flame stability. Moreover, main combustion characteristics such as flame propagation speed, combustion intensity and lean blow-off limits are also enhanced by the effect of plasma. Some active radicals such as excited O atom and excited N2 molecule are observed by spectrograph in the discharge area. Based on the results of numerical investigation we can conclude that these active radicals generated in discharge area can accelerate the production rate of active OH radical which plays a key role in the oxidation process of low heating value fuel, and thus the whole combustion process is accelerated. | Hongbin Hu Quanbin Song Yanji Xu Gang Li Chaoqun Nie | 2013 | Journal of Thermal Science2013，22，3： | 4 |
| 4 | Post-Orogenic Tectonic Evolution of the Jiangnan-Xuefeng Orogenic Belt:Insights from Multiple Geochronometric Dating of the Mufushan Massif,South China显示文摘The Mufushan massif, as continental intra-plate magmatites located in the Jiangnan-Xuefeng orogenic belt of the South China. The Mufushan massif constitutes the largest Mesozoic intrusive complex, intruded the Mesoproterozoic Lengjiaxi Formation. Multiple geochronometric dating was used to reconstruct their evolution from emplacement to exhumation. The Mufushan granitoids were emplaced at ~150 Ma(U-Pb zircon) as post-orogenic magmatites contributing to Triassic crustal thickening. Onset of regional extension at ~128 Ma(40Ar/39Ar white mica and biotite) manifests a tectonic regime switch. Intense exhumation prior to ~55 Ma was followed by slow denudation and peneplanation for the next 37 Ma(~55–18 Ma). Accelerated cooling since ~18 Ma may have been caused by a far-field effect of the collision between IndiaAsia Plate or the Pacific-Plate subduction. Through a multi-geochronometric approach, this study provides a new comprehensive model for the cause of the intra-plate magmatism formation in the South China, and also established a reliable geochronological framework of the post-orogenic tectonic evolutions of the Jiangnan-Xuefeng orogenic belt. | Chuanbo Shen Di Hu Kyoungwon Min Chaoqun Yang Xiaowei Zeng Hongyang Fu Xiang Ge | 2020 | Journal of Earth Science2020，31，5： | 4 |
| 5 | Characterization of mitochondrial genome of sea cucumber Stichopus horrens:A novel gene arrangement in Holothuroidea显示文摘The complete mitochondrial DNA sequence contains useful information for phylogenetic analyses of metazoa.In this study,the complete mitochondrial DNA sequence of sea cucumber Stichopus horrens (Holothuroidea:Stichopodidae:Stichopus) is presented.The complete sequence was determined using normal and long PCRs.The mitochondrial genome of Stichopus horrens is a circular molecule 16257 bps long,composed of 13 protein-coding genes,two ribosomal RNA genes and 22 transfer RNA genes.Most of these genes are coded on the heavy strand except for one protein-coding gene (nad6) and five tRNA genes (tRNA Ser(UCN),tRNA Gln,tRNA Ala,tRNA Val,tRNA Asp) which are coded on the light strand.The composition of the heavy strand is 30.8% A,23.7% C,16.2% G,and 29.3% T bases (AT skew=0.025;GC skew= 0.188).A non-coding region of 675 bp was identified as a putative control region because of its location and AT richness.The intergenic spacers range from 1 to 50 bp in size,totaling 227 bp.A total of 25 overlapping nucleotides,ranging from 1 to 10 bp in size,exist among 11 genes.All 13 protein-coding genes are initiated with an ATG.The TAA codon is used as the stop codon in all the protein coding genes except nad3 and nad4 that use TAG as their termination codon.The most frequently used amino acids are Leu (16.29%),Ser (10.34%) and Phe (8.37%).All of the tRNA genes have the potential to fold into typical cloverleaf secondary structures.We also compared the order of the genes in the mitochondrial DNA from the five holothurians that are now available and found a novel gene arrangement in the mitochondrial DNA of Stichopus horrens. | FAN SiGang HU ChaoQun WEN Jing ZHANG LvPing | 2011 | Science China(Life Sciences)2011，54，5： | 4 |
| 6 | Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer显示文摘Enolase 2(ENO2)is a key glycolytic enzyme in the metabolic process of glycolysis,but its potential function in pancreatic ductal adenocarcinoma(PDAC)is unclear.In this study,we observed a significant overexpression of ENO2 in PDAC tissues,and its expression was correlated with metastasis and poor prognosis in PDAC patients.K394 was identified as a major acetylation site in ENO2 that regulates its enzymatic activity,cell metabolism and PDAC progression.Knockdown of ENO2 suppressed tumor growth and liver metastasis in PDAC.Re-expression of wild-type(WT)ENO2,but not the K394 acetylation mimetic mutant,could reverse the decreased tumor malignancy.We further characterized histone deacetylase 3(HDAC3)and P300/CBP-associated factor(PCAF)as the potential deacetylase and acetyltransferase for ENO2,respectively.HDAC3-mediated deacetylation was shown to lead to ENO2 activation and enhancement of glycolysis.Importantly,insulin-like growth factor-1(IGF-1)was found to decrease K394 acetylation and stimulate ENO2 activity in a dose-and time-dependent manner.The PI3K/AKT/mTOR pathway facilitated the phosphorylation of HDAC3 on S424,which promoted K394 deacetylation and activation of ENO2.Linsitinib,an oral small-molecule inhibitor of IGF-1R,could inhibit IGF-1-induced ENO2 deacetylation by HDAC3 and the PI3K/AKT/mTOR pathway.Furthermore,linsitinib showed a different effect on the growth and metastasis of PDAC depending on the overexpression of WT versus K394-mutant ENO2.Our results reveal a novel mechanism by which acetylation negatively regulates ENO2 activity in the metastasis of PDAC by modulating glycolysis.Blockade of IGF-1-induced ENO2 deacetylation represents a promising strategy to prevent the development of PDAC. | Yan Zheng Chao Wu Jimeng Yang Yue Zhao Huliang Jia Min Xue Da Xu Feng Yang Deliang Fu Chaoqun Wang Beiyuan Hu Ze Zhang Tianen Li Shican Yan Xuan Wang Peter J.Nelson Christiane Bruns Lunxiu Qin Qiongzhu Dong | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 7 | All-trans retinoic acid reverses malignant biological behavior of hepatocarcinoma cells by regulating miR-200 family members显示文摘As a potential chemo-therapeutic agent,all-trans retinoic acid(ATRA)can signif-icantly reverse epithelial-mesenchymal transition(EMT)of hepal-6 hepatocarcinoma cell line in vitro,but the mechanism is unclear.The expression profile of microRNA-200(miR-200)families is different in hepatocellular carcinoma.In this study,we found that ATRA trea tment could up-regulate the expression of miR-200a-3p,200c-3p,and 141-3p,which were involved in ATRA regulated proliferation and apoptosis of hepal-6 cell,but not colony formation.Meanwhile,miR-200a-3p,200c-3p,and 141-3p could recovery ATRA inhibited migration and invasion abilities of hepal-6 cells at various levels.miR-200a-3p and 200c-3p prevented ATRA from inducing the differentia tion and hepatic functions of hepal-6 cells.An-tagomir specific for miR-200a-3p and 200c-3p down-regulated the expression of CK18,but only miR-200a-3p anta gomir played prominent role in regula ting the expression of these mesenchymal markers,N-Cadherin,Snail and Twist.The transcriptional activities of 8 tran-scription factors were up-regulated and 35 transcription factors were down-regulated by ATRA.Compared with ATRA group,inhibition of miR-200a-3p,200c-3p,and 141-3p significantly strengthened the expression of Fra1/Jun(AP1),Ets1/PEA3,Brn3,and Zeb1/AREB6 at varying degrees.Therefore,this result suggested that ATRA may suppress EMT through down-regulating miR-200a-3p,200c-3p and 141-3p related transcription factors.miR-200 and their downstream genes might be the potentially specific targets for the treat-ment of hepatocarcinoma. | Jiejie Cui Mengjia Gong Shuyu Fang Chaoqun Hu Yi Wang Jingfang Zhang Ni Tang Yun He | 2021 | Genes & Diseases2021，8，4： | 2 |
| 8 | The Karyotypes, C-banding Patterns and AgNORs of Epinephelus malabaricus显示文摘The chromosome specimens of Epinephelus malabaricus (Bloch & Schneider, 1801) are obtained from metaphase of kindney cell by vivi-injection of PHA and culture of colchicines, hypatoic-air drying technique, and then by studying their Giemsa stain, C-bands and AgNORs. The results are as follows: (1)E. malabaricus has a diploid chromosome number of 48 and its karyotype formula is 48t, NF=48, sex chromosome is not found. (2) There is a pair of chromosomes with secondary constriction near the centromere of chromosome t24. (3) 1~4 nucleoli appear in the nucleus of interphase, 55% nuclei has 1 nucleolus and only 2% for 4 nucleoli. (4) AgNORs appear in the chromosome t24 of 50% metaphase, sometimes in the chromosome t5, but not in other chromosomes. (5) The AgNORs polymorphisms are individually specific, 1~4 pairs of the number, and the frequency of 4 AgNORs are lowest. (6) The secondary constrictions and positive C-bands are coincident, close to the centromere of the chromosome, and mass constrictive heterochromatins appear in that region. (7) All the centromeres of chromosomes are darkly stained C-bands, and the whole arm of chromosome t24 and its centromere are same positive C-bands. (8) The evolutive regulation of the karyotype and the developing mechanism of AgNORs and C-bands are discussed. | 邹记兴 Hu Chaoqun Xiang Wenzhou YU Qixing Zhou Fei | 2004 | High Technology Letters2004，10，2： | 2 |
| 9 | Effect of Shrimp(Litopenaeus vannamei) Farming Waste on the Growth, Digestion, Ammonium-Nitrogen Excretion of Sea Cucumber(Stichopus monotuberculatus)显示文摘In this study, specific growth rate(SGR), ingestion rate(IR), food conversion ratio(FCR), apparent digestion ratio(ADR) and ammonium-nitrogen excretion were determined for sea cucumber(Stichopus monotuberculatus) reared in plastic containers(70 L; 4 containers each diet treatment). Sea cucumbers were fed with five diets containing different amounts of farming waste from shrimp(Litopenaeus vannamei)(100%, 75%, 50%, 25% and 0) and a formulated compound(20% sea mud and 80% powdered algae). Sea cucumbers grew faster when they were fed with diet D(25% shrimp waste and 75% formulated compound) than those fed with other diets. Although IR value of sea cucumber fed with diet A(shrimp waste) was higher than those fed with other diets, both the lowest SGR and the highest FCR occurred in this diet group. The highest and the lowest ADR occurred in diet E(formulated compound) and diet A group, respectively, and the same to ammonium-nitrogen excretion. The contents of crude protein, crude lipid and total organic matter(TOM) in feces decreased in comparison with corresponding diets. In the feces from different diet treatments, the contents of crude protein and TOM increased gradually as the contents of crude protein and TOM in diets increased, while crude lipid content decreased gradually as the crude lipid content in diets increased. | CHEN Yanfeng LUO Peng HU Chaoqun REN Chunhua | 2015 | Journal of Ocean University of China2015，14，3： | 1 |
| 10 | Chemical composition and nutritional quality of sea cucumbers显示文摘 | WEN Jing HU Chaoqun FAN Sigang | 2010 | J Sci Food Agric2010，90，14： | 1 |
| 11 | The Type III Secretion System of Vibrio Alginolyticus Induces Rapid Apoptosis,Cell Rounding,and Osmotic Lysis of Fish Cells显示文摘 | ZHAO Zhe CHEN Chang HU Chaoqun | 2010 | Microbiology2010，156，9： | 1 |
| 12 | Chloro-free synthesis of LiPF_(6)using the fluorine-oxygen exchange technique显示文摘A hydrogen fluoride-free and chloro-free method for synthesizing LiPF_(6) was developed.Employing CaF_(2) as the direct fluorinating reagent instead of hydrogen fluoride made it much safer and more environmentfriendly than conventional methods and reduced the metal residues in product owing to the relatively low-acid reaction conditions less corrosive to equipments.The use of P_(2)O_(5) as phosphorus source instead of traditionally employed PCl_(5) significantly reduced the chloro residue in product.Ca(H_(2)PO_(4))_(2),the only by-product of the process,could be easily converted into Ca_(3)(PO_(4))_(2),a best-selling chemical.The above advantages not only reduce the production costs by ca.20%,but also significantly improve the product purity.The fluorine-oxygen exchange reaction is a completely new technique for LiPF_(6) production and may bring about technological revolution in the related industry. | Jian Liu Yuanli Cai Huan Pang Bin Cao Chengzhi Luo Zhenghao Hu Chaoqun Xiao Hu Zhang Fulu Lv Yitao Cao Lei Yu | 2022 | Chinese Chemical Letters2022，33，8： | 1 |
| 13 | Exosomal S100A4 derived from highly metastatic hepatocellular carcinoma cells promotes metastasis by activating STAT3显示文摘Intercellular cross-talk plays important roles in cancer progression and metastasis.Yet how these cancer cells interact with each other is still largely unknown.Exosomes released by tumor cells have been proved to be effective cell-to-cell signal mediators.We explored the functional roles of exosomes in metastasis and the potential prognostic values for hepatocellular carcinoma(HCC).Exosomes were extracted from HCC cells of different metastatic potentials.The metastatic effects of exosomes derived from highly metastatic HCC cells(HMH)were evaluated both in vitro and in vivo.Exosomal proteins were identified with iTRAQ mass spectrum and verified in cell lines,xenograft tumor samples,and functional analyses.Exosomes released by HMH significantly enhanced the in vitro invasion and in vivo metastasis of low metastatic HCC cells(LMH).S100 calcium-binding protein A4(S100A4)was identified as a functional factor in exosomes derived from HMH.S100A4r,ch exosomes significantly promoted tumor metastasis both in vitro and in vivo compared with S100A4^(rich) exosomes or controls.Moreover,exosomal S100A4 could induce expression of osteopontin(OPN),along with other tumor metastasis/stemness-related genes.Exosomal S100A4 activated OPN transcription via STAT3 phosphorylation.HCC patients with high exosomal S100A4 in plasma also had a poorer prognosis.In conclusion,exosomes from HMH could promote the metastatic potential of LMH,and exosomal S100A4 is a key enhancer for HCC metastasis,activating STAT3 phosphorylation and up-regulating OPN expression.This suggested exosomal S100A4 to be a novel prognostic marker and therapeutic target for HCC metastasis. | Haoting Sun Chaoqun Wang Beiyuan Hu Xiaomei Gao Tiantian Zou Qin Luo Mo Chen Yan Fu Yuanyuan Sheng Kaili Zhang Yan Zheng Xudong Ren Shican Yan Yan Geng Luyu Yang Qiongzhu Dong Lunxiu Qin | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 1 |
| 14 | Heterotrophic bacteria of the Dapeng Bay in the South China Sea: community structure,abundance,and the relationships of culturablity with environmental factors显示文摘The community composition,abundance and culturablity of heterotrophic bacterioplankton in the Dapeng Bay of the South China Sea were investigated by morphological method,bacterial cultivation and biochemical methods over an annual cycle.Aeromonas and Pseudomonas were the predominant genera among the Gram-negative bacteria.The bacterioplankton abundance fluctuated from 2.07×10 8 to 2.44×10 9 cells/dm 3 ,and culturable bacteria abundance ranged between 0.1×10 6 and 16.07×10 6 CFU/dm 3 .The Culturablity of heterotrophic bacteria ranged between 0.01% and 1.31%.The relationship between bacterial culturablity and the environmental factors was also studied in different sites of the Dapeng Bay.Throughout the bay,a significantly positive relationship was evidenced between bacterial culturability and temperature,meanswhile bacterial culturability was significantly inversely related with salinity.The positive relationship was shown at the central bay while a negative relationship was observed at the bay mouth and there was no significant correlation at top bay between bacterial culturablity and chlorophyll a of sea water.A positive relationship was found between culturability and DIN all the bay,but DIP showed a significantly negative relationship with bacterial culturability only at the mouth of the bay. | JIANG Fajun HU Zhangli HU Chaoqun | 2010 | Acta Oceanologica Sinica2010，29，4： | 1 |
| 15 | A selective kernel-based cycle-consistent generative adversarial network for unpaired low-dose CT denoising显示文摘Low-dose computed tomography(LDCT)denoising is an indispensable procedure in the medical imaging field,which not only improves image quality,but can mitigate the potential hazard to patients caused by routine doses.Despite the improvement in performance of the cycle-consistent generative adversarial network(CycleGAN)due to the well-paired CT images shortage,there is still a need to further reduce image noise while retaining detailed features.Inspired by the residual encoder–decoder convolutional neural network(RED-CNN)and U-Net,we propose a novel unsupervised model using CycleGAN for LDCT imaging,which injects a two-sided network into selective kernel networks(SK-NET)to adaptively select features,and uses the patchGAN discriminator to generate CT images with more detail maintenance,aided by added perceptual loss.Based on patch-based training,the experimental results demonstrated that the proposed SKFCycleGAN outperforms competing methods in both a clinical dataset and the Mayo dataset.The main advantages of our method lie in noise suppression and edge preservation. | Chaoqun Tan Mingming Yang Zhisheng You Hu Chen Yi Zhang | 2022 | Precision Clinical Medicine2022，5，2： | 1 |
| 16 | Microsatellite and mitochondrial DNA assessment of the genetic diversity of captive Saiga antelopes(Saiga tatarica) in China显示文摘To estimate the genetic diversity of the only captive Saiga antelope(Saiga tatarica) population in China,40 umbilical cord samples were collected and mitochondrial(control region) and nuclear(microsatellite) variabilities were assessed.Both of the markers revealed low genetic variability(or high genetic homogeneity) within the population.The microsatellites yielded monitoring ranges of 2-6 alleles.The observed heterozygosities ranged from 0.28 to 0.83,and the expected heterozygosities were between 0.27 and 0.71.The Shannon information index(Shannon I) and Polymorphic Information Content(PIC) presented overall means of 0.87 and 0.43,respectively.The gene diversity was 0.49.We found only two haplotypes in the population,and the haplotype and nucleotide diversities were 39.1% and 1.13%,respectively.Founder events,bottlenecks and inbreeding have contributed to the low genetic variation observed in this population.Our findings revealed the extent of genetic diversity maintained in the present population and the urgency of implementing a protection plan,introducing animals from other populations to enhance saiga's genetic variation. | ZHAO ShaSha XU ChaoQun LIU Gang LIU ShuQiang ZHAO ChongXue CUI YaXiong HU DeFu | 2013 | Chinese Science Bulletin2013，58，17： | 1 |
| 17 | Chemical composition and nutritional quality of sea cucumbers显示文摘 | WEN JING HU CHAOQUN FAN SIGANG | 2010 | J Sci Food Agric2010，90，14： | 1 |
| 18 | Vibrio alginolyticus gyrB sequence analysis and gyrB-targeted PCR identification in environmental isolates 显示文摘 | LUO PENG HU CHAOQUN | 2008 | Diseases of Aquatic Organisms2008，82，： | 1 |
| 19 | Enhanced polysulfide redox kinetics by niobium oxynitrides via insitu adsorptive and catalytic effect in wide temperature range显示文摘The development of Li-S batteries(LSBs)is hindered by the low utilization of S species and sluggish redox reaction kinetics.Polar metal oxides always possess high adsorption to polar S species,while conductive metal nitrides show fast electron transport and ensure fast redox reaction of S species.The combination merits of metal oxides and metal nitrides in one provide an effective strategy to improve the electrochemical performance of LSBs.In this work,defect design of niobium oxynitrides highly dispersed on graphene(NbON-G)is evaluated as effective trapper and catalyst for S species.Owning to the effective structural merits including enriched active sites,alleviated volume variation,defect modulated electronic property,and in-situ chemisorption and catalytic conversion of soluble lithium polysulfides(LiPSs),the LSBs with NbON-G modified separator show remarkably enhanced performance compared to NbN-G and Nb_(2)O_(5)-G.Surprisingly,even at low temperature of−40°C,the LSBs with NbON-G can operate for 1,000 cycles with 0.04%capacity decay per cycle(Rate:2 C). | Benben Wei Chaoqun Shang Qiao Cu Le Hu Xuelian Fu Guofu Zhou Xin Wang | 2022 | Nano Research2022，15，7： | 0 |
| 20 | Crystalline-magnetism action in biomimetic mineralization of calcium carbonate显示文摘The influence of minor environmental factors,such as the geomagnetic field,on the biomineralization of nacres,is often ignored but a great deal of research has confirmed its important role in the normal mineralization of calcium carbonate.Although the geomagnetic field is weak,its cumulative effects need to be considered given that the biomineralization process can take years.Accordingly,the authors of this paper have investigated the effects of weak magnetic fields(25 Gs or 50 Gs)on calcium carbonate mineralization and analyzed the mechanism involved.The results show that even a weak magnetic field conduces to the formation of vaterite or aragonite,in the induction order of precursor→vaterite→aragonite.The stronger the magnetic field and the longer the time,the more obvious the induction effect.The effect of a magnetic field is strongest in the aging stage and weakest in the solution stage.Inductions by egg-white protein and by a magnetic field inhibit each other,but they both restrict particle growth.These findings highlight the importance of minor environmental factors for biomineralization and can serve as a reference for biomimetic preparation of a CaCO_(3)nacre-like structure and for anti-scale technology for circulating cooling water. | Chaoqun Wu Xun Liu Fujun Yao Xin Yang Yan Wang Wenyuan Hu | 2023 | Chinese Journal of Chemical Engineering2023，59，7： | 0 |
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