|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | METTL3-mediated N^6-methyladenosine mRNA modification enhances long-term memory consolidation显示文摘 | Zeyu Zhang Meng Wang Dongfang Xie Zenghui Huang Lisha Zhang Ying Yang Dongxue Ma Wenguang Li Qi Zhou Yun-Gui Yang Xiu-Jie Wang | 2018 | Cell Research2018，28，11： | 29 |
| 2 | Reversible hydrogels with tunable mechanical properties for optically controlling cell migration显示文摘 | Xin Wu Wenmao Huang Wen-Hao Wu Bin Xue Dongfang Xiang Ying Li Meng Qin Fei Sun Wei Wang Wen-Bin Zhang Yi Cao | 2018 | Nano Research2018，11，10： | 6 |
| 3 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 4 | Trending IC design directions in 2022显示文摘For the non-stop demands for a better and smarter society, the number of electronic devices keeps increasing exponentially;and the computation power, communication data rate, smart sensing capability and intelligence are always not enough. Hardware supports software, while the integrated circuit(IC) is the core of hardware. In this long review paper, we summarize and discuss recent trending IC design directions and challenges, and try to give the readers big/cool pictures on each selected small/hot topics. We divide the trends into the following six categories, namely, 1) machine learning and artificial intelligence(AI) chips, 2) communication ICs, 3) data converters, 4) power converters, 5) imagers and range sensors, 6) emerging directions. Hope you find this paper useful for your future research and works. | Chi-Hang Chan Lin Cheng Wei Deng Peng Feng Li Geng Mo Huang Haikun Jia Lu Jie Ka-Meng Lei Xihao Liu Xun Liu Yongpan Liu Yan Lu Kaiming Nie Dongfang Pan Nan Qi Sai-Weng Sin Nan Sun Wenyu Sun Jiangtao Xu Jinshan Yue Milin Zhang Zhao Zhang | 2022 | Journal of Semiconductors2022，43，7： | 3 |
| 5 | Sensitivity of Fusarium graminearum to Carbendazim and Prochloraz显示文摘[Objective]The paper was to understand the resistance of Fusarium graminearum to carbendazim and prochloraz in the main wheat producing areas in Hubei Province.[Method] Totally 350 F. graminearum strains isolated in 2014 were determined to clear their sensitivity to carbendazim and prochloraz. [Result]All isolates were sensitive to carbendazim and prochloraz in Hubei Province,and carbendazim was still valuable in controlling Fusarium head blight. The control effect of prochloraz was better than that of carbendazim,and the combination of prochloraz and carbendazim at the proportion of 1∶ 7 received the best control effect.[Conclusion]Combination of chemical agents will occupy a more and more important position in future prevention and control against Fusarium head blight. | Ma Dongfang Huang Shi Zhang Peng Sun Cai Huang Wendi Li Guangjun Zhang Changqing Fang Zhengwu | 2017 | Plant Diseases and Pests2017，8，1： | 2 |
| 6 | Bioassay of tetrodotoxix using ICR mouse strain 显示文摘 | HUANG Dongfang | 1991 | J Chin Biochem Soc1991，20，2： | 1 |
| 7 | Finite-Time Sideslip Differentiator-Based LOS Guidance for Robust Path Following of Snake Robots显示文摘This paper presents a finite-time sideslip differentiator-based line-of-sight(LOS)guidance method for robust path following of snake robots.Firstly,finite-time stable sideslip differentiator and adaptive LOS guidance method are proposed to counteract sideslip drift caused by cross-track velocity.The proposed differentiator can accurately observe the cross-track error and sideslip angle for snake robots to avoid errors caused by calculating sideslip angle approximately.In our method,the designed piecewise auxiliary function guarantees the finite-time stability of position errors.Secondly,for the case of external disturbances and state constraints,a Barrier Lyapunov functionbased backstepping adaptive path following controller is presented to improve the robot’s robustness.The uniform ultimate boundedness of the closed-loop system is proved by analyzing stability.Additionally,a gait frequency adjustment-based virtual velocity control input is derived to achieve the exponential convergence of the tangential velocity.At last,the availability and superiority of this work are shown through simulation and experiment results. | Yang Xiu Dongfang Li Miaomiao Zhang Hongbin Deng Rob Law Yun Huang Edmond Q.Wu Xin Xu | 2023 | IEEE/CAA Journal of Automatica Sinica2023，10，1： | 1 |
| 8 | Chain-shattering Pt(IV)-backboned polymeric nanoplatform for efficient CRISPR/Cas9 gene editing to enhance synergistic cancer therapy显示文摘CRISPR/Cas9 system has become a promising gene editing tool for cancer treatment.However,development of a simple and effective nanocarrier to incorporate CRISPR/Cas9 system and chemotherapeutic drugs to concurrently tackle the biological safety and packaging capacity of viral vectors and combine gene editing-chemo for cancer therapy still remains challenges.Herein,a chain-shattering Pt(IV)-backboned polymeric nanoplatform is developed for the delivery of EZH2-targeted CRISPR/Cas9 system(NPCSPt/pEZH2)and synergistic treatment of prostate cancer.The pEZH2/Pt(II)could be effectively triggered to unpack/release from NPCSPt/pEZH2 in a chain-shattering manner in cancer cells.The EZH2 gene disruption efficiency could be achieved up to 32.2%of PC-3 cells in vitro and 21.3%of tumor tissues in vivo,leading to effective suppression of EZH2 protein expression.Moreover,significant H3K27me3 downregulation could occur after EZH2 suppression,resulting in a more permissive chromatin structure that increases the accessibility of released Pt(II)to nuclear DNA for enhanced apoptosis.Taken together,substantial proliferation inhibition of prostate cancer cells and further 85.4%growth repression against subcutaneous xenograft tumor could be achieved.This chain-shattering Pt(IV)-backboned polymeric nanoplatform system not only provides a prospective nanocarrier for CRISPR/Cas9 system delivery,but also broadens the potential of combining gene editing-chemo synergistic cancer therapy. | Qingfei Zhang Gaizhen Kuang Shasha He Sha Liu Hongtong Lu Xiaoyuan Li Dongfang Zhou Yubin Huang | 2021 | Nano Research2021，14，3： | 1 |
| 9 | Numerical Investigations of a Class of Biological Models on Unbounded Domain显示文摘This paper is concerned with numerical computations of a class of biologi-cal models on unbounded spatial domains.To overcome the unboundedness of spatial domain,we first construct efficient local absorbing boundary conditions(LABCs)to re-formulate the Cauchy problem into an initial-boundary value(IBV)problem.After that,we construct a linearized finite difference scheme for the reduced IVB problem,and provide the corresponding error estimates and stability analysis.The delay-dependent dynamical properties on the Nicholson’s blowflies equation and the Mackey-Glass equa-tion are numerically investigated.Finally,numerical examples are given to demonstrate the efficiency of our LABCs and theoretical results of the numerical scheme. | Qiumei Huang Dongfang Li Jiwei Zhang | 2019 | Numerical Mathematics(Theory,Methods and Applications)2019，12，1： | 1 |
| 10 | The ubiquitin ligase Pelil inhibits ICOS and thereby Tfh-mediated immunity显示文摘T follicular helper(Tfh)cells are crucial for regulating autoimmune inflammation and protective immunity against viral infection.However,the molecular mechanism controlling Tfh cell differentiation is poorly understood.Here,through two mixed bone marrow chimeric experiments,we identified Peli1,a T cell-enriched E3 ubiquitin ligase,as an intrinsic regulator that inhibits Tfh cell differentiation.Peli1 deficiency significantly promoted c-Rel-mediated inducible T-cell costimulator(ICOS)expression,and PELI1 mRNA expression was negatively associated with ICOS expression on human CD4^(+)T cells.Mechanistically,increased ICOS expression on Peli1-KO CD4^(+)T cells enhanced the activation of PI3K-AKT signaling and thus suppressed the expression of Klf2,a transcription factor that inhibits Tfh differentiation.Therefore,reconstitution of Klf2 abolished the differences in Tfh differentiation and germinal center reaction between WT and Peli1-KO cells.As a consequence,Peli1-deficient CD4^(+)T cells promoted lupus-like autoimmunity but protected against H1N1 influenza virus infection in mouse models.Collectively,our findings established Peli1 as a critical negative regulator of Tfh differentiation and indicated that targeting Peli1 may have beneficial therapeutic effects in Tfhrelated autoimmunity or infectious diseases. | Xinfang Huang Shumeng Hao Junli Liu Yuanyuan Huang Manman Liu Chunyuan Xiao Yan Wang Siyu Pei Tao Yu Jing Xu Haikun Wang Dongfang Dai Xiao Su Yichuan Xiao | 2021 | Cellular & Molecular Immunology2021，18，4： | 1 |
| 11 | Improved genetic algorithm with two-level approximation for truss topology optimization显示文摘 | Li Dongfang Chen Shenyan Huang Hai | 2014 | Structural and Multidisciplinary Optimization(S1615-147X)2014，49，5： | 1 |
| 12 | Mesoporous zeolite-supported metal sulfide catalysts with high activities in the deep hydrogenation of phenanthrene显示文摘 | Wenqian Fu Lei Zhang Dongfang Wu Mei Xiang Qian Zhuo Kai Huang Zhongdong Tao Tiandi Tang | 2015 | Journal of Catalysis2015，，： | 1 |
| 13 | The efficacy assessment of convalescent plasma therapy for COVID-19 patients:a multi-center case series显示文摘Convalescent plasma(CP)transfusion has been indicated as a promising therapy in the treatment for other emerging viral infections.However,the quality control of CP and individual variation in patients in different studies make it rather difficult to evaluate the efficacy and risk of CP therapy for coronavirus disease 2019(COVID-19).We aimed to explore the potential efficacy of CP therapy,and to assess the possible factors associated with its efficacy.We enrolled eight critical or severe COVID-19 patients from four centers.Each patient was transfused with 200–400mL of CP from seven recovered donors.The primary indicators for clinical efficacy assessment were the changes of clinical symptoms,laboratory parameters,and radiological image after CP transfusion.CP donors had a wide range of antibody levels measured by serology tests which were to some degree correlated with the neutralizing antibody(NAb)level.No adverse events were observed during and after CP transfusion.Following CP transfusion,six out of eight patients showed improved oxygen support status;chest CT indicated varying degrees of absorption of pulmonary lesions in six patients within 8 days;the viral load was decreased to a negative level in five patients who had the previous viremia;other laboratory parameters also tended to improve,including increased lymphocyte counts,decreased C-reactive protein,procalcitonin,and indicators for liver function.The clinical efficacy might be associated with CP transfusion time,transfused dose,and the NAb levels of CP.This study indicated that CP might be a potential therapy for severe patients with COVID-19. | Hao Zeng Dongfang Wang Jingmin Nie Haoyu Liang Jiang Gu Anne Zhao Lixin Xu Chunhui Lang Xiaoping Cui Xiaolan Guo Changlong Zhou Haibo Li Bin Guo Jinyong Zhang Qiang Wang Li Fang Wen Liu Yishan Huang Wei Mao Yaokai Chen Quanming Zou | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 14 | Modified Appleby operation for carcinoma of the pancreatic body and tail显示文摘This is a case of a pancreatic tumor with invasion of the celiac stem treated using the modified Appleby operation.Preoperatively,routine B-ultrasound,computed tomography,and magnetic resonance imaging were performed.In the perioperative period,the combined gallbladder was excised;the duration of the operation was 5 h and volume of blood loss was approximately 500 ml.Postoperatively,the liver function temporarily returned and after a liver protection treatment,it returned to normal within 2 weeks.The liver had normal arterial blood supply,and the postoperative course was uneventful.It is safe and feasible to resect the whole pancreatic body and tail tumor combined with celiac stem resection.It can improve the resection rate of tumor and relieve pain. | Dongfang Huang | 2020 | Oncology and Translational Medicine2020，6，4： | 0 |
| 15 | 腹腔镜肝肿瘤切除术15例报道(英文)显示文摘Objective:The aim of our study was to retrospectively analyze 15 patients' clinical materials with laparoscopic resection of liver neoplasms.Methods:From December 2007,a total of 15 patients with liver neoplasms were performed with laparoscopic hepatectomy,and their clinical materials,perioperative dates,postoperative complications,postoperative recovery and short-term curative effects were analyzed and summarized respectively.Results:Laparoscopic hepatectomy(LH) were performed in 15 patients,including 1 case underwent laparoscopic hepatic left lobectomy,1 case of left lateral hepatectomy,13 cases of partial liver resection.Fourteen cases of total laparoscopic liver resections for liver neoplasms,1 case of hand-assisted laparoscopic liver resection of the tumor,there was no conversion to open approach.Of the 15 patients with liver neoplasms,13 cases of hepatic neoplasms with the maximum diameter was 8 cm x 8 cm × 9 cm,9 cases of the borderline micro hepatocellular carcinoma(MHCC) with the diameter not more than 2 cm,3 cases of hepatic benign tumor.The mean operation time was(120 ± 30) min,and the intraoperative average hemorrhage was 100 mL,beginning to eat and get out of bed following 1-2 days of operation.The average postoperative hospitalization was 8 days,WBC,ALT,AST,albumin,bilirubin returned to normal after one week of operation.There were no postoperative complications such as hemorrhage,bile leakage or air embolism etc.Twelve patients with HCC were confirmed by postoperative pathology,1 case of liver smooth muscle lipoma,2 case of hepatic hemangioma.By one year of followed-up in 12 cases of HCC,the longest survival was 38 months,and no recurrence or death,1 year survival rate was 100%.Conclusion:Among the choice of cases,the advantages of LH for liver neoplasms compared with open surgery were less trauma,faster recovery and less blood loss.it is safe and effective for choosing a reasonable surgical indication,especially for peripheral micro hepatocellular carcinoma. | Dongfang Huang Jinsheng Wu Jianhuai Zhang Shaochuang Wang Lei Liu Fuzhen Qi Dianhua Gu Yebo Wang Ling Liu Guofeng Chen Ping Wang Gang Xu Yong Sun Yong Cai | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，5： | 0 |
| 16 | Microbial Limit Test of Zhideke Granules显示文摘[Objectives]To test the microbial limit of Zhideke granules.[Methods]According to the relevant regulations on the testing of granules in Chinese Pharmacopoeia in 2015,the applicability of the methods for counting the total number of aerobic bacteria,molds and yeasts and objectionable organisms in Zhideke granules was studied.[Results]The total number of aerobic bacteria in Zhideke granules was determined by dilution plate method(1∶20,1 mL per dish),the total number of molds and yeasts was determined by conventional plate method(1∶10,1 mL per dish),and E.coli was detected by conventional method of TTB(1∶10 test solution,10-100 mL TSB).[Conclusions]The method was suitable for the microbial limit test of Zhideke granules. | Yunjuan PANG Yushan ZHOU Jie LIANG Hui XU Jinyu WEI Dongfang HUANG Zhengyi SUN | 2021 | Medicinal Plant2021，12，3： | 0 |
| 17 | Synergistic enhancement of immunological responses triggered by hyperthermia sensitive Pt NPs via NIR laser to inhibit cancer relapse and metastasis显示文摘The combination of tumor ablation and immunotherapy is a promising strategy against tumor relapse and metastasis.Photothermal therapy(PTT)triggers the release of tumor-specific antigens and damage associated molecular patterns(DAMPs)in-situ.However,the immunosuppressive tumor microenvironment restrains the activity of the effector immune cells.Therefore,systematic immunomodulation is critical to stimulate the tumor microenvironment and augment the anti-tumor therapeutic effect.To this end,polyethylene glycol(PEG)-stabilized platinum(Pt)nanoparticles(Pt NPs)conjugated with a PD-L1 inhibitor(BMS-1)through a thermo-sensitive linkage were constructed.Upon near-infrared(NIR)exposure,BMS-1 was released and maleimide(Mal)was exposed on the surface of Pt NPs,which captured the antigens released from the ablated tumor cells,resulting in the enhanced antigen internalization and presentation.In addition,the Pt NPs acted as immune adjuvants by stimulating dendritic cells(DCs)maturation.Furthermore,BMS-1 relieved T cell exhaustion and induced the infiltration of effector T cells into the tumor tissues.Thus,Pt NPs can ablate tumors through PTT,and augment the anti-tumor immune response through enhanced antigen presentation and T cells infiltration,thereby preventing tumor relapse and metastasis. | Jie Yu Sha Liu Yupeng Wang Xidong He Qingfei Zhang Yanxin Qi Dongfang Zhou Zhigang Xie Xiaoyuan Li Yubin Huang | 2022 | Bioactive Materials2022，7，1： | 0 |
| 18 | Roadmap for rechargeable batteries:present and beyond显示文摘Rechargeable batteries currently hold the largest share of the electrochemical energy storage market,and they play a major role in the sustainable energy transition and industrial decarbonization to respond to global climate change.Due to the increased popularity of consumer electronics and electric vehicles,lithium-ion batteries have quickly become the most successful rechargeable batteries in the past three decades,yet growing demands in diversified application scenarios call for new types of rechargeable batteries.Tremendous efforts are made to developing the next-generation post-Li-ion rechargeable batteries,which include,but are not limited to solid-state batteries,lithium–sulfur batteries,sodium-/potassium-ion batteries,organic batteries,magnesium-/zinc-ion batteries,aqueous batteries and flow batteries.Despite the great achievements,challenges persist in precise understandings about the electrochemical reaction and charge transfer process,and optimal design of key materials and interfaces in a battery.This roadmap tends to provide an overview about the current research progress,key challenges and future prospects of various types of rechargeable batteries.New computational methods for materials development,and characterization techniques will also be discussed as they play an important role in battery research. | Sen Xin Xu Zhang Lin Wang Haijun Yu Xin Chang Yu-Ming Zhao Qinghai Meng Pan Xu Chen-Zi Zhao Jiahang Chen Huichao Lu Xirui Kong Jiulin Wang Kai Chen Gang Huang Xinbo Zhang Yu Su Yao Xiao Shu-Lei Chou Shilin Zhang Zaiping Guo Aobing Du Guanglei Cui Gaojing Yang Qing Zhao Liubing Dong Dong Zhou Feiyu Kang Hu Hong Chunyi Zhi Zhizhang Yuan Xianfeng Li Yifei Mo Yizhou Zhu Dongfang Yu Xincheng Lei Jianxiong Zhao Jiayi Wang Dong Su Yu-Guo Guo Qiang Zhang Jun Chen Li-Jun Wan | 2024 | Science China Chemistry2024，67，1： | 0 |
| 19 | A common-gate bootstrapped CMOS rectifier for VHF isolated DC-DC converter显示文摘A common-gate bootstrapped CMOS rectifier dedicated for VHF(very high frequency) isolated DCDC converter is proposed.It uses common-gate bootstrapped technique to compensate the power loss due to the threshold voltage,and to solve the reflux problem in the conventional rectifier circuit.As a result,it improves the power conversion efficiency(PCE) and voltage conversion ratio(VCR).The design saves almost 90%of the area compared to a previously reported double capacitor structure.In addition,we compare the previous rectifier with the proposed common-gate bootstrapped rectifier in the case of the same area;simulation results show that the PCE and VCR of the proposed structure are superior to other structures.The proposed common-gate bootstrapped rectifier was fabricated by using CSMC 0.5 μm BCD process.The measured maximum PCE is 86%and VCR achieves 77%at the operating frequency of 20 MHz.The average PCE is about 79%and average VCR achieves71%in the frequency range of 30-70 MHz.Measured PCE and VCR have been improved compared to previous results. | Dongfang Pan Feng Zhang Lu Huang Jinliang Li | 2017 | Journal of Semiconductors2017，38，5： | 0 |
| 20 | Isolation of Antagonistic Bacteria against Fusarium graminearum and Its Antagonistic Activity显示文摘[Objective] To develop biological control resources of endophytic bacteria in wheat,the bacteria with antagonistic effect against Fusarium graminearum were screened and their antagonistic activity was studied. [Method] The endophytic bacteria of wheat with antagonistic effect were screened using plate confrontation method; the antagonistic bacteria were identified through physiological and biochemical characteristics and 16 S r DNA sequence analysis; the antagonistic spectrum of antagonistic bacteria was studied using plate confrontation method. [Result]The antagonistic bacterium XY-3 was isolated from wheat leaves,and was identified as Bacillus amyloliquefaciens according to the physiological and biochemical characteristics and 16 S r DNA sequence analysis. [Conclusion] XY-3 had antagonistic effect against four kinds of common pathogenic fungi,presenting broad spectrum antagonistic activity against plant pathogenic fungi. | Sun Cai Zhang Peng Huang Shi Li Hongyan Ma Dongfang Zhang Changqing | 2016 | Plant Diseases and Pests2016，7，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员