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| 1 | Prediction of high-speed train induced ground vibration based on train-track-ground system model显示文摘The development of analysis on train-induced ground vibration is briefly summarized. A train-track-ground integrated dynamic model is introduced in the paper to predict the ground vibration induced by high-speed trains. Representative dynamic responses of the train-track-ground system predicted by the model are presented. Some major results measured from two field tests on the ground vibration induced by two high-speed trains are reported. Numerical prediction with the proposed train-track-ground model is validated by the high-speed train running experiments. Research results show that the wheel/rail dynamic interaction caused by track irregularities has a significant influence on the ground acceleration and little influence on the ground displacement. The main frequencies of the ground vibration induced by high-speed trains are usually below 80 Hz. Compared with the ballasted track, the ballastless track structure can produce much larger train-induced ground vibration at frequencies above 40 Hz. The vertical ground vibration is much larger than the lateral and longitudinal components. | Zhai Wanming He Zhenxing Song Xiaolin | 2010 | Earthquake Engineering and Engineering Vibration2010，9，4： | 24 |
| 2 | Changing trends of disease burden of gastric cancer in China from 1990 to 2019 and its predictions:Findings from Global Burden of Disease Study显示文摘Objective:China is one of the countries with the heaviest burden of gastric cancer(GC)in the world.Understanding the epidemiological trends and patterns of GC in China can contribute to formulating effective prevention strategies.Methods:The data on incidence,mortality,and disability-adjusted life-years(DALYs)of GC in China from1990 to 2019 were obtained from the Global Burden of Disease Study(2019).The estimated annual percentage change(EAPC)was calculated to evaluate the temporal trends of disease burden of GC,and the package Nordpred in the R program was used to perform an age-period-cohort analysis to predict the numbers and rates of incidence and mortality in the next 25 years.Results:The number of incident cases of GC increased from 317.34 thousand in 1990 to 612.82 thousand in2019,while the age-standardized incidence rate(ASIR)of GC decreased from 37.56 per 100,000 in 1990 to 30.64 per 100,000 in 2019,with an EAPC of-0.41[95%confidence interval(95%CI):-0.77,-0.06].Pronounced temporal trends in mortality and DALYs of GC were observed.In the next 25 years,the numbers of new GC cases and deaths are expected to increase to 738.79 thousand and 454.80 thousand,respectively,while the rates of incidence and deaths should steadily decrease.The deaths and DALYs attributable to smoking were different for males and females.Conclusions:In China,despite the fact that the rates of GC have decreased during the past three decades,the numbers of new GC cases and deaths increased,and will continue to increase in the next 25 years.Additional strategies are needed to reduce the burden of GC,such as screening and early detection,novel treatments,and the prevention of risk factors. | Tongchao Zhang Hui Chen Xiaolin Yin Qiufeng He Jinyu Man Xiaorong Yang Ming Lu | 2021 | Chinese Journal of Cancer Research2021，33，1： | 19 |
| 3 | A Review on Graphene-Based Gas/Vapor Sensors with Unique Properties and Potential Applications显示文摘Graphene-based gas/vapor sensors have attracted much attention in recent years due to their variety of structures, unique sensing performances, room-temperature working conditions, and tremendous application prospects, etc.Herein, we summarize recent advantages in graphene preparation, sensor construction, and sensing properties of various graphene-based gas/vapor sensors, such as NH_3, NO_2, H_2, CO, SO_2, H_2S, as well as vapor of volatile organic compounds.The detection mechanisms pertaining to various gases are also discussed. In conclusion part, some existing problems which may hinder the sensor applications are presented. Several possible methods to solve these problems are proposed, for example, conceived solutions, hybrid nanostructures, multiple sensor arrays, and new recognition algorithm. | Tao Wang Da Huang Zhi Yang Shusheng Xu Guili He Xiaolin Li Nantao Hu Guilin Yin Dannong He Liying Zhang | 2016 | Nano-Micro Letters2016，8，2： | 18 |
| 4 | Genome of Wild Mandarin and Domestication History of Mandarin显示文摘官员(柠檬 reticulata ) 是世界范围的最重要的柠檬庄稼之一。它的驯服被相信发生在华南,它是四几千年的官员耕作的中心之一。我们在 Nanling 区域附近收集了官员的自然野人口并且在附近栽培了 landraces。我们发现柠檬性的酸水平戏剧性地在栽培官员被减少。理解 ? 官员驯服的基因基础,我们 de novo 装配了野官员的一个草稿染色体并且分析了一套 104 个柠檬染色体。我们发现 Mangshan 官员是一种原始类型并且二个独立驯服事件发生了,分别地导致在北方和南方 Nanling 山的二组栽培官员(MD1 和 MD2 ) 。二个瓶颈和有效人口尺寸的二扩大为栽培官员的 MD1 组被识别。然而,在 MD2 组织 ? 在人口尺寸有长、连续的减少。MD1 和 MD2 官员从栽培 pummelo 种类显示出种间的基因渗入的不同模式。我们在官员的驯服期间在选择下面可能在基因在柠檬酸盐内容的规定包含了的 aconitate hydratase (ACO ) 识别了高分叉的一个区域,它是。这研究为现存野官员人口的地理起源提供具体基因证据并且使驯服和官员的进化历史清楚些。 | Lun Wang Fa He Yue Huang Jiaxian He Shuizhi Yang Jiwu Zeng Chongling Deng Xiaolin Jiang Yiwen Fang Shaohua Wen Rangwei Xu Huiwen Yu Xiaoming Yang Guangyan Zhong Chuanwu Chen Xiang Yan Changfu Zhou Hongyan Zhang Zongzhou Xie Robert M. Larkin Xiuxin Deng Qiang Xu | 2018 | Molecular Plant2018，11，8： | 14 |
| 5 | Factors predicting sensory and motor recovery after the repair of upper limb peripheral nerve injuries显示文摘OBJECTIVE: To investigate the factors associated with sensory and motor recovery after the repair of upper limb peripheral nerve injuries. DATA SOURCES: The online PubMed database was searched for English articles describing outcomes after the repair of median, ulnar, radial, and digital nerve injuries in humans with a publication date between 1 January 1990 and 16 February 2011. STUDY SELECTION: The following types of article were selected:(1) clinical trials describing the repair of median, ulnar, radial, and digital nerve injuries published in English; and(2) studies that reported sufficient patient information, including age, mechanism of injury, nerve injured, injury location, defect length, repair time, repair method, and repair materials. SPSS 13.0 software was used to perform univariate and multivariate logistic regression analyses and to investigate the patient and intervention factors associated with outcomes. MAIN OUTCOME MEASURES: Sensory function was assessed using the Mackinnon-Dellon scale and motor function was assessed using the manual muscle test. Satisfactory motor recovery was defined as grade M4 or M5, and satisfactory sensory recovery was defined as grade S3+ or S4.RESULTS: Seventy-one articles were included in this study. Univariate and multivariate logistic regression analyses showed that repair time, repair materials, and nerve injured were independent predictors of outcome after the repair of nerve injuries(P < 0.05), and that the nerve injured was the main factor affecting the rate of good to excellent recovery. CONCLUSION: Predictors of outcome after the repair of peripheral nerve injuries include age, gender, repair time, repair materials, nerve injured, defect length, and duration of follow-up. | Bo He Zhaowei Zhu Qingtang Zhu Xiang Zhou Canbin Zheng Pengliang Li Shuang Zhu Xiaolin Liu Jiakai Zhu | 2014 | Neural Regeneration Research2014，9，6： | 12 |
| 6 | Feedback Regulation of FLC by FLOWERING LOCUS T (FT) and FD through a 5’ FLC Promoter Region in Arabidopsis显示文摘Dear Editor, Recently, it was reported that the florigenic FT protein bound to a 3’ region of the potent floral repressor FLC (FLOWERING LOCUS C) to activate the expression of long noncoding antisense RNAs known as COOLAIR and consequently repress FLC expression to control flowering time and seed dormancy in Arabidopsis (Chen and Penfield, 2018). Here, we show that FT represses FLC expression through a 5' promoter region, but not COOLAIR. | Xiao Luo Tao Chen Xiaolin Zeng Dingwei He Yuehui He | 2019 | Molecular Plant2019，12，3： | 10 |
| 7 | Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects.Low-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the disease.This randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active RA.Patients were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week follow-up.Three cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week break.All patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESR<2.6,and the change from baseline in CDAI or SDAI at week 24.Secondary endpoints included other clinical responses and safety.The primary outcomes were achieved in the perprotocol population.The improvements from baseline in CDAI and SDAI were significantly greater across time points for the LdIL2+MTX group(n=17)than for the placebo+MTX group(n=23)(P=0.018 and P=0.015,respectively).More patients achieved ACR20 response in the Ld-IL2+MTX group than those in the placebo+MTX group at week 12(70.6%vs 43.5%)and at week 24(76.5%vs 56.5%)(P=0.014).In addition,low Treg and high IL-21 were associated with good responses to Ld-IL2.Ld-IL-2 treatment was well-tolerated in this study.These results suggested that Ld-IL2 was effective and safe in RA.ClinicalTrials.gov number:NCT 02467504. | Xiaoying Zhang Miao Miao Ruijun Zhang Xu Liu Xiaozhen Zhao Miao Shao Tian Liu Yuebo Jin Jiali Chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying Liu Chun Li Yuhui Li Limin Ren Yin Su Xiaolin Sun Jing He Zhanguo Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 7 |
| 8 | Mycorrhizal symbiosis modulates the rhizosphere microbiota to promote rhizobia–legume symbiosis显示文摘Plants establish symbioses with mutualistic fungi,such as arbuscular mycorrhizal(AM)fungi,and bacteria,such as rhizobia,to exchange key nutrients and thrive.Plants and symbionts have coevolved and represent vital components of terrestrial ecosystems.Plants employ an ancestral AM signaling pathway to establish intracellular symbioses,including the legume–rhizobia symbiosis,in their roots.Nevertheless,the relationship between the AM and rhizobial symbioses in native soil is poorly understood.Here,we examined how these distinct symbioses affect root-associated bacterial communities in Medicago truncatula by performing quantitative microbiota profiling(QMP)of 16S rRNA genes.We found that M.truncatula mutants that cannot establish AM or rhizobia symbiosis have an altered microbial load(quantitative abundance)in the rhizosphere and roots,and in particular that AM symbiosis is required to assemble a normal quantitative root-associated microbiota in native soil.Moreover,quantitative microbial co-abundance network analyses revealed that AM symbiosis affects Rhizobiales hubs among plant microbiota and benefits the plant holobiont.Through QMP of rhizobial rpoB and AM fungal SSU rRNA genes,we revealed a new layer of interaction whereby AM symbiosis promotes rhizobia accumulation in the rhizosphere of M.truncatula.We further showed that AM symbiosis-conditioned microbial communities within the M.truncatula rhizosphere could promote nodulation in different legume plants in native soil.Given that the AM and rhizobial symbioses are critical for crop growth,our findings might inform strategies to improve agricultural management.Moreover,our work sheds light on the co-evolution of these intracellular symbioses during plant adaptation to native soil conditions. | Xiaolin Wang Huan Feng Yayu Wang Mingxing Wang Xingguang Xie Huizhong Chang Like Wang Jicheng Qu Kai Sun Wei He Chunyan Wang Chuanchao Dai Zhaohui Chu Changfu Tian Nan Yu Xuebin Zhang Huan Liu Ertao Wang | 2021 | Molecular Plant2021，14，3： | 6 |
| 9 | Value of MR perfusion imaging after intervention treatment of hepatic cancer显示文摘目的将在评估肝的癌症的干预治疗的药品效果调查先生灌注成像的价值。36 个病人在干预治疗以后经历了先生灌注成像的方法。量子化结果在癌残余和良性的组织之间被不同。并且诊断精确性被判定。在那里的结果是在在在外科和良性的改进区域以后的残余肿瘤之间的吝啬的 MSI 的有效差量。残余肿瘤的时间目的曲线被观察很快上升到达山峰,而改进织物的慢慢地上升了到达山峰。察觉上的 PWI 的敏感和特性剩余或再发性瘤分别地是 0.89 和 0.73。结论 PWI 是能被用来在外科以后区分肝织物状况的一种很敏感的成像技术。早贡献的 PWI 上演诊断和动态监视后面的 HCC 外科。 | You Guo ZhaoChen Xiaolin Zheng Chengfu Tang Xijin He Yikai Xu | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，1： | 6 |
| 10 | Stratigraphy and age of the Daohugou Bed in Ningcheng,Inner Mongolia显示文摘Recent fieldwork has extended the distribution of the Daohugou Bed deposits from the Daohugou Village to its several neighboring areas. The fossil-bearing Daohugou deposits uncomformably overlie complex bedrocks, and com- prise three major parts. The red shales in the lower part were misidentified as belonging to the Tuchengzi Formation. Field excavation has indicated that the shales of upper part of the bed are the major fossil-bearing horizon. Due to strong tectonic activities, sediments were often folded with the se- quences inverted in the region. Some newly recognized con- tacts between the Daohugou Bed and the volcanic rocks showed that the ignimbrite of the Tiaojishan Formation (159―164 Ma) underlies the Daohugou deposits, rather than overlying the latter as previously proposed. Thus, the age of the Daohugou deposits should be younger than the age of the ignimbrite, and thus it was incorrect to correlate the Dao- hugou Bed with the Middle Jurassic Jiulongshan Formation. Although biostratigraphic studies based on conchostracans and insects support a Middle Jurassic-early Late Jurassic age for the Daohugou deposits, vertebrate fossils such as Liaoxitriton, Jeholopterus and feathered maniraptorans show much resemblance to those of the Yixian Formation. In other words, despite the absence of Lycoptera, a typical fish of the Jehol Biota, the Daohugou vertebrate assemblage is closer to that of the Early Cretaceous Jehol Biota than to any other biota. We propose that the Daohugou fossil assemblage probably represents the earliest evolutionary stage of the Jehol Biota based on both vertebrate biostratigraphy and the sedimentological and volcanic features which suggest the Daohugou deposit belongs to the same cycle of volcanism and sedimentation as the Yixian Formation of the Jehol Group. | WANG Xiaolin ZHOU Zhonghe HE Huaiyu JIN Fan WANG Yuanqing ZHANG Jiangyong WANG Yuan XU Xing ZHANG Fucheng | 2005 | Chinese Science Bulletin2005，50，20： | 6 |
| 11 | Ultra-sensitive detection of uranyl ions with a specially designed high-efficiency SERS-based microfluidic device显示文摘The uranyl ion(UO22+) poses high risks to human health and the environment, hence its detection and monitoring is of utmost significance. However, the development of an ultra-sensitive, high-efficiency and convenient approach for on-site detection of UO22+ remains a challenge. Herein, a reliable and reusable surface-enhanced Raman spectroscopy(SERS)-based microfluidic biosensor was developed for rapid detection of UO22+ in real samples. The detection protocol involved the reaction of 5′-Rhodamine B(RhB)-labeled double-stranded DNA for UO22+-specific DNAzyme-cleavage reaction in a U-shaped microchannel. Then, the reaction products were delivered into three parallel samples for high-throughput tests by SERS biochips,where 3 D ZnO-Ag mesoporous nanosheet arrays(MNSs) were modified with a single-stranded DNA(ssDNA). The ssDNAwas sequence-complementary with the 5′-RhB-labeled cleaved-stranded DNA(csDNA) from the reaction products. By the hybridization of ssDNA and csDNA, the signal probe RhB was fixed close to the surface of the ZnO-Ag MNSs to enhance the Raman signal. The limit of detection for UO22+ with the microfluidic-SERS biosensor was 3.71×10-15 M. An over 20,000-fold selectivity towards UO22+ response was also achieved in the presence of 15 other metal ions. The high-throughput microfluidicSERS biosensor operated well for practical UO22+ detection, with excellent recoveries in contaminated river and tap water from95.2% to 106.3%(relative standard deviation(RSD)<6.0%, n=6). Although the SERS-based microfluidic biosensor developed in this study was deployed for the detection of UO22+, the reusable and high-efficiency system may be expanded to the detection of other analytes on-site. | Xuan He Shaofei Wang Yu Liu Xiaolin Wang | 2019 | Science China Chemistry2019，62，8： | 4 |
| 12 | Shumian capsule(舒眠胶囊) improves symptoms of sleep mood disorder in convalescent patients of Corona Virus Disease 2019显示文摘OBJECTIVE:To evaluate the clinical effectiveness of Shumian capsule(舒眠胶囊)in improving the symptoms of insomnia,anxiety,depression,and other symptoms of convalescent patients of COVID-19.METHODS:Totally 200 patients were collected and randomly divided into experiment group(n=100)and control group(n=100).The control group was treated with Shumian capsule simulator,and the experiment group was treated with Shumian capsule.The improvement of TCM symptom score,the total effective rate and symptom disappearance rate of TCM symptoms in the two groups before and after treatment were observed,and the clinical effect was evaluated.RESULTS:One week after treatment,the scores of anxiety symptoms in the experiment group were significantly different from those in the control group(P<0.05),but there was no significant difference in the scores of insomnia and depression between the experiment group and the control group(P>0.05).There was no significant difference in the total effective rate and disappearance rate of TCM symptoms of insomnia,anxiety and depression between the experiment group and the control group(P>0.05).After 2 weeks of treatment,the scores of insomnia,anxiety,depression and the total effective rate of TCM symptoms in the experiment group were significantly different from those in the control group(P<0.05).There was no significant difference in the disappearance rate of insomnia,anxiety and depression between the experiment group and the control group(P>0.05).There were no significant differences in heart rate,respiration,systolic blood pressure and diastolic blood pressure between the experiment group and the control group(P>0.05).CONCLUSION:Shumian capsule can significantly improve the symptoms of insomnia,anxiety and depression in COVID-19’s convalescent patients with sleep and mood disorders. | LI Li AN Xuedong ZHANG Qing TAO Junxiu HE Jing CHEN Yun LI Kejian LIU Ru GUO Juan ZHANG Hao TONG Xiaolin BA Yuanming | 2021 | Journal of Traditional Chinese Medicine2021，41，6： | 4 |
| 13 | Voltage-induced penetration effect in liquid metals at room temperature显示文摘Room-temperature liquid metal is discovered to be capable of penetrating through macro-and microporous materials by applying a voltage.The liquid metal penetration effects are demonstrated in various porous materials such as tissue paper;thick and fine sponges;fabrics;and meshes.The underlying mechanism is that the high surface tension of liquid metal can be significantly reduced to near-zero due to the voltage-induced oxidation of the liquid metal surface in a solution.It is the extremely low surface tension and gravity that cause the liquid metal to superwet the solid surface^leading to the penetration phenomena.These findings offer new opportunities for novel microfluidic applications and could promote further discovery of more exotic fluid states of liquid metals. | Frank F Yun Zhenwei Yu Yahua He Lei Jiang Zhao Wang Haoshuang Gu Xiaolin Wang | 2020 | National Science Review2020，7，2： | 3 |
| 14 | Allogeneic hematopoietic stem cell transplantation for patients with acute leukemia显示文摘Objective: The purposes of this study were to assess the efficacy of allogeneic hematopoietic stem cell transplantation (HSCT) for acute leukemia (AL) and analyze the factors affecting the prognosis of these patients. Methods: The clinical and follow-up data of 93 AL patients (median age, 30 years) undergoing allogeneic HSCT in Xiangya Hospital over the past 12 years were collected, and the potential factors affecting the efficacy and prognosis of allogeneic HSCT patients were determined. Results: Hematopoietic reconstitution was achieved in 90 patients. At the last follow-up, the incidences of severe acute graft versus host disease (aGvHD) and extensive chronic GvHD (cGvHD) were 14.0% and 20.0%, the 3-year cumulative incidence of transplantation related mortality (TRM) and relapse rate were 16.8%±6.1% and 21.3%±6.7%, and the estimated 3-year overall survival (OS) and disease-free survival (DFS) of the patients were 64.6%±5.4% and 56.5%±5.5%, respectively. Univariate analysis indicated that age older than 40 years, HLA mismatch, and severe lung infection within the first 100 days after transplantation were risk factors for severe aGvHD, age older than 40 years, HLA mismatch, severe lung infection within the first 100 days after transplantation, and severe aGvHD were risk factors for TRM, high-risk AL and lack of cGvHD were risk factors for relapse (all P<0.05). Survival estimation showed that HLA mismatch, severe lung infection occurring within the first 100 days post-transplantation, high-risk AL severe aGvHD and lack of cGvHD were risk factors associated with poor prognosis (all P<0.05). Further multivariate analyses revealed that severe lung infection within the first 100 days post-transplantation, severe aGvHD and lack of cGvHD were independent risk factors for unfavorable outcomes (all P<0.05). Conclusions: Allogeneic HSCT can improve the DFS of AL patients, and severe lung infection within the first 100 days post-transplantation, severe aGvHD and lack of cGvHD are independent risk factors affecting the prognosis. | Yan Chen Yajing Xu Gan Fu Yi Liu Jie Peng Bin Fu Xiaoyu Yuan Hongya Xin Yan Zhu Qun He Dengshu Wu Yigang Shu Xiaolin Li Xielan Zhao Fangping Chen | 2013 | Chinese Journal of Cancer Research2013，25，4： | 3 |
| 15 | Space qualification mechanical tests of HTS filters for satellite application显示文摘High performance high-temperature superconducting (HTS) filters have been designed and constructed for satellite application. The filters are actually a superconducting integration of an 8-pole band-pass filter with an adjustable band-stop filter onto a single piece of LaAlO3 substrate (with dimension of 0.5×45×20 mm3). Typical results of the filters, i.e., Filters A (made by YBCO) & B (made by TBCCO) will be reported. The measured responses of Filter A showed excellent specifications, e.g., an insertion loss less than 0.1 dB, a return loss better than -22.5 dB in pass-band, band-edge steepness greater than 12 dB/MHz and out-of-band rejection at a certain band deeper than -110 dB. To satisfy the requirement of rocket launch and space operation, three filters of the above design have undergone mechanical environmental simulation tests for space qualification. Detailed analysis of the response curves of Filter B measured before and after the tests showed that no noticeable change in the per-formance can be found. All the filters passed the rigorous ground simulation tests, which is the first time in China for HTS devices and provided a solid foundation for satellite applications of high-temperature superconductors in the near future. | HUANG JianDong SUN Liang LI ShunZhou MENG QingDuan ZHANG Qiang LI Fei ZHANG XueQiang LI ChunGuang HE AiSheng LI Hong GU ChangZhi LUO Qiang SUN QinFen WANG XiaoLin SUN YiFan WANG ZhiBing WANG YunFei LUO Sheng HE YuSheng | 2007 | Chinese Science Bulletin2007，52，13： | 3 |
| 16 | Phosphorus release from cyanobacterial blooms in Meiliang Bay of Lake Taihu, China显示文摘 | Xiaoming Chuai Wei Ding Xiaofeng Chen Xiaolin Wang Aijun Miao Beidou Xi Lianshen He Liuyan Yang | 2011 | Ecological Engineering2011，，6： | 3 |
| 17 | Molecular basis of CONSTANS oligomerization in FLOWERING LOCUS T activation显示文摘The transcription factor CONSTANS(CO)integrates day-length information to induce the expression of florigen FLOWERING LOCUS T(FT)in Arabidopsis.We recently reported that the C-terminal CCT domain of CO forms a complex with NUCLEAR FACTOR-YB/YC to recognize multiple cis-elements in the FT promoter,and the N-terminal tandem B-box domains form a homomultimeric assembly.However,the mechanism and biological function of CO multimerization remained unclear.Here,we report that CO takes on a head-to-tail oligomeric configuration via its B-boxes to mediate FT activation in long days.The crystal structure of B-boxesCOreveals a closely connected tandem B-box fold forming a continuous head-to-tail assembly through unique CDHH zinc fingers.Mutating the key residues involved in CO oligomerization resulted in a non-functional CO,as evidenced by the inability to rescue co mutants.By contrast,a transgene encoding a human p53-derived tetrameric peptide in place of the B-boxesCOrescued co mutant,emphasizing the essential role of BboxesCO-mediated oligomerization.Furthermore,we found that the four TGTG-bearing cis-elements in FT proximal promoter are required for FT activation in long days.Our results suggest that CO forms a multimer to bind to the four TGTG motifs in the FT promoter to mediate FT activation. | Xiaolin Zeng Xinchen Lv Rui Liu Hang He Shiqi Liang Lixian Chen Fan Zhang Liu Chen Yuehui He Jiamu Du | 2022 | Journal of Integrative Plant Biology2022，64，3： | 2 |
| 18 | 地下水位对植物群落叶片与细根氮磷化学计量特征的调控作用不同但影响显著显示文摘地下水作为干旱区水资源可利用性的决定因素,在调节植被分布和生态系统过程中具有至关重要的作用。尽管近年来在环境胁迫与群落水平性状的关系方面取得了较大的研究进展,但对于干旱区地下水变化所引起的水分胁迫如何影响植物群落水平化学计量比仍知之甚少。本研究的目的是评估植物群落地上地下部分化学计量比对地下水变化的不同响应。我们通过对典型干旱内陆河流域的110个样方进行调查,测定叶片和细根的氮磷含量,利用生物量加权法计算其化学计量比,并试图探究沿地下水位梯度,群落水平的化学计量比的变化模式及其关键驱动因素。研究结果表明,在群落水平上,地下水、植被类型以及物种组成是影响叶片与细根氮、磷与氮磷比的主要因素,其中地下水位起着主导性作用。地下水的作用主要表现为间接作用,其主要通过调控植被类型和物种组成来影响群落水平的氮磷化学计量比。植被类型和物种组成均对群落水平的氮磷化学计量比具有显著的直接作用。此外,在群落水平上,地下水对叶片与细根氮磷化学计量比的作用不同。地下水通过影响植被类型进而降低叶片氮、磷含量,以及增加叶片氮磷比与细根氮含量。地下水通过影响物种组成进而增加细根磷含量,降低细根氮磷比。综上所述,地下水而不是气候有效的调控了群落水平的氮磷化学计量比。此外,植物群落地上地下部分氮磷化学计量比对地下水位变化具有不同的响应。 | Yin Wang Jianming Wang Xiaolin Wang Yicheng He Guanjun Li Jingwen Li | 2021 | Journal of Plant Ecology2021，14，6： | 2 |
| 19 | Genetic and Epigenetic Understanding of the Seasonal Timing of Flowering显示文摘The developmental transition to flowering in many plants is timed by changing seasons,which enables plants to flower at a season that is favorable for seed production.Many plants grown at high latitudes perceive the seasonal cues of changing day length and/or winter cold(prolonged cold exposure),to regulate the expression of flowering-regulatory genes through the photoperiod pathway and/or vernalization pathway,and thus align flowering with a particular season.Recent studies in the model flowering plant Arabidopsis thaliana have revealed that diverse transcription factors engage various chromatin modifiers to regulate several key flowering-regulatory genes including FLOWERING LOCUS C(FLC)and FLOWERING LOCUS T(FT)in response to seasonal signals.Here,we summarize the current understanding of molecular and chromatin-regulatory or epigenetic mechanisms underlying the vernalization response and photoperiodic control of flowering in Arabidopsis.Moreover,the conservation and divergence of regulatory mechanisms for seasonal flowering in crops and other plants are briefly discussed. | Yuehui He Tao Chen Xiaolin Zeng | 2020 | Plant Communications2020，1，1： | 2 |
| 20 | Neuroprotective effect of early and short-time applying sophoridine in pMCAO rat brain: Down-regulated TRAF6 and up-regulated p-ERK1/2 expression, ameliorated brain infaction and edema显示文摘 | Zongjie Liu Dan He Xiangjian Zhang Yanhua Li Chunhua Zhu Lipeng Dong Xiaolin Zhang Yinxue Xing Chaohui Wang Huimin Qiao Linyu Chen | 2012 | Brain Research Bulletin2012，，4： | 2 |
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