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| 1 | 使用ATP酶敏感钾离子通道开放剂——尼可地尔静脉给药用于冠状动脉腔内血管成形术介入治疗的药学证据显示文摘1前言动物实验研究表明,反复短暂的冠脉闭塞导致心脏抗心肌缺血的发作,这种现象被称为缺血性预处理。一些研究表明,这种预处理的效果是由于ATP敏感性钾通道的激活(KATP通道)。人类涉及经皮冠状动脉成形术(PTCA)的临床研究发现KATP通道的关闭与格列本脲防止预处理的效果通常出现在反复球囊扩张期间血管成形术模型中,表明ATP敏感性钾通道在预处理中发挥了核心作用。 | Hitoshi Matsuo Sachiro Watanabe Tomonori Segawa Shinji Yasuda Takeshi Hirose Makoto Iwama Shinichiro Tanaka Takahiko Yamaki Yukihiko Matsuno Masaaki Tomita Shinya Minatoguchi Hisayoshi Fujiwara 魏丽莎 | 2015 | 首都食品与医药2015，0，8： | 3 |
| 2 | Cancer/testis antigen, Kita-Kyushu lung cancer antigen-1 and ABCD stratification for diagnosing gastric cancers显示文摘BACKGROUND The ABCD stratification[combination of serum pepsinogen(PG)levels and titers of antibody(immunoglobulin G,IgG)against Helicobacter pylori(H.pylori)]is effective for the classification of individuals at risk of developing gastric cancer(GC).The Kita–Kyushu lung cancer antigen-1(KK-LC-1)is a Cancer/Testis antigen frequently expressed in GC.AIM To evaluate the effectiveness of KK-LC-1 and ABCD stratification in the diagnosis of GC.METHODS We analyzed the gene expression of KK-LC-1 in surgical specimens obtained from GC tumors.The levels of serum PG I/PG II and IgG against H.pylori were measured.According to their serological status,the patients were classified into the four groups of the ABCD stratification.RESULTS Of the 77 examined patients,63(81.8%)expressed KK-LC-1.The IgG titers of H.pylori and PG II were significantly higher in patients expressing KK-LC-1 than those measured in patients not expressing KK-LC-1(P=0.0289 and P=0.0041,respectively).The expression of KK-LC-1 in group C[PG method(+)/H.pylori infection(+)]was as high as 93.9%high.KK-LC-1 was also detected in group A[-/-].CONCLUSION The KK-LC-1 expression in GC was associated with H.pylori infection and atrophic status,so that,KK-LC-1 may be a useful marker for the diagnosis of GC. | Akiko Shida Takashi Fukuyama Nobue Futawatari Haruki Ohmiya Yoshinobu Ichiki Tetsuro Yamashita Yatsushi Nishi Noritada Kobayashi Hitoshi Yamazaki Masahiko Watanabe Yoshihito Takahashi | 2020 | World Journal of Gastroenterology2020，26，4： | 3 |
| 3 | Early gastric cancer frequently has high expression of KKLC-1, a cancer-testis antigen显示文摘AIM To assess cancer-testis antigens(CTAs) expression in gastric cancer patients and examined their associations with clinicopathological factors.METHODS Eighty-three gastric cancer patients were evaluated in this study. Gastric cancer specimens were evaluated for the gene expression of CTAs, Kitakyushu lung cancer antigen-1(KK-LC-1), melanoma antigen(MAGE)-A1, MAGE-A3 and New York esophageal cancer-1(NYESO-1), by reverse transcription PCR. Clinicopathological background information, such as gender, age, tumor size, macroscopic type, tumor histology, depth of invasion, lymph node metastasis, lymphatic invasion, venous invasion, and pathological stage, was obtained. Statistical comparisons between the expression of each CTA and each clinicopathological background were performed using the χ2 test. RESULTS The expression rates of KK-LC-1, MAGE-A1, MAGE-A3, and NY-ESO-1 were 79.5%, 32.5%, 39.8%, and 15.7%, respectively. In early stage gastric cancer specimens, the expression of KK-LC-1 was 79.4%, which is comparable to the 79.6% observed in advanced stage specimens. The expression of KK-LC-1 was not significantly associated with clinicopathological factors, while there were considerable differences in the expression rates of MAGE-A1 and MAGE-A3 with vs without lymphatic invasion(MAGE-A1, 39.3% vs 13.6%, P = 0.034; MAGE-A3, 47.5% vs 18.2%, P = 0.022) and/or vascular invasion(MAGE-A1, 41.5% vs 16.7%, P = 0.028; MAGE-A3, 49.1% vs 23.3%, P = 0.035) and, particularly, MAGE-A3, in patients with early vs advanced stage(36.5% vs 49.0%, P = 0.044), respectively. Patients expressing MAGE-A3 and NYESO-1 were older than those not expressing MAGE-A3 and NY-ESO-1(MAGE-A3, 73.7 ± 7.1 vs 67.4 ± 12.3, P = 0.009; NY-ESO-1, 75.5 ± 7.2 vs 68.8 ± 11.2, P = 0.042). CONCLUSION The KK-LC-1 expression rate was high even in patients with stage I cancer, suggesting that KK-LC-1 is a useful biomarker for early diagnosis of gastric cancer. | Nobue Futawatari Takashi Fukuyama Rui Yamamura Akiko Shida Yoshihito Takahashi Yatsushi Nishi Yoshinobu Ichiki Noritada Kobayashi Hitoshi Yamazaki Masahiko Watanabe | 2017 | World Journal of Gastroenterology2017，23，46： | 3 |
| 4 | Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study显示文摘 | Kazuaki Kitajima Takahiro Fujimori Shigehiko Fujii Jun Takeda Yasuo Ohkura Hitoshi Kawamata Toshihide Kumamoto Shingo Ishiguro Yo Kato Tadakazu Shimoda Akinori Iwashita Yoichi Ajioka Hidenobu Watanabe Toshiaki Watanabe Tetsuichiro Muto Ko Nagasako | 2004 | Journal of Gastroenterology2004，，6： | 2 |
| 5 | The Class IV Semaphorin CD100 Plays Nonredundant Roles in the Immune System显示文摘 | Wei Shi Atsushi Kumanogoh Chie Watanabe Junji Uchida Xiaosong Wang Teruhito Yasui Kazunori Yukawa Masahito Ikawa Masaru Okabe Jane R Parnes Kanji Yoshida Hitoshi Kikutani | 2000 | Immunity2000，，5： | 2 |
| 6 | Longitudinal associations between anaerobic threshold and distance running performance显示文摘 | Kiyoji Tanaka Hitoshi Watanabe Yotaro Konishi Ryoichi Mitsuzono Satoshi Sumida Shinsuke Tanaka Takashi Fukuda Fumio Nakadomo | 1986 | European Journal of Applied Physiology and Occupational Physiology1986，，： | 2 |
| 7 | Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells显示文摘AIM: To elucidate the mechanisms of hepatocyte preconditioning by H2O2 to better understand the pathophysiology of ischemic preconditioning. METHODS: The in vitro effect of H2O2 pretreatment was investigated in rat isolated hepatocytes subjected to anoxia/reoxygenation. Cell viability was assessed with propidium iodide fluorometry. In other experiments, rat livers were excised and subjected to warm ischemia/ reperfusion in an isolated perfused liver system to determine leakage of liver enzymes. Preconditioning was performed by H2O2 perfusion, or by stopping the perfusion for 10 min followed by 10 min of reperfusion. To inhibit Kupffer cell function or reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, gadolinium chloride was injected prior to liver excision, or diphenyleneiodonium, an inhibitor of NADPH oxidase, was added to the perfusate, respectively. Histological detection of oxygen radical formation in Kupffer cells was performed by perfusion with nitro blue tetrazolium. RESULTS: Anoxia/reoxygenation decreased hepatocyte viability compared to the controls. Pretreatment with H2O2 did not improve such hepatocyte injury. In liver perfusion experiments, however, H2O2 preconditioning reduced warm ischemia/reperfusion injury, which wasreversed by inhibition of Kupffer cell function or NADPH oxidase. Histological examination revealed that H2O2 preconditioning induced oxygen radical formation in Kupffer cells. NADPH oxidase inhibition also reversed hepatoprotection by ischemic preconditioning. CONCLUSION: H2O2 preconditioning protects hepato- cytes against warm ischemia/reperfusion injury via NADPH oxidase in Kupffer cells, and not directly. NADPH oxidase also mediates hepatoprotection by ischemic preconditioning. | Kazuaki Tejima Masahiro Arai Hitoshi Ikeda Tomoaki Tomiya Mikio Yanase Yukiko Inoue Takako Nishikawa Naoko Watanabe Natsuko Ohtomo Masao Omata Kenji Fujiwara | 2007 | World Journal of Gastroenterology2007，13，38： | 2 |
| 8 | Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study显示文摘 | Kazuaki Kitajima Takahiro Fujimori Shigehiko Fujii Jun Takeda Yasuo Ohkura Hitoshi Kawamata Toshihide Kumamoto Shingo Ishiguro Yo Kato Tadakazu Shimoda Akinori Iwashita Yoichi Ajioka Hidenobu Watanabe Toshiaki Watanabe Tetsuichiro Muto Ko Nagasako | 2004 | Journal of Gastroenterology2004，，6： | 2 |
| 9 | Longitudinal associations between anaerobic threshold and distance running performance显示文摘 | Kiyoji Tanaka Hitoshi Watanabe Yotaro Konishi Ryoichi Mitsuzono Satoshi Sumida Shinsuke Tanaka Takashi Fukuda Fumio Nakadomo | 1986 | European Journal of Applied Physiology and Occupational Physiology1986，，3： | 2 |
| 10 | Malignant Transformation Arising From Mature Cystic Teratoma of the Ovary: A Retrospective Study of 20 Cases显示文摘 | Michiko Sakuma Takeo Otsuki Kosuke Yoshinaga Hiroki Utsunomiya Satoru Nagase Tadao Takano Hitoshi Niikura Kiyoshi Ito Keiko Otomo Toru Tase Yoh Watanabe Nobuo Yaegashi | 2010 | International Journal of Gynecological Cancer2010，，5： | 2 |
| 11 | 楼梯间内人流合并特性研究(英文)显示文摘探讨了楼梯间内人流合并的影响以及随着人员密度的变化,合流方向和楼梯间与大厅之间门开启与关闭状态对人流合并难易程度的影响。研究结果表明:(1)人员密度小时合流较容易;(2)如果加入人流与楼梯内人员疏散方向相同时,人流合并较容易;(3)门处于开启状态时,合流较容易。如果门处于关闭状态,人员的疏散速度将降低30%。 | NAOHIRO TAKEICHI YOSHIYUKI YOSHIDA TOMONORI SANO TAKESHI KIMURA HITOSHI WATANABE YOSHIFUMI OHMIYA5 | 2007 | 消防科学与技术2007，26，4： | 2 |
| 12 | Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction显示文摘 | Kazuo Takayama Mitsuru Inamura Kenji Kawabata Michiko Sugawara Kiyomi Kikuchi Maiko Higuchi Yasuhito Nagamoto Hitoshi Watanabe Katsuhisa Tashiro Fuminori Sakurai Takao Hayakawa Miho Kusuda Furue Hiroyuki Mizuguchi | 2012 | Journal of Hepatology2012，，3： | 1 |
| 13 | Relationship between the proliferative capability of hepatocytes andthe intrahepatic expression of hepatocyte growth factor and c-Met in the courseof cirrhosis development in rats显示文摘 | Hideyuki Inoue Fumi Yokoyama Yuko Kita Hitoshi Yoshiji Tatsuhiro Tsujimoto Akihiro Deguchi Seiji Nakai Asahiro Morishita Naohito Uchida Tsutomu Masaki Seishiro Watanabe Shigeki Kuriyama | 2006 | International Journal of Molecular Medicine2006，，5： | 1 |
| 14 | Vitreous levels of angiopoietin 2 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy显示文摘 | Daisuke Watanabe Kiyoshi Suzuma Izumi Suzuma Hirokazu Ohashi Tomonari Ojima Masafumi Kurimoto Tomoaki Murakami Tetsushi Kimura Hitoshi Takagi | 2005 | American Journal of Ophthalmology2005，，3： | 1 |
| 15 | Thymosin-α1 increases intrahepatic NKT cells and CTLs in patients with chronic hepatitis B显示文摘 | Satoshi Sugahara Takafumi Ichida Satoshi Yamagiwa Toru Ishikawa Kazuhiro Uehara Yuhei Yoshida Xiu-Hua Yang Minoru Nomoto Hisami Watanabe Toru Abo Hitoshi Asakura | 2002 | Hepatology Research2002，，4： | 1 |
| 16 | Application of monoclonal antibody against ginsenoside in ginseng research:a review显示文摘Panax genus belonging to a family of Araliaceae grow in Asia(9 species)and in North America(2 species).Especially Panax ginseng was listed in Chinese medical book,Shennong's Classic of Materia Medica approximately 2 thousand years ago and Panax species are now one of the most important natural medicine.Since Panax species contain approximately 260 ginsenosides,its quality control and pharmacological movement of ginsenoside in body are not enough understanding.Monoclonal antibodies against ginsenosides were prepared and set up the enzyme linked immunosorbent assay system for the quality control of natural product.Furthermore,we developed Eastern blotting system using monoclonal antibodies resulted that protopanaxadiol and protopanaxatriol group ginsenosides can be separately stained by two corresponding monoclonal antibodies,respectively.It became evident that the ginseng slice was stained by Eastern blotting system.Histochemical staining of ginseng can make clear the ginsenoside-Rb1 distribution in cells and tissues.Double Eastern blotting system facilitated by two monoclonal antibodies like anti-ginsenoside-Rb1 and anti-ginsenoside-Rg1 monoclonal antibodies gives several information such as sugar number,structure,and qualitative/quantitative evaluation.Immunoaffinity column combined with monoclonal antibodies succeeded one-step isolation of ginsenoside and make it possible to prepare knockout extract of which only antigen molecule was removed suggesting the pharmacological and biological value of antigen molecule in the crude extract. | Yui Sasaki Koichi Shimizu Hitoshi Watanabe Yukihiro Shoyama | 2021 | Traditional Medicine Research2021，6，3： | 1 |
| 17 | The value of narrow band imaging for early detection of laryngeal cancer显示文摘 | Akihito Watanabe Masanobu Taniguchi Hitoshi Tsujie Masao Hosokawa Masahiro Fujita Shigeyuki Sasaki | 2009 | European Archives of Oto - Rhino - Laryngology2009，，7： | 1 |
| 18 | Vitreous levels of angiopoietin 2 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy显示文摘 | Daisuke Watanabe Kiyoshi Suzuma Izumi Suzuma Hirokazu Ohashi Tomonari Ojima Masafumi Kurimoto Tomoaki Murakami Tetsushi Kimura Hitoshi Takagi | 2005 | American Journal of Ophthalmology2005，，3： | 1 |
| 19 | The value of narrow band imaging for early detection of laryngeal cancer显示文摘 | Akihito Watanabe Masanobu Taniguchi Hitoshi Tsujie Masao Hosokawa Masahiro Fujita Shigeyuki Sasaki | 2009 | European Archives of Oto - Rhino - Laryngology2009，，7： | 1 |
| 20 | Novel role of erythropoietin in proliferative diabetic retinopathy显示文摘 | Hitoshi Takagi Daisuke Watanabe Kiyoshi Suzuma Masafumi Kurimoto Izumi Suzuma Hirokazu Ohashi Tomonari Ojima Tomoaki Murakami | 2007 | Diabetes Research and Clinical Practice2007，，3： | 1 |
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