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| 1 | High-Resolution Genome-wide Association Study Identifies Genomic Regions and Candidate Genes for Important Agronomic Traits in Wheat显示文摘Wheat(Triticum aestivum)is a major staple food crop worldwide.Genetic dissection of important agronomic traits is essential for continuous improvement of wheat yield to meet the demand of the world's growing population.We conducted a large-scale genome-wide association study(GWAS)using a panel of 768 wheat cultivars that were genotyped with 327609 single-nucleotide polymorphisms generated by genotyping-by-sequencing and detected 395 quantitative trait loci(QTLs)for 12 traits under 7 environments.Among them,273 QTLs were delimited to≤1.0-Mb intervals and 7 of them are either known genes(Rht-D,Vrn-B1,and Vrn-D1)that have been cloned or known QTLs(TaGA2ox8,APO1,TaSus1-7B,and Rht12)that were previously mapped.Eight putative candidate genes were identified for three QTLs that enhance spike seed setting and grain size using gene expression data and were validated in three bi-parental populations.Protein sequence analysis identified 33 putative wheat orthologs that have high identity with rice genes in QTLs affecting similar traits.Large r^2 values for additive effects observed among the QTLs for most traits indicated that the phenotypes of these identified QTLs were highly predictable.Results from this study demonstrated that significantly increasing GWAS population size and marker density greatly improves detection and identification of candidate genes underlying a QTL,solidifying the foundation for large-scale QTL fine mapping,candidate gene validation,and developing functional markers for genomics-based breeding in wheat. | Yunlong Pang Chunxia Liu Danfeng Wang Paul St.Amand Amy Bernardo Wenhui Li Fang He Linzhi Li Liming Wang Xiufang Yuan Lei Dong Yu Su Huirui Zhang Meng Zhao Yunlong Liangi Hongze Jia Xitong Shen Yue Lu Hongming Jiang Yuye Wu Anfei Li Honggang Wang Lingrang Kong Guihua Bai Shubing Liu | 2020 | Molecular Plant2020，13，9： | 8 |
| 2 | Coagulation factors VII, IX and X are effective antibacterial proteins against drug-resistant Gram-negative bacteria显示文摘Infections caused by drug-resistant“superbugs”pose an urgent public health threat due to the lack of effective drugs;however, certain mammalian proteins with intrinsic antibacterial activity might be underappreciated. Here, we reveal an antibacterial property against Gram-negative bacteria for factors VII, IX and X, three proteins with well-established roles in initiation of the coagulation cascade. These factors exert antibacterial function via their light chains (LCs). Unlike many antibacterial agents that target cell metabolism or the cytoplasmic membrane, the LCs act by hydrolyzing the major components of bacterial outer membrane, lipopolysaccharides, which are crucial for the survival of Gram-negative bacteria. The LC of factor VII exhibits in vitro efficacy towards all Gram-negative bacteria tested, including extensively drug-resistant (XDR) pathogens, at nanomolar concentrations. It is also highly effective in combating XDR Pseudomonas aeruginosa and Acinetobacter baumannii infections in vivo. Through decoding a unique mechanism whereby factors VII, IX and X behave as antimicrobial proteins, this study advances our understanding of the coagulation system in host defense, and suggests that these factors may participate in the pathogenesis of coagulation disorder-related diseases such as sepsis via their dual functions in blood coagulation and resistance to infection. Furthermore, this study may offer new strategies for combating Gram-negative “superbugs”. | Jinwu Chen Xiaojie Li Ling Li Ting Zhang Qing Zhang Fangming Wu Diyue Wang Hongze Hu Changlin Tian Dongsheng Liao Liang Zhao Danxia Song Yongyun Zhao Chuanfang Wu Xu Song | 2019 | Cell Research2019，29，9： | 6 |
| 3 | Application of a novel constrained wavelet threshold denoising method in ensemble-based background-error variance显示文摘A more efficient noise filtering technique is needed in ensemble data assimilation, to improve traditional spectral filtering methods that cannot reflect the local characteristics of spatial scales. In this paper, we present the design of a novel constrained wavelet threshold denoising method(CWTDNM) by introducing an improved threshold value and a new constraining parameter.The proposed method aims to filter noise swamped over different scales. We prepared an ideal experiment object based on the two-dimensional barotropic vorticity equation. A suitable wavelet basis function(i.e., Db11) and the optimal number of decomposition levels(i.e., five) were first selected. The results show that, given the wavelet coefficients are constrained by the parameter, the CWTDNM can produce better filtering results with the smallest root mean square error(RMSE) compared to similar methods. In addition, the filtering accuracy of 10 ensemble sample variances using the CWTDNM is equivalent to that estimated directly from 80 ensemble samples, but with the runtime reduced to approximately one-seventh. Furthermore, a large peak signal-to-noise ratio, which implies a low RMSE, suggests that the proposed method suitably preserves most of the information after denoising. | HUANG QunBo LIU BaiNian ZHANG WeiMin ZHU MengBin SUN JingZhe CAO XiaoQun XING Xiang LENG HongZe ZHAO YanLai | 2018 | Science China(Technological Sciences)2018，61，6： | 2 |
| 4 | Parameter inversion and location determination of evolutionary weak layer for open-pit mine slope显示文摘In light of the complex and dynamic mechanical properties of evolving weak strata in open-pit mines,and the consequent difficulty of determining their mechanical parameters,this study uses the ultimate balance theory,along with the back analysis method combined with monitoring data on field displacement,to carry out parameter inversion using the FLAC3D numerical simulation software.The edge slope of a working pit of the Weijiamao open-pit mine was used as research object to this end.As the results obtained by the constitutive model were consistent with the field monitoring data,the evolving weak strata in the slope and the position of the landslide in the mine could be obtained.The landslide was directed northeast.The mechanism of the edge slope of the working pit was identified as unloading shear failure,and the feasibility of the method of parameter inversion was verified.The internal friction angle φand cohesion C of evolving weak strata in the slope of the open-pit mine were also obtained,where this compensated for the deficiency of laboratory tests and enabled the transformation from qualitative to quantitative analysis.This can provide a reliable basis for the safe operation of open-pit mines. | Zhao Hongze Wang Dongyu Ma Ming Zheng Kaihui | 2020 | International Journal of Coal Science & Technology2020，7，4： | 2 |
| 5 | Homeobox B8 Targets Sterile Alpha Motif Domain-Containing Protein 9 and Drives Glioma Progression显示文摘Gliomas are the most commonly occurring tumors of the central nervous system. Glioblastoma multiforme (GBM) is the most malignant and aggressive brain cancer in adults. Further understanding of the mechanisms underlying the aggressive nature of GBM is urgently needed. Here we identified homeobox B8(HOXB8), a member of the homeobox family, as a crucial contributor to the aggressiveness of GBM. Data mining of publicly accessible RNA sequence datasets and our patient cohorts confirmed a higher expression of HOXB8 in the tumor tissue of GBM patients, and a strong positive correlation between the expression level and pathological grading of tumors and a negative correlation between the expression level and the overall survival rate. We next showed that HOXB8 promotes the proliferation and migration of glioblastoma cells and is crucial for the activation of the PI3K/AKT pathway and expression of epithelial–mesenchymal transition-related genes, possibly through direct binding to the promoter of SAMD9 (Sterile Alpha Motif Domain-Containing Protein 9) and activating its transcription. Collectively, we identified HOXB8 as a critical contributor to the aggressiveness of GBM, which provides insights into a potential therapeutic target for GBM and opens new avenues for improving its treatment outcome. | Wenping Ma Hongze Jin Wenjie Liu Xiaojuan Li Xingang Zhou Xinwu Guo Runfa Tian Qi Cui Junjie Luo Yueying Jiao Youtao Yu Haifeng Yang Hongshan Zhao | 2020 | Neuroscience Bulletin2020，36，4： | 2 |
| 6 | Sinomenine derivatives with embedment of nitrogen-containing heterocycles exhibiting potent TNF-inhibitory activity显示文摘Inhibitory effect on tumor necrosis factor-(TNF-) production by sinomenine derivatives with embedment of small drug-like nitrogen hetereocyclic moieties has been studied in this work.Several new sinomenine derivatives having chlorophenyl substituent have been found to exhibit much more potent TNF-α inhibitory activity than natural sinomenine and other derivatives. | WANG Meng MA LiYan LOU YangTong BIAN Chao ZHOU TingTing ZHOU HaiBin LIAO HongZe MA Zhao YIN DongSheng CHEN AiZhong WANG ShaoZhong YANG ZhenYu SUN Bing YAO ZhuJun | 2012 | Science China Chemistry2012，55，12： | 1 |
| 7 | Simplified numerical models for complex air supply diffusers显示文摘 | Ren Hongze Zhao Bin Li Xianting | 2003 | Building and Environment2003，9，4： | 1 |
| 8 | Annual Electric Load Forecasting by a Least Squares Support Vector Machine with a Fruit Fly Optimization Algorithm显示文摘 | Hongze Li Sen Guo Huiru Zhao Chenbo Su Bao Wang | 2012 | Energies2012，5，： | 1 |
| 9 | The slope creep law for a soft rock in an open-pit mine in the Gobi region of Xinjiang, China显示文摘The lithology of the strata in the Gobi region of the Xinjiang autonomous region of China is mainly composed of mudstone,silty mudstone,and other soft rocks.Because of the low strength of the rock mass and the serious effects of physical weathering in this area,the slope stability in open-pit mines is poor,and creep deformation and instability can readily occur.Taking the Dananhu No.2 open-pit mine as a typical example,the creep test of a mudstone sample under different stress levels was studied.Then,based on a bottom friction experiment and a FLAC3D numerical simulation,the deformation and failure processes of the slope were analyzed.The stress–displacement curve and the displacement–time curve for the monitoring points were plotted to obtain the relationship between the stress and displacement for the slope of the soft rock.The results showed that the long-term strength of the mudstone was between 8.0 and 8.8 MPa,and that stable creep occurred when the slope was under low stress.The potential failure mode for this type of slope is that the front edge creeps along the weak layer and then a crack is formed at the trailing edge of the slope.When the crack penetrates the weak layer,cutting bedding and bedding sliding occur.The deformation process of the stable creep slope includes an initial deformation stage,an initial creep stage,a constant velocity creep stage and a deceleration creep stage. | Hongze Zhao Yu Tian Qingyong Guo Meijie Li Jianwen Wu | 2020 | International Journal of Coal Science & Technology2020，7，2： | 1 |
| 10 | Development of a double antibodies sandwich ELISA for the detection of avian leukosis virus subgroup J based on monoclonal antibodies against gp85显示文摘Avian leukosis virus(ALV)belongs to the genus Alpharetrovirus of the family Retroviridae and can cause various types of neoplastic diseases,even mortality in infected chickens[1].ALV is categorized into seven subgroups,including A,B,C,D,E,J,and K,based on the pathogenicity and antibody neutralization characteristics[2].The subgroup E is endogenous and transmitted by Mendelian inheritance.The subgroups A,B,C,D,J,and K are exogenous and oncogenic,transmitted horizontally and vertically and caused different pathological lesions[3].Among them,subgroups A and B were most common in commercial poultry and subgroup J is the major cause for myeloid leukosis and nephromas in broilers.In 1980,ALV subgroup J(ALV-J)was first isolated and identified from infected broilers in Britain.It caused significant economic losses in the poultry industry because of increased myelocytomas and other tumors[4].In China,ALV-J was first detected in broilers in 1999 and,subsequently,spread to other chicken types.Compared to other ALV subgroups,ALV-J has been a serious issue in China poultry industry since 2007.Currently,there is no effective vaccine and drugs against ALV-J infection;thus,early detection and elimination of ALV-positive breeder chickens are key measures to block vertical and horizontal ALV-J transmission.Given the importance of ALV to the poultry industry,many ALV detection methods,including virus isolation,immunofluorescence assays,neutralization tests,reverse transcription polymerase chain reaction(PCR)or real-time fluorescent quantitative PCR-based molecular diagnosis ways,and enzyme-linked immunosorbent assays(ELISA)have been developed.Among them,ELISA is widely used for its efficiency,convenience,and sensitivity.Yun et al.[5]developed an antigen-capture ELISA for the detection of ALV based on highly conserved antigen p27.Yu et al.[6]exploited a colloidal gold test strip specific for the detection of ALV p27 antigen.These antigen capture-based serological detection methods share obviously simple,accurate,and rapid advantages in comparison with conventional time-consuming methods of indirect immunofluorescence assay or neutralization tests.However,it is difficult to identify different subgroups of ALV using p27-coated antibodies. | Lili Cao Panpan Zhao He Ding Nan Wang Xue Zhang Shuxian Yuan Hang Dong Yanbing Guo Xinhua Yao Qinlei Yu Hongze Shao Pengtao Gong | 2021 | Acta Biochimica et Biophysica Sinica2021，53，10： | 1 |
| 11 | Annual electric load forecasting by a least squares support vector machine with a fruit fly optimization algorithm显示文摘 | LI Hongze GUO Sen ZHAO Huiru | 2012 | Energies2012，5，11： | 1 |
| 12 | A novel TNKS/USP25 inhibitor blocks the Wnt pathway to overcome multi-drug resistance in TNKS-overexpressing colorectal cancer显示文摘Modulating Tankyrases(TNKS),interactions with USP25 to promote TNKS degradation,rather than inhibiting their enzymatic activities,is emerging as an alternative/specific approach to inhibit the Wnt/β-catenin pathway.Here,we identified UAT-B,a novel neoantimycin analog isolated from Streptomyces conglobatus,as a small-molecule inhibitor of TNKS-USP25 protein-protein interaction(PPI)to overcome multi-drug resistance in colorectal cancer(CRC).The disruption of TNKS-USP25 complex formation by UAT-B led to a significant decrease in TNKS levels,triggering cell apoptosis through modulation of the Wnt/β-catenin pathway.Importantly,UAT-B successfully inhibited the CRC cells growth that harbored high TNKS levels,as demonstrated in various in vitro and in vivo studies utilizing cell line-based and patient-derived xenografts,as well as APC^(min/+)spontaneous CRC models.Collectively,these findings suggest that targeting the TNKS-USP25 PPI using a small-molecule inhibitor represents a compelling therapeutic strategy for CRC treatment,and UAT-B emerges as a promising candidate for further preclinical and clinical investigations. | Hongrui Zhu Yamin Gao Liyun Liu Mengyu Tao Xiao Lin Yijia Cheng Yaoyao Shen Haitao Xue Li Guan Huimin Zhao Li Liu Shuping Wang Fan Yang Yongjun Zhou Hongze Liao Fan Sun Houwen Lin | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 13 | Self-Assembly of Luminescent Twisted Fibers Based on Achiral Quinacridone Derivatives显示文摘It is a great challenge to spontaneously assemble achiral molecules into twisted nanostructures in the absence of chiral substances.Here we show that two achiral centrosymmetric quinacridone(QA)derivatives,N,N’-di(n-hexyl)-1,3,8,10-tetramethylquinacridone(C6TMQA)and N,N’-di(n-decyl)-1,3,8,10-tetramethylquinac ridone(C10TMQA),can be employed as building blocks to fabricate well-defi ned twisted nanostructures by controlling the solvent composition and concentration.Bowknot-like bundles with twisted fiber arms were prepared from C6TMQA,whilst uniform twisted fibers were generated from C10TMQA in ethanol/THF solution.Spectroscopic characterization and molecular simulation calculations revealed that the introduction of ethanol into the solution could induce a staggered aggregation of C6TMQA(or C10TMQA)molecules and the formation of twisted nanostructures.Such twisted materials generated from achiral organic functional molecules may be valuable in the design and fabrication of new materials for optoelectronic applications. | Yunfeng Zhao Yan Fan Xiaoyue Mu Hongze Gao Jia Wang Jingying Zhang Wensheng Yang Lifeng Chi Yue Wang | 2009 | Nano Research2009，2，6： | 0 |
| 14 | Distributed Beamforming for Energy-Harvesting Relaying in Vehicular Networks显示文摘Recently,battery capacity and charging speed have been the bottlenecks of mobile communication networks.Energy harvesting(EH)relaying has become a promising solution for green 5th generation mobile communication with the advancement of wireless power transfer technology.In this paper,we investigate EH relaying in vehicular networks and adopt distributed beamforming(DB)to enhance the reliability and capacity of EH relaying.To be more specific,we propose a DB solution based on the joint optimization of power-splitting(PS)factors.For amplify-and-forward relaying,to transform the optimization problem into a quasi-convex one,we apply the semidefinite relaxation(SDR)method so that we can effectively attain the global optimal solution,while the suboptimal DB solution with distributed optimal PS factor which only requires local channel state information is also proposed.For decode-and-forward relaying,to get the optimal PS factors,we set a signal-to-noise ratio threshold at the relays,which can reduce the system error rate caused by the poor transmission link.Simulation results demonstrate the efficiency of our proposed DB-based EH relaying scheme in vehicular networks. | Yuxiang Liang Bing Li Rongqing Zhang Hongze Li Shengjie Zhao | 2020 | Journal of Communications and Information Networks2020，5，2： | 0 |
| 15 | Indirubin-30 -monoxime-loaded PLGA-PEG nanoparticles for potential Alzheimer's disease treatment显示文摘Alzheimer's disease(AD)is an irreversible neurodegenerative disorder,which is pathologically characterized by the deposits of β-amyloid(Aβ),and plays an important role in neuronal death.Indirubin-30-monoxime(I3M)showed neuroprotective effects against Aβ-induced neuronal apoptosis.However,the use of I3M in AD treatment is limited due to its low bioavailability.Herein,PLGA-PEG nanoparticles were synthesized for I3M loading.I3M could release sustainedly sustain release from the I3M-loaded PLGA-PEG nanoparticles(PLGA-PEG-I3M NPs)without obvious burst release.What's more,the PLGA-PEG-I3M NPs could significantly promote the uptake of I3M by PC12 cells through nanoparticle-mediated transport,and improve the efficacy of I3M on the inhibition of Aβfibrillization and oligomerization as well as the neuroprotective activity of I3M on Aβoligomers-induced neuronal death.Thus,the PLGA-PEG-I3M NPs may be a promising platform for AD therapy. | Lingli Jin Qiyao Wang Mengxiang Yang Jiaying Zhang Hongze Liang Hui Tan Zhenjiang Liang Xiaopeng Ma Junying Liu Haiyan Li Xiaodong Cai Wei Cui Lingling Zhao | 2022 | Medicine in Novel Technology and Devices2022，，3： | 0 |
| 16 | Validation of the multi-satellite merged sea surface salinity in the South China Sea显示文摘Sea surface salinity(SSS)is an essential variable of ocean dynamics and climate research.The Soil Moisture and Ocean Salinity(SMOS),Aquarius,and Soil Moisture Active Passive(SMAP)satellite missions all provide SSS measurements.The European Space Agency(ESA)Climate Change Initiative Sea Surface Salinity(CCI-SSS)project merged these three satellite SSS data to produce CCI L4SSS products.We validated the accuracy of the four satellite products(CCI,SMOS,Aquarius,and SMAP)using in-situ gridded data and Argo floats in the South China Sea(SCS).Compared with in-situ gridded data,it shows that the CCI achieved the best performance(RMSD:0.365)on monthly time scales.The RMSD of SMOS,Aquarius,and SMAP(SMOS:0.389;Aquarius:0.409;SMAP:0.391)are close,and the SMOS takes a slight advantage in contrast with Aquarius and SMAP.Large discrepancies can be found near the coastline and in the shelf seas.Meanwhile,CCI with lower RMSD(0.295)perform better than single satellite data(SMOS:0.517;SMAP:0.297)on weekly time scales compared with Argo floats.Overall,the merged CCI have the smallest RMSD among the four satellite products in the SCS on both weekly time scales and monthly time scales,which illustrates the improved accuracy of merged CCI compared with the individual satellite data. | Huipeng WANG Junqiang SONG Chengwu ZHAO Xiangrong YANG Hongze LENG Nan ZHOU | 2023 | Journal of Oceanology and Limnology2023，41，6： | 0 |
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