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| 1 | Schisandra sphenanthera extract(Wuzhi Tablet)protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice显示文摘Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently available.Wuzhi Tablet(WZ), a preparation of extract from Schisandra sphenanthera that is a traditional hepatoprotective herb, exerted a significant protective effect against acetaminophen-induced liver injury in our recent studies, but whether WZ can alleviate alcohol-induced toxicity remains unclear. This study aimed to investigate the contribution of WZ to alcohol-induced liver injury by using chronic-binge and acute models of alcohol feeding. The activities of ALT and AST in serum were assessed as well as the level of GSH and the activity of SOD in the liver. The expression of CYP2E1 and proteins in the NRF2-ARE signaling pathway including NRF2, GCLC, GCLM, HO-1 were measured, and the effect of WZ on NRF2 transcriptional activity was determined. We found that both models resulted in liver steatosis accompanied by increased transaminase activities, but that liver injury was significantly attenuated by WZ. WZ administration also inhibited CYP2E1 expression induced by alcohol, and elevated the level of GSH and the activity of SOD in the liver. Moreover, the NRF2-ARE signaling pathway was activated by WZ andthe target genes were all upregulated. Furthermore, WZ significantly activated NRF2 transcriptional activity. Collectively, our study demonstrates that WZ protected against alcohol-induced liver injury by reducing oxidative stress and improving antioxidant defense, possibly by activating the NRF2-ARE pathway. | Xuezhen Zeng Xi Li Chenshu Xu Fulin Jiang Yufei Mo Xiaomei Fan Yaoting Li Yiming Jiang Dongshun Li Min Huang Huichang Bi | 2017 | Acta Pharmaceutica Sinica B2017，7，5： | 13 |
| 2 | Flexible high energy density zinc-ion batteries enabled by binder-free MnO_(2)/reduced graphene oxide electrode显示文摘We demonstrate a rechargeable zinc-ion battery with high energy density and cyclability using MnO_(2)and reduced graphene oxide(MnO_(2)/rGO)electrode.The flexible and binder free electrode,with high MnO_(2)mass ratio(80 wt%of MnO_(2)),is fabricated using vacuum filtration without any additional additives other than rGO.Compared to batteries with conventional MnO_(2)electrodes,the Zn-MnO_(2)/rGO battery shows a significant enhanced capacity(332.2 mAh g^(-1)at 0.3 A g^(-1)),improved rate capability(172.3 mAh g^(-1)at 6 A g^(-1))and cyclability.The capacity retention remains 96%after 500 charge/discharge cycles at 6 A g^(-1).The high MnO_(2)mass ratio makes MnO_(2)/rGO electrode advantageous when the capacity is normalized to the whole electrode,particularly at high rates.The calculated gravimetric energy density of Zn-MnO_(2)/rGO battery is 33.17Wh kg^(-1),which is comparable to the existing commercial lead-acid batteries(30-40Wh kg^(-1)).Furthermore,the discharge profile and capacity of our Zn-MnO_(2)/rGO battery shows no deterioration during bending test,indicating good flexibility.As a result,zinc-ion battery is believed to be a promising technology for powering next generation flexible electronics. | Yuan Huang Jiuwei Liu Qiyao Huang Zijian Zheng Pritesh Hiralal Fulin Zheng Dilek Ozgit Sikai Su Shuming Chen Ping-Heng Tan Shengdong Zhang Hang Zhou | 2018 | npj Flexible Electronics2018，2，1： | 4 |
| 3 | Distribution and sources of polycyclic aromatic hydrocarbons from urban to rural soils: A case study in Dalian, China显示文摘 | Zhen Wang Jingwen Chen Xianliang Qiao Ping Yang Fulin Tian Liping Huang | 2007 | Chemosphere2007，，5： | 2 |
| 4 | Effect of Konjac Food on Blood Glucose Level in Patients with Diabetes显示文摘Seventy-two type II diabetic subjects were given Konjac food for 65 days. The data analyzed by multiple F test indicate that the fasting blood glucose (FBG) and the 2-h postprandial blood glucose (PBG) on the 30th and the 65th days after the food was ingested were significantly reduced (P = 0.001, P < 0.001, respectively), as was the glycosylated hemoglobin level at the end of the trial (P < 0.05). The final FBG and PBG of the subjects with initial FBG-O >200 mg% decreased on the average by 51.8 and 84.6 mg%. respectively; those with FBG-0 150-200 mg% decreased by 24.1 and 68.7 mg%; and those with FBG-O < 150 mg% decreased by 4.8 and 21.4 mg%. No significant changes in blood lipid indexes were observed, except that the triglycer-ide values of subjects with hypertriglyceridemia (>200 mg%) significantly decreased by 118.7 mg%. It was concluded that Konjac food is very useful in the prevention and treatment of hyperglycemia. (C)1990 Academic Press. Inc. | HUANG CHENG-YU,~*ZHANG MAO-YU,~*PENG SHU-SHENG,~*HONG JUN-RONG,~*WANG XU,~*JIANG HUIJUN,~*ZHANG FULIN,~*BAI YUNXIANG,~*LIANG JINZHONG,Yu YERONG,LUO ZHAOTIAN,ZHANG XIANGXUN,AND ZHOU ZANCHENG~*School of Public Health, West China University of Medical Sciences (WCUMS). Chengdu, China Department of Endocrinology, First University Hospital of WCUMS, Chengdu, China and Staff Hospital of 107 Post Office Box, Chengdu, China | 1990 | Biomedical and Environmental Sciences1990，3，2： | 2 |
| 5 | The opposite prognostic significance of nuclear and cytoplasmic p21 expression in resectable gastric cancer patients显示文摘 | Yefei Huang Weimin Wang Yansu Chen Yulin Huang Jianbing Zhang Song He Yongfei Tan Fulin Qiang Aiping Li Oluf Dimitri R?e Shouyu Wang Yan Zhou Jianwei Zhou | 2014 | Journal of Gastroenterology2014，，11： | 2 |
| 6 | Ribonuclease H-like gene SMALL GRAIN2 regulates grain size in rice through brassinosteroid signaling pathway显示文摘Grain size is a key agronomic trait that determines the yield in plants.Regulation of grain size by brassinosteroids(BRs)in rice has been widely reported.However,the relationship between the BR signaling pathway and grain size still requires further study.Here,we isolated a rice mutant,named small grain2(sg2),which displayed smaller grain and a semi-dwarf phenotype.The decreased grain size was caused by repressed cell expansion in spikelet hulls of the sg2 mutant.Using map-based cloning combined with a Mut Map approach,we cloned SG2,which encodes a plant-specific protein with a ribonuclease H-like domain.SG2 is a positive regulator downstream of GLYCOGEN SYNTHASE KINASE2(GSK2)in response to BR signaling,and its mutation causes insensitivity to exogenous BR treatment.Genetical and biochemical analysis showed that GSK2 interacts with and phosphorylates SG2.We further found that BRs enhance the accumulation of SG2 in the nucleus,and subcellular distribution of SG2 is regulated by GSK2 kinase activity.In addition,Oryza sativa OVATE family protein 19(OsOFP19),a negative regulator of grain shape,interacts with SG2 and plays an antagonistic role with SG2 in controlling gene expression and grain size.Our results indicated that SG2 is a new component of GSK2-related BR signaling response and regulates grain size by interacting with Os OFP19. | Yunshuai Huang Hui Dong Changling Mou Ping Wang Qixian Hao Min Zhang Hongmin Wu Fulin Zhang Tengfei Ma Rong Miao Kai Fu Yaping Chen Ziyan Zhu Cheng Chen Qikai Tong Zhuoran Wang Shirong Zhou Xi Liu Shijia Liu Yunlu Tian Ling Jiang Jianmin Wan | 2022 | Journal of Integrative Plant Biology2022，64，10： | 1 |
| 7 | Clinical observation on the treatment of advanced colorectal and gastric carcinoma with Low-Dose Leucovorin and 5-Fluorouracil continuous IV infusion for 120 hours: resuits in 25 case显示文摘 | Zgeng Xinli Pan Liangxi Huang Fulin | 1992 | Journal of Nanjing Medical College1992，1，： | 1 |
| 8 | Clinical observation on the treatment of advanced colorectal and gastric carcinoma with low- does leucovorin and 5- fluorouracil continuous Ⅳ infusion for 120hours: results in 25 cases 显示文摘 | Zhang Xinli Pan Liangxi Huang Fulin | | J Nanjing Med Coll0，，： | 1 |
| 9 | MILD Combustion for Hydrogen and Syngas at Elevated Pressures显示文摘As gas recirculation constitutes a fundamental condition for the realization of MILD combustion, it is necessary to determine gas recirculation ratio before designing MILD combustor. MILD combustion model with gas recirculation was used in this simulation work to evaluate the effect of fuel type and pressure on threshold gas recirculation ratio of MILD mode. Ignition delay time is also an important design parameter for gas turbine combustor, this parameter is kinetically studied to analyze the effect of pressure on MILD mixture ignition. Threshold gas recirculation ratio of hydrogen MILD combustion changes slightly and is nearly equal to that of 10 MJ/Nm3syngas in the pressure range of 1-19 atm, under the conditions of 298 K fresh reactant temperature and 1373 K exhaust gas temperature, indicating that MILD regime is fuel flexible. Ignition delay calculation results show that pressure has a negative effect on ignition delay time of 10 MJ/Nm3syngas MILD mixture, because OH mole fraction in MILD mixture drops down as pressure increases, resulting in the delay of the oxidation process. | HUANG Mingming ZHANG Zhedian SHAO Weiwei XIONG Yan LEI Fulin XIAO Yunhan | 2014 | Journal of Thermal Science2014，23，1： | 1 |
| 10 | 靶向肾癌中的E3连接酶接头蛋白SPOP的小分子抑制剂显示文摘近年来肾癌发病率上升幅度在恶性肿瘤中排名第一。临床治疗表明,肾癌对放疗和化疗均不敏感,以索拉非尼和舒尼替尼为代表的靶向抗肿瘤药物是晚期肾癌的一线治疗药物,但对转移性肾癌的疗效十分有限,并且容易产生耐药。因此,发现并确证治疗肾癌特异性药物作用新靶标是一项十分紧迫并意义重大的任务。 | Zhong-Qiang Guo Tong Zheng Baoen Chen Cheng Luo Sisheng Ouyang Shouzhe Gong Jiafei Li Liu-Liang Mao Fulin Lian Yong Yang Yue Huang Li Li Jing Lu Bidong Zhang Luming Zhou Hong Ding Zhiwei Gao Liqun Zhou Guoqiang Li Ran Zhou Ke Chen Jingqiu Liu Yi Wen Likun Gong Yuwen Ke Shang-Dong Yang Xiao-Bo Qiu Naixia Zhang Jin Ren Dafang Zhong 杨财广 刘江 蒋华良 | 2017 | 科学新闻2017，19，4： | 1 |
| 11 | A novel halogen-free flame retardant for glass-fiber-reinforced poly(ethylene terephthalate)显示文摘 | Zhao Chengshou Huang Fulin Xiong Weicheng | 2008 | Polymer Degradation and Stability2008，93，6： | 1 |
| 12 | Invasive weed optimization algorithm for optimizating the parameters of mixed kernel twin support vecotr machines 显示文摘 | Huang Huajuan Ding Shifei Wu Fulin | 2013 | Journal of Computers2013，8，8： | 1 |
| 13 | Effects of Chinese Herbal Medicine Feed Additives on Growth Performance and Dietary Nutrient Metabolism of Black-bone Chickens显示文摘[Objectives]To study the effects of Chinese herbal medicine feed additives on the growth performance and dietary nutrient metabolic rate of black-one chickens.[Methods]480 pieces of 1-day-old Donglan Black-bone Chickens were selected and divided into 4 groups,with 6 replicates in each group,with 20 pieces in each replicate.Among them,group A was the control group and was fed the basal diet;the groups B,C,and D were the experimental groups,which were separately supplemented with 0.25%,0.50%and 1.00%of Chinese herbal medicine additives in the basal diet,and the experimental period was 70 d.At the end of the feeding experiment,24 experimental chickens with similar body weight were selected from each group,and the same design of the feeding experiment was used to continue to feed the original diet for the metabolic experiment to determine the nutrient metabolic rate.[Results]Except the 50-70 d stage,the average daily gain(ADG)of group B in other stages was increased by 5.00%-9.15%(P<0.05),and the average body weight of group B at 70 d was also increased by 4.86%(P<0.05);the ADG of group C at 36-49,1-49 and 1-70 d and the average individual weight at 70 d were also higher than that of group A by 5.90%,2.66%,2.68%and 2.57%,respectively(P>0.05);at 36-49 d,the average daily feed intake(ADFI)of group A was higher than that of group B by 6.04%(P<0.01),and was also higher than that of groups C and D by 5.12%and 4.13%(P<0.05),respectively;at 1-49 d,the ADFI of group A was higher than that of group C by 2.86%(P<0.05),and there was no significant difference between the four groups of experimental chickens at each stage(P>0.05);at 22-35 and 1-70 d,the feed to gain ratio(F/G)of group B was 6.32%and 3.41%lower than that of group A(P<0.05),and at 36-49 and 1-49 d,the F/G of group B was even lower;at 36-49 d,the F/G of group C was 10.15%lower than that of group A(P<0.05),and at 1-49 d,it was also lower than that of group A by 5.29%(P<0.01);there was no significant difference between the two groups at other stages.In terms of nutrient metabolism:the three different amounts of this additive have increased the metabolic rate of DM,CP,CF,NFE,CA,Ca,P,TE and other nutrients in the diet to varying degrees,especially the addition of 0.25%and 0.50%had the significant increase.[Conclusions]The addition of 0.25%Chinese herbal medicine additives in the diet can significantly improve the growth performance and main nutrient metabolic rate of Donglan Black-bone Chickens. | Cui YANG Fulin WANG Siqian WU Zhuyue WU Limei QIN Huofu WAN Zhengzhong XIAO Chunhua HUANG Jiahuang YANG Fengying WEI | 2022 | Asian Agricultural Research2022，14，11： | 0 |
| 14 | How Can Chinese Goods Directly Enter The American Super Market An Interview with Mr. Du Nianshen, President of CTR Corp.USA (Ⅱ)显示文摘Spare No Pains in Opening up Market Reporter:It is objectively required by market economy to attach importance to maker. International trade enterprise must especially set great store by market to march towards foreign market. What is your opinion about this? Du: In international commodity competition, there is such a formula for calculating the sales: Aggregate sales=fixed number of customers×purchase frequency price. It means that the success of sales doesn’t only lie in the high or low price, but also in the number of ’regular customers’, market share and turnover rate. This shows the fundamental difference between the old and new ideas of commodity. But some Chinese businessmen engaged in foregin trade have got used to bargaining with their foreign coun- | Huang Xunping FuLin Liu Xiaoxi | 1997 | 大经贸1997，，9： | 0 |
| 15 | Prion protein oligomer and its neurotoxicity显示文摘prion 疾病,也作为能递送的海绵状的 encephalopathies 知道,是致命的 neurodegenerative 混乱。根据蛋白质仅仅假设,在 prion 疾病的致病的关键分子的事件是导出主人的细胞的 prion 蛋白质(PrPC ) 的 conformational 变换进一种错误褶层形式(scrapie PrP, PrPSc ) 。增加的证据证明了最传染的因素是 prion 蛋白质形成的更小的 subfibrillar oligomers。prion oligomer 和 PrPSc 富于表结构并且对朊酶 K 的解朊作用抵抗。而 PrPSc 是不可溶解的, prion oligomer 在生理的环境是可溶的。各种各样的 prion oligomers 处于不同条件被形成。Prion oligomers 比 PrPSc 的纤丝状的形式在 vitro 并且在 vivo 展出了更多的 neurotoxicity,暗示 prion oligomers 能是为攻击 prion 疾病的潜在的药目标。在这篇文章,我们关于 prion oligomers 描述最近的试验性的证据,与 prion oligomer 形成和它的 neurotoxicity 的一个特殊焦点。 | Pei Huang Fulin Lian Yi Wen Chenyun Guo Donghai Lin | 2013 | Acta Biochimica et Biophysica Sinica2013，45，6： | 0 |
| 16 | Distribution of methane and its homologues in low-layer atmosphere over eastern China and seas显示文摘Systematic, fixed_point and long observations and sample testing make clear distributions of methane and the homologues in the low_layer air over eastern China and sea areas. Within about 250 km from epicenter of moderate and strong earthquakes, oil_gas areas have methane concentration anomaly and CO\-2 anomaly in the low_layer atmosphere around the earthquakes, have a temperature increase by 1-6℃ at the occurrence of moderate and strong earthquakes and indicate that concentration anomaly of methane family in the low_layer air can be used as an important index for petroleum geochemical exploration. | Fulin Huang Xunhua Zhang Xianghua Xia Zuji Qiang Changgong Lin Yingkai Zhang | 1998 | Chinese Science Bulletin1998，43，22： | 0 |
| 17 | Impact of surface-reflected seismic waves on the seismic isolation performance of circular tunnel isolation layers显示文摘Seismic isolation is an effective strategy to mitigate the risk of seismic damage in tunnels.However,the impact of surface-reflected seismic waves on the effectiveness of tunnel isolation layers remains under explored.In this study,we employ the wave function expansion method to provide analytical solutions for the dynamic responses of linings in an elastic half-space and an infinite elastic space.By comparing the results of the two models,we investigate the seismic isolation effect of tunnel isolation layers induced by reflected seismic waves.Our findings reveal significant differences in the dynamic responses of the lining in the elastic half-space and the infinitely elastic space.Specifically,the dynamic stress concentration factor(DSCF)of the lining in the elastic half-space exhibits periodic fluctuations,influenced by the incident wave frequency and tunnel depth,while the DSCF in the infinitely elastic space remain stable.Overall,the seismic isolation application of the tunnel isolation layer is found to be less affected by surface-reflected seismic waves.Our results provide valuable insights for the design and assessment of the seismic isolation effect of tunnel isolation layers. | LU Jiahui LUO Junjie HUANG Xiangyun HONG Junliang HE YanXin ZHOU Fulin | 2024 | Journal of Mountain Science2024，21，3： | 0 |
| 18 | Prevalence and Determinants of Secondhand Smoke Exposure Among Adolescent Girls-China,2019显示文摘Summary What is already known about this topic?The rate of secondhand smoke(SHS)exposure among female junior high students in 2013-2014 in China was 69.9%.What is added by this report?The rate of SHS among adolescent girls in 2019 in China was 62.8%,with 60.8%in junior high and 65.3%in senior high school,meanwhile,higher SHS exposure was correlated to higher grade levels,senior high school over junior high school,urban areas,those with more pocket money,those who’ve attempted smoking,exposure to tobacco advertisements,those with parents who smoke,those with close friends who smoke,use of e-cigarettes,and belief that SHS exposure is detrimental to health.What are the implications for public health practice?The rate of SHS exposure among adolescent girls in China still remains extraordinarily high.Targeted public health initiatives to curb SHS exposure among adolescent girls are urgently needed in China. | Fulin Huang Xinying Zeng Xinbo Di Lin Xiao Shiwei Liu | 2022 | China CDC weekly2022，4，44： | 0 |
| 19 | Effects of Diet with Picria fel-tarrae Lour Particle on the Growth Performance, Blood Biochemical Indexes, Immune and Antioxidant Function of Hongguang Yellow Chickens显示文摘[Objectives]To investigate the effect of diet with Picria fel-tarrae Lour particle(PFLp)on growth performance,blood biochemical indexes,immune and antioxidant function of Hongguang yellow chickens(HYC).[Methods]80 HYC in age of 1 d were divided into 4 groups randomly and each group was assigned to 5 replicates with 24 chicks in each replicate.Group A was control group fed only basal diet.Group B,C and D were treatment groups and fed diets with 0.125%,0.25%and 0.50%of PFLp respectively during the trial of 49 d.Serum samples were taken from 10 chicks in each group in the age of 21,35 and 49 d respectively and analyzed for biochemical,immune and antioxidant parameters in blood.[Results]ADG from group C in 21 d was increased significantly than that from group A,B and D(P<0.01),and ADG in 35 d from group C was also significantly greater than that from group A,B and D(P<0.05),but not much difference was found on ADG among the 4 groups in 49 d(P>0.05);ADFI from group C in 35 d was significantly higher than that from group A,B and D(P<0.05).ADFI from group C in 21 and 49 d were also higher than that from group A(P>0.05).FCR from group C in 21 d was much better than that from the other three groups(P<0.01).Death rate of group C was 50 percent lower than group A;There was no difference occurred in serum biochemical and immune parameters among the 4 groups during the trial(P>0.05).However,the T-AOC from group C and D in 21 d was enhanced significantly than that from group A and B(P<0.01),and the one from group C in 35 d was also increased greatly than that from group A,B and D(P<0.05).GSH from group C and D in 21 d was much higher than that from group A and B(P<0.05),and the ones from group C and D in 35 d were also significantly higher than those from group A and B(P<0.01).T-SOD in three stages trended up also in group C and D(P>0.05).[Conclusions]The diet with 0.25%PFLp in 21 and 35 d could dramatically improve the growth performance,significantly increase the antioxidant capacity and effectively reduce death rate.Diet with 0.25%PFLp is the most appropriate among the three different additions. | Cui YANG Zhuyue WU Tingjun HU Qiang WU Yingfei HUANG Huofu WAN Jixian DENG Fengying WEI Li HUANG Liang WU Junhua ZHOU Hongye HUANG Fulin WANG Yuying LIAO Jiahuang YANG | 2019 | Medicinal Plant2019，10，5： | 0 |
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