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| 1 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 2 | Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats显示文摘AIM To investigate protective effects and molecular mechanisms of green tea polyphenols(GTP) on nonalcoholic fatty liver disease(NAFLD) in Zucker fatty(ZF) rats.METHODS Male ZF rats were fed a high-fat diet(HFD) for 2 wk then treated with GTP(200 mg/kg) or saline(5 m L/kg) for 8 wk, with Zucker lean rat as their control. At the end of experiment, serum and liver tissue were collected for measurement of metabolic parameters, alanine aminotransferase(ALT) and aspartate aminotransferase(AST), inflammatory cytokines and hepatic triglyceride and liver histology. Immunoblotting was used to detect phosphorylation of AMP-activated protein kinase(AMPK) acetyl-Co A carboxylase(ACC), and sterol regulatory element-binding protein 1c(SREBP1c). RESULTS Genetically obese ZF rats on a HFD presented with metabolic features of hepatic pathological changes comparable to human with NAFLD. GTP intervention decreased weight gain(10.1%, P = 0.052) and significantly lowered visceral fat(31.0%, P < 0.01). Compared with ZF-controls, GTP treatment significantly reduced fasting serum insulin, glucose and lipids levels. Reduction in serum ALT and AST levels(both P < 0.01) were observed in GTP-treated ZF rats. GTP treatment also attenuated the elevated TNFα and IL-6 in the circulation. The increased hepatic TG accumulation and cytoplasmic lipid droplet were attenuated by GTP treatment, associated with significantly increased expression of AMPK-Thr172(P < 0.05) and phosphorylated ACC and SREBP1c(both P < 0.05), indicating diminished hepatic lipogenesis and triglycerides out flux from liver in GTP treated rats. CONCLUSION The protective effects of GTP against HFD-induced NAFLD in genetically obese ZF rats are positively correlated to reduction in hepatic lipogenesis through upregulating the AMPK pathway. | Yi Tan Jane Kim Jing Cheng Madeleine Ong Wei-Guo Lao Xing-Liang Jin Yi-Guang Lin Linda Xiao Xue-Qiong Zhu Xian-Qin Qu | 2017 | World Journal of Gastroenterology2017，23，21： | 11 |
| 3 | Contemporary management of locally advanced rectal cancer:Resolving issues, controversies and shifting paradigms显示文摘Advancements in rectal cancer treatment have resulted in improvement only in locoregional control and have failed to address distant relapse, which is the predominant mode of treatment failure in rectal cancer. As the efficacy of conventional chemoradiotherapy(CRT) followed by total mesorectal excision(TME) reaches a plateau, the need for alternative strategies in locally advanced rectal cancer(LARC) has grown in relevance. Several novel strategies have been conceptualized to address this issue, including: 1) neoadjuvant induction and consolidation chemotherapy before CRT; 2) neoadjuvant chemotherapy alone to avoid the sequelae of radiation; and 3) nonoperative management for patients who achieved pathological or clinical complete response after CRT. This article explores the issues, recent advances and paradigm shifts in the management of LARC and emphasizes the need for a personalized treatment plan for each patient based on tumor stage, location, gene expression and quality of life. | Aeris Jane D.Nacion Youn Young Park Nam Kyu Kim | 2018 | Chinese Journal of Cancer Research2018，30，1： | 10 |
| 4 | European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013显示文摘 | Michele Baccarani Michael W. Deininger Gianantonio Rosti Andreas Hochhaus Simona Soverini Jane F. Apperley Francisco Cervantes Richard E. Clark Jorge E. Cortes Fran?ois Guilhot Henrik Hjorth-Hansen Timothy P. Hughes Hagop M. Kantarjian Dong-Wook Kim Richa | 2013 | Blood2013，，6： | 3 |
| 5 | Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study显示文摘 | Mark S Pearce Jane A Salotti Mark P Little Kieran McHugh Choonsik Lee Kwang Pyo Kim Nicola L Howe Cecile M Ronckers Preetha Rajaraman Alan W Craft Louise Parker Amy Berrington de González | 2012 | The Lancet . 2012 (9840)2012，，： | 3 |
| 6 | Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction 显示文摘 | JAMES L JANUZZI JR MD SHAFIQ U REHMAN M D ASIM A MOHAMMED M D ANJU BHARDWAJ M D LINDA BARAJAS R N JUSTINE BARAJAS HAN-NA KIM M D MPH AARON L BAGGISH M D RORY B WEINER M D ANNABEL CHEN-TOURNOUX MD JANE E MARSHALL RDCS STEPHANIE A MOORE M D WILLIAM D CARLSON M D GREGORY D LEWIS M D JORDAN SHIN M D DOROTHY SULLIVAN ANP KIMBERLY PARKS D O THOMAS J WANG M D SHAWN A GREGORY M D SHANMUGAM UTHAMALINGAM M D MARC J SEMIGRAN M D | 2011 | J Am Coll Cardiol2011，58，18： | 1 |
| 7 | Validation and Implementation of Targeted Capture and Sequencing for the Detection of Actionable Mutation, Copy Number Variation, and Gene Rearrangement in Clinical Cancer Specimens显示文摘 | Colin C. Pritchard Stephen J. Salipante Karen Koehler Christina Smith Sheena Scroggins Brent Wood David Wu Ming K. Lee Suzanne Dintzis Andrew Adey Yajuan Liu Keith D. Eaton Renato Martins Kari Stricker Kim A. Margolin Noah Hoffman Jane E. Churpek Jonathan | 2014 | The Journal of Molecular Diagnostics2014，，1： | 1 |
| 8 | Regional Angiographic Grading System for Collateral Flow: Correlation With Cerebral Infarction in Patients With Middle Cerebral Artery Occlusion显示文摘 | Jane J. Kim Nancy J. Fischbein Ying Lu Daniel Pham William P. Dillon | 2004 | Stroke: Journal of the American Heart Association2004，，6： | 1 |
| 9 | The role of etail quality, e-satisfaction and e-trust in online loyalty development process显示文摘 | KIM J BYOUNGHO J JANE L S | 2009 | Journal of Retailing and Consumer Services2009，16，4： | 1 |
| 10 | Gean Imaging for the Diagnosis and Management of Traumatic Brain Injury 显示文摘 | Jane J Kim Alisa D | 2011 | Neurotherapeu- tics2011，8，1： | 1 |
| 11 | Heterogeneity in Nsp2 of European-like porcine reproductive and respiratory syndrome viruses isolated in the United States显示文摘 | Ying Fang Dal-Young Kim Susan Ropp Pam Steen Jane Christopher-Hennings Eric A. Nelson Raymond R.R. Rowland | 2004 | Virus Research2004，，2： | 1 |
| 12 | Physical activity and risk of colon cancer in a cohort of Danish middle-aged men and women显示文摘 | Nina F?ns Johnsen Jane Christensen Birthe Lykke Thomsen Anja Olsen Steffen Loft Kim Overvad Anne Tj?nneland | 2006 | European Journal of Epidemiology2006，，12： | 1 |
| 13 | Immune-correlates analysis of an HIV-1 vaccine efficacy trial 显示文摘 | Haynes BF Gilbert PB McElrath MJ Zolla-Pazner S Tomaras GD Alam SM Evans DT Montefiori DC Kar- nasuta C Sutthent R Liao HX DeVico AL Lewis GK Williams C Pinter A Fong Y Janes H DeCamp A Huang Y Rao M Billings E Karasavvas N Robb ML Ngauy V de Souza MS Paris R Ferrari G Bailer RT Soderberg KA Andrews C Berman PW Frahm N De Ro- sa SC Alpert MD Yates NL Shen X Koup RA Pitisut- tithum P Kaewkungwal J Nitayaphan S Rerks-Ngarm S Michael NL Kim JH | 2012 | N Engl J Med2012，366，14： | 1 |
| 14 | Comparison of fracture resistance of pressable metal ceramic custom implant abutments with CAD/CAM commercially fabricated zirconia implant abutments显示文摘 | Sungtae Kim Hyeong-Il Kim Jane D. Brewer Edward A. Monaco | 2009 | The Journal of Prosthetic Dentistry2009，，4： | 1 |
| 15 | Real-Time Optical Biopsy of Colon Polyps With Narrow Band Imaging in Community Practice Does Not Yet Meet Key Thresholds for Clinical Decisions显示文摘 | Uri Ladabaum Ann Fioritto Aya Mitani Manisha Desai Jane P. Kim Douglas K. Rex Thomas Imperiale Naresh Gunaratnam | 2013 | Gastroenterology2013，，： | 1 |
| 16 | Optimization of a stator blade using response surface method in a single-stage transonic axial compressor显示文摘 | Jane C M Kim K Y | 2005 | Proceedings of the Institution of Mechanical Engineers Part A:Journal of Power and Energy2005，219，8： | 1 |
| 17 | Optimization of blade sweep in a transonic axial compressor rotor 显示文摘 | Jane C M Li P Kim K Y | 2005 | JSME International Journal-Series B2005，48，4： | 1 |
| 18 | Use of Amino-Terminal Pro–B-Type Natriuretic Peptide to Guide Outpatient Therapy of Patients With Chronic Left Ventricular Systolic Dysfunction显示文摘 | James L. Januzzi Shafiq U. Rehman Asim A. Mohammed Anju Bhardwaj Linda Barajas Justine Barajas Han-Na Kim Aaron L. Baggish Rory B. Weiner Annabel Chen-Tournoux Jane E. Marshall Stephanie A. Moore William D. Carlson Gregory D. Lewis Jordan Shin Dorothy Sul | 2011 | Journal of the American College of Cardiology2011，，18： | 1 |
| 19 | An Association Between Dietary Arachidonic Acid, Measured in Adipose Tissue, and Ulcerative Colitis显示文摘 | Punyanganie S.A. de Silva Anja Olsen Jane Christensen Erik Berg Schmidt Kim Overvaad Anne Tjonneland Andrew R. Hart | 2010 | Gastroenterology2010，，： | 1 |
| 20 | Photocatalytic properties of rutile TiO2 acicular particles in aqueous 4- chlorophenol solution显示文摘 | Sun Jane Kim Jong Kuk Lee Eun Gu Lee | 2003 | J Mater Res2003，18，3： | 1 |
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