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| 1 | Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma显示文摘AIM: To conduct a retrospective study in 400 chronic hepatitis B patients in order to identify hepatitis B viral factors associated with complications of liver disease or development of hepatocellular carcinoma.METHODS: The mean follow-up time was 83.6 ± 39.6 mo. Alpha-fetoprotein test and abdominal ultrasound were used for cancer surveillance. Hepatitis B basal core promoter mutants, precore mutants, genotypes, hepatitis B viral DNA (HBV DNA) level and hepatitis B e antigen (HBeAg) were measured. Univariate analysis and logistic regression were used to assess odds ratios for viral factors related to liver deaths and hepatocellular carcinoma development. RESULTS: During follow-up, 38 patients had liver deaths not related to hepatocellular carcinoma. On multivariate analysis, older age [odds ratio: 95.74 (12.13-891.31); P < 0.0001], male sex [odds ratio: 7.61 (2.20-47.95); P = 0.006], and higher log10 HBV DNA [odds ratio: 4.69 (1.16-20.43); P < 0.0001] were independently predictive for these liver related deaths. Also, 31 patients developed hepatocellular carcinoma. Multivariate analysis showed that older age [odds ratio: 26.51 (2.36-381.47); P = 0.007], presence of precore mutants [odds ratio: 4.23 (1.53-19.58); P = 0.02] and presence of basal core promoter mutants [odds ratio: 2.93 (1.24-7.57); P = 0.02] were independent predictors for progression to hepatocellular carcinoma.CONCLUSION: Our results show that high levels of baseline serum HBV DNA are associated with non- hepatocellular carcinoma-related deaths of liver failure, while genetic mutations in the basal core promoter and precore regions are predictive for development of hepatocellular carcinoma. | Myron J Tong Lawrence M Blatt Jia-Horng Kao Jason Tzuying Cheng William G Corey | 2006 | World Journal of Gastroenterology2006，12，41： | 11 |
| 2 | Resveratrol engages selective apoptotic signals in gastric adenocarcinoma cells显示文摘AIM: To investigate the intracellular apoptotic signals engaged by resveratrol in three gastric adenocarcinoma cancer cell lines, two of which (AGS and SNU-1) express p53 and one (KATO-Ⅲ) with deleted p53. METHODS: Nuclear fragmentation was used to quanti- tate apoptotic cells; caspase activity was determined by photometric detection of cleaved substrates; formation of oxidized cytochrome C was used to measure cytochrome C activity, and Western blot analysis was used to determine protein expression. RESULTS: Gastric cancer cells, irrespective of their p53 status, responded to resveratrol with fragmentation of DNA and cleavage of nuclear lamins A and B and PARP. Resveratrol, however, has no effect on mitochondria-associated apoptotic proteins Bcl-2, Bcl- xl, Bax, Bid or Smac/Diablo, and did not promote sub- cellular redistribution of cytochrome C, indicating that resveratrol-induced apoptosis of gastric carcinoma cells does not require breakdown of mitochondrial membrane integrity. Resveratrol up-regulated p53 protein in SNU-1 and AGS cells but there was a difference in response of intracellular apoptotic signals between these cell lines. SNU-1 cells responded to resveratrol treatment with down-regulation of survivin, whereas in AGS and KATO- Ⅲ cells resveratrol stimulated caspase 3 and cytochrome C oxidase activities. CONCLUSION: These findings indicate that even within a specific cancer the intracellular apoptotic signals engaged by resveratrol are cell type dependent and suggest that such differences may be related to differentiation or lack of differentiation of these cells. | William L Riles Jason Erickson Sanjay Nayyar Mary Jo Atten Bashar M Attar Oksana Holian | 2006 | World Journal of Gastroenterology2006，12，35： | 8 |
| 3 | Use of the Endocuff during routine colonoscopy examination improves adenoma detection: A meta-analysis显示文摘AIM To perform meta-analysis of the use of Endocuff during average risk screening colonoscopy.METHODS Scopus, Cochrane databases, MEDLINE/Pub Med, and CINAHL were searched in April 2016. Abstracts from Digestive Disease Week, United European Gastroenterology, and the American College of Gastroenterology meeting were also searched from 2004-2015. Studies comparing EC-assisted colonoscopy(EAC) to standard colonoscopy, for any indication, were included in the analysis. The analysis was conducted by using the Mantel-Haenszel or DerS imonian and Laird models with the odds ratio(OR) to assess adenoma detection, cecal intubation rate, and complications performed. RESULTS Nine studies(n = 5624 patients) were included in the analysis. Compared to standard colonoscopy, procedures performed with EC had higher frequencies for adenoma(OR = 1.49, 95%CI: 1.23-1.80; P = 0.03), and sessile serrated adenomas detection(OR = 2.34 95%CI: 1.63-3.36; P < 0.001). There was no significant difference in cecal intubation rates between the EACgroup and standard colonoscopy(OR = 1.26, 95%CI: 0.70-2.27, I2 = 0%; P = 0.44). EAC was associated with a higher risk of complications, most commonly being superficial mucosal injury without higher frequency for perforation.CONCLUSION The use of an EC on colonoscopy appears to improve pre-cancerous polyp detection without any difference in cecal intubation rates compared to standard colonoscopy. | Matthew Chin William Karnes M Mazen Jamal John G Lee Robert Lee Jason Samarasena Matthew L Bechtold Douglas L Nguyen | 2016 | World Journal of Gastroenterology2016，22，43： | 4 |
| 4 | The alternative of CubeSat-based advanced infrared and microwave sounders for high impact weather forecasting显示文摘近年来,小卫星技术的发展给传统气象卫星提供了经济有效的替补方案。本文针对可能出现的传统气象卫星的缺失情形,借助快速的区域观测系统模拟试验,探索了利用小卫星填补空缺的可能性。研究表明,单个小卫星,无论是近红外高光谱还是微波探测仪,都能够对局地强风暴天气的预报有所改进。然而,为了填补传统卫星缺失带来的影响,需要发射三颗甚至更多的小卫星来增加观测的覆盖面,以弥补小卫星精度略低、通道略少的缺陷。 | LI Zhenglong LI Jun SCHMIT Timothy J. WANG Pei LIM Agnes LI Jinlong NAGLE Fredrick W. BAI Wenguang OTKIN Jason A. ATLAS Robert HOFFMAN Ross N. BOUKABARA Sid-Ahmed ZHU Tong BLACKWELL William J. PAGANO Thomas S. | 2019 | Atmospheric and Oceanic Science Letters2019，12，2： | 3 |
| 5 | 抗生素耐药性环境中产生和转移的人类健康风险评估(HHRA)显示文摘[背景]直到最近,人们才明确环境能影响抗生素耐药性风险对临床结果的影响,但迄今为止,很少有文献记录正式评估这些风险的方法。[目标]我们研究可能的方法,并试图确定人类健康风险评估(HHRA)的研究需求,这项评估注重环境在抗生素耐药性病原体所致的抗生素治疗失败中所起的作用。[方法]作者参加了2012年3月4—8日在加拿大魁北克省举行的研讨会,定义抗生素耐药性风险与人类健康环境评估的范围和目标。我们专注于环境中耐药性产生'热点区域'的关键要素,(与食品无关的)暴露评估以及剂量反应,以描述风险特征,从而改善抗生素耐药性管理的方案。[讨论]识别传统风险评估中有助于评估环境中抗生素耐药性的各个新方面。包括:a)解释附加的选择压力对环境耐药基因组的作用,即随着时间的推移,促使抗生素耐药性细菌(ARB)产生;b)在相关的环境组成部分的'热点区域'中识别和描述水平基因转移(HGT)率;c)针对不同健康结局和途径的ARB剂量修改传统的剂量反应方法。[结论]我们建议将抗生素耐药性产生造成的环境影响纳入所有涉及ARB的HHRA过程之中。由于可用的数据有限,一种多标准决策分析方法将有助于进行环境中抗生素耐药性的HHRA,并使风险管理者了解环境抗生素耐药性。 | Nicholas J.Ashbolt Alejandro Amézquita Thomas Backhaus Peter Borriello Kristian K.Brandt Peter Collignon Anja Coors Rita Finley William H.Gaze Thomas Heberer John R.Lawrence D.G.Joakim Larsson Scott A.McEwen James J.Ryan Jens Schnfeld Peter Silley Jason R.Snape Christel Van den Eede Edward Topp 王晓宇 张伊人 操仪 | 2014 | 环境与职业医学2014，31，2： | 3 |
| 6 | Wnt4/β-Catenin Signaling Induces VSMC Proliferation and Is Associated With Intimal Thickening显示文摘 | Aikaterini Tsaousi Helen Williams Cressida A. Lyon Victoria Taylor Amanda Swain Jason L. Johnson Sarah J. George | 2011 | Circulation Research2011，，4： | 3 |
| 7 | Modulation of the fecal bile acid profile by gut microbiota in cirrhosis显示文摘 | Genta Kakiyama William M. Pandak Patrick M. Gillevet Phillip B. Hylemon Douglas M. Heuman Kalyani Daita Hajime Takei Akina Muto Hiroshi Nittono Jason M. Ridlon Melanie B. White Nicole A. Noble Pamela Monteith Michael Fuchs Leroy R. Thacker Masoumeh Sikaro | 2013 | Journal of Hepatology2013，，5： | 3 |
| 8 | Endoscopic mucosal resection and endoscopic submucosal dissection显示文摘 | Sergey V. Kantsevoy Douglas G. Adler Jason D. Conway David L. Diehl Francis A. Farraye Richard Kwon Petar Mamula Sarah Rodriguez Raj J. Shah Louis Michel Wong Kee Song William M. Tierney | 2008 | Gastrointestinal Endoscopy2008，，1： | 2 |
| 9 | Advanced Donor Age Alone Does Not Affect Patient or Graft Survival after Liver Transplantation显示文摘 | Christopher D. Anderson Neeta Vachharajani Majella Doyle Jeffrey A. Lowell Jason R. Wellen Surendra Shenoy Mauricio Lisker-Melman Kevin Korenblat Jeff Crippin William C. Chapman | 2008 | Journal of the American College of Surgeons2008，，6： | 2 |
| 10 | Efficacy of Neoadjuvant Chemoradiation, Followed by Liver Transplantation, for Perihilar Cholangiocarcinoma at 12 US Centers显示文摘 | Sarwa Darwish Murad W. Ray Kim Denise M. Harnois David D. Douglas James Burton Laura M. Kulik Jean F. Botha Joshua D. Mezrich William C. Chapman Jason J. Schwartz Johnny C. Hong Jean C. Emond Hoonbae Jeon Charles B. Rosen Gregory J. Gores Julie K. Heimbac | 2012 | Gastroenterology2012，，1： | 2 |
| 11 | GATA3 controls Foxp3^sup +^ regulatory T cell fate during inflammation in mice显示文摘 | Wohlfert Elizabeth A Grainger John R Bouladoux Nicolas Konkel Joanne E Oldenhove Guillaume Ribeiro Carolina Hager Hall Jason A Yagi Ryoji Naik Shruti Bhairavabhotla Ravikiran Paul William E Bosselut Remy Wei Gang Zhao Keji Oukka Mohamed Zhu | 2011 | Journal of Clinical Investigation2011，，11： | 2 |
| 12 | Preoperative serum YKL-40 is a marker for detection and prognosis of endometrial cancer显示文摘 | Catherine S.M. Diefenbach Zharna Shah Alexia Iasonos Richard R. Barakat Douglas A. Levine Carol Aghajanian Paul Sabbatini Martee L. Hensley Jason Konner William Tew David Spriggs Martin Fleisher Howard Thaler Jakob Dupont | 2006 | Gynecologic Oncology2006，，： | 2 |
| 13 | Rapid and efficient reprogramming of human fetal and adult blood CD34~ cells into mesenchymal stem cells with a single factor显示文摘进体的干细胞的皮房间的直接变换在再生药打开了新治疗学的可能性。这里,我们证明人的导致的间充质的干细胞(iMSCs ) 能高效地从绳索血(CB ) 被产生 - 或由有一个单个因素的直接 reprogramming 的成年的外部血(PB )-CD34+ 房间, OCT4。面对一个 GSK3 禁止者, 16% OCT4-transduced CD34 + 房间在 2 个星期以内被变换成 iMSCs。有效直接 reprogramming 与两 episomal 被完成调停向量的短暂 OCT4 表示和 lentiviral 调停向量的 OCT4 transduction。iMSCs 快车 MSC 标记,类似于骨头髓(BM ) 在形态学的 -MSCs,并且在 vitro multilineage 区别能力拥有,还与 BM-MSCs 相比有一个更大的 proliferative 能力。类似于 BM-MSCs,植入的 iMSCs 形式骨头和结缔组织,并且是在老鼠的 non-tumorigenic。然而, BM-MSCs 不而 iMSCs 确实形成肌肉纤维,显示 iMSCs 的一个潜在的功能的优点。另外,我们观察到 OCT4 表示的高水平为起始的 reprogramming 和最佳的 iMSC 自强被要求,当 OCT4 表示的减小为 multilineage 区别被要求时。我们的方法将贡献病人特定的 iMSCs 的产生,它能在再生药有应用。这发现可以也为血房间的直接变换便于策略的发展进临床的重要性的房间的另外的类型。 | Xianmei Meng Rui-Jun Su David J Baylink Amanda Neises Jason B Kiroyan Wayne Yuk-Wai Lee Kimberly J Payne Daila S Gridley Jun Wang K-H William Lau Gang Li Xiao-Bing Zhang | 2013 | Cell Research2013，23，5： | 2 |
| 14 | A global perspective on cadmium pollution and toxicity in non-occupationally exposed population显示文摘 | Soisungwan Satarug Jason R Baker Supanee Urbenjapol Melissa Haswell-Elkins Paul E.B Reilly David J Williams Michael R Moore | 2002 | Toxicology Letters2002，，1： | 2 |
| 15 | Diagnosis and Management of Gallbladder Polyps显示文摘 | William C. Gallahan Jason D. Conway | 2010 | Gastroenterology Clinics of North America2010，，2： | 2 |
| 16 | Endocytoscopy显示文摘 | Richard S. Kwon Louis-Michel Wong Kee Song Douglas G. Adler Jason D. Conway David L. Diehl Francis A. Farraye Sergey V. Kantsevoy Vivek Kaul Sripathi R. Kethu Petar Mamula Marcos C. Pedrosa Sarah A. Rodriguez William M. Tierney | 2009 | Gastrointestinal Endoscopy2009，，4： | 2 |
| 17 | Basal core promoter T1762/A1764 and precore A1896 gene mutations in hepatitis B surface antigen‐positive hepatocellular carcinoma: a comparison with chronic carriers显示文摘 | Myron J.Tong Lawrence M.Blatt Jia‐HorngKao Jason TzuyingCheng William G.Corey | 2007 | Liver International2007，，10： | 2 |
| 18 | Transforming growth factor-β and the hallmarks of cancer显示文摘 | Maozhen Tian Jason R. Neil William P. Schiemann | 2010 | Cellular Signalling2010，，6： | 1 |
| 19 | Bending-fatigue Damage-detection on Notched-tooth Spiral-bevel Gears Using the Average-log-ratio,ALR,Algorithm显示文摘 | Jason A Hines William D Mark | 2014 | Mechanical Systems and Signal Processing2014，43，12： | 1 |
| 20 | Late gadolinium enhancement: precursor to cardiomyopathy in Duchenne muscular dystrophy?显示文摘 | Michael D. Puchalski Richard V. Williams Bojana Askovich C. Todd Sower Kan H. Hor Jason T. Su Nathan Pack Edward Dibella William M. Gottliebson | 2009 | The International Journal of Cardiovascular Imaging2009，，1： | 1 |
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