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| 1 | Contrast-enhanced ultrasonography assessment of gastric cancer response to neoadjuvant chemotherapy显示文摘AIM:To quantitatively assess the ability of double contrast-enhanced ultrasound(DCUS) to detect tumor early response to pre-operative chemotherapy.METHODS:Forty-three patients with gastric cancer treated with neoadjuvant chemotherapy followed by curative resection between September 2011 and February 2012 were analyzed.Pre-operative chemotherapy regimens of fluorouracil + oxaliplatin or S-1 + oxaliplatin were administered in 2-4 cycles over 6-12 wk periods.All patients underwent contrast-enhanced computed tomography(CT) scan and DCUS before and after two courses of pre-operative chemotherapy.The therapeutic response was assessed by CT using the response evaluation criteria in solid tumors(RECIST 1.1) criteria.Tumor area was assessed by DCUS as enhanced appearance of gastric carcinoma due to tumor vascularity during the contrast phase as compared to the normal gastric wall.Histopathologic analysis was carried out according to the Mandard tumor regression grade criteria and used as the reference standard.Receiver operating characteristic(ROC) analysis was used to evaluate the efficacy of DCUS parameters in differentiating histopathological responders from non-responders.RESULTS:The study population consisted of 32 men and 11 women,with mean age of 59.7 ± 11.4 years.Neither age,sex,histologic type,tumor site,T stage,nor N stage was associated with pathological response.The responders had significantly smaller mean tumor size than the non-responders(15.7 ± 7.4 cm vs 33.3 ± 14.1 cm,P < 0.01).According to Mandard's criteria,27 patients were classified as responders,with 11(40.7%) showing decreased tumor size by DCUS.In contrast,only three(18.8%) of the 16 non-responders showed decreased tumor size by DCUS(P < 0.01).The area under the ROC curve was 0.64,with a 95%CI of 0.46-0.81.The effects of several cut-off points on diagnostic parameters were calculated in the ROC curve analysis.By maximizing Youden's index(sensitivity + specificity-1),the best cut-off point for distinguishing responders from non-responders was determined,which had optimal sensitivity of 62.9% and specificity of 56.3%.Using this cut-off point,the positive and negative predictive values of DCUS for distinguishing responders from non-responders were 70.8% and 47.4%,respectively.The overall accuracy of DCUS for therapeutic response assessment was 60.5%,slightly higher than the 53.5% for CT response assessment with RECIST criteria(P = 0.663).Although the advantage was not statistically significant,likely due to the small number of cases assessed.DCUS was able to identify decreased perfusion in responders who showed no morphological change by CT imaging,which can be occluded by such treatment effects as fibrosis and edema.CONCLUSION:DCUS may represent an innovative tool for more accurately predicting histopathological response to neoadjuvant chemotherapy before surgical resection in patients with locally-advanced gastric cancer. | Jian Ang Liang Hu Pin-Tong Huang Jin-Xiu Wu Ling-Na Huang Chun-Hui Cao Yi-Xiong Zheng Li Chen | 2012 | World Journal of Gastroenterology2012，18，47： | 18 |
| 2 | Clinical characteristics and prognostic factors of patients with gastric neuroendocrine carcinoma treated with radical surgery显示文摘 | Xu Xuefeng Li Jian'ang Han Xu Shi Chenye Jin Dayong Lou Wenhui | 2014 | Chinese Medical Journal2014，，13： | 17 |
| 3 | The Clinical Outcomes of Three Surgical Managements on Primary Angle-closure Glaucoma显示文摘Purpose: To investigate the efficacy of trabeculectomy, phacotrabeculectomy and phaco-emulsification in the management of primary angle closure glaucoma (PACG). Methods: A prospective observational study was performed in 88 chronic PACG patients (97 eyes) who were divided into three groups following defined indications to receive different surgical interventions. The indications and clinical outcomes were evaluated. The mean follow-up was (17.7±4.9) months. Results: Success rate in trabeculectomy, phacotrabeculectomy and phacoemulsification group was 81.08%, 78.57‰ and 81.25‰, respectively. The anterior chamber depth was deeper and the angle was wider postoperatively vs. preoperatively both in phaco-trabeculectomy and phacoemulsification group. No obvious changes were seen in trabeculectomy group. The coefficient of outflow facility of aqueous humor (C values) significantly increased in three groups postoperatively (P < 0.01). No severe intra-operative complications were found and the incidence of postoperative complications was low. Five eyes sustained hypotony 3±1.87 months in trabeculectomy group and 1 eye happened malignant glaucoma in phacotrabeculectomy group. The visual acuity in patients with phacotrabeculectomy plus intraocular lens implantation and those only with phacoemulsification plus intraocular lens implantation were improved 78.57% and 93.74%, respectively. No significant improvement was found in trabeculectomy group (χ2 = 47.10, P < 0.001). Conclusion: Three surgical interventions were beneficial to manage PACG and with co-existing cataract. The indication choosing was suggested according to visual acuity, angle closure circumference, cataract, medication requirements and optic nerve damage. Phacotrabeculectomy was recommended for angle closed ≥180° circumference while phacoemulsification for angle closed < 180°. | Xiulan Zhang Leilei Teng Ang Li Shaolin Du Yunyun Zhu Jian Ge | 2007 | 眼科学报2007，23，2： | 16 |
| 4 | CCA-secure unidirectional proxy re-encryption in the adaptive corruption model without random oracles显示文摘Up to now, it is still an open question of how to construct a chosen-ciphertext secure unidirectional proxy re-encryption scheme in the adaptive corruption model. To address this problem, we propose a new unidirectional proxy re-encryption scheme, and prove its chosen-ciphertext security in the adaptive corruption model without random oracles. Compared with the best known unidirectional proxy re-encryption scheme proposed by Libert and Vergnaud in PKC'08, our scheme enjoys the advantages of both higher efficiency and stronger security. | WENG Jian CHEN MinRong ANG YanJiang DENG Robert CHEN KeFei BAO Feng | 2010 | Science China(Information Sciences)2010，53，3： | 12 |
| 5 | Output Waveform Analysis of an Electro-hydraulic Vibrator Controlled by the Multiple Valves显示文摘The existing research of the electro-hydraulic vibrator mainly focuses on system stability,working frequency width and output waveform distortion.However,this high frequency performance of the electro-hydraulic vibrator is difficult to be improved greatly due to fast insufficiently frequency response of the servo valve itself and limited compensation capability of the control structure in the vibrator system.In this paper,to realize high frequency vibration,an improved two-dimensional valve(here within defined as a2D valve)as a main control component is adopted to the parallel connection with a servo valve to control the electro-hydraulic vibrator.Because the output waveforms of this electro-hydraulic vibrator are incapable to be verified through timely feedback as in the conventional electro-hydraulic servo system,the analysis to the output waveform becomes crucial to the design and control of the electro-hydraulic vibrator.The mathematical models of hydraulic actuation mechanism and the orifice area of the parallel valves connection are established first.And then the vibration process is divided into two sections in terms of the direction of the flow,the analytical expression of the excited waveform is solved.Based on the analytical results,the vibration boundary positions and the relationships exist between working states and the control parameters are derived.Finally an experimental system was built to validate the theoretical analysis.It is verified that this electro-hydraulic vibration system could achieve high working frequency,up to 2 000 Hz.The excited waveform is similar to the sinusoidal waveform.And the ascent and decent slopes of the waveforms are somewhat asymmetrical.This asymmetry is not only caused by the change of the direction of the elastic force but also dependent on the bias position of the vibration.Consequently the distortion of effective working waveform is less than 10%.This electro-hydraulic vibrator controlled by the multiple valves could not only greatly enhance the working frequency but also precisely control the vibration characteristic variables such as waveform shape. | REN Yan RUAN Jian JIA Wen'ang | 2014 | Chinese Journal of Mechanical Engineering2014，27，1： | 10 |
| 6 | Separate Control of High Frequency Electro-hydraulic Vibration Exciter显示文摘The working frequency of the conventional electro-hydraulic vibration exciters,which consist of a servo valve and a hydraulic cylinder,is generally restricted within a narrow range due to limited frequency response capability of the servo valve itself.To counteract such restriction,a novel scheme for an electro-hydraulic vibrator,controlled by a two-dimensional valve(2D valve) and a bias valve in parallel,is therefore proposed.The frequency,amplitude and offset are independently controlled by rotary speed,axial sliding of the spool of the 2D valve and axial sliding of the spool of the bias valve.The principle of separate control was presented and the regulation approach of frequency,amplitude and offset was discussed.A mathematical model of the hydraulic power mechanism for the proposed vibration exciter was established to investigate the relationship between the amplitude and the axial sliding of the 2D valve' spool,as well as that between the offset and the axial sliding of the bias valve's spool at various frequencies.An experimental system was built to validate the theoretical analysis.It is verified that the 2D exciter is capable of working smoothly in a frequency range of 5- 200 Hz.And its frequency,amplitude and offset can be controlled respectively by either closed loop or open loop method.There is a linear relationship between the output amplitude and the spool axial opening of the 2D valve until a point when the flow rate becomes saturate and the amplitude remains constant.The offset displacement of the cylinder's piston is linearly proportional to the axial displacement of the spool of the bias valve,when the valve opening is less than 25%.Thereafter,the slop of the offset curve decreases and tends to saturate.The proposed electro-hydraulic vibration controlled by the 2D valve not only facilitates the realization of high-frequency electro-hydraulic vibration,the high-accuracy of vibration can also be achieved by means of independent controls to the frequency,amplitude and offset. | JIA Wen'ang RUAN Jian REN Yan | 2011 | Chinese Journal of Mechanical Engineering2011，24，2： | 7 |
| 7 | The New Synthesis of Azo Urea from Substituted Semicarbazide显示文摘Using N-bromosuccinimide and pridine as the 0xidation s}-stem to dehydrogenale anly substituted semicarbazide to form azo compounds is described for the firs1 time in this paper Nine azo conlpounds have been prepared in excellent lield under mild condition This method onle needs simple instrument and short reaction | Xiao Yang WANG Yu Lu WANG Jian Ping LI Cai ’Lan W’ANG Hong WANG (Department of Chemistry ,Henan Normal University Xinxiang 453002 ) | 1997 | Chinese Chemical Letters1997，8，6： | 5 |
| 8 | Phase characterisation of metalenses显示文摘Metalenses have emerged as a new optical element or system in recent years,showing superior performance and abundant applications.However,the phase distribution of a metalens has not been measured directly up to now,hindering further quantitative evaluation of its performance.We have developed an interferometric imaging phase measurement system to measure the phase distribution of a metalens by taking only one photo of the interference pattern.Based on the measured phase distribution,we analyse the negative chromatic aberration effect of monochromatic metalenses and propose a feature size of metalenses.Different sensitivities of the phase response to wavelength between the Pancharatnam-Berry phase-based metalens and propagation phase-reliant metalens are directly observed in the experiment.Furthermore,through phase distribution analysis,it is found that the distance between the measured metalens and the brightest spot of focusing will deviate from the focal length when the metalens has a low nominal numerical aperture,even though the metalens is ideal without any fabrication error.We also use the measured phase distribution to quantitatively characterise the imaging performance of the metalens.Our phase measurement system will help not only designers optimise the designs of metalenses but also fabricants distinguish defects to improve the fabrication process,which will pave the way for metalenses in industrial applications. | Maoxiong Zhao Mu Ku Chen Ze-Peng Zhuang Yiwen Zhang Ang Chen Qinmiao Chen Wenzhe Liu Jiajun Wang Ze-Ming Chen Bo Wang Xiaohan Liu Haiwei Yin Shumin Xiao Lei Shi Jian-Wen Dong Jian Zi Din Ping Tsai | 2021 | Light(Science & Applications)2021，10，4： | 1 |
| 9 | Scale dependent wavelet selection for de-noising of partial dis- charge detection显示文摘 | LI Jian J]ANG Tian-yan GRIZYBOWSKI S | 2010 | IEEE Transactions on Dielectrics and Electrical Insulation2010，17，6： | 1 |
| 10 | A two-phase flow model coupling with volume of fluid and immersed boundary methods for free surface and moving structure problems显示文摘 | Cheng Zhang Wei Zhang Nansheng Lin Youhong Tang Chengbi Zhao Jian Gu Wei Lin Xiaoming Chen Ang Qiu | 2013 | Ocean Engineering2013，，： | 1 |
| 11 | Phosphorothioate modification of the TLR9 ligand CpG ODN inhibits poly(I:C)-induced apoptosis of hepatocellular carcinoma by entry blockade显示文摘 | Yuyi Zhang Ang Lin Qiangjun Sui Cai Zhang Zhigang Tian Jian Zhang | 2014 | Cancer Letters2014，，1： | 1 |
| 12 | Risk factors for sepsis-associated encephalopathy显示文摘Sepsis-associated encephalopathy(SAE) is a diffuse and acute cerebral dysfunction caused by sepsis.Many sepsis patients exhibit acute deterioration in mental status during the early stage of disease,and central nervous system dysfunction has been shown to increase patient mortality.The present study selected 284 sepsis patients who were admitted to the Intensive Care Unit of Beijing Friendship Hospital,Capital Medical University,from January to December 2009.The patients were assigned to SAE and non-SAE patient groups according to SAE occurrence.SAE incidence was 37.68%,and mortality was significantly greater in SAE patients compared with non-SAE patients(41.12% vs.17.51%,P < 0.01).Univariate analysis and multivariate logistic regression analysis indicated lower arterial partial pressure of oxygen and greater alanine aminotransferase and Acute Physiology and Chronic Health Evaluation II scores in the SAE group compared with the non-SAE group.Arterial partial pressure of oxygen,alanine aminotransferase,and Acute Physiology and Chronic Health Evaluation II scores were determined to be potential risk factors for SAE. | Jian Li Ang Li Yibing Weng Shuwen Zhang Meili Duan | 2011 | Neural Regeneration Research2011，6，4： | 1 |
| 13 | Effect of Meridional Characteristic Angle on Aerodynamic Performance of Ram-Rotor显示文摘A kind of meridional concept which has a shape of contraction-expansion(Con-Exp)was applied to the ram-rotor in the paper,and detailed numerical simulation to understand the impact of meridional shape and geometric characteristic angle on the aerodynamic behavior of ram-rotors has been undertaken.Compared to baseline,there was a positive effect in intensifying shock train and suppressing low momentum fluid in Con-Exp scheme,and the pressure ratio and efficiency of Con-Exp scheme increased by 2.075%and 3.160%,respectively.When the contracting angle was increasing,supersonic flow at and after throat region accelerated remarkably,and the static pressure rise was decreased gradually.The terminating shock train was transformed to terminating shock,and the efficiency of ram-rotor was unfavorable to improve due to low throttle extent.As expanding angle rose,the terminating shock moved forward and turned to shock train gradually.The pressure rise capacity and throttling ability of ram-rotor were raised.More low momentum fluid was accumulated near the middle and upper flow-path,yielding greater flow loss at large expanding angle. | HAN Ji'ang GUAN Jian ZHONG Jingjun CHEN Luting | 2020 | Journal of Thermal Science2020，29，3： | 1 |
| 14 | Guidelines for the diagnosis and treatment of acute pancreatitis in China (2021)显示文摘Acute pancreatitis(AP)is a common acute abdominal condition of the digestive system.In recent years,treatment concepts,methods,and strategies for the diagnosis of AP have advanced,and this has played an important role in promoting the standardization of AP diagnosis and treatment and improving the treatment quality of AP patients.On the basis of previous guidelines and expert consensus,this guideline adopts an evidence-based,problem-based expression;synthesizes important clinical research data at home and abroad in the most recent 5 years;and forms 29 recommendations through multidisciplinary expert discussion,including diagnosis,treatment,and follow-up.It is expected to provide evidence support for the treatment of AP in the clinical setting in China. | Fei Li Shouwang Cai Feng Cao Rufu Chen Deliang Fu Chunlin Ge Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Ang Li Haimin Li Shengping Li Weiqin Li Yixiong Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Changqing Yan Yinmo Yang Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 1 |
| 15 | The race to the nociceptor: mechanical versus temperature effects in thermal pain of dental neurons显示文摘The sensing of hot and cold stimuli by dental neurons differs in several fundamental ways. These sensations have been characterized quantitatively through the measured time course of neural discharge signals that result from hot or cold stimuli applied to the teeth of animal models. Although various hypotheses have been proposed to explain the underlying mechanism, the ability to test competing hypotheses against experimental recorded data using biophysical models has been hindered by limitations in our understanding of the specific ion channels involved in nociception of dental neurons. Here we apply recent advances in established biophysical models to test the competing hypotheses. We show that a sharp shooting pain sensa-tion experienced shortly following cold stimulation cannot be attributed to the activation of thermosensitive ion channels, thereby falsifying the so-called neuronal hypothesis,which states that rapidly transduced sensations of coldness are related to thermosensitive ion channels. Our results support a central role of mechanosensitive ion channels and the associated hydrodynamic hypothesis. In addition to the hydrodynamic hypothesis, we also demonstrate that the long time delay of dental neuron responses after hot stimulation could be attributed to the neuronal hypothesis—that a relatively long time is required for the temperature around nociceptors to reach some threshold. The results are useful as a model of how multiphysical phenomena can be combined to provide mechanistic insight into different mechanisms underlying pain sensations. | Min Lin Fusheng Liu Shaobao Liu Changchun Ji Ang Li Tian Jian Lu Feng Xu | 2017 | Acta Mechanica Sinica2017，33，2： | 1 |
| 16 | Single image hazeremoval using dark channel prior显示文摘 | HE KAI-MING SUN JIAN 丁ANG X1AO-OU | 2011 | IEEE Trans on Pattern Anal-ysis and Machine Intelligence2011，33，12： | 1 |
| 17 | Scale dependent wavelet selection for de-noising of partial dis- charge detection 显示文摘 | LI Jian J]ANG Tian-yan GRIZYBOWSKI S | 2010 | IEEE Transactions on Dielectrics and Electrical insulation2010，17，6： | 1 |
| 18 | Unravelling the enhanced vaccine immunity by heterologous KCONVAC/Ad5-nCoV COVID-19 vaccination显示文摘Dear Editor,Growing evidence has indicated that heterologous COVID-19 vaccination could generate higher antibody(Ab)and cellmediated immune(CMI)responses than homologous vaccination regimen.1–3 However,fundamental understanding of immunological mechanisms dictating the enhanced vaccine immunity is still lacking.To gain mechanistic insights,we comprehensively profiled the immune responses generated by homologous or heterologous booster vaccination in mice(Fig.1a). | Weijun Zhao Huajun Zhao Baoying Huang Tongyi Zhao Limei Wang Jian Zhang Yong Yang Xinying Tang Wenjie Tan Ang Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 0 |
| 19 | Inversion of Evaporation and Water Vapor Transport Using HY-2 Multi-Sensor Data显示文摘HY-2 satellite is the first marine dynamic environment satellite of China.In this study,global evaporation and water vapor transport of the global sea surface are calculated on the basis of HY-2 multi-sensor data from April 1 to 30,2014.The algorithm of evaporation and water vapor transport is discussed in detail,and results are compared with other reanalysis data.The sea surface temperature of HY-2 is in good agreement with the ARGO buoy data.Two clusters are shown in the scatter plot of HY-2 and OAFlux evaporation due to the uneven global distribution of evaporation.To improve the calculation accuracy,we compared the different parameterization schemes and adopted the method of calibrating HY-2 precipitation data by SSM/I and Global Precipitation Climatology Project(GPCP)data.In calculating the water vapor transport,the adjustment scheme is proposed to match the balance of the water cycle for data in the low latitudes. | LIU Dong’ang SUN Jian GUAN Changlong | 2020 | Journal of Ocean University of China2020，19，1： | 0 |
| 20 | Acquisition of a novel conjugative multidrug-resistant hypervirulent plasmid leads to hypervirulence in clinical carbapenem-resistant Klebsiella pneumoniae strains显示文摘The co-occurrence of plasmid-mediated multidrug resistance and hypervirulence in epidemic carbapenem-resistant Klebsiella pneumoniae has emerged as a global public health issue.In this study,an ST23 carbapenem-resistant hyper-virulent K.pneumoniae(CR-HvKP)strain VH1-2 was identified from cucumber in China and harbored a novel hybrid plasmid pVH1-2-VIR.The plasmid pVH1-2-VIR carrying both virulence and multidrug-resistance(MDR)genes was likely generated through the recombination of a virulence plasmid and an IncFIIK conjugative MDR plasmid in clinical ST2318622 isolated from a sputum sample.The plasmid pVH1-2-VIR exhibited the capacity for transfer to the clinical ST11 carbapenem-resistant K.pneumoniae(CRKP)strain via conjugation assay.Acquisition of pVH1-2-VIR plasmid directly converted a CRKP into CR-HvKP strain characterized by hypermucoviscosity,heightened virulence for Galleria mellonella larvae,and increased colonization ability in the mouse intestine.The emergence of such a hybrid plasmid may expedite the spread of CR-HvKP strains,posing a significant risk to human health. | Gong Li Ling Jia Lei Wan Lijuan Xia Ang Gao Runshi Yang Ruanyang Sun Minge Wang Juan Du Xinlei Lian Rongmin Zhang Liangxing Fang Xiaoping Liao Yahong Liu Bao-Tao Liu Jian Sun | 2023 | mLife2023，2，3： | 0 |
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