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| 1 | The Yellow Sea green tides were dominated by one species, Ulva (Enteromorpha) prolifera, from 2007 to 2011显示文摘Green tides have occurred in the Yellow Sea successively from 2007 to 2011. Genetic analysis of the 5-year green-tide-forming algae needs to be performed to determine the source of the biomass and understand the mechanism of the green tide blooms. In this study, free-floating green algae were collected at different sites in the Yellow Sea in 2010 and 2011. Data on 182 free-floating samples and 155 attached Ulva samples from previous studies on the Yellow Sea green tides from 2007 to 2009 were also taken into consideration. Morphology observation and molecular phylogenetic analyses indicated that the Yellow Sea green tides were dominated by a single species, Ulva prolifera, from 2007 to 2011. Considering that at least five Ulva species inhabit the north coast of China, the unialgal composition of the green tides implied that (1) there may be some special physiology and propagation pathways of U. prolifera for its rapid expansion, (2) the mechanisms of the Yellow Sea green tide formation were similar for the last five years, and (3) the intra-species genetic variation and population structure of U. prolifera need to be studied to determine the exact origin of the bloom-forming biomass. | ZHAO Jin JIANG Peng LIU ZhengYi WEI Wei LIN HanZhi LI FuChao WANG JinFeng QIN Song | 2013 | Chinese Science Bulletin2013，58，19： | 27 |
| 2 | ANALYSIS OF MECHANICS IN BALL SPINNING OF THIN-WALLED TUBE显示文摘Ball spinning is applied to manufacturing thin-walled tube with high precision and high mechanical properties. On the basis of plastic mechanics,by simplifying ball spinning of thin-walled tube as plane strain problem,slab method is used for the purpose of calculating the contact deformation pressure. The spinning force components,the torsional moment,the deformation power and the deformation work are calculated further as well. The influence of the two important process parameters such as the feed ratio and the ball diameter on the spinning force components is analyzed in order to further control the spinning force components by regulating the two process variables during the ball spinning process. The stress and strain state in deformable zone as well as mechanics boundary conditions in ball spinning are obtained. The effect of the three spinning force components on the formability of the spun part is analyzed and validated through the ball spinning experiments. The theoretical and experimental results show that the radial spinning component plays a significant role in ball spinning of thin-walled tube,and the mechanics situation in backward ball spinning contributes to enhancing the plasticity of the metal material,but that in forward ball spinning contributes to advancing the axial flow of the metal material. | JIANG Shuyong REN Zhengyi | 2008 | Chinese Journal of Mechanical Engineering2008，21，1： | 18 |
| 3 | CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys显示文摘Dear Editor,PINK1 mutations cause autosomal recessive and early-onset Parkinson’s disease(PD)with selective neurodegeneration.Unfortunately,current PINK1 knockout(KO)mouse1,2 and pig models3,4 are unable to recapitulate the selective and overt neurodegeneration seen in PD patients.Furthermore,endogenous Pink1 in the mouse brain is expressed at very low levels and can only be detected via immunoprecipitation,5 meaning that PINK1’s function in the mammalian brain needs to be assessed using larger animals that are closer to humans.We previously used CRISPR/Cas9 to target the monkey gene in one-cell stage embryos.6 Using the same approach,we designed two gRNAs to target exon 2(T1)and exon 4(T2),which encode a kinase domain in the PINK1 gene of rhesus monkeys(Fig.1a).CRISPR/Cas9 and PINK1 gRNAs were injected into one-cell stage rhesus monkey embryos.A T7E1 assay and sequencing of PCR products from the injected embryos showed high efficiency(61.5%)in targeting PINK1(Fig.1b and Supplementary information,Fig.S1).Transfer of 87 embryos to 28 surrogate rhesus monkeys resulted in 11 pregnancies(39.2%)(Fig.1b).Eleven fetuses developed to term and were born naturally.Of these live monkeys,eight carried PINK1 mutations(M),and three were wild type(WT).However,three mutant monkeys(M1,M3 and M4)were newborn triplets that struggled to survive and died 3-4 days after birth.One WT newborn monkey also died after a difficult labor.Another mutant monkey(M2)died 7 days after birth without noticeable warning signs or symptoms.The other three mutant monkeys(M6,M7 and M8)have lived for three years;M5,however,reduced its food intake and showed weakness at the age of 1.5 years,and died 30 days after anesthesia for MRI examination. | Weili Yang Yunbo Liu Zhuchi Tu Chong Xiao Sen Yan Xishan Ma Xiangyu Guo Xiusheng Chen Peng Yin Zhengyi Yang Su Yang Tianzi Jiang Shihua Li Chuan Qin Xiao-Jiang Li | 2019 | Cell Research2019，29，4： | 12 |
| 4 | Analysis of genetic variation within and among Ulva pertusa (Ulvaceae,Chlorophyta) populations using ISSR markers显示文摘Ulva pertusa is a native species to Asia along the western coast of Pacific Ocean,with new occurrence records in the eastern coast of Pacific,the northwest coast of Atlantic and the Mediterranean Sea.However,little is known about its population genetic structure.In this study,twelve U.pertusa populations from 3 coastal areas of China:Qingdao,Yantai and Dalian,were applied to ISSR analysis.The selected 4 ISSR primers amplified 120 polymorphic bands totally.Nei's gene diversity (H) ranged from 0.0729 to 0.1496,and Shannon's information index (I) ranged from 0.1072 to 0.2196.Genetic diversity was greater within Qingdao populations (H=0.2069,I=0.3232).Analysis of molecular variance (AMOVA) showed the greatest variance within populations (68.57%),much less variance among populations (22.63%) and among areas (8.79%).Unweighted pair-group mean analysis (UPGMA) indicated that clustering of U.pertusa individuals mainly relates to their populations and geographic distances separating those populations.Genetic differentiation and limited gene flow among U.pertusa populations were indicated by ISSR analysis. | ZHAO Jin JIANG Peng LI Nan WANG JinFeng LIU ZhengYi QIN Song | 2010 | Chinese Science Bulletin2010，55，8： | 6 |
| 5 | An App knock-in rat model for Alzheimer’s disease exhibiting Aβand tau pathologies,neuronal death and cognitive impairments显示文摘A major obstacle in Alzheimer’s disease(AD)research is the lack of predictive and translatable animal models that reflect disease progression and drug efficacy.Transgenic mice overexpressing amyloid precursor protein(App)gene manifest non-physiological and ectopic expression of APP and its fragments in the brain,which is not observed in AD patients.The App knock-in mice circumvented some of these problems,but they do not exhibit tau pathology and neuronal death.We have generated a rat model,with three familiar App mutations and humanized Aβsequence knocked into the rat App gene.Without altering the levels of full-length APP and other APP fragments,this model exhibits pathologies and disease progression resembling those in human patients:deposit of Aβplaques in relevant brain regions,microglia activation and gliosis,progressive synaptic degeneration and AD-relevant cognitive deficits.Interestingly,we have observed tau pathology,neuronal apoptosis and necroptosis and brain atrophy,phenotypes rarely seen in other APP models.This App knock-in rat model may serve as a useful tool for AD research,identifying new drug targets and biomarkers,and testing therapeutics. | Keliang Pang Richeng Jiang Wei Zhang Zhengyi Yang Lin-Lin Li Makoto Shimozawa Simone Tambaro Johanna Mayer Baogui Zhang Man Li Jiesi Wang Hang Liu Ailing Yang Xi Chen Jiazheng Liu Bengt Winblad Hua Han Tianzi Jiang Weiwen Wang Per Nilsson Wei Guo Bai Lu | 2022 | Cell Research2022，32，2： | 6 |
| 6 | Precise Modulation Strategies for Transcranial Magnetic Stimulation:Advances and Future Directions显示文摘Transcranial magnetic stimulation(TMS)is a popular modulatory technique for the noninvasive diagnosis and therapy of neurological and psychiatric diseases.Unfortunately,current modulation strategies are only modestly effective.The literature provides strong evidence that the modulatory effects of TMS vary depending on device components and stimulation protocols.These differential effects are important when designing precise modulatory strategies for clinical or research applications.Developments in TMS have been accompanied by advances in combining TMS with neuroimaging techniques,including electroencephalography,functional nearinfrared spectroscopy,functional magnetic resonance imaging,and positron emission tomography.Such studies appear particularly promising as they may not only allow us to probe affected brain areas during TMS but also seem to predict underlying research directions that may enable us to precisely target and remodel impaired cortices or circuits.However,few precise modulation strategies are available,and the long-term safety and efficacy of these strategies need to be confirmed.Here,we review the literature on possible technologies for precise modulation to highlight progress along with limitations with the goal of suggesting future directions for this field. | Gangliang Zhong Zhengyi Yang Tianzi Jiang | 2021 | Neuroscience Bulletin2021，37，12： | 4 |
| 7 | Simulation of Fluid Flow, Heat Transfer and Micro-Segregation in Twin-roll Strip Casting of Stainless Steel显示文摘在扔过程的成双转动的长带,在熔融的水池的金属流动和温度分发直接影响这个过程的稳定性和产品的质量。在这篇论文, 3D 联合了热流动的 fenite 元素建模(女性) 为成双转动的长带扔不锈钢的模拟被执行。流的温度和扔的速度在温度地的影响从数字模拟被获得。溶质微分离在长带期间,扔不锈钢的过程也被模仿。一个 developedmicro 分离模型被用来计算在不锈钢的成双转动的扔的溶质微分离。在团结和温度的部分被给的在先令之间的关系,被用来决定 LIT,液体透不过的温度) , ZST (零力量温度) 和在非平衡团结的时期的 ZDT (零韧性温度) 。温度在上的效果微分离被讨论。根据计算结果,在不锈钢扔的成双转动的长带的团结结束温度然后被决定,它能为控制团结结束温度的地点并且分析扔的长带的裂缝提供一个基础。 | Xiaomin ZHANG Zhengyi JIANG Xianghua LIU Guodong WANG | 2006 | Journal of Materials Science & Technology2006，22，3： | 4 |
| 8 | Microstructure and Mechanical Properties of Nb- and Nb+ Ti-Stabilised 18Cr-2Mo Ferritic Stainless Steels显示文摘To explore the optimum use of stabilised elements and study the influences of stabilisation in 18 Cr-2 Mo grades,the Nb and Nb+Ti microalloying investigation focused on the relationships of the microstructure and mechanical properties of the microalloyed 18 Cr-2 Mo ferritic stainless steel thick plates.Thermo-Calc calculation was performed to predict the equilibrium phase diagrams.Afterwards,the microstructure,i.e.grain size and precipitation,of as-annealed specimens was analysed by means of optical microscopy,scanning electron microscopy and transmission electron microscopy,X-ray diffraction and energydispersive spectroscopy.Also,electron backscatter diffraction mapping was constructed to characterise grain boundary.The mechanical properties,including tensile strength and impact toughness,were tested to correlate with the microstructure.The results show that the grain sizes of Nb-stabilised steel are comparatively smaller,which is related to the fine precipitation at the grain boundaries and beneficial to the impact toughness.The increase in its strength is not apparent due to the inhomogeneous grain sizes.The grain boundary characters are similar,which is not the main factor related to their mechanical properties.When Ti is added,TiN forms above the liquidus,and large TiN particles evidently impair impact toughness. | Jian Han Zhixiong Zhu Gang Wei Xingxu Jiang Qian Wang Yangchuan Cai Zhengyi Jiang | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，5： | 4 |
| 9 | Modeling uniaxial tensile deformation of polycrystalline Al using CPFEM显示文摘The crystal plasticity finite element modeling(CPFEM)is realized in commercial finite element code ABAQUS with UMAT subroutine on the basis of the crystal plasticity theory of rate dependent polycrystal constitutive relations in the mesoscopic scale.The initial orientations obtained by electron backscatter diffraction(EBSD)are directly input into the CPFEM to simulate the mechanical response of polycrystaUine 1050 pure Al in uniaxial tensile deformation.Two polycrystal models and two tensile strain rates were used in the simulations.The stress-strain curves of tensile deformation were analyzed.The predictions and the corre- sponding experiment result show reasonable agreement and slight deviation with experiments.The flow true stress of strain rate 0.01 s^(-1)is higher than that of strain rate 0.001 s^(-1).At the strain less than 0.05,the stress saturated rate of the experiment is higher than the simulated results.However,the stress saturated rate of the experiment becomes gentler than the corresponding simulated predictions at the strain over 0.05.Also,necking was simulated by the two models,but the necking strain is not well predicted.Tensile textures at strain 0.25 were predicted at the low strain rate of 0.001 s^(-1).The predictions are in good accord with the experimental results. | Huachun pi Jingtao Han Chuanguo Zhang A. Kiet Tieu Zhengyi Jiang | 2008 | Journal of University of Science and Technology Beijing2008，15，1： | 4 |
| 10 | Recent Advancements on Photothermal Conversion and Antibacterial Applications over MXenes-Based Materials显示文摘The pernicious bacterial proliferation and emergence of super-resistant bacteria have already posed a great threat to public health,which drives researchers to develop antibiotic-free strategies to eradicate these fierce microbes.Although enormous achievements have already been achieved,it remains an arduous challenge to realize efficient sterilization to cut off the drug resistance generation.Recently,photothermal therapy(PTT)has emerged as a promising solution to efficiently damage the integrity of pathogenic bacteria based on hyperthermia beyond their tolerance.Until now,numerous photothermal agents have been studied for antimicrobial PTT.Among them,MXenes(a type of two-dimensional transition metal carbides or nitrides)are extensively investigated as one of the most promising candidates due to their high aspect ratio,atomic-thin thickness,excellent photothermal performance,low cytotoxicity,and ultrahigh dispersibility in aqueous systems.Besides,the enormous application scenarios using their antibacterial properties can be tailored via elaborated designs of MXenes-based materials.In this review,the synthetic approaches and textural properties of MXenes have been systematically presented first,and then the photothermal properties and sterilization mechanisms using MXenes-based materials are documented.Subsequently,recent progress in diverse fields making use of the photothermal and antibacterial performances of MXenes-based materials are well summarized to reveal the potential applications of these materials for various purposes,including in vitro and in vivo sterilization,solar water evaporation and purification,and flexible antibacterial fabrics.Last but not least,the current challenges and future perspectives are discussed to provide theoretical guidance for the fabrication of efficient antimicrobial systems using MXenes. | Shuyan Hao Hecheng Han Zhengyi Yang Mengting Chen Yanyan Jiang Guixia Lu Lun Dong Hongling Wen Hui Li Jiurong Liu Lili Wu Zhou Wang Fenglong Wang | 2022 | Nano-Micro Letters2022，14，11： | 4 |
| 11 | Micromanufacturing of composite materials:a review显示文摘Composite materials exhibit advantages from the combination of multiple properties,which cannot be achieved by a monolithic material.At present,the use of composite materials in miniaturized scale is receiving much attention in the fields of medicine,electronics,aerospace,and microtooling.A common method for producing miniaturized composite parts is micromanufacturing.There has been,however,no comprehensive literature published that reviews,compares,and discusses the ongoing micromanufacturing methods for producing miniaturized composite components.This study identifies the major micromanufacturing methods used with composite materials,categorizes their subclasses,and highlights the latest developments,new trends,and effects of key factors on the productivity,quality,and cost of manufacturing composite materials.A comparative study is presented that shows the potential and versatility associated with producing composite materials along with possible future applications.This review will be helpful in promoting micromanufacturing technology for fabricating miniaturized products made of composite materials to meet the growing industrial demand. | Mahadi Hasan Jingwei Zhao Zhengyi Jiang | 2019 | International Journal of Extreme Manufacturing2019，1，1： | 3 |
| 12 | Towards understanding the brittle–ductile transition in the extreme manufacturing显示文摘The brittle–ductile transition(BDT) widely exists in the manufacturing with extremely small deformation scale, thermally assisted machining, and high-speed machining. This paper reviews the BDT in extreme manufacturing. The factors affecting the BDT in extreme manufacturing are analyzed, including the deformation scale and deformation temperature induced brittle-to-ductile transition, and the reverse transition induced by grain size and strain rate. A discussion is arranged to explore the mechanisms of BDT and how to improve the machinability based on the BDT. It is proposed that the mutual transition between brittleness and ductility results from the competition between the occurrence of plastic deformation and the propagation of cracks. The brittleness or ductility of machined material should benefit a specific manufacturing process, which can be regulated by the deformation scale, deformation temperature and machining speed. | Tao Zhang Feng Jiang Hui Huang Jing Lu Yueqin Wu Zhengyi Jiang Xipeng Xu | 2021 | International Journal of Extreme Manufacturing2021，3，2： | 3 |
| 13 | Shining light on transition metal sulfides:New choices as highly efficient antibacterial agents显示文摘Globally,millions of people die of microbial infection-related diseases every year.The more terrible situation is that due to the overuse of antibiotics,especially in developing countries,people are struggling to fight with the bacteria variation.The emergence of super-bacteria will be an intractable environmental and health hazard in the future unless novel bactericidal weapons are mounted.Consequently,it is critical to develop viable antibacterial approaches to sustain the prosperous development of human society.Recent researches indicate that transition metal sulfides(TMSs)represent prominent bactericidal application potential owing to the meritorious antibacterial performance,acceptable biocompatibility,high solar energy utilization efficiency,and excellent photo-to-thermal conversion characteristics,and thus,a comprehensive review on the recent advances in this area would be beneficial for the future development.In this review article,we start with the antibacterial mechanisms of TMSs to provide a preliminary understanding.Thereafter,the state-of-the-art research progresses on the strategies for TMSs materials engineering so as to promote their antibacterial properties are systematically surveyed and summarized,followed by a summary of the practical application scenarios of TMSs-based antibacterial platforms.Finally,based on the thorough survey and analysis,we emphasize the challenges and future development trends in this area. | Hecheng Han Jingjing Yang Xiaoyan Li Yuan Qi Zhengyi Yang Zejun Han Yanyan Jiang Martina Stenzel Hui Li Yixin Yin Yi Du Jiurong Liu Fenglong Wang | 2021 | Nano Research2021，14，8： | 2 |
| 14 | Experimental Investigation on Micro Deep Drawing of Stainless Steel Foils with Different Microstructural Characteristics显示文摘In the present work,austenitic stainless steel(ASS)304 foils with a thickness of 50μm were first annealed at temperatures ranging from 700 to 1100℃for 1 h to obtain different microstructural characteristics.Then the effects of microstructural characteristics on the formability of ASS 304 foils and the quality of drawn cups using micro deep drawing(MDD)were studied,and the mechanism involved was discussed.The results show that the as-received ASS 304 foil has a poor formability and cannot be used to form a cup using MDD.Serious wrinkling problem occurs on the drawn cup,and the height profile distribution on the mouth and the symmetry of the drawn cup is quite non-uniform when the annealing temperature is 700℃.At annealing temperatures of 900 and 950℃,the drawn cups are both characterized with very few wrinkles,and the distribution of height profile,symmetry and mouth thickness are uniform on the mouths of the drawn cups.The wrinkling becomes increasingly significant with a further increase of annealing temperature from 950 to 1100℃.The optimal annealing temperatures obtained in this study are 900 and 950℃for reducing the generation of wrinkling,and therefore improving the quality of drawn cups.With non-optimized microstructure,the distribution of the compressive stress in the circumferential direction of the drawn foils becomes inhomogeneous,which is thought to be the cause of the occurrence of localized deformation till wrinkling during MDD. | Jingwei Zhao Tao Wang Fanghui Jia Zhou Li Cunlong Zhou Qingxue Huang Zhengyi Jiang | 2021 | Chinese Journal of Mechanical Engineering2021，34，2： | 2 |
| 15 | Novel supramolecular organocatalysts of hydroxyprolinamide based on calix[4]arene scaffold for the enantioselective Biginelli reaction显示文摘A series of novel supramolecular organocatalysts of hydroxyprolinamide based on the upper rim of calix[4]arene scaffold have been developed to catalyze enantioselective multi-component Biginelli reaction. Under the optimal conditions, the reactions occurred with moderate-to-excellent enantioselectivities (up to 98% ee). A plausible transition state constructed by the supra- molecular interaction of hydrogen bond and cation-π between catalysts and substrates has been proposed. | LI ZhengYi XING HuaiJie HUANG GuoLi SUN XiaoQiang JIANG JuLi WANG LeYong | 2011 | Science China Chemistry2011，54，11： | 2 |
| 16 | Role of ball size in backward ball spinning of thin-walled tubular part with longitudinal inner ribs 显示文摘 | JIANG Shuyong REN Zhengyi LI Chunfeng | 2009 | Journal of Materials Processing Technology2009，209，4： | 1 |
| 17 | Optimal Clamping Scheme of Thin-Walled Cavity Workpiece显示文摘 | Zhengyi Jiang Shanqing Li Jianmin Zeng | 2011 | Advanced Materials Research2011，2，： | 1 |
| 18 | Effect of adenine moiety on DNA binding property of copper( II)-terpyridine complexes显示文摘 | JIANG Qin WU Zhengyi ZHANG Yangmiao | 2008 | Dalton Transactions2008，21，23： | 1 |
| 19 | Analysis of premature failure of work rolls in a cold strip plant 显示文摘 | Li Hongchun Jiang Zhengyi Kiet A Tieu Sun Weihua | 2007 | Wear2007，263，： | 1 |
| 20 | Analysis of premature failure of work rolls in a cold strip plant 显示文摘 | Li Hongchun Jiang Zhengyi Kiet A | 2007 | Wear2007，263，： | 1 |
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