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17篇 您的检索式:作者名="Jianying Ding"
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1Transgenic breeding of anti-Bombyx mori L. nuclear polyhedrosis virus silkworm Bombyx mori显示文摘对 Bombyx 粗腐殖质 i L 抵抗的蚕紧张。原子 polyhedrosis 病毒通过转基因的实验被获得。与一个 A3 倡导者一起的小猪用绳子拖的平底渡船 transposon 随机被插入到蚕,驾驶进蚕染色体的提高的绿荧光灯的蛋白质(EGFP ) 记者基因。聚合酶链反应结果证实体外的 EGFP 基因的插入,和荧光显微镜学证明 EGFP 在中间的内脏织物被表示。原子 polyhedrosis 的病态比率在转基因的蚕紧张在原来的蚕紧张从 90% 减少了到 66.7% 。与到 Bombyx 粗腐殖质 i L 的抵抗相比。在 Qiufeng 紧张的原子 polyhedrosis 病毒,通常在生产被使用,有在转基因的蚕的 33 个百分的点的增加。在 ChunhuaxQiuyue 紧张的 antivirotic 特性,从一个不同转基因的家庭被引起,比在 QiufengxBaiyu,另一个生气品种在生产使用了高是大约 10 个百分的点。我们的结果在繁殖 anti-BmNPV 蚕紧张显示了插入 transposon 的变化的好申请价值。Huijuan Yang Wei Fan Hao Wei Jinwei Zhang Zhonghua Zhou Jianying Li Jianrong Lin Nong Ding Boxiong Zhong 2008Acta Biochimica et Biophysica Sinica2008,40,10:6
2Short-term biochar effect on soil physicochemical and microbiological properties of a degraded alpine grassland显示文摘Soil remediation is an important part of the restoration process of degraded terrestrial ecosystems.Due to its unique properties,biochar is being used widely as an effective soil modifier in agricultural systems,but research is still rare on biochar application in grassland ecosystems,especially in degraded alpine grasslands.In this study,we conducted a plot experiment to investigate the effect of biochar application on soil physicochemical properties and microorganisms at the 0–20 cm soil depth of a degraded alpine grassland in Qinghai-Tibet Plateau,China.The experiment consisted of four corn straw biochar application levels(0%,0.5%,1%and 2%,with the percentage representing the ratio of biochar weight to the dry weight of soil in the surface 20 cm soil layer).When the biochar addition increased from 0%to 2%,total nitrogen,total organic carbon and available phosphorus in the 0–10 cm soil layer increased by 41%,55%and 45%,respectively,in the second year after biochar addition.Meanwhile,soil electrical conductivity decreased,and soil water content increased.Total microbial,fungal and bacterial biomasses in the 0–10 cm soil layer increased from 9.15 to 12.68,0.91 to 1.34,and 3.85 to 4.55μg g^(-1),respectively.The relative biomasses of saprophytic fungi and methanotrophic bacteria decreased,while the relative biomasses of ectomycorrhizal fungi and arbuscular mycorrhizal fungi increased.These results indicate that biochar has a great potential in improving microbial activity and soil fertility in soil remediation of the degraded alpine grassland.Jinsheng LI Xinqing SHAO Ding HUANG Kesi LIU Jianying SHANG Qian ZHANG Tianci ZHAO Xiaomeng YANG 2022Pedosphere2022,32,3:3
3Reserve Constrained Dynamic Economic Dispatch with Valve-point Effect:A Two-stage Mixed Integer Linear Programming Approach显示文摘This paper proposes a deterministic two-stage mixed integer linear programming(TSMILP)approach to solve the reserve constrained dynamic economic dispatch(DED)problem considering valve-point effect(VPE).In stage one,the nonsmooth cost function and the transmission loss are piecewise linearized and consequently the DED problem is formulated as a mixed integer linear programming(MILP)problem,which can be solved by commercial solvers.In stage two,based on the solution obtained in stage one,a range compression technique is proposed to make a further exploitation in the subspace of the whole solution domain.Due to the linear approximation of the transmission loss,the solution obtained in stage two dose not strictly satisfies the power balance constraint.Hence,a forward procedure is employed to eliminate the error.The simulation results on four test systems show that TSMILP makes satisfactory performances,in comparison with the existing methods.Zhaolong Wu Jianying Ding Q.H.Wu Zhaoxia Jing Jiehui Zheng 2017CSEE Journal of Power and Energy Systems2017,3,2:3
4Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu 2023Science China(Life Sciences)2023,66,5:2
5Efficacy and safety of darbepoetin alfa injection replacing epoetin alfa injection for the treatment of renal anemia in Chinese hemodialysis patients:A randomized,open-label,parallel-group,noninferiority phase III trial显示文摘Background:This study was to explore the clinical efficacy and safety of darbepoetin alfa injection replacing epoetin alfa injection(recombinant human erythropoietin injection,rHuEPO)for the treatment of anemia associated with chronic kidney failure in Chinese patients undergoing hemodialysis.Method:This study was a multicenter,randomized,open-label,intergroup parallel control phase III noninferiority trial from April 19,2013 to September 9,2014 at 25 sites.In this study,the members of the darbepoetin alfa group underwent intravenous administration once per week or once every two weeks.The members of the control drug epoetin alfa group underwent intravenous administration two or three times per week.All subjects underwent epoetin alfa administration during the 8-week baseline period.After that,subjects were randomly assigned to the darbepoetin alfa group or epoetin alfa group.The noninferiority in the changes of the average Hb concentrations from the baseline to the end of the evaluation period(noninferiority threshold:-1.0 g/dl)was tested between the two treatments.The time-dependent hemoglobin(Hb)concentration and the maintenance rate of the target Hb concentration(the proportion of subjects with Hb concentrations between 10.0 and 12.0 g/dl)were also evaluated.Iron metabolism,including changes in the serum iron,total iron-binding capacity,ferritin,transferrin saturation,and comparisons of the dose adjustments between the two groups during the treatment period were analyzed further.Adverse events(AEs)were also observed and compared,and the safety was analyzed between the two treatment groups.The conversion rate switching from epoetin alfa to darbepoetin alfa was also discussed.SAS?software version 9.2 was used to perform all statistical analyses.Descriptive statistics were used for all efficacy,safety,and demographic variable analyses,including for the primary efficacy indicators.Results:Four hundred and sixty-six patients were enrolled in this study,and ultimately 384 cases were analyzed for safety,including 267 cases in the darbepoetin alfa group and 117 cases in the epoetin alfa group.There were 211 cases in the per-protocol set,including 152 cases in the darbepoetin alfa group and 59 cases in the epoetin alfa group.The changes in the average Hb concentrations from the baseline to the end of the evaluation period were-0.07 and-0.15 g/dl in the darbepoetin alfa group and epoetin alfa group respectively.The difference between the two groups was 0.08 g/dl(95%confidence interval[CI]:-0.22 to 0.39),and the lower limit of the 95%CI was-0.22>-1.0 g/dl.The average Hb concentrations of the two groups were 10.88-11.43 g/dl(darbepoetin alfa)and 10.91-11.38 g/dl(epoetin alfa)during the study period of Weeks 0-28,with the maintenance rates of the target Hb concentration ranging within 71%-87%and 78%-95%in the darbepoetin alfa group and epoetin alfa group respectively.During the period of comparison between the two groups,the incidence of AEs in the darbepoetin alfa group was 61.42%,while in the epoetin alfa group it was 56.41%.All of the adverse events and reactions in the study were those commonly associated with hemodialysis.Conclusion:The overall efficacy and safety of darbepoetin alfa for the treatment of Chinese renal anemia patients undergoing hemodialysis are consistent with those of epoetin alfa.Bicheng Liu Nan Chen Jinghong Zhao Aiping Yin Xiongfei Wu Changying Xing Gengru Jiang Junzhou Fu Mei Wang Rong Wang Jianying Niu Ping Fu Zhaohui Ni Fanfan Hou Jiuyang Zhao Jing Chen Yuqing Chen Wei Shi Jianghua Chen Wenge Li Gang Xu Ling Zhong Wenhu Liu Guohua Ding Yuichiro Kondo Changhe Yue Changlin Mei 2022Chronic Diseases and Translational Medicine2022,8,2:1
6Maternal heterozygous mutation in CHEK1 leads to mitotic arrest in human zygotes显示文摘Dear Editor,The first mitotic division in zygotes is crucial for the beginning of the life cycle for the human.After fertilization,zygotes reactivate cell cycle,both paternal and maternal genomes replicate and reprogram to become totipotent.In the meantime,the male and female pronucleus move to the center of the zygote and merge.Then zygotes enter the metaphase,and sister chromatids separate into two daughter cells(Eckersley-Maslin et al.,2018;Reichmann et al.,2018).This is a sensitive time window and many perturbances may cause the first mitosis to fail.Beili Chen Jianying Guo Ting Wang Qianhui Lee Jia Ming Fangfang Ding Haitao Li Zhiguo Zhang Lin Li Yunxia Cao Jie Na 2022Protein & Cell2022,13,2:1
7Darbepoetin alfa injection versus epoetin alfa injection for treating anemia of Chinese hemodialysis patients with chronic kidney failure:A randomized,open-label,parallel-group,non-inferiority Phase III trail显示文摘Background:Erythropoietin is a glycoprotein that mainly regulates erythropoiesis.In patients with chronic renal failure with anemia,darbepoetin alfa can stimulate erythropoiesis,correct anemia,and maintain hemoglobin levels.This study was designed to demonstrate the efficacy and safety of darbepoetin alfa injections as being not inferior to epoetin alfa injections(Recombinant Human Erythropoietin injection,rHuEPO)when maintaining hemoglobin(Hb)levels within the target range(10.0-12.0 g/dL)for the treatment of renal anemia.Methods:Ninety-five patients were enrolled in this study from April 15,2013 to April 10,2014 at 25 sites.In this study,patients(n=95)aged 18-70 years were randomized into a once per week intravenous darbepoetin alfa group(n=56)and a twice or three times per week intravenous epoetin alfa group(n=39)for 28 weeks,who had anemia with hemoglobin levels between 6 g/dL and 10 g/dL due to chronic kidney disease(CKD)and were undergoing hemodialysis or hemofiltration with ESA-naive(erythropoiesis stimulating agent-naive).The primary efficacy profile was the mean Hb level(the non-inferiority margin was-1.0 g/dL,week 21-28);the secondary efficacy profiles were the Hb increase rate(week 0-4),the target Hb achievement cumulative rate and time,the change trends of the Hb levels,and the target Hb maintenance ratio.Adverse events(AEs)were observed and compared,and the efficacy and safety were analyzed between the two treatment groups.Additionally,the frequencies of dose adjustments between the darbepoetin alfa and epoetin alfa groups were compared during the treatment period.SAS?software version 9.2 was used to perform all statistical analyses.Descriptive statistics were used for all efficacy,safety,and demographic variable analyses,including for the primary efficacy indicators.Results:The mean Hb level was 11.3 g/dL in the darbepoetin alfa group and 10.7 g/dL in the epoetin alfa group,respectively;the difference of the lower limits of the 95%confidence intervals(CI)between the two groups was 0.1 g/dL(>-1.0 g/dL),and non-inferiority was proven;the Hb levels started to increase in the first four weeks at a similar increase rate;no obvious differences were observed between the groups in the target Hb achievement cumulative rates,and the Hb levels as well as the target Hb level maintenance rate changed over time.The incidence of AEs was 62.5%in the darbepoetin alfa group and 76.9%in the epoetin alfa group.All the adverse events observed in the study were those commonly associated with hemodialysis.Conclusion:Darbepoetin alfa intravenously once per week can effectively increase Hb levels and maintain the target Hb levels well,which makes it not inferior to epoetin alfa intravenously twice or three times per week.Darbepoetin alfa shows an efficacy and safety comparable to epoetin alfa for the treatment of renal anemia.Nan Chen Changying Xing Jianying Niu Bicheng Liu Junzhou Fu Jiuyang Zhao Zhaohui Ni Mei Wang Wenhu Liu Jinghong Zhao Ling Zhong Xiongfei Wu Wenge Li Yuqing Chen Wei Shi Jianghua Chen Aiping Yin Ping Fu Rong Wang Gengru Jiang Fanfan Hou Guohua Ding Jing Chen Gang Xu Yuichiro Kondo Yuliang Su Changlin Mei 2022Chronic Diseases and Translational Medicine2022,8,1:1
8Mefatinib as first-line treatment of patients with advanced EGFR-mutant non-small-cell lung cancer:a phase Ib/II efficacy and biomarker study显示文摘EGFR inhibitors have revolutionized the treatment of advanced non-small-cell lung cancer(NSCLC).Mefatinib is a novel,bioavailable,second-generation,irreversible pan-EGFR inhibitor.This phase Ib/II open-label,single-arm,multi-center study investigated the efficacy,safety,biomarker,and resistance mechanisms of mefatinib in the first-line treatment of patients with advanced EGFR-mutant NSCLC.This study included 106 patients with EGFR-mutant stage IIIB-IV NSCLC who received first-line mefatinib at a daily dose of either 60 mg(n=51)or 80 mg(n=55).The primary endpoint was progression-free survival(PFS).Secondary endpoints were overall response rate(ORR),disease control rate(DCR),overall survival(OS),and safety.The cohort achieved an ORR of 84.9%and DCR of 97.2%.The median PFS was 15.4 months and the median OS was 31.6 months.Brain metastasis was detected in 29%of patients(n=31)at diagnosis and demonstrated an ORR of 87.1%,PFS of 12.8 months,and OS of 25.2 months.Adverse events primarily involved skin and gastrointestinal toxicities,which were well-tolerated and manageable.Analyses of mutation profiles were performed using targeted sequencing of plasma samples at baseline,first follow-up 6 weeks from starting mefatinib therapy(F1),and at progression.Patients with concurrent TP53 mutations had comparable PFS as wild-type TP53(14.0 vs 15.4 months;p=0.315).Furthermore,circulating tumor DNA clearance was associated with longer PFS(p=0.040)and OS(p=0.002).EGFR T790M was the predominant molecular mechanism of mefatinib resistance(42.1%,16/38).First-line mefatinib provides durable PFS and an acceptable toxicity profile in patients with advanced EGFR-mutant NSCLC.Pingli Wang Yuping Li Dongqing Lv Lingge Yang Liren Ding Jianya Zhou Wei Hong Youfei Chen Dongqing Zhang Susu He Jianying Zhou Kai Wang 2021Signal Transduction and Targeted Therapy2021,6,12:1
9Transcriptome and metabolome analysis reveal that oral secretions from Helicoverpa armigera and Spodoptera litura influence wound-induced host response in cotton显示文摘Cotton(Gossypium hirsutum)is an important fiber crop worldwide.Insect attack causes cotton yield and quality losses.However,little is known about the mechanism of cotton response to insect attack.We simulated insect feeding by applying insect oral secretions(OS)to wounds,and combined transcriptome and metabolome analysis to investigate how OS from two major pest species(Helicoverpa armigera and Spodoptera litura)affect cotton defense responses.We found that respectively 12,668 and 13,379 genes were differentially expressed in comparison with wounding alone.On addition of OS,the jasmonic acid signaling pathway was rapidly and strongly induced,whereas genes involved in salicylic acid biosynthesis were downregulated.On constructing a coexpression gene network,we identified a hub gene encoding a leucine-rich repeat receptor kinase that may play an important role in early signal recognition and transduction.OS from the two insect species altered the abundance of flavonoid-related compounds in different patterns.Gossypol remained in lower concentration after OS application than after wounding alone,suggesting a suppressive effect of OS on cotton defense response.This study illustrated transcriptional and metabolic changes of cotton in responding to OS from two chewing insect species,identified potential key response genes,and revealed evidence for OS inhibition of wounding-induced cotton defense response.Huan Si Hongling Liu Yiwen Sun Zhongping Xu Sijia Liang Bo Li Xiao Ding Jianying Li Qiongqiong Wang Lin Sun Xianlong Zhang Shuangxia Jin 2020The Crop Journal2020,8,6:1
10Model for automatic detection of eggshell crack显示文摘Liu Jianying Chen Jiayan Ding Youchun 2004Transactions of the CSAE2004,20,4:1
11Tongue coating microbiome regulates the changes in tongue texture andcoating in patients with post-menopausal osteoporosis of Gan-shen deficiency syndrometype显示文摘Wenna Liang Xihai Li Yachan Li Candong Li Bizheng Gao Huijuan Gan Sumin Li Jianying Shen Jie Kang Shanshan Ding Xuejuan Lin Linghong Liao 2013International Journal of Molecular Medicine2013,,:1
12Fluorescence fluctuation spectroscopy and its artifacts:simulations and tests显示文摘Fluorescence fluctuation spectroscopy (FFS) technique is capable of monitoring changes in concentration, mass, size and structure of fluorescent-labeled bio-molecules in microscopic volume and is suitable for measuring biological interactions in living cells. FFS data may be affected by many experimental factors in complicated biological systems. Using a Monte Carlo approach, we generate fluorescence fluctuation data for different experimental systems. This approach helps to separate the contributions by different experimental factors in a complicated fluorescence fluctuation spectrum. It also helps to validate new theoretical models and new fitting formulations. We describe the algorithm of the simulation program and tests on its statistical performance. The program is then used successfully to study the effects of several experimental factors on FFS detection.MENG Fanbo 1 , CHEN Bo 1 , LIU Guang 1 , DING Jianying 1 & MA Hui 2,1 1. Department of Physics and Key Laboratory of Atomic and Molecular Nano Sciences, Ministry of Educa- tion, Tsinghua University, Beijing 100084, China 2. Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China 2005Science China(Physics,Mechanics & Astronomy)2005,48,3:1
13The synthesis of MOF derived carbon and its application in water treatment显示文摘In recent years,since water pollution has aroused great public concern,various carbon materials have already been widely applied for water treatment.In this respect,tremendous effort has been made to provide different synthesis methods of carbon materials.Among all carbon materials,metal-organic framework(MOF)derived carbon has always been favored as it possesses several appealing merits such as high specific surface area,large pore volume,and outstanding chemical stability.This review presents the latest development of MOFs as templates and precursors for the fabrication of various carbon materials,including porous carbon,nanocarbon,and graphene,which are pyrolyzed at different temperatures.The article also emphasizes on their future trends and perspectives on the application of water treatment.Jiani Ding Yijian Tang Shasha Zheng Songtao Zhang Huaiguo Xue Qingquan Kong Huan Pang 2022Nano Research2022,15,8:1
14The distribution and economic losses of alien species invasion to China显示文摘Haigen Xu Hui Ding Mingyan Li Sheng Qiang Jianying Guo Zhengmin Han Zongguo Huang Hongying Sun Shunping He Hairong Wu Fanghao Wan 2006Biological Invasions2006,,7:1
15Diagenesis of Paleogene sandstone from Kong 1 Member of Southern Kongdian in Huanghua depression显示文摘Huanghua depression is one of the richest areas in petroleum and natural gas in China.The Paleogene mainly consists of sandstone with facies of river,delta,fan delta and littoral-shallow lacustrine.Diagenesis played an important role in the properties of reservoir rocks.Applying X-ray diffraction,on the basis of analyzing many cores and thin sections,the authors studied diagenesis of Paleogene sandstone reservoir rocks in kong1 Menber of southern Kongdian in Huanghua depression.Diagenetic complexity shows that the sandstone in this area underwent compaction,cementation,isolation,recrystallization during the burying of sediments,and the first three compose the major diagenesis.The compaction and cementation led to decreasing porosity,and the solution of unsteady minerals also results in increasing in porosity.Jinping MA Linfu XUE Ling DING Jianying LIU Danping WANG 2007Global Geology2007,10,1:0
16靶蛋白活性的可逆、定量光调控显示文摘文章简介蛋白是生命活动的主要物质基础和生物功能的执行者,在分子水平上精准调控蛋白的活性,对深入研究和操纵蛋白及其参与的生命活动过程至关重要。光作为一种高效、易于进行时空操作的刺激源,在蛋白研究领域备受青睐。Sitao Xie 邱丽萍 Liang Cui Honglin Liu Yang Sun Hao Liang Ding Ding Lei He Huixia Liu Jiani Zhang Zhou Chen Xiaobing Zhang 谭蔚泓 2018科学新闻2018,0,4:0
17Ecosystem service bundle index construction,spatiotemporal dynamic display,and driving force analysis显示文摘Introduction:Existing studies on ecosystem service relationships are mainly qualitative or semi-quantitative assessments,but lack of quantitative exploration of aggregated ecosystem services and their influencing factors.We mapped the distributions of 12 ecosystem services of Zhejiang Province in 2000 and 2015 at the district and county level,analyzed their relationships using Spearman’s correlation analysis,constructed ecosystem service bundle index(ESBI)for each district and county by structural equation model,and then through multiple linear regression,we explored factors associated with ESBI variations.Outcomes:Our results showed that(1)most ecosystem services were spatially clustered.There were synergies between individual ecosystem services in categories of provisioning and regulating services,respectively;(2)our proposed ESBI index system consists of overall index and sub-indices of provisioning,regulating,and cultural services.The higher the ESBI value,the more important the corresponding place for multiple aggregated ecosystem service provision.Compared to 2000,ESBI in 2015 distributed more unevenly,and the average dropped by 3.10%;and(3)the increase of ESBI was associated with its initial value,and four socioeconomic and natural factors;the decrease of ESBI was influenced by the initial value and six key socioeconomic factors.Discussion and Conclusion:Our proposed ESBI system has several advantages(e.g.,scale free,flexible weighting,quantitative and continuous indices for further analyses,and alternative non-monetary solution)in understanding and managing relationships among multiple ecosystem services.Yiyuan Hong Qian Ding Ting Zhou Lingqiao Kong Meiye Wang Jianying Zhang Wu Yang 2020Ecosystem Health and Sustainability2020,6,1:0
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