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| 1 | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies显示文摘Neutralizing monoclonal antibodies(nAbs)to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)represent promising candidates for clinical intervention against coronavirus disease 2019(COVID-19).We isolated a large number of nAbs from SARS-CoV-2-infected individuals capable of disrupting proper interaction between the receptor binding domain(RBD)of the viral spike(S)protein and the receptor angiotensin converting enzyme 2(ACE2).However,the structural basis for their potent neutralizing activity remains unclear.Here,we report cryo-EM structures of the ten most potent nAbs in their native full-length IgG-form or in both IgG-form and Fab-form bound to the trimeric S protein of SARS-CoV-2.The bivalent binding of the full-length IgG is found to associate with more RBDs in the“up”conformation than the monovalent binding of Fab,perhaps contributing to the enhanced neutralizing activity of IgG and triggering more shedding of the S1 subunit from the S protein.Comparison of a large number of nAbs identified common and unique structural features associated with their potent neutralizing activities.This work provides a structural basis for further understanding the mechanism of nAbs,especially through revealing the bivalent binding and its correlation with more potent neutralization and the shedding of S1 subunit. | Renhong Yan Ruoke Wang Bin Ju Jinfang Yu Yuanyuan Zhang Nan Liu Jia Wang Qi Zhang Peng Chen Bing Zhou Yaning Li Yaping Shen Shuyuan Zhang Long Tian Yingying Guo Lu Xia Xinyue Zhong Lin Cheng Xiangyang Ge Juanjuan Zhao Hong-Wei Wang Xinquan Wang Zheng Zhang Linqi Zhang Qiang Zhou | 2021 | Cell Research2021，31，5： | 4 |
| 2 | In situ polymerization on biomacromolecules for nanomedicines显示文摘 | Xiangqian Jia Luyao Wang Juanjuan Du | 2018 | Nano Research2018，11，10： | 3 |
| 3 | Optimization of a Heat Exchanger Using an ARM Core Intelligent Algorithm显示文摘In order to optimize heat transfer in a heat exchanger using an ARM(advanced RISC machine)core intelligent computer algorithm,a new type of controller has been designed.The whole control structure of the heat exchange unit has been conceived on the basis of seven functional modules,including data processing and output,human-computer interaction,alarm,and data communication.The main controller and communication controller have been used in a combined fashion and a new MCU(micro control unit)system scheme has been proposed accordingly.A fuzzy controller has been designed by using a fuzzy control algorithm,and a new mode of heat transfer for the heat exchanger has been implemented by combining the fuzzy controller and the PID(proportioning integral derivative)controller.Finally,the model has been applied to an actual heat exchange station to test and verify the performances of the new approach. | Yajuan Jia Juanjuan Wang Lisha Shang | 2020 | Fluid Dynamics & Materials Processing2020，16，5： | 2 |
| 4 | Detection of Staphylococcus aureus in Dairy Food by Loop-mediated Isothermal Amplification显示文摘[Objective] This study was to investigate the creditability of applying loop-mediated isothermal amplification method( LAMP) to detect Staphylococcus aureus in dairy products. [Methods]The primers for heat resistant nuclease gene( nuc) of Staphylococcus aureus were designed for establishing the LAMP method for rapidly detecting Staphylococcus aureus. [Results] The results of LAMP detection on Staphylococcus aureus in various dairy products were completely identical with that by bacterial isolation test; meanwhile it has a high specificity and a 10-fold sensitivity over the hemi-nested PCR. [Conclusion] LAMP can be used for the detection of Staphylococcus aureus in dairy products. | Cheng Xiao Wang Yongxin An Hong Liu Juanjuan Zhang Bo Jia Zhen Cheng Jian | 2014 | Animal Husbandry and Feed Science2014，6，3： | 2 |
| 5 | Silencing Fibronectin Extra Domain A Enhances Radiosensitivity in Nasopharyngeal Carcinomas Involving an FAK/Akt/JNK Pathway显示文摘 | Juanjuan Ou Feng Pan Peiliang Geng Xing Wei Ganfeng Xie Jia Deng Xueli Pang Houjie Liang | 2012 | International Journal of Radiation Oncology Biology Physics2012，，4： | 1 |
| 6 | Fibronectin extra domain A (EDA) sustains CD133 + /CD44 + subpopulation of colorectal cancer cells显示文摘 | Juanjuan Ou Jia Deng Xing Wei Ganfeng Xie Rongbin Zhou Liqing Yu Houjie Liang | 2013 | Stem Cell Research2013，，2： | 1 |
| 7 | Clinical implications of the tumor-infiltrating lymphocyte subsets in colorectal cancer显示文摘 | Yunmei Liao Juanjuan Ou Jia Deng Peiliang Geng Rui Zeng Yi Tian Houjie Liang Bing Ni Zhihua Ruan | 2013 | Medical Oncology2013，，： | 1 |
| 8 | Fast clustering segmentation method combining hill - climbing for color image 显示文摘 | DING Zhengjian JIA Juanjuan LI Dai | 2011 | lnfirmalion and Computational Science2011，8，14： | 1 |
| 9 | Advances in research of land surface evapotranspiration at home and abroad显示文摘Land surface evapotranspiration (ET) is an important part of the hydrologic cycle and energy balances.With the development of remote sensing technology,research on monitoring and estimating of evapotranspiration has made important progress.This paper summarizes advances in measuring and estimating regional evapotranspiration at home and abroad based on traditional methods and remote sensing.This summary includes such methods as Bowen,Gradient,Penman-Monteith,Water Balance,Eddy Correlation,SPAC,Energy Balance and Remote Sensing.Also,the evapotranspiration achievements in the Heihe River Basin are also discussed.Finally,the existing problems in regional evapotranspiration research and future development prospects are also discussed at the conclusion of this paper. | XinPing Luo KeLi Wang Hao Jiang Jia Sun JuanJuan Xu QingLiang Zhu ZhaoGuo Li | 2010 | Research in Cold and Arid Regions2010，2，2： | 1 |
| 10 | Development of a γ ‐alumina‐ nanoparticle‐functionalized porous polymer monolith for the enrichment of S udan dyes in red wine samples显示文摘 | Wanjun Li Xiao Zhou Juanjuan Ye Qiong Jia | 2013 | J Sep Science2013，，20： | 1 |
| 11 | Visible-light-induced photocatalyst based on C-doped LaCoO3synthesizedby novel microorganism chelate methed显示文摘 | Jia Lishan Li Juanjuan Feng Weiping | 2009 | CatalysisCommunications2009，10，8： | 1 |
| 12 | Water-Driven Malleable,Weldable and Eco-Friendly Recyclable Carbon Fiber Reinforced Dynamic Composites显示文摘Traditional carbon fiber-reinforced polymers based on thermoset matrix have been extensively used in the fields of wind turbine blades,automotive sector,and aerospace,among many others.However,there is still a major challenge of recycling those polymers due to the high cost and adverse impacts on the environment.In this work,we apply a polyimine network as matrix,which possess considerable tensile and thermal properties,to prepare the carbon fiber reinforced polyimine materials with trifluoromethyl diphenoxybenzene units(CFRFP)using a prepreg-based compression molding method.The CFRFP can be reshaped or reprocessed by heat or with water rapidly,and exhibited multifunction,including welding,chemical recycling,etc.These unique findings gained from our study will facilitate the manufacturing capability and enrich the types of fiber-reinforced composites. | Ping Yu Qirui Huang Yi Wang Wan Peng Zichen Jia Haiyue Wang Juanjuan Ma Chunyu Wang Xuzhou Yan | 2024 | Chinese Journal of Chemistry2024，42，5： | 0 |
| 13 | A Simulation of the Response of a Sounding Temperature Sensor Based on the Combination of a Genetic Algorithm and Computational Fluid Dynamics显示文摘The present study aims at improving the accuracy of weather forecast by providing useful information on the behavior and response of a sounding temperature sensor.A hybrid approach relying on Computational Fluid Dynamics and a genetic algorithm(GA)is used to simulate the system represented by the bead thermistor and the surrounding air.In particular,the influence of different lead angles,sensor lead length,and lead number is considered.The results have shown that when the length of the lead wire of the bead thermistor is increased,the radiation temperature rise is reduced;when the number of lead wire is four and the angle between the lead wires is 180°,the solar radiation angle has a scarce influence on the radiation temperature rise of the sounding temperature sensor. | Juanjuan Wang Yajuan Jia Jiangping Nan | 2020 | Fluid Dynamics & Materials Processing2020，16，6： | 0 |
| 14 | Acute intestinal GVHD following donor-derived CD7-CAR-T-cell infusion in a child with Omicron COVID-19显示文摘1.INTRODUCTION。CD7 is an ideal chimeric antigen receptor(CAR)target for T-cell acute lymphocytic leukemia(T-ALL).Donor-derived CAR-T-cell therapy,as an emerging treatment strategy,shows excellent efficacy in refractory/relapsed(r/r)T-ALL,with over 90%of complete remission(CR),brings new promise to improve prognosis and survival quality,and provides more opportunities for following bridging transplantation.1 However,CD7-CAR-T-cell recipients are always immunocompromised for a number of reasons:depletion of healthy T and NK cells;the need for drugs,which are lymphodepleting,prior to CAR-T-cell therapy;a history of hematological malignancies;multiple-lines chemotherapy;and hematopoietic stem-cell transplantation(HSCT).Meanwhile,patients post donor-derived CAR-T-cell therapy are at high risk of graft-versus-host disease(GVHD)considering infusion of allogeneic cell and increase incidence of infection. | Yu Lian Zhilin Gao Juanjuan Ti Zhuanzhuan Yu Liangming Ma Jia Wei | 2023 | Blood Science2023，5，4： | 0 |
| 15 | Graphene controlled phase evolution in Sr-deficient Sr(Ti, Nb)O_(3) thermoelectric ceramics显示文摘Correlated phase and microstructural evolution are systematically investigated by electron microscopies in Sr-deficient Sr(Ti,Nb)O_(3)(STNO)thermoelectric ceramics incorporated with different fraction of reduced graphene oxide(RGO).It is found that while no impurity except for very few Ti_(3)O_(5) precipitates are observed in monolithic STNO,the Nb-enriched rutile TiO_(2) appears in RGO/STNO composites.With increasing RGO content,the amount of precipitates increase at first and then decrease when RGO content becomes high,which can be ascribed to the formation of local Magneli phase.In addition,the energy-dispersive X-ray spectra combined with cathodoluminescence characterization indicates that the variation of Sr deficiency experiences the opposite trend with respect to the precipitates content.These findings clearly reveal the unique reducing effect of RGO on the microstructure of doped SrTiO_(3) with Sr deficiency,which can greatly facilitate the design of perovskite based thermoelectric materials of hierarchical structure. | Jia Li Cao Wu Jilong Huang Juanjuan Xing Yuchi Fan Qingqiao Fu Ying Jiang Hui Gu | 2021 | Journal of Materiomics2021，7，2： | 0 |
| 16 | LAL test and RPT for endotoxin detection of CPT-11/DSPE-mPEG_(2000) nanoformulation: What if traditional methods are not applicable?显示文摘Endotoxin detection is an important step in drug characterization. Herein we found that a chemotherapeutic drug nanoformulation composed of irinotecan hydrochloride(CPT-11) and an amphiphilic molecule DSPE-mPEG_(2000) can interfere with the limulus amebocyte lysate assay(LAL). Furthermore, the rabbit pyrogen test(RPT) results indicated that at a relatively high dosage, the drug irinotecan hydrochloride can induce a hypothermia effect which may render the RPT results ambiguous in determination of the safety of the drug formulation.Our findings demonstrate limitations of endotoxin detection in micellar drugs,and call for the necessity of developing reliable endotoxin detection methods that can overcome the interference of nanomaterials in order to better ensure the drug safety of patients in future pharmaceutical drug development. | Yanan Jin Juanjuan Jia Chan Li Jianqi Xue Jiabei Sun Kaiyuan Wang Yaling Gan Jing Xu Yaqin Shi Xingjie Liang | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，3： | 0 |
| 17 | Edible mushrooms as a potent therapeutics of subclinical thyroid dysfunction among adults,especially in obese individuals:a prospective cohort study显示文摘Background:Mushrooms are a good source of many nutrients which are potentially beneficial for chronic diseases.We speculated that due to its abundant nutrients edible mushrooms might have a beneficial effect on the prevention of subclinical thyroid dysfunction(SCTD).Therefore,we designed a large-scale cohort study to examine whether mushrooms consumption is a protective factor for SCTD in adults.Methods:This prospective cohort study investigated 6631 participants(mean age:(45.0±10.2)years;55.1%men).Edible mushrooms consumption was measured at baseline using a validated food frequency questionnaire.SCTD was defined as abnormal serum thyroid-stimulating hormone levels and normal free thyroxine.Cox proportional hazards regression models were used to examine the association of edible mushrooms consumption with incident SCTD.Results:During follow-up period,a total of 262 new cases of SCTD were identified,the incidence rate of subclinical hypothyroidism was 8.9/1000 person-years and subclinical hyperthyroidism was 7.2/1000 person-years.After adjusting potential confounding factors,the multivariable hazard ratios(95%confidence intervals)for subclinical hypothyroidism were 1.00(reference)for almost never,0.53(0.29,0.97)for 1-3 times/week and 0.30(0.10,0.87)for≥4 times/week(P for trend=0.02).It also showed edible mushrooms consumption was inversely associated with subclinical hypothyroidism in obese individuals but not non-obese individuals,the final hazard ratios(95%confidence intervals)were 0.14(0.03,0.73)(P for trend<0.01).Conclusions:This population-based prospective cohort study has firstly demonstrated that higher edible mushrooms consumption was significantly associated with lower incidence of subclinical hypothyroidism among general adult population,especially in obese individuals. | Juanjuan Zhang Sabina Rayamajhi Amrish Thapa Ge Meng Qing Zhang Li Liu Hongmei Wu Yeqing Gu Shunming Zhang Tingjing Zhang Xuena Wang Zhixia Cao Jun Dong Xiaoxi Zheng Xu Zhang Xinrong Dong Xing Wang Shaomei Sun Ming Zhou Qiyu Jia Kun Song Kaijun Niu | 2023 | Food Science and Human Wellness2023，12，1： | 0 |
| 18 | A novel hierarchical targeting and controllable smart nanoparticles for enhanced in situ nuclear photodynamic therapy显示文摘Photodynamic therapy(PDT)is a promising and non-invasive treatment for various cancers.Although nuclear PDT has considerable therapeutic prospects,it is still hindered by the non-specific recognition of tumor tissues or the degradation of nuclear targeting cationic groups by enzymes in the blood.Herein,a hierarchical targeted and controlled release strategy is proposed by using folate-modified poly-β-cyclodextrin(poly-β-CD)as a nano-carrier for loading nuclear localization signals(NLSs)-conjugated photosensitizer PAP(PAP=pyropheophorbide a-PAAKRVKLD).Excitingly,the obtained FA-CD@PAP(FA=folic acid)and nanoparticles(NPs)can specifically recognize tumor cells overexpressing folate receptors(FR)to remarkedly enhance the intracellular accumulation.Furthermore,the encapsulated PAP can be released under acidic conditions to realize precise nuclear localization.The reactive oxygen species(ROS)generated by the intranuclear-accumulated PAP upon irradiation can oxidize and destroy DNA chains or DNA repair enzymes instantaneously,which can directly induce cell death.As a result,FA-CD@PAP NPs exhibit excellent tumor regression and negligible side effects.This work provides an intelligent nuclear-targeted delivery strategy for in situ nuclear PDT with extremely prominent efficacy and high biological safety. | Gankun Yuan Qilu Wang Zifan You Xuening Chen Jinping Xue Xiao Jia Juanjuan Chen | 2022 | Nano Research2022，15，5： | 0 |
| 19 | An Edge-assisted, Object-oriented Random Forest Approach for Refined Extraction of Tea Plantations Using Multi-temporal Sentinel-2 and High-resolution Gaofen-2 Imagery显示文摘As a consumed and influential natural plant beverage,tea is widely planted in subtropical and tropical areas all over the world.Affected by(sub)tropical climate characteristics,the underlying surface of the tea distribution area is extremely complex,with a variety of vegetation types.In addition,tea distribution is scattered and fragmentized in most of China.Therefore,it is difficult to obtain accurate tea information based on coarse resolution remote sensing data and existing feature extraction methods.This study proposed a boundary-enhanced,object-oriented random forest method on the basis of high-resolution GF-2 and multi-temporal Sentinel-2 data.This method uses multispectral indexes,textures,vegetable indices,and variation characteristics of time-series NDVI from the multi-temporal Sentinel-2 imageries to obtain abundant features related to the growth of tea plantations.To reduce feature redundancy and computation time,the feature elimination algorithm based on Mean Decrease Accuracy(MDA)was used to generate the optimal feature set.Considering the serious boundary inconsistency problem caused by the complex and fragmented land cover types,high resolution GF-2 image was segmented based on the MultiResolution Segmentation(MRS)algorithm to assist the segmentation of Sentinel-2,which contributes to delineating meaningful objects and enhancing the reliability of the boundary for tea plantations.Finally,the object-oriented random forest method was utilized to extract the tea information based on the optimal feature combination in the Jingmai Mountain,Yunnan Province.The resulting tea plantation map had high accuracy,with a 95.38%overall accuracy and 0.91 kappa coefficient.We conclude that the proposed method is effective for mapping tea plantations in high heterogeneity mountainous areas and has the potential for mapping tea plantations in large areas. | Juanjuan YU Xiufeng HE Jia XU Zhuang GAO Peng YANG Yuanyuan CHEN Jiacheng XIONG | 2023 | Journal of Geodesy and Geoinformation Science2023，6，1： | 0 |
| 20 | Modified intratympanic steroid therapy for sudden sensorineural hearing loss via tympanic tube and gelfoam as a salvage treatment显示文摘Background: Sudden sensorineural hearing loss(SSNHL) is a prevalent emergency in ear, nose, and throat practice. Previous studies have demonstrated that intratympanic steroid therapy(IST) can serve as a salvage treatment for SSNHL after the failure of systemic steroid therapy(SST).Objective: This study aimed to analyze the efficacy of modified IST involving the insertion of a tympanic tube and gelfoam as a salvage treatment for patients with SSNHL, and to explore its associated factors.Methods: Totally, 74 patients who were aged 22–81 years with SSNHL were enrolled and allocated to either the control group(n = 25) or the treatment group(n = 49) based on their treatment modalities. All patients received SST lasting for at least 7 days. Subsequently, patients in the treatment group, after SST failure, underwent IST twice a week for 2–6 weeks, while the control group did not. Efficacy was assessed by the improvement in pure tone average at the affected frequency at the beginning and end of IST.Results: Hearing improvement in all patients after IST in the treatment group was 9.71 ± 14.84 dB, with significant improvement at affected frequencies(250-8000 Hz) compared with the control group(P < 0.05). The findings indicated the duration from the onset of SSNHL to the beginning of IST as an independent factor for pure tone average improvement after treatment(P = 0.002), whereas age, duration of SST, and time of IST were not(P > 0.05).Conclusion: The modified IST was demonstrated to be a safe and effective method as a salvage treatment for SSNHL. This study explored the efficacy of a modified IST approach, incorporating the utilization of tympanic tubes and gelfoam as key components. The findings underscore the advantages of gelfoam as a strategic drug carrier placed in the round window niche. By minimizing drug loss, extending action time, and increasing perilymph concentration, gelfoam enhances the therapeutic impact of IST, contributing to improved hearing outcomes in patients with SSNHL. | Sichao Liang Yunshuo Li Zhenping Guo Manlin Lu Xin Li Jia Xu Wenjing Chen Juanjuan Gao Haijin Yi | 2024 | Journal of Otology2024，19，1： | 0 |
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