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| 1 | Relative Contributions of Boundary-Layer Meteorological Factors to the Explosive Growth of PM2.5 during the Red-Alert Heavy Pollution Episodes in Beijing in December 2016显示文摘Based on observations of urban mass concentration of fine particulate matter smaller than 2.5 μm in diameter(PM_(2.5)), ground meteorological data, vertical measurements of winds, temperature, and relative humidity(RH), and ECMWF reanalysis data, the major changes in the vertical structures of meteorological factors in the boundary layer(BL) during the heavy aerosol pollution episodes(HPEs) that occurred in winter 2016 in the urban Beijing area were analyzed. The HPEs are divided into two stages: the transport of pollutants under prevailing southerly winds, known as the transport stage(TS), and the PM_(2.5) explosive growth and pollution accumulation period characterized by a temperature inversion with low winds and high RH in the lower BL, known as the cumulative stage(CS). During the TS, a surface high lies south of Beijing, and pollutants are transported northwards. During the CS, a stable BL forms and is characterized by weak winds, temperature inversion, and moisture accumulation. Stable atmospheric stratification featured with light/calm winds and accumulated moisture(RH > 80%) below 250 m at the beginning of the CS is closely associated with the inversion, which is strengthened by the considerable decrease in near-surface air temperature due to the interaction between aerosols and radiation after the aerosol pollution occurs. A significant increase in the PLAM(Parameter Linking Aerosol Pollution and Meteorological Elements) index is found, which is linearly related to PM mass change. During the first 10 h of the CS, the more stable BL contributes approximately 84% of the explosive growth of PM_(2.5) mass. Additional accumulated near-surface moisture caused by the ground temperature decrease, weak turbulent diffusion, low BL height, and inhibited vertical mixing of water vapor is conducive to the secondary aerosol formation through chemical reactions, including liquid phase and heterogeneous reactions, which further increases the PM_(2.5) concentration levels. The contribution of these reaction mechanisms to the explosive growth of PM_(2.5) mass during the early CS and subsequent pollution accumulation requires further investigation. | junting zhong xiaoye zhang yaqiang wang junying sun yangmei zhang jizhi wang kaiyan tan xiaojing shen haochi che lu zhang zhouxiang zhang xuefei qi huarong zhao sanxue ren yang li | 2017 | Journal of Meteorological Research2017，31，5： | 25 |
| 2 | Traditional Chinese Medicine syndrome-related herbal prescriptions in treatment of malignant tumors显示文摘OBJECTIVE: To investigate the distribution characteristics of TCM syndromes and the related herbal prescriptions for malignant tumors (MT). METHODS: A clinical database of the TCM syndromes and the herbal prescriptions in treatment of 136 MT patients were established. The data were then analyzed using cluster and frequency analysis. RESULTS: According to the cluster analysis, the TCM syndromes in MT patients mainly included two patterns: deficiency of both Qi and Yin and internal accumulation of toxic heat. The commonly-prescribed herbs were Huangqi (Astraglus), Nüzhen-zi (Fructus Ligustri Lucidi), Lingzhi (Ganoderma Lucidum), Huaishan (Dioscorea Opposita), Xiakucao (Prunella Vulgaris), and Baihuasheshecao (Herba Hedyotidis). CONCLUSION: Deficiency of Qi and Yin is the primary syndrome of MT, and internal accumulation of toxic heat is the secondary syndrome. The herbs for Qi supplementation and Yin nourishment are mainly used, with the assistance of herbs for heat-clearance and detoxification. | Zhizhen Liu Songyi Chen Jing Cai Enda Zhang Lan Lan Junting Zheng Lianming Liao Xuemei Yang Changen Zhou Jian Du | 2013 | Journal of Traditional Chinese Medicine2013，33，1： | 7 |
| 3 | ENPP1/PC-1 Gene K121Q Polymorphism Is Associated with Obesity in European Adult Populations: Evidence from A Meta-Analysis Involving 24 324 Subjects显示文摘Objective Findings from the previous studies have suggested a relationship between ectonucleotide pyrophosphatase /phosphodiesterase 1 (ENPP‐1) or plasma cell membrane glycoprotein 1 (PC‐1) gene single nucleotide polymorphism (K121Q, rs1044498) and genetic susceptibility to obesity. However, such relationship is not reproduced by some currently available studies. In this context, the present study is aimed to quantitatively analyze the association of K121Q variant with obesity in all published case‐control studies in European adult populations. Methods Published literature from PubMed, EMBASE, and ISI web of science databases were retrieved. The studies evaluating the association of ENPP1/PC1 gene K121Q polymorphism with obesity were included, in which sufficient data were presented to calculate the odds ratio (OR) with 95% confidence intervals (CIs). Results Ten case‐control studies meeting the inclusion criteria identified a total of 24,324 subjects including 11,372 obese and 12,952 control subjects. The meta‐analysis results showed a statistically significant association of K121Q with obesity [OR (95%CI): 1.25 (1.04‐1.52) P=0.021] under a recessive model of inheritance (QQ vs. KK+KQ) without heterogeneity or publication bias. Conclusions The results from the present study have indicated that ENPP1/PC1 Q121 variant may increase the risk of obesity and that more well‐designed studies based on a larger population will be required to further evaluate the role of ENPP1/PC1 gene K121Q polymorphism in obesity and other related metabolic syndromes. | WANG RuoQi ZHOU DongHao XI Bo GE XiuShan ZHU Ping WANG Bo ZHOU MingAi HUANG YuBei LIU JunTing YU Yang WANG ChunYu | 2011 | Biomedical and Environmental Sciences2011，24，2： | 4 |
| 4 | Preparation and characterization of spherical mesoporous ZrO_(2)-Al_(2)O_(3) composites with high thermal stability显示文摘Spherical mesoporous ZrO_(2)-Al_(2)O_(3) composites containing different zirconia content have been synthesized by an oil-column sol-gel method.A mixed alumina-zirconia hydrosol and hexamethylenetetramine solution were mixed together and added dropwise into a hot oil column.Due to the surface tension,spherical gel particles were formed in the oil column.The spherical gel particles were then aged and washed by deionized water and dried at 120 ℃ for 12 h and then calcined at 600 ℃ for 8 h,960 ℃ for 8 h or 1200 ℃ for 12 h.X-ray diffraction and nitrogen adsorption-desorption measurements indicated that the presence of zirconia prevents the sintering of alumina and the obtained ZrO_(2)-Al_(2)O_(3) composites have much larger surface areas than pure alumina.Temperature-programmed desorption of ammonia results illustrated that the addition of zirconia leads to an increase in the number of strong acid sites and the total number of acid sites compared with pure alumina.Thus,the spherical mesoporous ZrO_(2)-Al_(2)O_(3) composites prepared in this way were shown to be suitable for high temperature catalytic processes as a catalyst support. | LI Yang FENG JunTing LI DianQing | 2011 | Science China Chemistry2011，54，7： | 2 |
| 5 | Nonlinear optical absorption properties of InP nanowires and applications as a saturable absorber显示文摘Indium phosphide(InP)nanowires(NWs)have attracted significant attention due to their exotic properties that are different from the bulk counterparts,and have been widely used for light generation,amplification,detection,modulation,and switching,etc.Here,high-quality InP NWs were directly grown on a quartz substrate by the Au-nanoparticle assisted vapor-liquid-solid method.We thoroughly studied their nonlinear optical absorption properties at 1.06μm by the open-aperture Z-scan method.Interestingly,a transition phenomenon from satu-rable absorption(SA)to reverse saturable absorption(RSA)was observed with the increase of the incident laser intensity.In the analysis,we found that the effective nonlinear absorption cofficient(βeff-10^2 cm/MW)under the SA process was 3 orders of magnitude larger than that during the RSA processes.Furthermore,the SA proper-ties of InP NWs were experimentally verified by using them as a saturable absorber for a passively Q-switched Nd:YVO4 solid-state laser at 1.06μm,where the shortest pulse width of 462 ns and largest single pulse energy of 1.32μJ were obtained.Moreover,the ultrafast carrier relaxation dynamics were basically studied,and the intraband and inter-band ultrafast carrier relaxation times of 8.1 and 63.8 ps,respectively,were measured by a degenerate pump-probe method with the probe laser of 800 nm.These results well demonstrate the nonlinear optical absorption properties,which show the excellent light manipulating capabilities of InP NWs and pave a way for their applications in ultrafast nanophotonic devices. | JUNTING LIU HONGKUN NIE BINGZHENG YAN KEJIAN YANG HE YANG VLADISLAV KHAYRUDINOV HARRI LIPSANEN BAITAO ZHANG JINGLIANG HE | 2020 | Photonics Research2020，8，6： | 2 |
| 6 | Controllable synthesis, structure, and catalytic activity of highly dis- persed Pd catalyst supported on whisker-modified spheri- cal alumina 显示文摘 | LI Yang FENG Junting HE Yufei | 2012 | Ind Eng Chem Res2012，51，11： | 1 |
| 7 | Influence ofElectron Donors on the Tacticity and the Composition Distribu- tion of Propylene-Butene Copolymers Produced by Supported Ziegler-Natta Catalysts 显示文摘 | Xu Junting Feng Linxian Yang Shilin | 1997 | Macromolecules1997，30，25： | 1 |
| 8 | Controllable synthe- sis, structure, and catalytic activity of highly dispersed Pd catalyst supported on whisker-modified spherical alumina 显示文摘 | Li Yang Feng Junting He Yufei | 2012 | IndEngChemRes2012，51，11： | 1 |
| 9 | Influence of electrondonors on the tacticity and the composition distribution of propylene-butene copolymers produced by supported ziegler-nattacatalysts显示文摘 | Xu Junting Feng Linxian Yang Shilin | 1997 | Macromolecules1997，30，25： | 1 |
| 10 | Influence of Electron Donors on the Tacticity and the Composition Distribution of Propylene-Butene Copolymers Produced by Supported Ziegler-Natta Catalysts显示文摘 | Xu Junting Feng Linxian Yang Shilin | 1997 | Macromolecules1997，30，25： | 1 |
| 11 | Temperature Rising Elution Fractionation of Polypropylene Produced by Heterogeneous Ziegler-Natta Catalysts显示文摘 | Xu Junting Feng Linxian Yang Shilin | 1998 | Eur Polym J1998，34，34： | 1 |
| 12 | Influence ofelectron donors on the tacticity and the composition distributionof propylene-butene copolymers produced by supportedZiegler-Natta catalysts显示文摘 | Xu Junting Feng Linxian Yang Shilin | 1997 | Macromolecules1997，30，25： | 1 |
| 13 | Isolation, identification and antioxidative capacity of water-soluble phenylpropanoid compounds from Rhodiola crenulata显示文摘 | Danjun Chen Junting Fan Peng Wang Lanying Zhu Yang Jin Yan Peng Shuhu Du | 2012 | Food Chemistry2012，，4： | 1 |
| 14 | Semi-quantitative design of synergetic surficial/interfacial sites for the semi-continuous oxidation of glycerol显示文摘Qualitatively identifying the dominant catalytic site for each step of a semi-continuous reaction and semi-quantitatively correlating such different sites to the catalytic performance is of great significance toward the integration of multiple well-optimized sites on a heterogeneous catalyst.Herein,a series of structurally defined TiO_(x)-based catalysts were synthesized to provide a feasible approach to investigate the aforementioned issues using the semi-continuous oxidation of glycerol as a model reaction.Detailed investigations have verified the simultaneous presence of two kinds of Pt active sites:1)Negatively charged Pt bound to the oxygen vacancies of modified TiO_(x)in the form of Pt^(δ−)-O_(v)-Ti^(3+) sites and 2)metallic Pt(Pt_(0)site)located away from the inter-face.Meanwhile,the proportion of surficial and interfacial sites varies over this series of catalysts.Combined in situ FTIR experiments revealed that the reaction network was well-tuned via a site cooperation mechanism:The surficial Pt_(0)sites dissociatively adsorb the OH group of glycerol with a monodentate bonding geometry and the Pt^(δ−)-O_(v)-Ti^(3+) sites dissociate the C=O bond of the aldehyde group in a bidentate form.Furthermore,CO-FTIR spectroscopy confirmed a correlation between the reaction rate/product selectivity and the fraction of surficial/interfacial sites.A rational proportion of surficial and interfacial sites is key to enabling a high yield of glyceric acid.The most active catalyst with 32%surface sites and 68%interfacial sites exhibited 90.0%glycerol conversion and 68.5%GLYA selectivity.These findings provide a deeper understanding of the structure-activity relationships using qualitative identification and semi-quantitative analysis. | Mingyu Gao Pengfei Yang Xinyi Zhang Yani Zhang Dianqing Li Junting Feng | 2022 | Fundamental Research2022，2，3： | 0 |
| 15 | MCU knockdown in hippocampal neurons improves memory performance of an Alzheimer’s disease mouse model显示文摘Alzheimer’s disease(AD)is a progressive and degenerative disorder accompanied by cognitive decline,which could be promoted by mitochondrial dysfunction induced by mitochondrial Ca^(2+)(mCa^(2+))homeostasis Mitochondrial calcium uniporter(MCU),a key channel of mCa^(2+) uptake,may be a target for AD treatment.In the present study,we reveal for the first time that MCU knockdown in hippocampal neurons improves the memory performance of APP/PS1/tau mice through radial arm maze task.Western blot analysis,transmission electron microscopy(TEM),Golgi staining,immunohistochemistry(IHC)and ELISA results demonstrate that MCU knockdown in hippocampal neurons upregulates the levels of postsynaptic density protein 95(PSD95)and synaptophysin(SYP),and increases the numbers of synapses and dendritic spines.Meanwhile,MCU knockdown in hippocampal neurons decreases the neuroinflammatory response induced by astrogliosis and high levels of IL-1βand TNF-α,and improves the PINK1-Parkin mitophagy signaling pathway and increases the level of Beclin-1 but decreases the level of P62.In addition,MCU knockdown in hippocampal neurons recovers the average volume and number of mitochondria.These data confirm that MCU knockdown in hippocampal neurons improves the memory performance of APP/PS1/tau mice through ameliorating the synapse structure and function,relieving the inflammation response and recovering mitophagy,indicating that MCU inhibition has the potential to be developed as a novel therapy for AD. | Hongyan Cai Jing Qiao Siru Chen Junting Yang Christian Hölscher Zhaojun Wang Jinshun Qi Meina Wu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，10： | 0 |
| 16 | ADAR1 regulates vascular remodeling in hypoxic pulmonary hypertension through N1-methyladenosine modification of circCDK17显示文摘Pulmonary hypertension(PH)is an extremely malignant pulmonary vascular disease of unknown etiology.ADAR1 is an RNA editing enzyme that converts adenosine in RNA to inosine,thereby affecting RNA expression.However,the role of ADAR1 in PH development remains unclear.In the present study,we investigated the biological role and molecular mechanism of ADAR1 in PH pulmonary vascular remodeling.Overexpression of ADAR1 aggravated PH progression and promoted the proliferation of pulmonary artery smooth muscle cells(PASMCs).Conversely,inhibition of ADAR1 produced opposite effects.High-throughput whole transcriptome sequencing showed that ADAR1 was an important regulator of circRNAs in PH.CircCDK17 level was significantly lowered in the serum of PH patients.The effects of ADAR1 on cell cycle progression and proliferation were mediated by circCDK17.ADAR1 affects the stability of circCDK17 by mediating A-to-I modification at the A5 and A293 sites of circCDK17 to prevent it from mlA modification.We demonstrate for the first time that ADAR1 contributes to the PH development,at least partially,through m1A modification of circCDK17 and the subsequent PASMCs proliferation.Our study provides a novel therapeutic strategy for treatment of PH and the evidence for circCDK17 as a potential novel marker for the diagnosis of this disease. | Junting Zhang Yiying Li Jianchao Zhang Lu Liu Yuan Chen Xusheng Yang Xueyi Liao Muhua He Zihui Jia Jun Fan Jin-Song Bian Xiaowei Nie | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 0 |
| 17 | Towards high-density storage of text and images into DNA by the“Xiao-Pang”codec system显示文摘Dear Editor,The information about human civilization has been passed down through texts and images.Owing to its remarkable property,DNA has been suggested as an excellent medium for the long-term storage of texts and images.Codec systems to convert the data into A/T/C/G sequence and vice versa have become quite critical.The current well-known codec systems(Blawat et al.,2016;Church et al.,2012;Erlich and Zielinski,2017;Goldman et al.,2013;Grass et al.,2015) | Mingwei Lu Yang Wang Wei Qiang Junting Cui Yu Wang Xiaoluo Huang Junbiao Dai | 2023 | Science China(Life Sciences)2023，66，6： | 0 |
| 18 | Sulfur-substitution-enhanced crystallization and crystal structure of poly(trimethylene monothiocarbonate)显示文摘In this paper,the crystallization behavior of a novel poly(monothiocarbonate),poly(trimethylene monothiocarbonate)(PTMMTC),was investigated and compared with its polycarbonate analogue,poly(trimethylene carbonate)(PTMC).It is found that PTMMTC exhibits strong crystallizability,while un-stretched PTMC is amorphous.DSC and DMA results reveal that PTMMTC possesses higher glass transition temperature(T_(g))andβ-transition temperature(T_(β))than PTMC.Simulation based on density functional theory(DFT)shows that,the bond angle of C-S-C is evidently smaller than that of C-O-C,and thus a larger dipole moment.This leads to the stronger intermolecular interaction and more rigid chain confor-mation in PTMMTC,which is the origin of sulfur-substitution enhanced crystallization.The crystal struc-ture of PTMMTC was preliminarily determined for the first time.PTMMTC has an orthorhombic crystal structure with a planar zig-zag chain conformation.The parameters of unit cell are a=10.74 A,b=4.79 A,and c(fiber axis)=7.74 A. | Xiaohan Cao Hongliang Wang Jialiang Yang Ruiyang Wang Xin Hong Xinghong Zhang Junting Xu Hai Wang | 2022 | Chinese Chemical Letters2022，33，2： | 0 |
| 19 | Common Postzygotic Mutational Signatures in Healthy Adult Tissues Related to Embryonic Hypoxia显示文摘Postzygotic mutations are acquired in normal tissues throughout an individual’s lifetime and hold clues for identifying mutagenic factors.Here,we investigated postzygotic mutation spectra of healthy individuals using optimized ultra-deep exome sequencing of the time-series samples from the same volunteer as well as the samples from different individuals.In blood,sperm,and muscle cells,we resolved three common types of mutational signatures.Signatures A and B represent clocklike mutational processes,and the polymorphisms of epigenetic regulation genes influence the proportion of signature B in mutation profiles.Notably,signature C,characterized by C>T transitions at GpCpN sites,tends to be a feature of diverse normal tissues.Mutations of this type are likely to occur early during embryonic development,supported by their relatively high allelic frequencies,presence in multiple tissues,and decrease in occurrence with age.Almost none of the public datasets for tumors feature this signature,except for 19.6%of samples of clear cell renal cell carcinoma with increased activation of the hypoxia-inducible factor 1(HIF-1)signaling pathway.Moreover,the accumulation of signature C in the mutation profile was accelerated in a human embryonic stem cell line with drug-induced activation of HIF-1α.Thus,embryonic hypoxia may explain this novel signature across multiple normal tissues.Our study suggests that hypoxic condition in an early stage of embryonic development is a crucial factor inducing C>T transitions at GpCpN sites;and individuals’genetic background may also influence their postzygotic mutation profiles. | Yaqiang Hong Dake Zhang Xiangtian Zhou Aili Chen Amir Abliz Jian Bai Liang Wang Qingtao Hu Kenan Gong Xiaonan Guan Mengfei Liu Xinchang Zheng Shujuan Lai Hongzhu Qu Fuxin Zhao Shuang Hao Zhen Wu Hong Cai Shaoyan Hu Yue Ma Junting Zhang Yang Ke Qian-Fei Wang Wei Chen Changqing Zeng | 2022 | Genomics, Proteomics & Bioinformatics2022，20，1： | 0 |
| 20 | Spectrum Usage Anomaly Detection from Sub-Sampled Data Stream via Deep Neural Network显示文摘Anomaly detection is an essential part of any practical system in order to remedy any malfunction and accident early to create a secure and robust system.Malicious users and malfunctioning cognitive radio(CR)devices may cause severe interference to legitimate users.However,there are no effective methods to detect spontaneous and irregular anomaly behaviors in sub-sampling data stream from wideband compressive spectrum sensing as an important function of a CR device.In this article,to detect anomaly utilization of spectrum from sub-sampled data stream,a multiple layer perceptron/feed-forward neural network(FFNN)based solution is proposed.The proposed solution would learn the pattern of legitimate and anomalous usages autonomously without expert's knowledge.The proposed neural network(NN)framework has also shown benefits such as more than 80%faster detection speed and lower detection error rate. | Han Zhang Jian Yang Junting Chen Yue Gao | 2023 | Journal of Communications and Information Networks2023，8，1： | 0 |
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