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| 1 | Oleanolic Acid Induces Apoptosis in Human Leukemia Cells through Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage显示文摘它被看了那 Fructus Ligustri Lucidi (FLL ) ,有希望的 traditionalChinesemedicine,能禁止肿瘤的生长。然而,有效部件和 FLL 的分子的机制行动禁止肿瘤增长是不清楚的。在这研究,我们表明了 thatoleanolic 酸(OA ) , FLL 的一个主要化学部件,在文化禁止了人的白血病 HL60 房间的增长。MTT 试金与 FLL 粗略的摘录显示出 HL60 细胞的那个处理或 OA 戏剧性地在 time-dependentmanner 和 dose-dependentmanner 堵住了目标肿瘤房间的生长。原子核和 DNA 破碎的词法变化证明 apoptotic 房间死亡在与 FLL 摘录(20 mg/ml ) 或 OA 对待以后发生在 HL60 房间(3.65xl0 ^(-2) mg/ml ) 。而且,流动 cytometry 试金与 FLL 显示出 HL60 房间的那个处理或 OA 引起了 G1 和 sub-G1 潜水艇人口的增加的累积。蛋白质印迹分析证明 caspase-9and caspase-3 被激活,由劈开伴随了 poly (自动数据处理核糖) 在目标房间的聚合酶(PARP ) 在导致 FLL 或导致 OA 的 apoptosis 期间。这些结果建议 OA 由通过 caspases 的激活和 PARP 的劈开向目标肿瘤房间施加它的 cytotoxicity 充当 FLL 的有效部件。 | Pengxia ZHANG Hongmei LI Dong CHEN Juhua NI Yuming KANG Shuqiu WANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，10： | 26 |
| 2 | Spider web-like carbonized bacterial cellulose/MoSe_(2) nanocomposite with enhanced microwave attenuation performance and tunable absorption bands显示文摘It is essential to manufacture microwave absorbers with strong absorption as well as tunable absorption bands at a low filler content.However,it remains challenging for pure biomass material to reach this goal without loading other components.MoSe_(2),as a transition metal chalcogenide with semiconductor properties,has emerged as a potential microwave absorber filler.Herein,bacterial cellulose(BC)-derived carbon nanofibers/MoSe_(2) nanocomposite was fabricated and phosphoric acid was used to dope phosphorus in BC,in which MoSe_(2) microspheres were dropped on the BC network like a dew-covered spider web.This unique network structure enhances conductive loss and multiple reflections of the incident wave.The collocation of BC and MoSe_(2) is helpful to impedance match and introduces interfacial/dipolar polarization loss;moreover,the P-doping of BC helps to tune the absorption bands.Overall,the optimal reflection loss of undoped one reaches−53.33 dB with only 20 wt.%filler content,whose main absorption peaks focus on X-band.Interestingly,after the P-doping of BC,the main absorption peaks move to Ku-band and the optimal reflection loss gets stronger(−66.84 dB)with the same filler loading.Strong absorption and tunable absorption bands can be realized,and thus wide frequency range is covered.This work is expected to enlighten future exploration of biomass carbon materials on high-performance microwave absorption materials. | Zhengjian Xu Man He Yuming Zhou Shuangxi Nie Yongjuan Wang Yao Huo Yifan Kang Ruili Wang Ran Xu Hao Peng Xi Chen | 2021 | Nano Research2021，14，3： | 6 |
| 3 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 4 | Stake ruptured liver cancer diagnosis and treatment of bleeding in 27 cases显示文摘 | Jiyong Feng Kang Yuming | 2011 | Ningxia Med J2011，33，8： | 1 |
| 5 | An operational radar current observing and data service platform in the East China Sea显示文摘An ocean state monitor and analysis radar(OSMAR), developed by Wuhan University in China, have been mounted at six stations along the coasts of East China Sea(ECS) to measure velocities(currents, waves and winds) at the sea surface. Radar-observed surface current is taken as an example to illustrate the operational high-frequency(HF) radar observing and data service platform(OP), presenting an operational flow from data observing, transmitting, processing, visualizing, to end-user service. Three layers(systems): radar observing system(ROS), data service system(DSS) and visualization service system(VSS), as well as the data flow within the platform are introduced. Surface velocities observed at stations are synthesized at the radar data receiving and preprocessing center of the ROS, and transmitted to the DSS, in which the data processing and quality control(QC) are conducted. Users are allowed to browse the processed data on the portal of the DSS, and access to those data files. The VSS aims to better show the data products by displaying the information on a visual globe. By utilizing the OP, the surface currents in East China Sea are monitored, and hourly and seasonal variabilities of them are investigated. | DENG Zeng'an ZHANG Anmin ZHAI Jingsheng YU Ting WU Shuangquan ZHANG Xuefeng KANG Linchong ZHANG Yuming | 2016 | Acta Oceanologica Sinica2016，35，11： | 1 |
| 6 | Distributed Asynchronous Learning for Multipath Data Transmission Based on P-DDQN显示文摘Adaptive packet scheduling can efficiently enhance the performance of multipath Data Transmission.However,realizing precise packet scheduling is challenging due to the nature of high dynamics and unpredictability of network link states.To this end,this paper proposes a distributed asynchronous deep reinforcement learning framework to intensify the dynamics and prediction of adaptive packet scheduling.Our framework contains two parts:local asynchronous packet scheduling and distributed cooperative control center.In local asynchronous packet scheduling,an asynchronous prioritized replay double deep Q-learning packets scheduling algorithm is proposed for dynamic adaptive packet scheduling learning,which makes a combination of prioritized replay double deep Q-learning network(P-DDQN)to make the fitting analysis.In distributed cooperative control center,a distributed scheduling learning and neural fitting acceleration algorithm to adaptively update neural network parameters of P-DDQN for more precise packet scheduling.Experimental results show that our solution has a better performance than Random weight algorithm and Round-Robin algorithm in throughput and loss ratio.Further,our solution has 1.32 times and 1.54 times better than Random weight algorithm and Round-Robin algorithm on the stability of multipath data transmission,respectively. | Kang Liu Wei Quan Deyun Gao Chengxiao Yu Mingyuan Liu Yuming Zhang | 2021 | China Communications2021，18，8： | 1 |
| 7 | Techniques and performance of post-prestressed tunnel liner 显示文摘 | Kang Jingfu Hu Yuming | 2005 | ASCE Practice Periodical on Structural Design and Construction2005，10，2： | 1 |
| 8 | The Development Roadmap of Direct Current Buildings(2020-2030)(Ⅱ)显示文摘2.1Development background2.1.1Greenhouse gas emission reduction is imminent Climate change is one of the most severe global challenges.China has made a solemn commitment to the international community at the national level to reach the peak of carbon dioxide emissions around 2030 and strive to reach the peak as soon as possible[30]. | Jiang Yi Hao Bin Li Yutong Ma Zhao Tong Yibin Kang Jing Li Yemao Pan Wenyu Lu Yuanyuan Zhao Yuming Shen Yuxiang Zhang Ning Zhao Jinbin Zhao Zhigang Chen Wenbo Wang Dawei Hou Enzhe | 2021 | 建筑节能(中英文)2021，49，9： | 0 |
| 9 | Nanchang:New Explorations in Low-Carbon Development显示文摘WITH the modern world chasing economic growth and development while attempting to balance the challenges of dwindling resources and preserving the environment, Nanchangin East China’s Jiangxi Province is part of a pilot project covering eight cities(Nanchang, Tianjin, Chongqing, | staff reporter TANG SHUBIAO, LIU YUMING & KANG NING | 2012 | China Today2012，61，10： | 0 |
| 10 | A major vernalization-independent QTL for tiller angle on chromosome arm 2BL in bread wheat显示文摘Tiller angle(TA)strongly influences plant architecture and grain yield in cereals.However,the genetic basis of TA in wheat is largely unknown.We identified three TA-related quantitative trait loci(QTL).One of them was QTa.sau-2 B-769,a major QTL localized on chromosome arm 2 BL.QTa.sau-2 B-769 was detected in seven environments,explaining 18.1%–51.1%of phenotypic variance.We developed a linked Kompetitive Allele-Specific Polymerase chain reaction(KASP)marker,KASP-AX-108792274,to further validate this locus in three additional populations in multiple environments.QTa.sau-2 B-769 increased TA by up to 24.9%in these populations.There were significant and positive correlations between TA and flag leaf angle(FLANG).However,TA was not correlated with plant height or anthesis date,suggesting that expression of QTa.sau-2 B-769 is independent of vernalization.Traes CS2 B01 G583800,a gene known to be involved in leaf angle regulation,was identified as the most likely candidate gene for QTa.sau-2 B-769.These results enrich our understanding of the mechanisms regulating wheat TA at maturity and may support precise mapping and cloning of gene(s)underlying QTa.sau-2 B-769. | Jiajun Liu Jieguang Zhou Huaping Tang Yang Tu Yang Mu Lulu Gou Qiantao Jiang Yaxi Liu Guoyue Chen Jirui Wang Pengfei Qi Wei Li Yunfeng Jiang Zehong Yan Houyang Kang Yuming Wei Xiujin Lan Youliang Zheng Jian Ma | 2022 | The Crop Journal2022，10，1： | 0 |
| 11 | Voltammetry and fluorescence studies on the interaction between Eu(phen)_3^(+3)and DNA显示文摘The binding mode of Eu(phen) 33+ with DNA is studied by fluorescence and voltammetric methods. From theScatchard graph and the fluorescence quenching phenomenon, it is concluded that the mode of interaction betweenEu(phen) 33+ and DNA is intercalation bind by inserting the phen π-π conjugate surface between the base pairs of theDNA duplex. Voltammetry was used to confirm the results obtained from the fluorescence method, the result from bothmethods agrees with each other. The binding constant (K) and the binding site size (ns) were calculated from voltammetricdata such as the shifts in potential and limiting currents in the process of adding DNA, according to the positive shifts ofpeak potential. It was considered that the complex of the +2 ion interacted more favorably with the nucleotide bases thanthat of the +3 ion by hydrophobic interaction. | KANG Jingwan, CHEN Jing, LU Xiaoquan, SONG Yuming, ZENG Hongjuan, LIU Hongde, and WANG yongshengDepartment of Chemistry, Northwest Normal University, Lanzhou 730070, China (Received 2002-04-02) | 2003 | Rare Metals2003，22，2： | 0 |
| 12 | Effects of nanometer particles and water decoction of the Chinese medicine mixture of pinellia ternate and scorpion on P53 protein contents and apoptosis in the cerebral cortex and hippocampus of epileptic rats显示文摘BACKGROUND: Water decoction of the Chinese traditional medicine mixture of pinellia ternate and scorpion is an effective treatment for epilepsy. OBJECTIVE: To compare nanometer particles and effects of water decoction of Chinese traditional medicine mixture on P53 protein levels and apoptosis in the cerebral cortex and hippocampus of epileptic rats. DESIGN, TIME AND SETTING: This randomized, controlled molecular biology study was performed at the Key Laboratory of Child Neural Rehabilitation of Jiamusi University from October to December 2007. MATERIALS: Forty healthy male Wistar rats were used in this study. Convulsion rat models were established by intraperitoneal infusion of 35 mg/kg pentylenetetrazol, once a day, for 28 successive days. The Chinese traditional medicine mixture, comprising pinellia ternate, scorpion, centipede, bupleurum, peach pit and glycyrrhiza, was purchased from Beijing Tongrentang, China. The mixture was made into nanometer particles and water decoction. The apoptosis determination kit and P53 immunohistochemistry kit were bought from Boster, China. METHODS: Forty Wistar rats were randomly divided into four groups of ten rats per group, control, nanometer particle, water decoction and epileptic model groups. Rats in the nanometer particle and water decoction groups were respectively treated with 300 mg/kg Chinese herb nanometer particle suspension and water decoction by gavage, once a day, for 28 days. Rats in the epileptic model group were fed an equal volume of saline by gavage. Rats in the control group were only administered with the same volume of saline by ga- vage. MAIN OUTCOME MEASURES: Terminal deoxynucleotidyl Transferase Biotin-dUTP Nick End Labeling (TUNEL) and immunohistochemistry were used to respectively detect neuronal apoptosis and P53 protein expression in the rat brain cortex and hippocampus at 28 days following administration. RESULTS: The number of apoptotic neurons was lower in the nanometer particle and water decoction groups compared with the epileptic model group. The number of apoptotic cells and P53 protein expression in the rat cerebral cortex and hippocampus was greater in the epileptic model group compared with the control group (P < 0.05), but lower in the nanometer particle and water decoction groups compared with the epileptic model group (P < 0.05), and lower in the nanometer particle group compared with the water decoction group (P < 0.05). CONCLUSION: Chinese traditional medicine mixture decreases neuronal apoptosis and P53 protein expression in epileptic rats. The effect of nanometer particles is significant compared with water decoction. | Shuxiang Wang Lei Liu Yuming Kang Shuqiu Wang Dixiang Sun Xiaoru Ma Yanfeng Liang Fangfang Wang | 2008 | Neural Regeneration Research2008，3，7： | 0 |
| 13 | Inhibitory Effects of Atorvastatin on the mRNA Expression of ICAM-1 and VCAM-1 Activated by TNF-α in Cultured Human Umbilical Vein Endothelial Cells显示文摘Objectives To investigate the effects of atorvastatin on the mRNA expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) activated by TNF-α in cultured human umbilical vein endothelial cells (HUVEC). Methods and Results Lactic dehydrogenase (LDH) activity in the culture media increased when HUVEC were incubated with TNF-α, suggesting a cytotoxic effect of TNF-α on HUVEC. The mRNA expression of ICAM-1 and VCAM-1 increased in HUVEC incubated with 10μg/L TNF-α and reached peak in HUVEC incubated with 30μg/L TNF-α. The mRNA expression of ICAM-1 and VCAM-1 in HUVEC incubated with 30μg/L TNF-α began to increase at 6 h, reached peak at 48 h, and kept a plateau until 72 h. Atorvastatin dose-dependently inhibited the mRNA expressions of ICAM-1 and VCAM-1 activated by incubating HUVEC with 30μg/L TNF-α for 48 hours. Conclusions Atorvastatin might stabilize plaque and decelerate the process of AS by inhibiting the mRNA expressions of ICAM-1 and VCAM-1. | Zhiming Yang Zhanhai Li Gaiying Fan Bin Liang Ying Ma Chuanshi Xiao Yuming Kang | 2007 | South China Journal of Cardiology2007，8，4： | 0 |
| 14 | Mapping a stable adult-plant stripe rust resistance QTL on chromosome 6AL in Chinese wheat landrace Yibinzhuermai显示文摘Stripe rust,caused by Puccinia striiformis f.sp.tritici(Pst),is one of the most important diseases threatening the yield and stability of wheat production in China and many other countries.Identification and utilization of new genes for durable stripe rust resistance are important for ongoing control of this disease.The objectives of this study were to identify quantitative trait loci(QTL)associated with adult-plant stripe rust resistance in the Chinese wheat landrace Yibinzhuermai(YBZR)and to provide wheat breeders with new sources of potentially durable resistance.A total of 117 recombinant inbred lines(RILs)(F5:8)derived from a cross between YBZR and highly susceptible cultivar Taichung 29(TC29)were assessed for stripe rust severity in field experiments at Wenjiang in 2016 and 2017 and Chongzhou in 2016,2017,2018,and 2019 in Sichuan following inoculation with a mixture of current Pst races.The RILs were genotyped using the Wheat55K single nucleotide polymorphism(SNP)array.Three QTL were identified on chromosome arms 6AL,5BL and 7DS.QYr.YBZR-6AL and QYr.YBZR-7DS conferred major effects in all field environments,explaining 10.6%to 14.7%and 11.5%to 21.2%of phenotypic variation,respectively.The QTL on 5BL and 7DS likely correspond to previously known QTL,whereas QYr.YBZR-6AL is probably novel.Haplotype analysis revealed that the resistance allele at QYr.YBZR-6AL was present in 2.8%of 324 Chinese wheat landraces.SNP markers closely linked with QYr.YBZR-6AL were converted to kompetitive allele-specific PCR markers and validated in the RIL population and a subset of 92 wheat cultivars.QYr.YBZR-6AL and its markers should be useful in breeding programs to improve the level and durability of stripe rust resistance. | Mei Deng Li Long Yukun Cheng Fangjie Yao Fangnian Guan Yuqi Wang Hao Li Zhien Pu Wei Li Qiantao Jiang Yuming Wei Jian Ma Houyang Kang Pengfei Qi Jirui Wang Youliang Zheng Yunfeng Jiang Guoyue Chen | 2022 | The Crop Journal2022，10，4： | 0 |
| 15 | Product Promotion Prediction Model Based on Evaluation Information显示文摘This paper mainly studies the impact of evaluation information on e-commerce platform on the future of products.Through natural language processing and rating,an evaluation model based on user rating and evaluation is defined to measure product quality.Among them,evaluations are differentiated:review sentiment coefficient(R)and review length(L).The evaluation model is:.In order to predict the future reputation of products,based on the above evaluation model,time series is used to rank the products studied.Each customer purchases the product through Markov chain model,so as to predict the probability of future word-of-mouth spread of the product.Use TOPSIS method to select monthly sales,stars and comment sentiment coefficient as indicators.The comprehensive measurement method based on text and score is determined to predict whether the product is successfully promoted. | Qixiu Kang Jing Tang Yuming Wang | 2021 | Modern Electronic Technology2021，5，1： | 0 |
| 16 | Fine mapping and transcriptome sequencing reveal candidate genes conferring all-stage resistance to stripe rust on chromosome arm 1AL in Chinese wheat landrace AS1676显示文摘Stripe rust, caused by Puccinia striiformis f. sp. tritici(Pst), threatens wheat production worldwide, and resistant varieties tend to become susceptible after a period of cultivation owing to the variation of pathogen races. In this study, a new resistance gene against Pst race CYR34 was identified and predicted using the descendants of a cross between AS1676, a highly resistant Chinese landrace, and Avocet S, a susceptible cultivar. From a heterozygous plant from a F7recombinant inbred line(RIL) population lacking the Yr18 gene, a near-isogenic line(NIL) population was developed to map the resistance gene. An allstage resistance gene, YrAS1676, was identified on chromosome arm 1AL via bulked-segregant exomecapture sequencing. By analyzing a large NIL population consisting of 6537 plants, the gene was further mapped to the marker interval between KA1A_485.36 and KA1A_490.13, spanning 485.36–490.13 Mb on1AL. A total of 66 annotated genes have been reported in this region. To characterize and predict the candidate gene(s), an RNA-seq was performed using NIL-R and NIL-S seedlings 3 days after CYR34 inoculation. Compared to NIL-S plants, NIL-R plants showed stronger immune reaction and higher expression levels of genes encoding pathogenesis-associated proteins. These differences may help to explain why NIL-R plants were more resistant to Pst race CYR34 than NIL-S plants. By combining fine-mapping and transcriptome sequencing, a calcium-dependent protein kinase gene was finally predicted as the potential candidate gene of YrAS1676. This gene contained a single-nucleotide polymorphism. The candidate gene was more highly expressed in NIL-R than in NIL-S plants. In field experiments with Pst challenge,the YrAS1676 genotype showed mitigation of disease damage and yield loss without adverse effects on tested agronomic traits. These results suggest that YrAS1676 has potential use in wheat stripe rust resistance breeding. | Xiu Yang Yunfeng Jiang Xianghai Yu Haipeng Zhang Yuqi Wang Fangnian Guan Li Long Hao Li Wei Li Qiantao Jiang Jirui Wang Yuming Wei Jian Ma Houyang Kang Pengfei Qi Qiang Xu Meng Deng Yazhou Zhang Youliang Zheng Yonghong Zhou Guoyue Chen | 2023 | The Crop Journal2023，11，5： | 0 |
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