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| 1 | Trending IC design directions in 2022显示文摘For the non-stop demands for a better and smarter society, the number of electronic devices keeps increasing exponentially;and the computation power, communication data rate, smart sensing capability and intelligence are always not enough. Hardware supports software, while the integrated circuit(IC) is the core of hardware. In this long review paper, we summarize and discuss recent trending IC design directions and challenges, and try to give the readers big/cool pictures on each selected small/hot topics. We divide the trends into the following six categories, namely, 1) machine learning and artificial intelligence(AI) chips, 2) communication ICs, 3) data converters, 4) power converters, 5) imagers and range sensors, 6) emerging directions. Hope you find this paper useful for your future research and works. | Chi-Hang Chan Lin Cheng Wei Deng Peng Feng Li Geng Mo Huang Haikun Jia Lu Jie Ka-Meng Lei Xihao Liu Xun Liu Yongpan Liu Yan Lu Kaiming Nie Dongfang Pan Nan Qi Sai-Weng Sin Nan Sun Wenyu Sun Jiangtao Xu Jinshan Yue Milin Zhang Zhao Zhang | 2022 | Journal of Semiconductors2022，43，7： | 3 |
| 2 | Rotavirus VP7 epitope chimeric proteins elicit cross-immunoreactivity in guinea pigs显示文摘VP7 of group A rotavirus(RVA) contains major neutralizing epitopes. Using the antigenic protein VP6 as the vector, chimeric proteins carrying foreign epitopes have been shown to possess good immunoreactivity and immunogenicity. In the present study, using modified VP6 as the vector,three chimeric proteins carrying epitopes derived from VP7 of RVA were constructed. The results showed that the chimeric proteins reacted with anti-VP6 and with SA11 and Wa virus strains.Antibodies from guinea pigs inoculated with the chimeric proteins recognized VP6 and VP7 of RVA and protected mammalian cells from SA11 and Wa infection in vitro. The neutralizing activities of the antibodies against the chimeric proteins were significantly higher than those against the vector protein VP6 F. Thus, development of chimeric vaccines carrying VP7 epitopes using VP6 as a vector could be a promising alternative to enhance immunization against RVAs. | Bingxin Zhao Xiaoxia Pan Yumei Teng Wenyue Xia Jing Wang Yuling Wen Yuanding Chen | 2015 | Virologica Sinica2015，30，5： | 2 |
| 3 | A new parameterization scheme for sea surface aerodynamic roughness显示文摘更少的粗糙长度从维的分析导出的尺寸有一种关系少些挥动年龄,和尺寸粗糙的形式长度能与重要波浪高度与关系被表示。基于六个实验(HEXMAX, RASEX,简历稳定的站台,安大略湖数据分析取, CBLAST 低风) ,我们证实 Charnock 参数, zch,和尺寸更少粗糙长度, z0/Hs,依赖于波浪年龄, u */cp。而且,我们为粗糙长度构造了一个新计划,并且探索了它的敏感到磨擦速度和波浪年龄。把最新发达的 parameterization 计划(PS07 ) 与 COARE (联合海洋空气反应实验 V.3.0 ) 相结合算法,我们在 1985 年 12 月从北方海平台实验计算了数据,并且尝试了与 COARE 的另外的三个计划相比验证 PS07 的适用性。我们发现计算结果基于 PS07 接近大小。我们也进行了 PS07 与在发生在 Zhanjiang 海港的 3 台风的数据集联合的波浪的嵌套的模型在被相结合的一个实验。在在 Naozhou 岛附近的计算、观察的波浪之间的比较结果显示新 parameterization 计划(PS07 ) 有好适用性。 | Yuping Pan Wenyu Sha Shouxian Zhu Sufang Ge | 2008 | Progress in Natural Science:Materials International2008，18，11： | 2 |
| 4 | Self-assembly synthesis of LAPO4 hierarchical hollow spheres with enhanced photocatalytic CO2-reduction performance显示文摘像顽童的 LaPO 4 空范围被一条灵巧的答案线路成功地作为一个指导结构的代理人用柠檬性的酸(CA ) 综合。尺寸三维(3D ) 空范围被改变 CA 的集中调节。3D LaPO 4 的形成机制空范围被学习时间依赖者形态学进化过程揭示。重要地,与 monodispersed 相比一个维(1D ) LaPO 4 nanorods,从 nanorods 自我装配的空范围显示出的 3D LaPO 4 在为公司 2 减小的 photocatalytic 活动的 6.8 褶层改进,它被归因于他们的层次空结构,更高轻收获的能力,和更快的电子转移的 synergistic 效果。我们的调查结果为提高 photocatalytic 表演为层次空 micro/nanoarchitectures 而且一条有效线路的合成提供一个简单、灵巧的方法不仅。 | Bao Pan Yangen Zhou Wenyue Su Xuxu Wang | 2017 | Nano Research2017，10，2： | 2 |
| 5 | Studies of the Geodesic Acoustic Mode Zonal Flow in HL-2A Tokamak Plasmas显示文摘 | ZHAO Kaijun DONG Jiaqi YAN Longwen HONG Wenyu QIAN Jun CHENG Jun YU Deliang YANG Qingwei DING Xuantong LIU Yong PAN Chuanhong | 2006 | Southwestern Institute of Physics Annual Report2006，，1： | 2 |
| 6 | Anti-Seizure and Neuronal Protective Effects of Irisin in Kainic Acid-Induced Chronic Epilepsy Model with Spontaneous Seizures显示文摘An increased level of reactive oxygen species is a key factor in neuronal apoptosis and epileptic seizures.Irisin reportedly attenuates the apoptosis and injury induced by oxidative stress.Therefore,we evaluated the effects of exogenous irisin in a kainic acid(KA)-induced chronic spontaneous epilepsy rat model.The results indicated that exogenous irisin significantly attenuated the KA-induced neuronal injury,learning and memory defects,and seizures.Irisin treatment also increased the levels of brain-derived neurotrophic factor(BDNF)and uncoupling protein 2(UCP2),which were initially reduced following KA administration.Furthermore,the specific inhibitor of UCP2(genipin)was administered to evaluate the possible protective mechanism of irisin.The reduced apoptosis,neurodegeneration,and spontaneous seizures in rats treated with irisin were significantly reversed by genipin administration.Our findings indicated that neuronal injury in KA-induced chronic epilepsy might be related to reduced levels of BDNF and UCP2.Moreover,our results confirmed the inhibition of neuronal injury and epileptic seizures by exogenous irisin.The protective effects of irisin may be mediated through the BDNF-mediated UCP2 level.Our results thus highlight irisin as a valuable therapeutic strategy against neuronal injury and epileptic seizures. | Jie Yu Yao Cheng Yaru Cui Yujie Zhai Wenshen Zhang Mengdi Zhang Wenyu Xin Jia Liang Xiaohong Pan Qiaoyun Wang Hongliu Sun | 2022 | Neuroscience Bulletin2022，38，11： | 1 |
| 7 | OBV(obscure vein),a C_(2)H_(2)zinc finger transcription factor,positively regulates chloroplast development and bundle sheath extension formation in tomato(Solanum lycopersicum)leaf veins显示文摘Leaf veins play an important role in plant growth and development,and the bundle sheath(BS)is believed to greatly improve the photosynthetic efficiency of C_(4) plants.The OBV mutation in tomato(Solanum lycopersicum)results in dark veins and has been used widely in processing tomato varieties.However,physiological performance has difficulty explaining fitness in production.In this study,we confirmed that this mutation was caused by both the increased chlorophyll content and the absence of bundle sheath extension(BSE)in the veins.Using genome-wide association analysis and map-based cloning,we revealed that OBV encoded a C_(2)H_(2) L domain class transcription factor.It was localized in the nucleus and presented cell type-specific gene expression in the leaf veins.Furthermore,we verified the gene function by generating CRISPR/Cas9 knockout and overexpression mutants of the tomato gene.RNA sequencing analysis revealed that OBV was involved in regulating chloroplast development and photosynthesis,which greatly supported the change in chlorophyll content by mutation.Taken together,these findings demonstrated that OBV affected the growth and development of tomato by regulating chloroplast development in leaf veins.This study also provides a solid foundation to further decipher the mechanism of BSEs and to understand the evolution of photosynthesis in land plants. | Jinghua Lu Chunyang Pan Xin Li Zejun Huang Jinshuai Shu Xiaoxuan Wang Xiaoxiao Lu Feng Pan Junling Hu Hui Zhang Wenyue Su Min Zhang Yongchen Du Lei Liu Yanmei Guo Junming Li | 2021 | Horticulture Research2021，8，1： | 1 |
| 8 | Environmental microcystin exposure triggers the poor prognosis of prostate cancer: Evidence from case-control, animal, and in vitro studies显示文摘Microcystin-leucine-arginine(MC-LR)is positively linked with multiple cancers in humans.However,the association between MC-LR and the risk and prognosis of prostate cancer has not been conducted in epidemiological studies.No reported studies have linked MC-LR exposure to the poor prognosis of prostate cancer by conducting experimental studies.The content of MC-LR was detected in most of the aquatic food in wet markets and supermarkets in Nanjing and posed a health risk for consumers.MC-LR levels in both prostate cancer tissues and serum were significantly higher than controls.The adjusted odds ratio(OR)for prostate cancer risk by serum MC-LR was 1.75(95%CI:1.21-2.52)in the whole subjects,and a positive correlation between MC-LR and advanced tumor stage was observed.Survival curve analysis indicated patients with higher MC-LR levels in tissues exhibited poorer overall survival.Human,animal,and cell studies confirmed that MC-LR exposure increases the expression of estrogen receptor-α(ERα)and promotes epithelial-mesenchymal transition(EMT)in prostate cancer.Moreover,MC-LR-induced decreased E-cadherin levels,increased vimentin levels,and increased migratory and invasive capacities of prostate cancer cells were markedly suppressed upon ERαknockdown.MC-LR-induced xenograft tumor growth and lungmetastasis in BALB/c nude mice can be effectively alleviated with ERαknockdown.Our data demonstrated that MC-LR upregulated vimentin and downregulated E-cadherin through activating ERα,promoting migration and invasion of prostate cancer cells.Our findings highlight the role of MC-LR in prostate cancer,providing new perspectives to understand MC-LR-induced prostatic toxicity. | Chun Pan Haixiang Qin Minghao Yan Xuefeng Qiu Wenyue Gong Wenxin Luo Hongqian Guo Xiaodong Han | 2023 | Journal of Environmental Sciences2023，，5： | 1 |
| 9 | Validation of MODIS C6 AOD Products Retrieved by the Dark Target Method in the Beijing–Tianjin–Hebei Urban Agglomeration,China显示文摘The quality of the MODIS C6 3-km and 10-km aerosol optical depth(AOD) products retrieved by the Dark Target(DT)method is discussed using ground-based observations in the Beijing–Tianjin–Hebei region from 1 August 2007 to 31 July2008. Good consistency exists between the 3-km and 10-km products and ground-based observations. The retrieval accuracy of the two products both show distinctive seasonality. The percentage falling within the expected error(EE) is largest in the winter, moderate in the spring and autumn, and smallest in the summer. A worse overestimation appears in the spring and summer(27%–66%). However, the 3-km and 10-km products over different surfaces still exhibit obvious deviations. The 10-km product performs better in the large cities, while the 3-km product has advantages in the suburbs. In urban areas, the percentage falling within EE of the 3-km AOD product(18%–59%) is lower than that for the 10-km AOD product(31%–69%). However, in suburban areas, the percentage falling within EE of the 3-km AOD product(61%–84%) is higher than for the 10 km AOD product(54%–83%).The percentages falling within EE differ considerably when the AOD is greater than1.5(73% and 63% for the 3-km and 10-km products, respectively). On the whole, the 3-km(10-km) AOD product performs better in suburban(urban) areas. | Jie ZHANG Jinyuan Xin Wenyu ZHANG Shigong WANG Lili WANG Wei XIE Guojie XIAO Hela PAN Lingbin KONG | 2017 | Advances in Atmospheric Sciences2017，34，8： | 1 |
| 10 | Clinical validation of serum immunosignatures in early diagnosis of Crohn's disease显示文摘Background:The search for biomarkers suitable for early diagnosis of Crohn's disease(CD)is challenging.This study investigated the efficacy of serological markers for the early diagnosis of CD.Methods:This was a retrospective nested cohort study.Indirect immuno-fluorescence and enzyme‐linked immunosorbent assay were used to detect ASCA IgG,ASCA IgA,AYMA IgG,AYCA IgG,FI2Y IgG,p‐ANCA IgG,GAB IgG and PAB IgG in patient serum samples.Results:The positive rates of ASCA IgG,ASCA IgA,AYMA IgG,AYCA IgG,FI2Y IgG,p‐ANCA IgG,GAB IgG and PAB IgG in patients with early CD,advanced CD and other intestinal diseases were 37.0%versus 56.8%versus 27.8%;3.7%versus 20.5%versus 19.4%;14.8%versus 2.3%versus 2.8%;25.9%versus 9.1%versus 8.3%;18.5%versus 15.9%versus 8.3%;0.0%versus 2.8%,18.5%;13.6%versus 18.2%versus 16.7%;and 7.4%versus 20.5%versus 0.0%,respectively.The positive rates of ASCA IgG,AYCA IgG and PAB IgG were significantly different among the three groups(p<0.05).In 85.2%of early CD patients,at least one antibody was detected 1 year before diagnosis.The sensitivity of the ASCA/AYMA/AYCA/FI2Y/GAB combination for early diagnosis was 85.2%.The sensitivity of the ASCA/AYMA/AYCA/FI2Y/GAB/PAB/PANCA combination for differentiating CD from other diseases was 87.3%.Conclusions:ASCA IgG and AYCA IgG have potential value in identifying the course of CD.AYCA IgG may be a potential marker for the early diagnosis of CD,and ASCA IgG indicates an advanced stage.The combination of ASCA,AYMA,AYCA,FI2Y,and GAB improves early diagnostic accuracy of CD. | Xianzong Ma Wenyu Zhang Xin Wang Lang Yang Juan Jiao Yan Jia Dezhi Wang Junfeng Xu Peng Jin Mingjie Zhang Shirong Li Yuanming Pan Jianqiu Sheng | 2023 | iLABMED2023，1，3： | 0 |
| 11 | Experimental and Theoretical Study on CHF of a Ultra-Supercritical Circulating Fluidized Bed Boiler Water-Wall Tube at near-Critical Pressures显示文摘The experimental and theoretical research on the critical heat flux(CHF)in a uniformly heated water-wall tube of the efficient ultra-supercritical circulating fluidized bed(USCFB)boiler has been conducted.In particular,the experimental pressure varies from 18 MPa to 21 MPa,which is from 0.814Pcr–0.95Pcr(Pcr:critical pressure).The mass flux varies from 310 kg·m^(–2)·s^(–1)to 550 kg·m^(–2)·s^(–1).The inlet sub-cooling temperatures vary from 5°C to 10°C.The material of the tube is 12Cr1MoVg.From experimental investigation,the near critical pressure CHF test data of water are obtained.We find that the CHF mainly occurs when the vapor qualities are less than 0.4,and it occurs earlier(at lower vapor quality)when the pressure is closer to 22.115 MPa or the mass flux is smaller.From the experimental data,a correlation function for the CHF is established via regression and machine learning.Correlations established via machine learning greatly improved the regression accuracy.To study the CHF phenomenon mechanically,a theoretical model is established based on the near-surface bubble crowding model describing the DNB-type CHF.In the development of the CHF model,the friction resistance coefficient is determined according to our test results.By comparison with different experimental results,the near-surface bubble crowding model is well suited to describe DNB-type CHF.The calculation results of the model can provide reference for the optimal design of the USCFB boiler. | WANG Wenyu MA Zhan QING Hao NIE Chao YANG Haoyu BI Lingfeng YANG Dong PAN Wenxiao | 2023 | Journal of Thermal Science2023，32，1： | 0 |
| 12 | The Development Roadmap of Direct Current Buildings(2020-2030)(Ⅱ)显示文摘2.1Development background2.1.1Greenhouse gas emission reduction is imminent Climate change is one of the most severe global challenges.China has made a solemn commitment to the international community at the national level to reach the peak of carbon dioxide emissions around 2030 and strive to reach the peak as soon as possible[30]. | Jiang Yi Hao Bin Li Yutong Ma Zhao Tong Yibin Kang Jing Li Yemao Pan Wenyu Lu Yuanyuan Zhao Yuming Shen Yuxiang Zhang Ning Zhao Jinbin Zhao Zhigang Chen Wenbo Wang Dawei Hou Enzhe | 2021 | 建筑节能(中英文)2021，49，9： | 0 |
| 13 | Low fabrication cost wavelength tunable WG-FP hybrid-cavity laser working over 1.7μm显示文摘A wide wavelength tuning range and single-mode hybrid cavity laser consists of a square Whispering-Gallery(WG)microcavity and a Fabry–Pérot(FP)was introduced and demonstrated.A wavelength tuning range over 12.5 nm from 1760.87 to 1773.39 nm which was single-mode emitting was obtained with the side-mode suppression ratio over 30 dB.The hybrid cavity laser does not need grating etching and special epitaxial structure,which reduces the fabrication difficulty and cost,and shows the potential for gas sensing with absorption lines in this range. | Fangyuan Meng Hongyan Yu Xuliang Zhou Mengqi Wang Yejin Zhang Wenyu Yang Jiaoqing Pan | 2022 | Journal of Semiconductors2022，43，6： | 0 |
| 14 | Three Dimensional Identification of Zonal Flows in the HL-2A Tokamak显示文摘 | YAN Longwen HONG Wenyu LAN Tao ZHAO Kaijun DONG Jiaqi LIU Adi YU Changxuan QIAN Jun CHENG Jun YU Deliang YANG Qingwei DING Xuantong LIU Yong PAN Chuanhong | 2006 | Southwestern Institute of Physics Annual Report2006，，1： | 0 |
| 15 | Early development and functional properties of tryptase/chymase double-positive mast cells from human pluripotent stem cells显示文摘Mast cells (MCs) play a pivotal role in the hypersensitivity reaction by regulating the innate and adaptive immune responses. Humans have two types of MCs. The first type, termed MCTC, is found in the skin and other connective tissues and expresses both tryptase and chymase, while the second, termed MCT, which only expresses tryptase, is found primarily in the mucosa. MCs induced from human adult-type CD34+ cells are reported to be of the MCT type, but the development of MCs during embryonic/fetal stages is largely unknown. Using an efficient coculture system, we identified that a CD34+c-kit+ cell population, which appeared prior to the emergence of CD34+CD45+ hematopoietic stem and progenitor cells (HSPCs), stimulated robust production of pure Tryptase+Chymase+ MCs (MCTCs). Single-cell analysis revealed dual development directions of CD34+c-kit+ progenitors, with one lineage developing into erythro-myeloid progenitors (EMP) and the other lineage developing into HSPC. Interestingly, MCTCs derived from early CD34+c-kit+ cells exhibited strong histamine release and immune response functions. Particularly, robust release of IL-17 suggested that these early developing tissue-type MCTCs could play a central role in tumor immunity. These findings could help elucidate the mechanisms controlling early development of MCTCs and have significant therapeutic implications. | Guohui Bian Yanzheng Gu Changlu Xu Wenyu Yang Xu Pan Yijin Chen Mowen Lai Ya Zhou Yong Dong Bin Mao Qiongxiu Zhou Bo Chen Tatsutoshi Nakathata Lihong Shi Min Wu Yonggang Zhang Feng Ma | 2021 | Journal of Molecular Cell Biology2021，13，2： | 0 |
| 16 | Divertor Experiments with MBI and Strong Gas Puffing on HL-2A显示文摘 | DUAN Xuru DING Xuantong YANG Qingwei YAN Longwen YAO Lianghua HONG Wenyu XUAN Weiming LIU Dequan CHEN Liaoyuan SONG Xianming ZHANG Jinhua CAO Zeng CUI Zhengying LI Wei LIU Yi PAN Yudong PAN Li ZHENG Yinjia ZHOU Yan MAO Weicheng LIU Yong 无 | 2006 | Southwestern Institute of Physics Annual Report2006，，1： | 0 |
| 17 | Influence of cellulose crystal plane on cellulose hydrolysis显示文摘Cellulose polymerization degree and crystal plane changing are both considered to affect acid hydrolysis,however,it is uncertain to identify which one is more important.In this study,the filter paper was treated with dilute hydrochloric acid to investigate the cellulose polymerization degree changing,and cotton linter was treated with NaOH for the purpose of changing its crystal plane.Both the treated and untreated samples were hydrolyzed under the condition of 1.0 wt%dilute hydrochloric acid with solid-liquid ratio 1:40 at 140℃for 30 min to compare the hydrolysis effects.It was found that the glucose yield increased from 9.5%to 19.7%when treated with 15%NaOH at 50℃for 30 min,and new crystal planes(1-10)(1-20)appeared after alkali treatment.According to the experimental results,it is concluded that crystal plane plays a vital role in cellulose acid hydrolysis. | Li Wenzhi Lu Wenyu Li Minghao Wu Hao Pan Guoqiang | 2016 | International Journal of Agricultural and Biological Engineering2016，9，4： | 0 |
| 18 | Ⅲ–Ⅴ compound materials and lasers on silicon显示文摘Silicon-based photonic integration has attracted the interest of semiconductor scientists because it has high luminous efficiency and electron mobility.Breakthroughs have been made in silicon-based integrated lasers over the past few decades.Here we review three main methods of integration ofⅢ–Ⅴ materials on Si,namely direct growth,bonding,and selectivearea hetero-epitaxy.TheⅢ–Ⅴmaterials we introduced mainly include materials such as GaAs and InP.The lasers are mainly lasers of related communication bands.We also introduced the advantages and challenges of the three methods. | Wenyu Yang Yajie Li Fangyuan Meng Hongyan Yu Mengqi Wang Pengfei Wang Guangzhen Luo Xuliang Zhou Jiaoqing Pan | 2019 | Journal of Semiconductors2019，40，10： | 0 |
| 19 | Targeting FAPα-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis显示文摘Lymphatic metastasis is the main metastatic route for colorectal cancer, which increases the risk of cancer recurrence and distant metastasis. The properties of the lymph node metastatic colorectal cancer(LNM-CRC) cells are poorly understood, and effective therapies are still lacking. Here, we found that hypoxia-induced fibroblast activation protein alpha(FAPα) expression in LNM-CRC cells. Gain-or loss-function experiments demonstrated that FAPα enhanced tumor cell migration, invasion, epithelial-mesenchymal transition, stemness, and lymphangiogenesis via activation of the STAT3 pathway. In addition, FAPα in tumor cells induced extracellular matrix remodeling and established an immunosuppressive environment via recruiting regulatory T cells, to promote colorectal cancer lymph node metastasis(CRCLNM). Z-GP-DAVLBH, a FAPα-activated prodrug, inhibited CRCLNM by targeting FAPα-positive LNM-CRC cells. Our study highlights the role of FAPα in tumor cells in CRCLNM and provides a potential therapeutic target and promising strategy for CRCLNM. | Shuran Fan Ming Qi Qi Qi Qun Miao Lijuan Deng Jinghua Pan Shenghui Qiu Jiashuai He Maohua Huang Xiaobo Li Jie Huang Jiapeng Lin Wenyu Lyu Weiqing Deng Yingyin He Xuesong Liu Lvfen Gao Dongmei Zhang Wencai Ye Minfeng Chen | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
| 20 | Improved data-driven performance of Charpy impact toughness via literature-assisted production data in pipeline steel显示文摘Pipeline transportation is one of the most economical ways to transport crude oil and natural gas over long distances.High toughness is one of the important qualities of pipeline steel to ensure safe transportation,wherein a key factor characterizing toughness is Charpy impact toughness(CIT).In this work,according to the production line data provided by a steel mill and the experimental data collected in literature,two machine learning model construction strategies were proposed.One was based solely on the production line dataset,and the other was based on the production line dataset together with the literature dataset.In these two strategies,the random forest model displayed the best prediction results,the accuracy of strategy I was 0.58,and the accuracy of strategy II was 0.90,wherein literature data effectively improved the CIT prediction accuracy.Finally,an optimized CIT model based on machine learning algorithms was established.The proposed strategy of literature data-assisted production line data provides a new perspective for optimizing and predicting the performance of traditional structural materials. | SHANG ChunLei WANG ChuanJun WU HongHui LIU WenYue CHEN YiMian PAN GuangFei WANG ShuiZe WU GuiLin GAO JunHeng ZHAO HaiTao ZHANG ChaoLei MAO XinPing | 2023 | Science China(Technological Sciences)2023，66，7： | 0 |
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