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| 1 | Cervical Infection of Oncogenic Human Papillomavirus(HPV) Types in Beijing,China显示文摘Objective This study was designed to determine the prevalence of oncogenic human papillomavirus(HPV) in cervical infections in Beijing,China,and to investigate the odds ratio(OR) of HPV single and multiple infections in abnormal cytology.Methods A total of 19,018 specimens from outpatients in the department of obstetric and gynecology were collected.They were detected using high-risk HPV genotyping real-time polymerase chain reaction(PCR) kit and analyzed by ThinP rep cytology test for cervical pathological diagnosis.HPV prevalence,age-specific prevalence,and OR of each type of HPV in abnormal cytology were analyzed.Results Overall,19.1%(3,623/19,018) of the individuals were positive for HPV infection,14.9%(2,833/19,018) were positive for a single HPV type,and 4.2%(790/19,018) were positive for multiple types.Among the 3,623 HPV-positive individuals,the most predominant HPV types were HPV52(4.4%,834/19,018),HPV16(3.7%,710/19,018),and HPV58(3.4%,644/19,018).The OR of multiple infections and single infection differed significantly among disease severities.The OR of dual infection was higher than that of each of the two single infection types,respectively.Conclusion HPV prevalence in the outpatients was 19.1%,and the most predominant HPV types in the study were HPV52,HPV16,and HPV58.Women with multiple infectionswere more likely to have abnormal cytology. | LI Ying HUANG Ke JI Pei Li SONG Lei LIU Hong Tu | 2016 | Biomedical and Environmental Sciences2016，29，10： | 22 |
| 2 | Infliximab monotherapy for Chinese patients with moderate to severe plaque psoriasis: a randomized, double-blind, placebo-controlled multicenter trial显示文摘 | YANG Hai-zhen WANG Ke JIN Hong-zhong GAO Tian-wen XIAO Sheng-xiang XU Jin-hua WANG Bao-xi ZHANG Fu-ren LI Chun-yang LIU Xiao-ming TU Cai-xia JI Su-zhen SHEN Yang ZHU Xue-jun | 2012 | Chinese Medical Journal2012，，11： | 20 |
| 3 | Pico-satellite Autonomous Navigation with Magnetometer and Sun Sensor Data显示文摘This article presents a near-Earth satellite orbit estimation method for pico-satellite applications with light-weight and low-power requirements. The method provides orbit information autonomously from magnetometer and sun sensor, with an extended Kalman filter (EKF). Real-time position/velocity parameters are estimated with attitude independently from two quantities: the measured magnitude of the Earth’s magnetic field, and the measured dot product of the magnetic field vector and the sun vector. To guarantee the filter’s effectiveness, it is recommended that the sun sensor should at least have the same level of accuracy as magnetometer. Furthermore, to reduce filter’s computation expense, simplification methods in EKF’s Jacobian calculations are introduced and testified, and a polynomial model for fast magnetic field calculation is developed. With these methods, 50% of the computation expense in dynamic model propagation and 80% of the computation burden in measurement model calculation can be reduced. Tested with simulation data and compared with original magnetometer-only methods, filter achieves faster convergence and higher accuracy by 75% and 30% respectively, and the suggested simplification methods are proved to be harmless to filter’s estimation performance. | HAN Ke WANG Hao TU Binjie JIN Zhonghe | 2011 | Chinese Journal of Aeronautics2011，24，1： | 8 |
| 4 | Using multi-satellite microwave remote sensing observations for retrieval of daily surface soil moisture across China显示文摘The objective of this study was to retrieve daily composite soil moisture by jointly using brightness temperature observations from multiple operating satellites for near real-time application with better coverage and higher accuracy.Our approach was to first apply the single-channel brightness radiometric algorithm to estimate soil moisture from the respective brightness temperature observations of the SMAP,SMOS,AMSR2,FY3B,and FY3C satellites on the same day and then produce a daily composite dataset by averaging the individual satellite-retrieved soil moisture.We further evaluated our product,the official soil moisture products of the five satellites,and the ensemble mean (i.e.,arithmetic mean) of the five official satellite soil moisture products against ground observations from two networks in Central Tibet and Anhui Province,China.The results show that our product outperforms the individual released products of the five satellites and their ensemble means in the two validation areas.The root mean square error (RMSE ) values of our product were 0.06 and 0.09 m3/m3 in Central Tibet and Anhui Province,respectively.Relative to the ensemble mean of the five satellite products,our product improves the accuracy by 9.1% and 57.7% in Central Tibet and Anhui Province,respectively.This demonstrates that jointly using brightness temperature observations from multiple satellites to retrieve soil moisture not only improves the spatial coverage of daily observations but also produces better daily composite products. | Ke Zhang Li-jun Chao Qing-qing Wang Ying-chun Huang Rong-hua Liu Yang Hong Yong Tu Wei Qu Jin-yin Ye | 2019 | Water Science and Engineering2019，12，2： | 7 |
| 5 | High levels of circulating GM-CSF^(+) CD4^(+) T cells are predictive of poor outcomes in sepsis patients: a prospective cohort study显示文摘Granulocyte colony-stimulating factor(GM-CSF),produced by CD4^(+)T cells,has recently been implicated in the pathogenesis of inflammatory diseases,such as multiple sclerosis and juvenile arthritis.However,the role of GM-CSF-producing CD4^(+)T cells in sepsis remains unknown.This study reports peripheral changes in GM-CSF-producing CD4^(+)T cells in septic patients and the possible underlying mechanism by which GM-CSF influences the outcome of sepsis.Forty-three septic patients,20 SIRS patients,and 20 healthy controls were enrolled in this study and followed for 28 days to assess mortality.We measured the peripheral frequency of GM-CSF^(+)CD4^(+)T cells and recorded their associated relationship with disease progression.Our data demonstrated that peripheral GM-CSF-producing CD4^(+)T cells were significantly higher in septic patients than in both SIRS patients and healthy controls.These cells exhibit a memory phenotype and impaired IFN-γ-secreting capacity in sepsis patients.Using a receiver operating curve analysis with 8.01%as a cut-off point,the percentage of GM-CSF^(+)CD4^(+)T cells could predict the outcome of septic patients.Combined with the increase in GM-CSF-producing CD4^(+)T cells,inflammatory cytokines IL-1βand IL-6 were also upregulated.Using an in vitro neutrophil model,we found that GM-CSF inhibited C3aR expression,while inducing IL-8 production.Furthermore,this effect was transferrable in plasma from sepsis patients and was attenuated by inhibition of GM-CSF using an anti-GM-CSF antibody.These results indicate that GM-CSF-producing CD4^(+)T cells may serve as a marker of sepsis severity.Thus,targeting GM-CSF overproduction may benefit sepsis patients. | Huihuang Huang Siyu Wang Tianjun Jiang Rong Fan Zheng Zhang Jinsong Mu Ke Li Yonggang Wang Lei Jin Fang Lin Jie Xia Lijian Sun Biao Xu Chengcheng Ji Jing Chen Juan Chang Bo Tu Bing Song Chao Zhang Fu-Sheng Wang Ruonan Xu | 2019 | Cellular & Molecular Immunology2019，16，6： | 6 |
| 6 | Yield and tillering response of super hybrid rice Liangyoupeijiu to tillage and establishment methods显示文摘Tillering is an important agronomic trait for rice grain production. To evaluate yield and tillering response, Liangyoupeijiu(super hybrid rice) was grown in Hunan, China during 2011–2012 under different methods of tillage(conventional and no-tillage system) and crop establishment methods(transplanting at a spacing of 20 cm × 20 cm with one seedling per hill and direct seeding at a seeding rate of 22.5 kg ha-1). Our results revealed that, at maximum tillering(Max.) and at maturity(MA) stages, direct seeding(DS) resulted in 22% more tillers than transplanting(TP) irrespective of tillage system. Tiller mortality reached a peak between panicle initiation(PI) and booting(BT) stages, and was 16% higher under conventional tillage(CT) than under no-tillage(NT). Transplanting required 29% more time for the completion of tillering and less for DS. Tillering rate was 43% higher in DS than TP under either CT or NT. There was a positive correlation between panicle number per m2and maximum tiller number per m2, but not panicle-bearing tiller rate. The panicle bearing tiller rate was higher under DS than TP and higher under NT than CT. Tiller dry weight gradually increased up to heading(HD) stage, and was 14% higher under TP than DS. Leaf area(cm2tiller-1) gradually increased from Max. to HD stage and then decreased by 34% in conventional tillage transplanting(CTTP) and 45% in no-tillage transplanting(NTTP) from 12DAH–24DAH(days after heading), but was similar(35%) under DS under either CT or NT. Grain yield was higher under CTTP owing to the larger sink size(heavier panicle, more spikelets in per cm length of panicle) than under DS. | M.A.Badshah Naimei Tu Yingbin Zou M.Ibrahim Ke Wang | 2014 | The Crop Journal2014，2，1： | 5 |
| 7 | Responses of N_2O reductase gene(nosZ)-denitrifier communities to long-term fertilization follow a depth pattern in calcareous purplish paddy soil显示文摘The effect of long-term fertilization on soil denitrifying communities was analysed by measuring the abundance and diversity of the nitrous oxide(N_2O)reductase gene,nos Z.Soil samples were collected from plots of a long-term fertilization experiment established in 1982 in Suining City,China.The fertilizer treatments were no fertilizer(CK),three chemical fertilizer(CF)treatments(N,NP,NPK),manure(M)alone,and manure with chemical fertilizers(NM,NPM,NPKM).The abundance and diversity of the denitrifying bacteria were assessed by real-time quantitative PCR,terminal restriction fragment length polymorphism(T-RFLP),and cloning and sequencing of nos Z genes.The diversity and abundance of nos Z-denitrifiers was higher in soil amended with manure and chemical fertilizers(CFM)than in soil amended with CF alone,and the highest in topsoil(0–20 cm).The nos Z-denitrifier community composition was more complex in CFM soil than in CF soil.Specific species were detected only in the CFM soil.The abundance of nos Z-denitrifier in the NPKM treatment was approximately two times higher than that in the CK,N,and NPK treatments.Most of the cloned nos Z sequences were closely related to nos Z sequences from Bradyrhizobiaceae and Rhodospirillaceae in Alphaproteobacteria.Of the measured abiotic factors,soil organic matter correlated significantly with the abundance(P<0.01);available phosphorus correlated significantly with the topsoil community composition(P<0.01),whereas soil organic matter correlated significantly with the subsoil(20–90 cm)community composition(P<0.01).This study demonstrated that long-term CFM fertilization affected both the abundance and composition of the nos Z-denitrifier community. | WANG Ying-yan LU Sheng-e XIANG Quan-ju YU Xiu-mei ZHAO Ke ZHANG Xiao-ping TU Shi-hua GU Yun-fu | 2017 | Journal of Integrative Agriculture2017，16，11： | 5 |
| 8 | Prevention of common bile duct injury during laparoscopic cholecystectomy显示文摘BACKGROUND:Since the widespread adoption of laparoscopic cholecystectomy(LC)in the late 1980s,a rise in common bile duct(CBD)injury has been reported.We analyzed the factors contributing to a record of zero CBD injuries in 10 000 consecutive LCs. METHODS:The retrospective investigation included 10 000 patients who underwent LC from July 1992 to June 2007. LC was performed by 4 teams of surgeons.The chief main surgeon of each team has had over 10 years of experience in hepatobiliary surgery.Calot's triangle was carefully dissected,and the relationship of the cystic duct to the CBD and common hepatic duct was clearly identified.A clip was applied to the cystic duct at the neck of the gallbladder and the duct was incised with scissors proximal to the clip.The cystic artery was dissected by the same method. Then,the gallbladder was dissected from its liver bed.A drain was routinely left at the gallbladder bed for 1-2 days postoperatively. RESULTS:No CBD injuries occurred in 10 000 consecutive LCs,and there were 16 duct leaks(0.16%).Among these, there were 10 Luschka duct leaks(0.1%)and 6 cystic duct leaks(0.06%).Four hundred thirty cases were converted to open cholecystectomy(OC),giving a conversion rate of 4.3%.After a mean follow-up of 17.5 months(range 6-24 months),no postoperative death due to LC occurred,and good results were observed in 95%of the patients. CONCLUSIONS:In our 10 000 LCs with zero CBD injuries, the techniques used and practices at our department have been successful.Surgeon's expertise in biliary surgery,preoperative imaging,precise operative procedures,and conversion from LC to OC when needed are important measures to prevent CBD injuries. | Ou, Zhi-Bing Li, Sheng-Wei Liu, Chang-An Tu, Bing Wu, Chuan-Xin Ding, Xiong Liu, Zuo-Jin Sun, Ke Feng, Hu-Yi Gong, Jian-Ping | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，4： | 5 |
| 9 | The modified bilobed flap for reconstructing sacral decubitus ulcers显示文摘Background:Sacral pressure ulcers are associated with high morbidity and,in some cases,result in mortality from severe sepsis.Local flaps are frequently used for reconstruction of stage III and IV pressure ulcers.An ideal flap should be simple to design,have a reliable vascular supply and minimal donor site morbidity.Our study evaluates the use of a bilobed flap based on the superficial branch of the superior gluteal artery or the posterior branch of the fourth lumbar artery to reconstruct the sacral pressure ulcer.Case presentation:We performed a retrospective analysis of paraplegic patients with sacral pressure ulcers treated with our bilobed flaps from January 2015 to December 2019.A description of our management,operative protocol,outcome and complications is outlined.Seven paraplegic patients(6 male,1 female;average age 53.1 years)with sacral pressure ulcers were treated with our bilobed flap based on the superficial branch of the superior gluteal artery or the posterior branch of the fourth lumbar artery.The average size of the pressure ulcers was 7×5 cm(range 6.2×4.5 cm to 11×10 cm).All 7 flaps survived.The patients were followed up for 12 months without significant complications,such as flap necrosis or recurrence.Conclusions:The superficial branch of the superior gluteal artery or the posterior branch of the fourth lumbar artery reliably supplies the bilobed flap.The superior cluneal nerve can be included in the design.The technique is simple and reliable.It should be included in the reconstructive algorithm for the management of sacral pressure ulcers. | Xiangong Jiao Chunxiao Cui Sally Kiu-Huen Ng Zhangjia Jiang Chihui Tu Jiemin Zhou Xiandong Lu Xianwen Ouyang Tong Luo Ke Li Yixin Zhang | 2020 | Burns & Trauma2020，8，1： | 4 |
| 10 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 11 | Three new eudesmane sesquiterpenes from Artemisia vestita显示文摘Three eudesmane sesquiterpene lactones,namely artemivestinolides A–C(1–3),along with three known 11-epimeric lactones(4–6),were isolated from the aerial parts of Artemisia vestita.Their structures were elucidated on the basis of extensive spectroscopic analyses(IR,HR-ESIMS,1D NMR and 2D NMR),and the absolute confgurations were determined by single-crystal X-ray diffraction(with copper radiation).Furthermore,in an in vitro assay,the three new compounds exhibited a moderate inhibition of the lipopolysaccharide(LPS)-induced nitric oxide(NO)production in BV-2 microglial cells. | Shuai-Hua Tian Xing-Yun Chai Ke Zan Ke-Wu Zeng Peng-Fei Tu | 2013 | Chinese Chemical Letters2013，24，9： | 3 |
| 12 | Synthesis of substituted benzoxazoles by the iron(Ⅲ)-catalyzed aerobic oxidation process显示文摘The FeCl3-catalyzed aerobic oxidation process for the synthesis of benzoxazoles,benzothiazole and benzimidazole has been discovered.This method has proved to be effective to a wide range of substrates,and it has been applied for the synthesis of JTP-426467. | CAO Ke,TU YongQiang & ZHANG FuMin P State Key Laboratory of Applied Organic Chemistry and Department of Chemistry,Lanzhou University,Lanzhou 730000,China | 2010 | Science China Chemistry2010，53，1： | 3 |
| 13 | Design,synthesis,and biological evaluation of Bcr-Abl PROTACs to overcome T315I mutation显示文摘Bcr-Abl threonine 315 to isoleucine 315(T315 I)gatekeeper mutation induced drug resistance remains an unmet clinical challenge for the treatment of chronic myeloid leukemia(CML).Chemical degradation of Bcr-AblT315 Iprotein has become a potential strategy to overcome drug resistance.Herein,we first described the design,synthesis,and evaluation of a new class of selective Bcr-AblT315 I proteolysis-targeting chimeric(PROTAC)degraders based on GZD824(reported as Bcr-AblT315 Iinhibitor by our group).One of the degrader 7 o with 6-member carbon chain linkage with pomalidomide exhibits the most potent degradation efficacy with DR of 69.89%and 94.23%at 100 and 300 nmol/L,respectively,and has an IC50 value of 26.8±9.7 nmol/L against Ba/F3T315 Icells.Further,7 o also displays substantial tumor regression against Ba/F3-Bcr-AblT315 Ixenograft model in vivo. | Liang Jiang Yuting Wang Qian Li Zhengchao Tu Sihua Zhu Sanfang Tu Zhang Zhang Ke Ding Xiaoyun Lu | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 2 |
| 14 | Multiplexed intracellular detection based on dual-excitation/dualemission upconversion nanoprobes显示文摘Multiplexed intracellular detection is desirable in biomedical sciences for its higher eficiency and accuracy compared to the single-analyte detection.However,it is very challenging to construct nanoprobes that possess multiple fluorescent signals to recognize the different intracellular species synchronously.Herein,we proposed a novel dual-excitation/dual-emission upconversion strategy for multiplexed detection through the design of upconversion nanoparticles(UCNP)loaded with two dyes for sensitization and quenching of the upconversion luminescence(UCL),respectively.Based on the two independent energy transfer processes of near-infrared(NIR)dye IR845 to UCNP and UCNP to visible dye PAPS-Zn,CIO-and Zn2+were simultaneously detected with a limit of detection(LOD)of41.4 and 10.5 nM,respectively.By tilizing a purpose built 830/980 nm dual-laser confocal microscope,both intrinsic and exogenous CIO and Zn2+in live MCF-7 cells have been accurately quantified.Such dual-excitation/dual-emission ratiometric UCL detection mode enables not only monitoring multiple intracellular analytes but also eliminating the detection deviation caused by inhomogeneous probe distribution in cells.Through modulation of NIR dye and visible dye with other reactive groups,the nanoprobes can be extended to analyze various intraellular species,which provides a promising tool to study the biological activities in live cells and diagnose diseases. | Jianxi Ke Shan Lu Zhuo Li Xiaoying Shang Xingjun Li Renfu Li Datao Tu Zhuo Chen Xueyuan Chen | 2020 | Nano Research2020，13，7： | 2 |
| 15 | PEG-asparaginase in BFM-90 regimen improves outcomes in adults with newly diagnosed lymphoblastic lymphoma显示文摘Objective: Although L-asparaginase(L-ASP) is a standard treatment for lymphoblastic lymphoma(LBL),hypersensitivity reactions by some patients limit its application. Polyethylene glycol-conjugated asparaginase(PEGASP) has a lower immunogenicity and is a standard treatment in all pediatric acute lymphoblastic leukemia(ALL).In this study, we investigated the efficacy and toxicity of PEG-ASP instead of L-ASP as used in the BFM-90regimen(PEG-ASP-BFM-90) for adult LBL.Methods: Between June 2012 and July 2015, we treated 30 adult patients with newly diagnosed LBL, using PEGASP-BFM-90 in a prospective, multicenter and single-arm clinical study at 5 participating institutions in China.Results: All the 30 patients, including 19 males and 11 females with a median age of 30(range: 18–62) years,completed 128 times of the PEG-ASP, with the median of 4(range: 2–6) times. Patients did not receive radiotherapy at this time. The overall response rate was 86.7%(26/30), with 50.0%(15/30) complete response and36.7%(11/30) partial response. The 3-year overall survival was 46.0% [95% confidence interval(95% CI),28.2%–64.8%], and the 3-year progression-free survival was 43.0%(95% CI, 25.7%–62.0%). Major adverse events were myelosuppression, reduced fibrinogen, liver dysfunction and digestive tract toxicities. No allergic reaction and no treatment-related mortality or severe complications were recorded.Conclusions: Our clinical data and observed outcomes indicate that 1 dose of PEG-ASP can replace multiple doses of native L-ASP in BFM-90, with predominantly grade 3–4 neutropenia for adult LBL, and no therapyrelated deaths. The effect is similar to previous reports of PEG-ASP-containing regimens for adult ALL. Major advantages include less serious allergic reactions, 2–3 weeks of action duration, and convenience for patients and physicians. | Wen Zheng Hanyun Ren Xiaoyan Ke Mei Xue Yongqing Zhang Yan Xie Ningjing Lin Meifeng Tu Weiping Liu Lingyan Ping Zhitao Ying Chen Zhang Lijuan Deng Xiaopei Wang Yuqin Song Jun Zhu | 2017 | Chinese Journal of Cancer Research2017，29，1： | 2 |
| 16 | Crucial control measures to contain China's first Delta variant outbreak显示文摘The SARS-C oV-2 B.1.617.2(Delta) variant flared up in late May in Guangzhou,China.Transmission characteristics of Delta variant were analysed for 153 confirmed cases and two complete transmission chains with seven generations were fully presented.A rapid transmission occurred in five generations within10 days.The basic reproduction number(R_0) was 3.60(95% confidence interval:2.50-5.30).After redefining the concept of close contact,the proportion of confirmed cases discovered from close contacts increased from 43% to 100%.With the usage of a yellow health code,the potential exposed individuals were self-motivated to take a nucleic acid test and regained public access with a negative testing result.Facing the massive requirement of screening,novel facilities like makeshift inflatable laboratories were promptly set up as a vital supplement and 17 cases were found,with 1 pre-symptomatic.The dynamic adjustment of these three interventions resulted in the decline of Rt from 5.00 to 1.00 within 9 days.By breaking the transmission chain and eliminating the transmission source through extending the scope of the close-contact tracing,health-code usage and mass testing,the Guangzhou D elta epidemic was effectively contained. | Lei Luo Zifeng Yang Jingyi Liang Yu Ma Hui Wang Chitin Hon Mei Jiang Zhengshi Lin Wenda Guan Zhitong Mai Yongming Li Kailin Mai Zhiqi Zeng Chuanmeizi Tu Jian Song Bin Liu Yong Liu Jianfeng He Huiyuan Li Bosheng Li Hang Dong Yutian Miao Shujun Fan Lirui Fan Xingyi Liang Ke Li Chun Chen Huihong Deng Zhicong Yang Nanshan Zhong | 2022 | National Science Review2022，9，4： | 2 |
| 17 | China Internet Industry State Analysis and Prosperity Indexes显示文摘With the background of China's fast growing economy, Internet has become a key factor to keep the economy go steadily. It is important to quantitatively analyze the whole Internet industry and hence master its development direction clearly, which will provide regulators with reference for industry analysis, policy formulation, and policy evaluation. This article re-constructs the calculation method of traditional Prosperity Indexes, and builds up a new indicators portfolio for Internet Industry Prosperity Indexes. By calculation, the Internet Industry Coincidence Index value is 105.9. And the Leading Index and Coincidence Index are all within the up-going range, which suggests that China's Internet Industry is likely to remain in its usual fast growing state. | Xiaojie Tu Mingzhu Wang Ke Sun Chunfei Zhang Li Zhang | 2016 | China Communications2016，13，10： | 2 |
| 18 | Kinetic Characteristics of Neutralizing Antibody Responses Vary among Patients with COVID-19显示文摘Objective The coronavirus disease 2019(COVID-19) pandemic continues to present a major challenge to public health. Vaccine development requires an understanding of the kinetics of neutralizing antibody(NAb) responses to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Methods In total, 605 serum samples from 125 COVID-19 patients(from January 1 to March 14, 2020)varying in age, sex, severity of symptoms, and presence of underlying diseases were collected, and antibody titers were measured using a micro-neutralization assay with wild-type SARS-CoV-2.Results NAbs were detectable approximately 10 days post-onset(dpo) of symptoms and peaked at approximately 20 dpo. The NAb levels were slightly higher in young males and severe cases, while no significant difference was observed for the other classifications. In follow-up cases, the NAb titer had increased or stabilized in 18 cases, whereas it had decreased in 26 cases, and in one case NAbs were undetectable at the end of our observation. Although a decreasing trend in NAb titer was observed in many cases, the NAb level was generally still protective.Conclusion We demonstrated that NAb levels vary among all categories of COVID-19 patients. Longterm studies are needed to determine the longevity and protective efficiency of NAbs induced by SARS-CoV-2. | LI Ling Hua TU Hong Wei LIANG Dan WEN Chun Yan LI An An LIN Wei Yin HU Ke Qi HONG Wen Shan LI Yue Ping SU Juan ZHAO San Tao LI Wei YUAN Run Yu ZHOU Ping Ping HU Feng Yu TANG Xiao Ping KE Chang Wen KE Bi Xia CAI Wei Ping | 2021 | Biomedical and Environmental Sciences2021，34，12： | 1 |
| 19 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 20 | Characteristics of Viral Shedding in Respiratory Samples and Specific Antibodies Production in 564 COVID-19 Patients显示文摘Positive nucleic acid(NA)results have been found in recovered and discharged COVID-19 patients,but the proportion is unclear.This study was designed to analyze the recurrent positive rate of NA results after consecutively negative results,and the relationship between the specific antibody production and positive NA rate.According to Strengthening the Reporting of Observational Studies in Epidemiology guidelines,data of inpatients in Sino-French New City Branch of Tongji Hospital between Jan.28 and Mar.6,2020 were collected.A total of 564 COVID-19 patients over 14 years old who received the examinations of NA and antibodies against SARS-CoV-2 were included.Days of viral shedding and specific antibodies were recorded and assessed.Among NA tests in respiratory samples(throat swabs,nasopharyngeal swabs,sputum and flushing fluid in alveoli),the patients with all-negative NA results accounted for 17.20%,those with single-positive results for 46.63%,and those with multiple-positive results for 36.17%respectively.Besides,the recurrent positive NA results after consecutively negative results appeared in 66 patients(11.70%).For multiple-positive patients,median viral shedding duration was 20 days(range:1 to 57 days).Of the 205 patients who received 2 or more antibody tests,141(68.78%)had decreased IgG and IgM concentrations.IgM decreased to normal range in 24 patients,with a median of 44 days from symptom onset.Viral shedding duration was not significantly correlated with gender,age,disease severity,changes in pulmonary imaging,and antibody concentration.It is concluded that antibody level and antibody change had no significant correlation with the positive rate of NA tests and the conversion rate after continuous negative NA tests.In order to reduce the recurrent positive proportion after discharge,3 or more consecutive negative NA test results with test interval more than 24 h every time are suggested for the discharge or release from quarantine. | Jing GONG Hui DONG Ding-kun WANG Fu-er LU Zhao-yi HUANG Ke FANG Wen-ya HUANG Fen YUAN Xing CHEN Qing-song XIA Le-yi MA Fan WU Hao SU Min-min GONG Yue-heng TANG Ke-xin NIE Zhi WANG Sheng-hao TU Ming-min ZHANG Jing-bin LI | 2021 | Current Medical Science2021，41，1： | 1 |
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