|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third-or further-line treatment显示文摘Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and c-MET;therefore,it exhibits both antitumor and anti-angiogenetic activities.A phase III trial has shown that anlotinib improved progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small cell lung cancer(NSCLC),who presented with progressive disease or intolerance after standard chemotherapy.This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment.Methods:Data were collected from March 2015 to January 2017 from a randomized,double-blind,placebo-controlled,multicenter,phase III trial of anlotinib(ALTER0303).A total of 437 patients were enrolled and randomly allocated(2:1)to the anlotinib and placebo groups.Kaplan–Meier analysis and log-rank test were performed to compare PFS and OS.Cox proportional hazards model was adopted for multivariate prognostic analysis.Results:Multivariate analysis indicated that high post-therapeutic peripheral blood granulocyte/lymphocyte ratio and elevated alkaline phosphatase levels were independent risk factors for PFS.Meanwhile,elevated thyroid-stimulating hormone,blood glucose,and triglyceride levels;hypertension;and hand–foot syndrome were independent protective factors of PFS.High posttherapeutic peripheral blood granulocyte/lymphocyte ratio,an Eastern Cooperative Oncology Group(ECOG)score≥2,and the sum of the maximal target lesion length at baseline were independent risk factors of OS,and hypertriglyceridemia was an independent protective factor of OS.Conclusions:This study preliminarily explored the possible factors that affected PFS and OS after anlotinib treatment in patients with advanced refractory NSCLC,and the baseline characteristics of the therapeutically dominant populations were then identified. | Jing Wang Yizhuo Zhao Qiming Wang Li Zhang Jianhua Shi Zhehai Wang Ying Cheng Jianxing He Yuankai Shi Hao Yu Yang Zhao Weiqiang Chen Yi Luo Xiuwen Wang Kejun Nan Faguang Jin Jian Dong Baolan Li Zhujun Liu Baohui Han Kai Li | 2018 | Cancer Biology & Medicine2018，15，4： | 46 |
| 2 | Quasi-equilibrium glide adaptive guidance for hypersonic vehicles显示文摘The entry-glide guidance strategy for hypersonic vehicles that can satisfy both terminal and path constraints is investigated in this paper.We propose a quasi-equilibrium glide adaptive guidance methodology based on the quasi-equilibrium glide condition(QEGC),which innovatively utilizes the quasi-equilibrium glide phenomenon in lifting entry.With the aid of QEGC,both range and terminal velocity can be predicted analytically with high precision.The path constraints are converted into angle of attack constraints,which has been difficult to realize by using traditional predictive guidance methods.The algorithm is independent of the standard trajectory.All the guidance commands,including the bank angle and the angle of attack,are calculated analytically in real time,which endows the algorithm with sufficient adapbility.The results of a CAV-H vehicle guidance test show that the algorithm leads the vehicle along a quasi-equilibrium glide trajectory satisfying both the terminal and path constraints and has sufficient flexibility for occasional mission changes.Furthermore,the robustness of the guidance algorithm under disturbances is validated through a Monte Carlo simulation. | XU MingLiang CHEN KeJun LIU LuHua TANG GuoJian | 2012 | Science China(Technological Sciences)2012，55，3： | 30 |
| 3 | Review of small aspheric glass lens molding technologies显示文摘 | Shaohui YIN Hongpeng JIA Guanhua ZHANG Fengjun CHEN Kejun ZHU | 2017 | Frontiers of Mechanical Engineering2017，12，1： | 9 |
| 4 | Artificial Hair-Like Sensors Inspired from Nature: A Review显示文摘 | Zhiwu Han Linpeng Liu Kejun Wang Honglie Song Daobing Chen Ze Wang Shichao Niu Junqiu Zhang Luquan Ren | 2018 | Journal of Bionic Engineering2018，15，3： | 6 |
| 5 | Effect of Oxygen Concentration and Annealing Theatment on the Optical Properties of the Transparent Conductive CdIn_2O_4 Thin Films显示文摘Transparent conductive cadmium indium oxide films (CdIn2O4) were prepared by r.f. reactive sputtering from Cd-In alloy targets under an Ar-O2 atmosphere. Electrical conductivity of the order of 105Ω-1.m-1 and the optical transmission as high as 94% are easily attained by postdeposition annealing treatment. The effects of oxygen concentration in the reactive gas mixture and post-deposition annealing treatment on the optical transmittance as well as optical parameters, such as refractive index (n), extinction coefficient (k), real part (ε’) and imaginary part (ε') of the dielectric constant, were studied in the visible and near-infrared region. The highfrequency dielectric constant ε∞ the plasma frequency ωP, and the conduction band effective mass mc of different samples were also | Bin WU Changyong CHEN and Shibin ZHANG(Physics Dept., Lanzhou University, Lanzhou 730000, China)Wanlu WANG and Kejun LIAO(Applied Physics Dept., Chongqing University, Chongqing 400044, China) | 1998 | Journal of Materials Science & Technology1998，14，2： | 4 |
| 6 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 7 | First results on ^(76)Ge neutrinoless double beta decay from CDEX-1 experiment显示文摘We report the first results on ^(76)Ge neutrinoless double beta decay from stage one of the China dark-matter experiment(CDEX).A p-type point-contact high-purity germanium detector with a mass of 994 g has been installed to detect neutrinoless double beta decay events, as well as to directly detect dark matter particles. An exposure of 304 kg d has been analyzed over a wide spectral band from 500 keV to 3 MeV. The average event rate obtained was about 0.012 counts per keV per kg per day over the 2.039 MeV energy range. The half-life of ^(76)Ge neutrinoless double beta decay derived based on this result is T^(0ν)1/2>6.4×10^(22) yr(90% C.L.). An upper limit on the effective Majorana-neutrino mass of 5.0 eV has been achieved. | Li Wang Qian Yue KeJun Kang JianPing Cheng YuanJing Li TszKing Henry Wong ShinTed Lin JianPing Chang JingHan Chen QingHao Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He QingJu He JinWei Hu HanXiong Huang TengRui Huang LiPing Jia Hao Jiang HauBin Li Hong Li JianMin Li Jin Li Jun Li Xia Li XueQian Li YuLan Li FongKay Lin ShuKui Liu Hao Ma JingLu Ma XingYu Pan Jie Ren XiChao Ruan ManBin Shen Vivek Sharma Lakhwinder Singh Manoj Kumar Singh Manoj Kumar Singh Arun Kumar Soma ChangJian Tang WeiYou Tang ChaoHsiung Tseng JiMin Wang Qing Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue LiTao Yang SongWei Yang Nan Yi ChunXu Yu HaiJun Yu WeiHe Zeng XiongHui Zeng Zhi Zeng Lan Zhang YunHua Zhang MingGang Zhao Wei Zhao JiFang Zhou ZuYing Zhou JingJun Zhu WeiBin Zhu ZhongHua Zhu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，7： | 3 |
| 8 | BASIC ELECTROLYTIC METHOD FOR RECOVERY OF LEAD FROM SCRAP BATTERIES显示文摘BASICELECTROLYTICMETHODFORRECOVERYOFLEADFROMSCRAPBATTERIES￥ChenWeiping;TianYizhuang;BianKejun;ZhengYue(InstituteforEnvironmen... | Chen Weiping Tian Yizhuang Bian Kejun Zheng Yue(Institute for Environmental Protection,Hunan University,Changsha 410082) | 1996 | 中国有色金属学会会刊:英文版1996，6，4： | 2 |
| 9 | Crack-based and Hair-like Sensors Inspired from Arthropods:A Review显示文摘Over a long period of time,arthropods evolve to have two excellent mechanical sensilla of slit sensilla and trichobothria sensilla,which construct a perfect perception system.The former mainly perceives the change of the in-the-plane force while the latter perceives that of the out-of-plane force.In recent years,these two sensilla have attracted researchers as the models for developing artificial mechanical sensors.This review mainly includes the biomechanics and biomimetic manufacturing techniques as well as their future application value.In order to better understand the advantages of biological strategies,this review describes the morphology,mechanical analysis,and information recognition of slit sensilla and trichobothria sensilla.Then this review highlights the recent development of Crack-based Sensors(CBSs)and Hair-like Sensors(HLSs)based on the analysis of biological mechanism.The manufacturing method and substrate of crack in CBS and those of hair rods in HLS are discussed respectively.Finally,the practical applications and potential value of two sensilla,such as flexible wearable electronic devices,robot sensing system,autopilot sensing and wind tunnel speed detection,are briefly discussed. | Changchao Zhang Junqiu Zhang Daobing Chen Xiancun Meng Linpeng Liu Kejun Wang Zhibin Jiao Tao Sun Dakai Wang Shichao Niu Zhiwu Han Luquan Ren | 2020 | Journal of Bionic Engineering2020，17，5： | 2 |
| 10 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 11 | Effects of pituitary-specific overexpression of FSHα/β on reproductive traits in transgenic boars显示文摘Background: Follicle-stimulating hormone(FSH) is a gonadotropin synthesized and secreted by the pituitary gland.FSH stimulates follicle development and maturation in females. It also plays an important role in spermatogenesis in males, including humans and mice. However, the effects of FSH on male pigs are largely unknown. In this study,we generated transgenic pigs to investigate the effects of FSHα/β overexpression on reproductive traits in boars.Results: After five transgenic F_0 founders were crossed with wide-type pigs, 193 F_1 animals were obtained. Of these,96 were confirmed as transgenic. FSHα and FSHβ m RNAs were detected only in pituitary tissue. Transgenic boars exhibited significantly higher levels of FSHα and FSHβ m RNA, serum FSH, and serum testosterone, compared to ful-sib non-transgenic boars. Significant increases in testis weight, vas deferens diameter, seminiferous tubule diameter,and the number of Leydig cel s were observed, suggesting that the exogenous FSHα/β affects reproductive traits. Final y,transgenic and non-transgenic boars had similar growth performance and biochemical profiles.Conclusions: Pituitary-specific overexpression of FSHα/β genes is likely to impact reproductive traits positively, as indicated by enhancements in serum testosterone level, testis weight, the development of vas deferens, seminiferous tubules, and Leydig cells in transgenic boars. A high level of serum FSH induces secretion of serum testosterone,possibly by boosting the number of Leydig cells, which presumably increases the libido and the frequency of sexual activity in transgenic boars. Our study provides a preliminary foundation for the genetic improvement of reproductive traits in male pigs. | Wenting Li Yujun Quan Mengmeng Zhang Kejun Wang Muzhen Zhu Ye Chen Qiuyan Li Keliang Wu | 2018 | Journal of Animal Science and Biotechnology2018，9，1： | 1 |
| 12 | Fine Structure of Scorpion Pectines for Odor Capture显示文摘 | Zhiwu Han Daobing Chen Ka Zhang Honglie Song Kejun Wang Shichao Niu Junqiu Zhang Luquan Ren | 2017 | Journal of Bionic Engineering2017，14，4： | 1 |
| 13 | Pressure-induced robust emission in a zero-dimensional hybrid metal halide (C_(9)NH_(20))_(6)Pb_(3)Br_(12)显示文摘Zero-dimensional(0D)hybrid metal halides are under intensive investigation owing to their unique physical properties,such as the broadband emission from highly localized excitons that is promising for white-emitting lighting.However,fundamental understanding of emission variations and structure–property relationships is still limited.Here,by using pressure processing,we obtain robust exciton emission in 0D(C_(9)NH_(20))_(6)Pb_(3)Br_(12) at room temperature that can survive to 80 GPa,the recorded highest value among all the hybrid metal halides.In situ experimental characterization and first-principles calculations reveal that the pressure-induced emission is mainly caused by the largely suppressed phonon-assisted nonradiative pathway.Lattice compression leads to phonon hardening,which considerably weakens the exciton–phonon interaction and thus enhances the emission.The robust emission is attributed to the unique structure of separated spring-like[Pb_(3)Br_(12)]^(6−)trimers,which leads to the outstanding stability of the optically active inorganic units.Our findings not only reveal abnormally robust emission in a 0D metal halide,but also provide new insight into the design and optimization of local structures of trimers and oligomers in lowdimensional hybrid materials. | Mengting Chen Songhao Guo Kejun Bu Sujin Lee Hui Luo Yiming Wang Bingyan Liu Zhipeng Yan Hongliang Dong Wenge Yang Biwu Ma Xujie Lü | 2021 | Matter and Radiation at Extremes2021，6，5： | 1 |
| 14 | Synergistic Effect and Electrochromic Mechanism of Nanoflake Li-doped NiO in LiOH Electrolyte显示文摘Inorganic metal oxide electrochromic materials have good application prospects for energy-saving windows in buildings and smart display applications.Therefore,the development of electrochromic films with good cycling stabilities,fast color-change response times,and high coloring efficiencies has attracted considerable attention.In this study,nanoflake Li-doped NiO electrochromic films were prepared using a hydrothermal method,and the films exhibited superior electrochromic performances in the LiOH electrolyte.Li^(+)ions doping increased the ion transmission rates of the NiO films,and effectively promoted the transportation of ions from the electrolyte into NiO films.Meanwhile,the nanoflake microstructure caused the NiO films to have larger specific surface areas,providing more active sites for electrochemical reactions.It was determined that the NiO-Li20%film exhibited an ultra-fast response in the LiOH electrolyte(coloring and bleaching times reached 3 and 1.5 s,respectively).Additionally,the coloration efficiency was 62.1 cm^(2)C^(−1),and good cycling stability was maintained beyond 1500 cycles.Finally,the simulation calculation results showed that Li doping weakened the adsorption strengths of the NiO films to OH^(−),which reduced the generation and decomposition of NiOOH and helped to improve the cycling stabilities of the films.Therefore,the research presented in this article provides a strategy for designing electrochromic materials in the future. | Kejun Xu Liuying Wang Gu Liu Chaoqun Ge Long Wang Weichao Wang Mengzhou Chen | 2023 | Energy & Environmental Materials2023，6，3： | 1 |
| 15 | Recent advances in the utilization of copper sulfide compounds for electrochemical CO2 reduction显示文摘Converting carbon dioxide(CO2)into value-added chemicals by CO2 reduction has been considered as a potential way to solve the current energy crisis and environmental problem.Among the methods of CO2 reduction,the electrochemical method has been widely used due to its mild reaction condition and high reaction efficiency.In the electrochemical reduction system,the CO2 electrocatalyst is the most important part.Although many CO2 electrocatalysts have been developed,efficient catalysts with high activity,selectivity and stability are still lacking.Copper sulfide compound,as a low-toxicity and emerging material,has broad prospects in the field of CO2 reduction due to its unique structural and electrochemical properties.Much progress has been achieved with copper sulfide nanocrystalline and the field is rapidly developing.This paper summarizes the preparation,recent progress in development,and factors affecting the electrocatalytic CO2 reduction performance with copper sulfide compound as a catalyst.Prospects for future development are also outlined,with the aim of using copper sulfide compound as a highly active and stable electrocatalyst for CO2 reduction. | Yingkang Chen Kejun Chen Junwei Fu Akira Yamaguchi Hongmei Li Hao Pan Junhua Hu Masahiro Miyauchi Min Liu | 2020 | Nano Materials Science2020，2，3： | 1 |
| 16 | On the existence of Skew Room flames of type l^u显示文摘 | Chen Kejun Zhu Lie | 1996 | Ars Combinatoria1996，43，： | 1 |
| 17 | Electrochemical investigation on the interaction of benzene sulfonyl 5-fluorouracil derivatives with double-stranded DNA and G-quadruplex DNA显示文摘The interaction of double-stranded(ds) and G-quadruplex(G4) DNA with sulfonyl 5-fluorouracil derivatives(5-fluoro-1-(arylsulfonyl) pyrimidine-2,4(1H,3H)-diones) was investigated in this research,in which Au electrodes modified with ds-DNA or G4-DNAs were used as a working electrode.The investigation showed that the binding affinity with G4-DNA was significantly increased when 5-fluorouracil(5-FU) was modified with arylsulfonyl groups.The presence of strong electron-withdrawing groups on benzene sulfonyl 5-FU greatly enhanced the binding selectivity(k G4-DNA /k ds-DNA).Such results provided new insights into the potential connections between the chemical structure of drug candidates and their anticancer activities. | HU Quan ZHANG KeJun JIN HuiLe CHEN XiAn HU MaoLin WANG Shun | 2012 | Science China Chemistry2012，55，7： | 1 |
| 18 | Are China's Nationally Determined Contributions(NDCs) so bad?显示文摘A recent article by Robiou du Pont and Meinshausen [1](hereafter RM2018) declared that when taken as benchmark by other countries, the Nationally Determined Contributions (NDCs) of India, the EU, the USA and China lead to 2.6, 3.2, 4 and over 5.1 °C warmings. RM2018 was quickly referred in media that China's NDC is 'one of the worst to contribute to the global effort to reach the targets under Paris Agreement”. | Kejun Jiang Chenmin He Chenfei Qu Chunyan Dai Yifei Zhang Sha Chen Pianpian Xiang | 2019 | Science Bulletin2019，64，6： | 1 |
| 19 | The FDK algorithm with an expanded definition domain for cone-beam reconstruction preserving oblique line integrals 显示文摘 | LI Liang KANG Kejun CHEN Zhiqiang | 2006 | J X Ray Sci Tech2006，14，4： | 1 |
| 20 | Micro/nano-scale Characterization and Fatigue Fracture Resistance of Mechanoreceptor with Crack-shaped Slit Arrays in Scorpion显示文摘The nocturnal scorpion Heterometrus petersii uses Basitarsal Compound Slit Sensilla (BCSS) as mechanoreceptor to detect mechanical signal (e.g. substrate vibration, cyclic loads caused by walking) without fatigue failure such as initiation of fatigue crack and further propagation of crack-shaped slit. The outstanding perceptive function has been discovered for over half a century. However, it is not yet clear about the microstructure, material composition and micromechanical property which are all important factors that determine the fatigue fracture resistance of the BCSS. Here, the microscopic characteristics of the BCSS were thoroughly studied. The results dicate that anti-fatigue resilin and stiff chitinous cuticle form multilayered composite as the main body of the BCSS. Meanwhile, the pre-existing slit as mechanosensory structure is covered by cuticular membrane which has different mechanical property with the epicuticle. Theoretical analysis shows that the structure-composition-property synergistic relations of composites confer on the BCSS with extreme fatigue fracture tolerance. | Kejun Wang Junqiu Zhang Yuqiang Fang Daobing Chen Linpeng Liu Zhiwu Han Luquan Ren | 2019 | Journal of Bionic Engineering2019，16，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员