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| 1 | Geomatics for smart cities-concept,key techniques,and applications显示文摘The progressive transition from digital to smart cities has become a reality in recent years.Studies on the fundamental concept of smart cities,along with their supporting techniques,have attracted unprecedented attention.This study first discusses the concept of smart cities,where it is pointed out that the real city and the digital city can be integrated into a smart city by using ubiquitous sensor networks(USN)or the Internet of Things.More intelligent services for city management and public services can be provided in smart cities through massive and complex calculation,analysis,and data mining on cloud computing platforms.A smart city’s representative characteristics are summarized here to demonstrate that smart cities are superior for offering technical securities and intelligent services.Smart municipal supervision,smart transportation,smart environment monitoring,and smart tourism are used as examples to support the discussion. | LI Deren SHAN Jie SHAO Zhenfeng ZHOU Xiran YAO Yuan | 2013 | Geo-Spatial Information Science2013，16，1： | 22 |
| 2 | Biological drug and drug delivery-mediated immunotherapy显示文摘The initiation and development of major infammatory diseases,i.e.,cancer,vascular infammation,and some autoimmune diseases are closely linked to the immune system.Biologics-based immunotherapy is exerting a critical role against these diseases,whereas the usage of the immunomodulators is always limited by various factors such as susceptibility to digestion by enzymes in vivo,poor penetration across biological barriers,and rapid clearance by the reticuloendothelial system.Drug delivery strategies are potent to promote their delivery.Herein,we reviewed the potential targets for immunotherapy against the major infammatory diseases,discussed the biologics and drug delivery systems involved in the immunotherapy,particularly highlighted the approved therapy tactics,and finally offer perspectives in this feld. | Qingqing Xiao Xiaotong Li Yi Li Zhenfeng Wu Chenjie Xu Zhongjian Chen Wei He | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 15 |
| 3 | The new era for geo-information显示文摘Along with the forthcoming of Google Earth,Virtual Earth,the next generation of Internet,Web 2.0,grid computing and smart sensor web,comes the new era for geo-information. In this paper,main features of new geo-information era are discussed. This new era is characterized by these features:serviced users are extended from professionals to all public users,the users are data and information providers as well,geospatial data provided are no longer measurement-by-specification but measurement-on-demand through smart sensor web,and services are transferred from being data-driven to application-driven. Such problems as out-of-order issues in geographic data collection and information proliferation,quality issues in geographic information updating,security issues in geographic information services,privacy issues in sharing geographic information and property issues in sharing geographic information,which are brought about by new geo-information era,especially those confronted in geo-information science and geo-spatial information industry,are analyzed. Then strategies concerning standards,planning,laws,technology and applications are proposed. | LI DeRen SHAO ZhenFeng | 2009 | Science in China(Series F)2009，52，7： | 11 |
| 4 | Image City sharing platform and its typical applications显示文摘In this paper,the trend of urban spatial information sharing service from the electronic map to image is analyzed and its sharing framework based on service-oriented architecture is designed.Moreover,the service implementation,feedback data service procedure and its processing service model are explored. Based on the software with independent intellectual property rights,image city of Taizhou is developed as an example to realize various image data and processing servicesLastly,the bright future prospects of image city are described. | SHAO ZhenFeng Li DeRen | 2011 | Science China(Information Sciences)2011，54，8： | 11 |
| 5 | From digital Earth to smart Earth显示文摘This article will analyze the achievements of the digital Earth concept and further introduce two key technologies,the internet of things and cloud computing.Both these technologies are accelerating the development of digital Earth toward a new concept—smart Earth.The objective of this article is to discuss the architecture,infrastructure,and typical applications for smart Earth and to elaborate on trends of the movement from digital Earth to smart Earth. | Deren Li Yuan Yao Zhenfeng Shao Le Wang | 2014 | Chinese Science Bulletin2014，59，8： | 9 |
| 6 | Geology and hydrocarbon accumulations in the deepwater of the northwestern South China Sea——with focus on natural gas显示文摘The deepwater of the northwestern South China Sea is located in the central to southern parts of the Qiongdongnan Basin(QDN Basin),which is a key site for hydrocarbon exploration in recent years.In this study,the authors did a comprehensive analysis of gravity-magnetic data,extensive 3D seismic survey,cores and cuttings,paleontology and geochemical indexes,proposed the mechanism of natural gas origin,identified different oil and gas systems,and established the model of hydrocarbon accumulations in the deep-water region.Our basin tectonic simulation indicates that the evolution of QDN Basin was controlled by multiple-phased tectonic movements,such as Indochina-Eurasian Plate collision,Tibetan Uplift,Red River faulting and the expansion of the South China Sea which is characterized by Paleogene rifting,Neogene depression,and Eocene intensive faulting and lacustrine deposits.The drilling results show that this region is dominated by marineterrestrial transitional and neritic-bathyal facies from the early Oligocene.The Yacheng Formation of the early Oligocene is rich in organic matter and a main gas-source rock.According to the geological-geochemical data from the latest drilling wells,Lingshui,Baodao,Changchang Sags have good hydrocarbon-generating potentials,where two plays from the Paleogene and Neogene reservoirs were developed.Those reservoirs occur in central canyon structural-lithologic trap zone,Changchang marginal trap zone and southern fault terrace of Baodao Sag.Among them,the central canyon trap zone has a great potential for exploration because the various reservoirforming elements are well developed,i.e.,good coal-measure source rocks,sufficient reservoirs from the Neogene turbidity sandstone and submarine fan,faults connecting source rock and reservoirs,effective vertical migration,late stage aggregation and favorable structural–lithological composite trapping.These study results provide an important scientific basis for hydrocarbon exploration in this region,evidenced by the recent discovery of the significant commercial LS-A gas field in the central canyon of the Lingshui Sag. | WANG Zhenfeng SUN Zhipeng ZHANG Daojun ZHU Jitian LI Xushen HUANG Baojia GUO Minggang JIANG Rufeng | 2015 | Acta Oceanologica Sinica2015，34，10： | 9 |
| 7 | Geochemistry of Pore Water and Associated Diagenetic Reactions in the Diapiric Area of Yinggehai Basin, Northwestern South China Sea显示文摘这研究在 Yinggehai 盆的 diapiric 区域检验了毛孔水的 geochemical 特征,西北的华南海,并且照亮了盆液体的起源和进化。甚至没有大气的水渗入,有低咸度的毛孔水在 diapiric 区域发生在海洋的沉积。在内的低咸度的水的存在深, overpressured 分隔空间被假定由于 smectite-illite 转变。Howerver 在有正常压力的 diapiric 区域的浅部分(不到 2 000 m ) ,毛孔水在 overpressured 间隔比那有一个宽得多的变化和低得多的咸度。它的全部的溶解固体(TDS ) 内容是 5 336 ~ 35 939 mg/L。而且,当 kaolinite 和 illite 在更浅的间隔满足增加,绿土和绿泥石内容严厉地减少。在 diapiric 结构的毛孔水的 geochemical 变化显示逐出低咸度,沿着垂直差错的 overpressured 液体。从深 overpressured 沉积的热液体的强壮的注射在浅水库导致快速的泥土矿物质转变。因而,从更深的 overpressured 沉积物由于液体逐出混合的液体象一些 diagenetic 反应一样在咸度和离子的作文导致变化。这包括更深热的液体的更高的 temperatur 引起的泥土矿物质的转变,例如,到 illite 的绿土和到 kaolinite 的绿泥石的 transfromation。因此,在咸度的变化和在各种各样的迫使的系统的离子的作文提供线索给流动小径和联系 diagenetic 反应。 | Tao Jiang Xinong Xie Hui Chen Zhenfeng Wang Xushen Li | 2015 | Journal of Earth Science2015，26，3： | 6 |
| 8 | Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling显示文摘室的肥大是心血管的疾病的事件的一个强大、独立的预言者。低剂量的乙酰水杨酸酸(阿司匹林) 的脉管的性质通过血小板 cyclooxygenase 的不可逆的抑制提供心血管的好处 1;然而,可能的 anti-hypertrophic 性质和阿司匹林的潜在的机制没详细被调查。在这研究,健康野类型的雄的老鼠随机被划分成三个组并且使遭到了到横向的大动脉的收缩(TAC ) 或假冒的操作。操作 TAC 的老鼠与低剂量的阿司匹林的人的等价物被对待(10 mg 吗? | Samuel Chege Gitau Xuelian Li Dandan Zhao Zhenfeng Guo Haihai Liang Ming Qian Lifang Lv Tianshi Li Bozhi Xu Zhiguo Wang Yong Zhang Chaoqian Xu Yanjie Lu Zhiming Du Hongli Shan Baofeng Yang | 2015 | Frontiers of Medicine2015，9，4： | 6 |
| 9 | Study of Longitudinal-Vertical Dynamics for In-Wheel Motor-Driven Electric Vehicles显示文摘The in-wheel motor(IWM)-driven electric vehicles(EVs)attract increasing attention due to their advantages in dimensions and controllability.The majority of the current studies on IWM are carried out with the assumption of an ideal actuator,in which the coupling effects between the non-ideal IWM and vehicle are ignored.This paper uses the braking process as an example to investigate the longitudinal-vertical dynamics of IWM-driven EVs while considering the mechanical-electrical coupling effect.First,a nonlinear switched reluctance motor model is developed,and the unbalanced electric magnetic force(UEMF)induced by static and dynamic mixed eccentricity is analyzed.Then,the UEMF is decomposed into longitudinal and vertical directions and included in the longitudinal-vertical vehicle dynamics.The coupling dynamics are demonstrated under different vehicle braking scenarios;numerical simulations are carried out for various road grades,road friction,and vehicle velocities.A novel dynamics vibration absorbing system is adopted to improve the vehicle dynamics.Finally,the simulation results show that vehicle vertical dynamic performance is enhanced. | Yechen Qin Ze Zhao Zhenfeng Wang Guofa Li | 2021 | Automotive Innovation2021，4，2： | 5 |
| 10 | A multi-scale and multi-orientation image retrieval method based on rotation-invariant texture features显示文摘Texture retrieval is a vital branch of content-based image retrieval.Rotation-invariant texture retrieval plays a key role in texture retrieval.This paper addresses three major issues in rotation-invariant texture retrieval: how to select the texture measurement methods,how to alleviate the influence of rotation for texture retrieval and how to apply the proper multi-scale analysis theory for texture images.First,the spectrum influence between a Radon transform and a Log-polar transform was compared after the rotation effect was eliminated.The average retrieval performance of wavelet and NSCT with different retrieval parameters was also evaluated.Based on such analysis,we developed a multi-scale and multi-orientation texture transform spectrum,as well as a rotation-invariant feature vector and its measurement criteria,which can represent the human visual perception sensitive to texture energy.Then a new rotation-invariant texture retrieval algorithm was proposed.The algorithm was developed based on non-parametric statistical features and it applies low band and high frequency directional bands of NSCT coefficients for coarse filtering and fine retrieval,respectively.Experiments on the Brodatz image database show that the constructed rotation-invariant feature vector is appropriate for capturing major orientations and describing detail information.Besides,the combination of the two-step progressive retrieval strategy and multi-scale analysis method can effectively improve retrieval efficiency while ensuring a high precision compared with traditional algorithms. | SHAO ZhenFeng LI DeRen ZHU XianQiang | 2011 | Science China(Information Sciences)2011，54，4： | 4 |
| 11 | Hypertrophic adenoids in patients with nasopharyngeal carcinoma:appearance at magnetic resonance imaging before and after treatment显示文摘Introduction:Patients with nasopharyngeal carcinoma(NPC) sporadically develop abnormal adenoids.Nasopharyngeal adenoids are usually included in the gross tumor volume(GTV) but may have different therapeutic responses than tumor tissue.Therefore,distinguishing adenoids from tumor tissue may be required for precise and efficient chemoradiotherapy and radiotherapy.We characterized nasopharyngeal adenoids and investigated the therapeutic responses of NPC and nasopharyngeal adenoids using magnetic resonance imaging(MRI).Methods:MRI data from 40 NPC patients with a coexisting adenoid mass before and after treatment were analyzed.The features of the adenoid masses,including location,striped appearance,size,interface,symmetry/asymmetry,and cysts,were evaluated.Treatment response were scored according to the World Health Organization guidelines.Results:A striped appearance was observed in 36 cases before treatment and in all cases after treatment.In these 36 cases,the average GTVs including and excluding the uninvolved adenoids were 19.8 cm^3 and 14.8 cm^3,respectively.The average percentage change after excluding the uninvolved adenoids from the GTV was 31.0%.Stable disease in the adenoids was identified in 27(96.4%) of 28 patients after neoadjuvant chemotherapy,while NPC clearly regressed.Partial adenoid responses were identified in 33(82.5%) of 40 patients at 3 months after chemoradiotherapy or radiotherapy,whereas complete tumor responses were achieved in all patients.Six months after treatment,the adenoids continued to atrophy but did not disappear,and tumor recurrence was not found.Conclusions:Nasopharyngeal adenoids and carcinoma tissue in NPC patients can be distinguished by using MRI and have different responses to chemoradiotherapy and radiotherapy.These findings contribute to better delineating the GTV of NPC,based on which spatially optimized strategies can be developed to render precise and efficient chemoradiotherapy and radiotherapy.Additionally,we observed a clear difference in the responses of these two tissue types to current therapies.This finding may reduce or avoid unnecessary biopsies or overtreatment. | Yao-Pan Wu Pei-Qiang Cai Li Tian Jie-Hua Xu Richard Alan Mitteer Jr Yi Fan Zhenfeng Zhang | 2015 | Chinese Journal of Cancer2015，34，3： | 4 |
| 12 | Nonlinear relationship between enteric-coated mycophenolate sodium dose and mycophenolic acid exposure in Han kidney transplantation recipients显示文摘The aim of the research was to investigate the pharmacokinetics(PK) of enteric-coated mycophenolate sodium(EC-MPS) by quantification of the active metabolite of mycophenolic acid(MPA)after multiple escalating oral doses in Han kidney transplant recipients. A total of 28 Han postoperative kidney transplant recipients were given a multiple-dose of 540, 720 or 900 mg of EC-MPS two times a day in combination with tacrolimus for 6 days. Blood specimens were collected at each time point from0 to 12 h after EC-MPS administration. MPA plasma concentrations were measured by UPLC–UV. The relationship between the EC-MPS dose and its PK parameters was assessed. In the range from 540 to900 mg, C_(max) and AUC_(0–12h) did not increase with dose escalation. The AUC_(0–12h), C_(max), C_0 and T_(max) for the 540 720 and 900 mg doses were not significantly different, respectively(P 40.05). AUC_0–12 h and C_(max) were increased less than proportionally with increasing EC-MPS dose levels. Inter-individual variability in AUC_(0–12h), C_(max) and C_0 were considerable. Nonlinear PK relationships were found from the doses of 540–900 mg of EC-MPS. | Jun Zhang Mengmeng Jia Lihua Zuo Na Li Yonggang Luo Zhi Sun Xiaojian Zhang Zhenfeng Zhu | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 3 |
| 13 | Changes in progenitors and differentiated epithelial cells of neonatal piglets显示文摘This study aimed to assess the changes of small intestinal morphology,progenitors,differentiated epithelial cells,and potential mechanisms in neonatal piglets.Hematoxylin and eosin staining of samples from 36 piglets suggested that dramatic changes were observed in the jejunum crypts depth and crypt fission index of neonatal piglets(P<0.001).The number of intestinal stem cells(ISC)tended to increase(P<0.10),and a decreased number of enteroendocrine cells appeared in the jejunal crypt on d 7(P<0.05).Furthermore,the mRNA expression of jejunal chromogranin A(ChgA)was down-regulated in d 7 piglets(P<0.05).There was an up-regulation of the adult ISC marker gene of SPARC related modular calcium binding 2(Smoc2),and Wnt/b-catenin target genes on d 7(P<0.05).These results were further verified in vitro enteroid culture experiments.A mass of hollow spheroids was cultured from the fetal intestine of 0-d-old piglets(P<0.001),whereas substantial organoids with budding and branching structures were cultured from the intestine of 7-d-old piglets(P<0.001).The difference was reflected by the organoid budding efficiency,crypt domains per organoid,and the surface area of the organoid.Furthermore,spheroids on d 0 had more Ki67-positive cells and enteroendocrine cells(P<0.05)and showed a decreasing trend in the ISC and goblet cells(P<0.10).Moreover,the mRNA expression of spheroids differed markedly from that of organoids,with low expression of intestinal differentiation gene(Lysozyme;P<0.05),epithelial-specific markers(Villin,E-cadherin;P<0.05),and adult ISC markers(leucine-rich repeat-containing G protein-coupled receptor 5[Lgr5],Smoc2;P<0.001),and upregulation of fetal marker(connexin 43[Cnx43];P<0.05).The mRNA expression of relevant genes was up-regulated,and involved in Wnt/b-catenin,epidermal growth factor(EGF),Notch,and bone morphogenetic protein(BMP)signaling on d 7 organoids(P<0.05).Spheroids displayed low differentiated phenotype and high proliferation,while organoids exhibited strong differentiation potential.These results indicated that the conversion from the fetal progenitors(spheroids)to adult ISC(normal organoids)might largely be responsible for the fast development of intestinal epithelial cells in neonatal piglets. | Lanmei Yin Jun Li Yitong Zhang Qing Yang Cuiyan Yang Zhenfeng Yi Yuebang Yin Qiye Wang Jianzhong Li Nengshui Ding Zhigang Zhang Huansheng Yang Yulong Yin | 2022 | Animal Nutrition2022，，1： | 3 |
| 14 | Subtyping of type A influenza by sequencing the variable regions of HA gene specifically amplified with RT-PCR显示文摘The outbreak of a novel influenza A(H1N1) virus across the globe poses a threat to human health.It is of paramount importance to develop a rapid,reliable and inexpensive diagnostic procedure.Based on the bioinformatic information from public database,primers specific for influenza A virus surface protein haemagglutinin(HA) of several subtypes(including H1,H2,H3,H5,H7 and H9) were designed.Primer-specific PCR products were subjected to sequencing for accurately distinguishing H1 and H3 subtypes from others.This sequencing-based detection method will not only be applied to rapid detection and simultaneous subtype identification of new influenza A virus H1N1,but also provide the strategies to monitor other new types ofinfluenza virus with explosive potential. | YAN An DING GuoHui ZHOU ZhenFeng DONG Hui ZHANG YaKun ZHU Lei HE YunGang ZHANG GuoQing LI YiXue SUN Bing HUANG Zhong LAN Ke JIN Li WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang DAI JianXin GUO YaJun WANG Hao CHE XiaoYan WU Fan YUAN ZhenGan ZHANG Xi CAO ZhiWei ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi ZHAO GuoPing JIN WeiRong XIONG Hui | 2009 | Chinese Science Bulletin2009，54，13： | 3 |
| 15 | The development of real time data driving multi-axis linkage and synergic movement control system of 3D variable cross-section roll forming machine显示文摘The three dimensional variable cross-section roll forming is a kind of new metal forming technology which combines large forming force,multi-axis linkage movement and space synergic movement,and the sequential synergic movement of the ganged roller group is used to complete the metal sheet forming according to the shape of the complicated and variable forming part data.The control system should meet the demands of quick response to the test requirements of the product part.A new kind of real time data driving multi-axis linkage and synergic movement control strategy of 3D roll forming is put forward in the paper.In the new control strategy,the forming data are automatically generated according to the shape of the parts,and the multi-axis linkage movement together with cooperative motion among the six stands of the 3D roll forming machine is driven by the real-time information,and the control nodes are also driven by the forming data.The new control strategy is applied to a 48axis 3D roll forming machine developed by our research center,and the control servo period is less than 10ms.A forming experiment of variable cross section part is carried out,and the forming precision is better than±0.5mm by the control strategy.The result of the experiment proves that the control strategy has significant potentiality for the development of 3D roll forming production line with large scale,multi-axis ganged and synergic movement. | 管延智 Li Qiang Wang Haibo Yang Zhenfeng Zheng Yuting | 2013 | High Technology Letters2013，19，3： | 2 |
| 16 | Spatio-temporal-spectral-angular observation model that integrates observations from UAV and mobile mapping vehicle for better urban mapping显示文摘In a complex urban scene,observation from a single sensor unavoidably leads to voids in observations,failing to describe urban objects in a comprehensive manner.In this paper,we propose a spatio-temporal-spectral-angular observation model to integrate observations from UAV and mobile mapping vehicle platform,realizing a joint,coordinated observation operation from both air and ground.We develop a multi-source remote sensing data acquisition system to effectively acquire multi-angle data of complex urban scenes.Multi-source data fusion solves the missing data problem caused by occlusion and achieves accurate,rapid,and complete collection of holographic spatial and temporal information in complex urban scenes.We carried out an experiment on Baisha Town,Chongqing,China and obtained multi-sensor,multi-angle data from UAV and mobile mapping vehicle.We first extracted the point cloud from UAV and then integrated the UAV and mobile mapping vehicle point cloud.The inte-grated results combined both the characteristics of UAV and mobile mapping vehicle point cloud,confirming the practicability of the proposed joint data acquisition platform and the effectiveness of spatio-temporal-spectral-angular observation model.Compared with the observation from UAV or mobile mapping vehicle alone,the integrated system provides an effective data acquisition solution toward comprehensive urban monitoring. | Zhenfeng Shao Gui Cheng Deren Li Xiao Huang Zhipeng Lu Jian Liu | 2021 | Geo-Spatial Information Science2021，24，4： | 2 |
| 17 | Metal phenolic network-stabilized nanocrystals of andrographolide to alleviate macrophage-mediated inflammation in-vitro显示文摘Macrophages play a crucial role in initiating,maintaining,and resolving inflammation through the phenotypic shift,inducing or inhibiting the production of inflammatory cytokines.Therefore,macrophages are potential targets for treating inflammatory diseases.Andrographolide(AND)is a potent anti-inflammatory drug that can reduce pro-inflammatory cytokines and suppress NF-κB/MAPK pathway in activated macrophages.Although AND has many medicinal properties,its lower water solubility and first-pass effect in the liver have hindered its clinical application.In this context,by using a metal phenolic network as a stabilizer,we designed and prepared highly stabilized AND nanocrystals(AND-MPN Ns)with high drug loading capacity to facilitate the clinical application of AND.Our findings showed that AND-MPN Ns could be used to enhance the anti-inflammation in-vitro via macrophage polarization,reducing proinflammatory cytokines IL-6 and TNF-α,and suppressing the NF-κB signaling pathway activation.The results demonstrated the potential of AND-MPN Ns to combat inflammatory diseases effectively. | Kosheli Thapa Magar George Frimpong Boafo Makhloufi Zoulikha Xiaohong Jiang Xiaotong Li Qingqing Xiao Xuyang Xing Xiaochun Wang Lifang Fan Zhenfeng Wu Wei He | 2023 | Chinese Chemical Letters2023，34，1： | 2 |
| 18 | Archaeal chromatin proteins显示文摘Archaea, along with Bacteria and Eukarya, are the three domains of life. In all living cells, chromatin proteins serve a crucial role in maintaining the integrity of the structure and function of the genome. An array of small, abundant and basic DNA-binding proteins, considered candidates for chromatin proteins, has been isolated from the Euryarchaeota and the Crenarchaeota, the two major phyla in Archaea. While most euryarchaea encode proteins resembling eukaryotic histones, crenarchaea appear to synthesize a number of unique DNA-binding proteins likely involved in chromosomal organization. Several of these proteins (e.g., archaeal histones, Sac10b homologs, Sul7d, Cren7, CC1, etc.) have been extensively studied. However, whether they are chromatin proteins and how they function in vivo remain to be fully understood. Future investiga- tion of archaeal chromatin proteins will lead to a better understanding of chromosomal organization and gene expression in Archaea and provide valuable information on the evolution of DNA packaging in cellular life. | ZHANG ZhenFeng GUO Li HUANG Li | 2012 | Science China(Life Sciences)2012，55，5： | 2 |
| 19 | Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma显示文摘我们以前在 hepatocellular 癌(HCC ) 识别了体的拷贝数字改变(CNA ) 的 1 241 个区域。在现在的学习,我们发现那新奇周期性的焦点的 amplicon, 1q24.1-24.2,在 HCC 指向 MPZL1 基因。尤其是,在 MPZL1 和 HCC 标本的 intrahepatic 转移的表示层次之间有积极关联。MPZL1 能显著地提高 HCC 房间的迁移、变形的潜力。而且,我们发现 MPZL1 由支持 HCC 房间移植的机制之一由导致支持 metastatic 蛋白质的 phosphorylation 和激活, cortactin。另外,我们发现 Src kinase 调停 cortactin 的 phosphorylation 和激活由 MPZL1 overexpression 导致了。一起拿,这些调查结果建议 MPZL1 是拷贝数字扩大的一个周期性的区域在 HCC 目标为 1q24.1-24.2 的新奇支持 metastatic 基因。 | Deshui Jia Ying Jing Zhenfeng Zhang Li Liu Jie Ding Fangyu Zhao Chao Ge Qifeng Wang Taoyang Chen Ming Yao Jinjun Li Jianren Gu Xianghuo He | 2014 | Cell Research2014，24，2： | 2 |
| 20 | Self-powered electrochemical system by combining Fenton reaction and active chlorine geheration for organic contaminant treatment显示文摘Environmental deterioration,especially water pollution,is widely dispersed and could affect the quality of people's life at large.Though the sewage treatment plants are constructed to meet the demands of cities,distributed treatment units are still in request for the supplementary of centralized purification beyond the range of plants.Electrochemical degradation can reduce organic pollution to some degree,but it has to be powered.Triboelectric nanogenerator(TENG)is a newly-invented technology for low-frequency mechanical energy harvesting.Here,by integrating a rotary TENG(R-TENG)as electric power source with an electrochemical cell containing a modified graphite felt cathode for hydrogen peroxide(H2O2)along with hydroxyl radical(·OH)generation by Fenton reaction and a platinum sheet anode for active chlorine generation,a self-powered electrochemical system(SPECS)was constructed.Under the driven of mechanical energy or wind flow,such SPECS can efficiently degrade dyes after power management in neutral condition without any O2 aeration.This work not only provides a guideline for optimizing self-powered electrochemical reaction,but also displays a strategy based on the conversion from distributed mechanical energy to chemical energy for environmental remediation. | Yawei Feng Kai Han Tao Jiang Zhenfeng Bian Xi Liang Xia Cao Hexing Li Zhong Lin Wang | 2019 | Nano Research2019，12，11： | 2 |
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