|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cloning of a gene-edited macaque monkey by somatic cell nuclear transfer显示文摘Cloning of macaque monkeys by somatic cell nucleus transfer(SCNT) allows the generation of monkeys with uniform genetic backgrounds that are useful for the development of non-human primate models of human diseases. Here, we report the feasibility of this approach by SCNT of fibroblasts from a macaque monkey(Macaca fascicularis), in which a core circadian transcription factor BMAL1 was knocked out by clustered regularly interspaced short palindromic repeat/Cas9 gene editing(see accompanying paper).Out of 325 SCNT embryos transferred into 65 surrogate monkeys, we cloned five macaque monkeys with BMAL1 mutations in both alleles without mosaicism, with nuclear genes identical to that of the fibroblast donor monkey. Further peripheral blood m RNA analysis confirmed the complete absence of the wild-type BMAL1 transcript. This study demonstrates that the SCNT approach could be used to generate cloned monkeys from fibroblasts of a young adult monkeys and paves the way for the development of macaque monkey disease models with uniform genetic backgrounds. | Zhen Liu Yijun Cai Zhaodi Liao Yuting Xu Yan Wang Zhanyang Wang Xiaoyu Jiang Yuzhuo Li Yong Lu Yanhong Nie Xiaotong Zhang Chunyang Li Xinyan Bian Mu-ming Poo Hung-Chun Chang Qiang Sun | 2019 | National Science Review2019，6，1： | 14 |
| 2 | Preparation of Fe–Co based MOF-74 and its effective adsorption of arsenic from aqueous solution显示文摘To obtain a cost-effective adsorbent for the removal of arsenic in water,a novel nanostructured Fe–Co based metal organic framework(MOF-74)adsorbent was successfully prepared via a simple solvothermal method.The adsorption experiments showed that the optimal molar ratio of Fe/Co in the adsorbent was 2:1.The Fe_2Co_1MOF-74 was characterized by various techniques and the results showed that the nanoparticle diameter ranged from60 to 80 nm and the specific surface area was 147.82 m^2/g.The isotherm and kinetic parameters of arsenic removal on Fe_2Co_1MOF-74 were well-fitted by the Langmuir and pseudo-second-order models.The maximum adsorption capacities toward As(III)and As(V)were 266.52 and 292.29 mg/g,respectively.The presence of sulfate,carbonate and humic acid had no obvious effect on arsenic adsorption.However,coexisting phosphate significantly hindered the removal of arsenic,especially at high concentrations(10 mmol/L).Electrostatic interaction and hydroxyl and metal–oxygen groups played important roles in the adsorption of arsenic.Furthermore,the prepared adsorbent had stable adsorption ability after regeneration and when used in a real-water matrix.The excellent adsorption performance of Fe_2Co_1MOF-74 material makes it a potentially promising adsorbent for the removal of arsenic. | Jianqiang Sun Xiaobing Zhang Anping Zhang Chunyang Liao | 2019 | Journal of Environmental Sciences2019，31，6： | 11 |
| 3 | Primary investigation of the pollution status of polycyclic aromatic hydrocarbons (PAHs) in water and soil of Xuanwei and Fuyuan,Yunnan Province,China显示文摘Lung cancer incidence in Xuanwei and Fuyuan is extremely high. The air pollution, especially indoor airborne PAHs generated by burning smoky coals, has been considered as the most probable reason. The air pollution may affect drinking water and soil through dry and wet deposition. In this study, the concentrations of PAHs in water and soil samples from Xuanwei and Fuyuan were monitored to investigate the influence of atmospheric PAHs pollution on water and soil. No obvious PAHs pollution in water was found in these two areas, indicating that airborne PAHs have no apparent effect on the drinking water (well water). The smoky coal combustion from household and industry, such as the activities related to power plants, coking plants and chemical industries, is responsible for the soil PAHs pollution in these two areas. The soil pollution might be the reemission source and would pose long-term threat to the local environment and health of residents. | LU JunGang XU RenJi ZHANG QingHua LIU JiYan LIAO ChunYang WEI FuSheng | 2009 | Chinese Science Bulletin2009，54，19： | 4 |
| 4 | Hollow TiO_2 spheres with improved visible light photocatalytic activity synergistically enhanced by multi-stimulative: Morphology advantage,carbonate-doping and the induced Ti^(3+)显示文摘Great efforts have been devoted to improve the photocatalytic activity of TiO_2 in the visible light region. Rational design of the external structure and adjustment of intrinsic electronic status by impurity doping are two main effective ways to achieve this purpose. A facile onepot synthetic approach was developed to prepare C-doped hollow TiO_2 spheres, which simultaneously realized these advantages. The synthesized TiO_2 exhibits a mesoporous hollow spherical structure composed of fine nanocrystals, leading to high specific surface area(~180 m^2/g) and versatile porous texture. Carbonate-doping was achieved by a postthermal treatment at a relatively low temperature(200°C), which makes the absorption edge red-shifted to the visible region of the solar spectrum. Concomitantly, Ti^(3+) induced by C-doping also functions in improving the visible-light photocatalytic activity by reducing the band gap. There exists a synergistic effect from multiple stimulatives to enhance the photocatalytic effect of the prepared TiO_2 catalyst. It is not out of expectation that the asprepared C-doped hollow TiO_2 spheres exhibits an improved photocatalytic activity under visible light irradiation in organic pollutant degradation. | Guoliang Li Chunyang Liao Guibin Jiang | 2018 | Journal of Environmental Sciences2018，30，10： | 3 |
| 5 | Excretion of PFOA and PFOS in male rats during a subchronic exposure 显示文摘 | CUI Lin LIAO Chunyang ZHOU Qunfang | 2010 | Archives of Environmental Contamination and Toxicology2010，58，1： | 1 |
| 6 | Analysis of the Spherical-Circular Patch Antenna显示文摘AnalysisoftheSpherical-CircularPatchAntenna￥LiaoChengenandLiuQing(Xi'anInstituteofPostsandTelecommunications,Xi'an,710061,P.R... | Liao Chengen and Liu Qing(Xi’an Institute of Posts and Telecommunications, Xi’an, 710061, P. R. China)Yu Chunyang(Xi’an Jiaotong University, Xi’an 710049, P. R. China) | 1996 | The Journal of China Universities of Posts and Telecommunications1996，3，2： | 1 |
| 7 | Occurrence of eight bisphenol analogues in indoor dust from the United States and several Asian countries: implications for human exposure 显示文摘 | LIAO Chunyang LIU Fang GUO Ying | 2012 | Environmental Science & Technology2012，46，16： | 1 |
| 8 | Bisphenol analogues in sediments from industrialized areas in the United States, Japan, and Korea: spatial and temporal distributions 显示文摘 | LIAO Chunyang LIU Fang MOON H B | 2012 | Environmental Science & Technology2012，46，11： | 1 |
| 9 | Concentrations and profiles of bisphenol A and other bisphenol analogues in foodstuffs from the United States and their implications for human exposure 显示文摘 | LIAO Chunyang KANNAN K | 2013 | Journal of Agricultural and Food Chemistry2013，61，19： | 1 |
| 10 | Concentrations and Proles Of Bisphenol A and Other Bisphenol Analogues in Foodstus from the United States and Their Implications for Human Exposure显示文摘 | Liao Chunyang Kurunthachalam Kannan | 2013 | Journal of Agricultural and Food Chemistry2013，61，19： | 1 |
| 11 | Molecular phy- logenies and evolutionary behavior of AhR (aryl hydrocarbon receptor) pathway genes in aquatic animals:Implications for the toxicology mechanism of some persistent organic pollutants (POPs) 显示文摘 | Zhou Hailong Qu Ying Wu Huifeng Liao Chunyang | 2010 | Chemosphere2010，78，2： | 1 |
| 12 | Occurrence of and dietary exposure to parabens in foodstuffs from the United States 显示文摘 | LIAO Chunyang LIU Fang KANNAN K | 2013 | Environ Sci Technol2013，47，8： | 1 |
| 13 | Occurrence of parabens in foodstuffs from China and its implications for human dietary exposure 显示文摘 | LIAO Chunyang CHEN Lingxin KANNAN K | 2013 | Enviro Int2013，57，： | 1 |
| 14 | Occurrence and human exposure of p-hydroxybenzoic acid esters (parabens) , bisphenol A diglycidyl ether (BADGE), and their hydrolysis products in indoor dust from the United States and three east asian countries显示文摘 | WANG Lei LIAO Chunyang LIU Fang | 2012 | Environ Sci Technol2012，46，11： | 1 |
| 15 | Studies on the toxicological effects of PFOA and PFOS on rats using histological observation and chemical analysis显示文摘 | CUI Lin ZHOU Qunfang LIAO Chunyang | 2009 | Archives of Environmental Contamination and Toxicology2009，56，2： | 1 |
| 16 | Migration mechanism and risk assessment of perand polyfluoroalkyl substances in the Ya'Er Lake oxidation pond area,China显示文摘The migration mechanisms,sources,and environmental risks of 29 legacy and emerging perfluorinated and polyfluoroalkyl species present in an oxidation pond(Ya'Er Lake)were investigated for treating sewage based on the analysis of their occurrence and distribution.The concentration of per-and polyfluoroalkyl substances(PFAS)in pond area was between0.30 and 63.2 ng/g dw(dry weight),with the overall average concentration of 8.00 ng/g dw.Notably,the PFAS concentrations in the surface sediments near the sewage outlet in Pond-1(50.2 ng/g dw)and Pond-5(average 15.1 ng/g dw)were 1–2 orders of magnitude higher than those in other areas.In general,the legacy PFAS,i.e.,perfluorooctane sulfonic acid was considered to be the major pollutant in the polluted area,on average,accounting for 73.0%of the total concentration of PFAS pollutants.By evaluating the regional distribution of different PFAS homologs,the short-chain PFAS pollutants with lower K_(ow)were found to migrate farther in both horizontal and vertical directions.The sewage outlets in Pond-1 and Pond-5are the main pollution sources in polluted area and the emerging PFAS pollutants in Pond-5have replaced the legacy PFAS pollutants as the main pollutants.Based on positive matrix factorization analysis,three main industrial sources of PFAS pollutants in the study area were identified:protective coating,fire-fighting,and food packaging sources.Moreover,the environmental risk assessment results showed that most study areas exhibited medium environmental risk(0.01≤Risk quotient(RQ)<1),indicating that the ecological environment risks in this area need further attention. | Chang Li Huifang Zhong Jing Wu Lingyi Meng Yingjun Wang Chunyang Liao Yawei Wang Yujian He | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 17 | Recognition for avian influenza virus proteins based on support vector machine and linear discriminant analysis显示文摘Total 200 properties related to structural characteristics were employed to represent structures of 400 HA coded proteins of influenza virus as training samples. Some recognition models for HA proteins of avian influenza virus (AIV) were developed using support vector machine (SVM) and linear discriminant analysis (LDA). The results obtained from LDA are as follows: the identification accuracy (Ria) for training samples is 99.8% and Ria by leave one out cross validation is 99.5%. Both Ria of 99.8% for training samples and Ria of 99.3% by leave one out cross validation are obtained using SVM model, respectively. External 200 HA proteins of influenza virus were used to validate the external predictive power of the resulting model. The external Ria for them is 95.5% by LDA and 96.5% by SVM, respectively, which shows that HA proteins of AIVs are preferably recognized by SVM and LDA, and the performances by SVM are superior to those by LDA. | LIANG GuiZhao CHEN ZeCong YANG ShanBin MEI Hu ZHOU Yuan YANG Li ZHOU Peng YANG ShengXi SHU Mao LIAO ChunYang WU ShiRong LI GenRong HE Liu GAO JianKun Gan MengYu LI DeJing CHEN GuoPing WANG GuiXue LONG Sha JING JuHua ZHENG XiaoLin ZENG Hui ZHANG QiaoXia ZHANG MengJun YANG Qi TIAN FeiFei TONG JianBo WANG JiaoNa LIU YongHong LI Bo QIU LiangJia CAI ShaoXi ZHAO Na YANG Yan SU XiaLi SONG Jian CHEN MeiXia ZHANG XueJiao SUN JiaYing LI JingWei CHEN GuoHua CHEN Gang DENG Jie PENG ChuanYou ZHU WanPing XU LuoNan WU YuQuan LIAO LiMin LI Zhi LI Jun LU DaJun SU QinLiang HUANG ZhengHu ZHOU Ping LI ZhiLiang | 2008 | Science China Chemistry2008，51，2： | 0 |
| 18 | Occurrence of Human Exposure to Benzothiazoles and Benzotriazoles in Indoor Dust in Suizhou and Beijing,China显示文摘Benzothiazoles(BTHs)and benzotriazoles(BTRs)are an important group of industrial chemicals.Due to large scale and long-term applications,they have been released to various environmental media,including indoor dust,and subsequently elicited a variety of toxic effects.In this study,the concentrations and composition profiles of BTHs and BTRs in indoor dust from Suizhou and Beijing,China,were investigated.The median concentrations ofΣ_(6)BTHs in indoor dust samples from Suizhou and Beijing were 133 and 439 ng/g dw,respectively,whereas theΣ5BTRs concentrations from Suizhou and Beijing were 28.4 and 40.1 ng/g dw,respectively(dw=dry weight).BTH,2-OH-BTH,1-H-BTR,and 5-Me-1-H-BTR were the predominant compounds in the dust.Human exposure to such chemicals was further evaluated.The intake for the population in Suizhou(0.163–0.939 ng/kg bw/day)and Beijing(0.0347–0.200 ng/kg bw/day)was minor(bw=body weight).The obtained results in this study will be able to add insight into human exposure to BTHs and BTRs.This study will help to identify the behavior and fate of BTHs and BTRs in the environment,and thus to scientifically assess their risk of exposure. | ZHU Qingqing LIAO Chunyang JIANG Guibin | 2023 | Chemical Research in Chinese Universities2023，39，3： | 0 |
| 19 | Effect of polybrominated diphenyl ether on development of cultured hippocampal neuron显示文摘Polybrominated diphenyl ether (PBDE) is a persistently environmental pollutant ubiquitously found in wildlife and humans. Although concern on PBDE’s toxic effects is steadily increasing, its action on the central nervous system (CNS) remains largely unknown. To address this issue, the present study ex- amined the development inhibition of PBDE in neurons. The primary cultured hippocampal neurons of rat were exposed to the commercial decabromodiphenyl ether (deca-BDE), and the neurite length, bi- furcation, and synapse formation and maturation were evaluated, based on the confocal microscope imaging. The results showed that the development inhibition in neurons occurred at 15 μmol/L, indi- cating that PBDE is a potent neurotoxicant and it might obviously inhibit the development of cultured neurons. | LIAO ChunYang DUAN ShuMin JIANG GuiBin | 2008 | Science China Chemistry2008，51，1： | 0 |
| 20 | 一种膜结合生物探针可视化检测剪切应力引起的细胞膜张力非均匀变化显示文摘文章简介细胞膜是细胞感受外界应力刺激并作出反应的第一介质,探讨细胞膜张力的变化有助于理解细胞受力作用下功能变化的应力信号转导机制。为此,本研究基于荧光共振能量转移技术. | Wang Li Xinlei Yu Fei Xie Baohong Zhang Shuai Shao Chunyang Geng Aziz ur Rehman Aziz Xiaoling Liao 刘波 | 2019 | 科学新闻2019，0，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员