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| 1 | Toripalimab plus chemotherapy as second-line treatment in previously EGFR-TKI treated patients with EGFR-mutant-advanced NSCLC:a multicenter phase-II trial显示文摘This multicenter phase-II trial aimed to investigate the efficacy,safety,and predictive biomarkers of toripalimab plus chemotherapy as second-line treatment in patients with EGFR-mutant-advanced NSCLC.Patients who failed from first-line EGFR-TKIs and did not harbor T790M mutation were enrolled.Toripalimab plus carboplatin and pemetrexed were administrated every three weeks for up to six cycles,followed by the maintenance of toripalimab and pemetrexed.The primary endpoint was objective-response rate(ORR).Integrated biomarker analysis of PD-L1 expression,tumor mutational burden(TMB),CD8+tumor-infiltrating lymphocyte(TIL)density,whole-exome,and transcriptome sequencing on tumor biopsies were also conducted.Forty patients were enrolled with an overall ORR of 50.0%and disease-control rate(DCR)of 87.5%.The median progression free survival(PFS)and overall survival were 7.0 and 23.5 months,respectively.The most common treatment-related adverse effects were leukopenia,neutropenia,anemia,ALT/AST elevation,and nausea.Biomarker analysis showed that none of PD-L1 expression,TMB level,and CD8+TIL density could serve as a predictive biomarker.Integrated analysis of whole-exome and transcriptome sequencing data revealed that patients with DSPP mutation had a decreased M2 macrophage infiltration and associated with longer PFS than those of wild type.Toripalimab plus chemotherapy showed a promising anti-tumor activity with acceptable safety profiles as the second-line setting in patients with EGFR-mutant NSCLC.DSPP mutation might serve as a potential biomarker for this combination.A phase-III trial to compare toripalimab versus placebo in combination with chemotherapy in this setting is ongoing(NCT03924050). | Tao Jiang Pingyang Wang Jie Zhang Yanqiu Zhao Jianying Zhou Yun Fan Yongqian Shu Xiaoqing Liu Helong Zhang Jianxing He Guanghui Gao Xiaoqian Mu Zhang Bao Yanjun Xu Renhua Guo Hong Wang Lin Deng Ningqiang Ma Yalei Zhang Hui Feng Sheng Yao Jiarui Wu Luonan Chen Caicun Zhou Shengxiang Ren | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 8 |
| 2 | Applicability and comparison of solar-air source heat pump systems between cold and warm regions of plateau by transient simulation and experiment显示文摘Solar-air source heat pump(solar-ASHP)system has a potential application in the field of hot water and space heating in residential buildings.Such system features the complementary advantages to solve the discontinuous operation of the single solar system and the frosting issue of the single ASHP system.This paper built the solar-ASHP systems in Kunming and Shangri-La,and tested the system performance under different weather conditions in these two regions of plateau.Meanwhile,the transient heat balance models of the system were established under the sunlight time and non-sunlight time and were verified by the experimental results.Moreover,the verified model was applied to reveal the energy balance performance between the energy supply and building heat demand.The law of the system performance affected by the ambient temperature,effective heat collecting area,and cumulative heating capacity of collector was explored by the validated model.The results indicate that when the ambient temperature decreases by 1℃during non-sunlight time,the energy efficiency ratio decreases by about 0.07.A square meter decline in the effective heat collecting area pushes an increase in the heating capacity of 5.75 MJ.Meanwhile,the cumulative heating capacity of collector increases by 5 MJ,and the ASHP energy consumption decreases by 0.54 kWh.The dynamic changes of the ambient temperature and instantaneous solar radiation are the main reasons of the heat balance errors.Therefore,both the developed system and model are feasible and reliable in different climate regions. | Luonan Xu Ming Li Ying Zhang Xi Luo | 2021 | Building Simulation2021，14，6： | 2 |
| 3 | Human endoderm stem cells reverse inflammation-related acute liver failure through cystatin SN-mediated inhibition of interferon signaling显示文摘Acute liver failure(ALF)is a life-threatening disease that occurs secondary to drug toxicity,infection or a devastating immune response.Orthotopic liver transplantation is an effective treatment but limited by the shortage of donor organs,the requirement for life-long immune suppression and surgical challenges.Stem cell transplantation is a promising alternative therapy for fulminant liver failure owing to the immunomodulatory abilities of stem cells.Here,we report that when transplanted into the liver,human endoderm stem cells(hEnSCs)that are germ layer-specific and nontumorigenic cells derived from pluripotent stem cells are able to effectively ameliorate hepatic injury in multiple rodent and swine drug-induced ALF models.We demonstrate that hEnSCs tune the local immune microenvironment by skewing macrophages/Kupffer cells towards an anti-inflammatory state and by reducing the infiltrating monocytes/macrophages and inflammatory T helper cells.Single-cell transcriptomic analyses of infiltrating and resident monocytes/macrophages isolated from animal livers revealed dramatic changes,including changes in gene expression that correlated with the change of activation states,and dynamic population heterogeneity among these cells after hEnSC transplantation.We further demonstrate that hEnSCs modulate the activation state of macrophages/Kupffer cells via cystatin SN(CST1)-mediated inhibition of interferon signaling and therefore highlight CST1 as a candidate therapeutic agent for diseases that involve over-activation of interferons.We propose that hEnSC transplantation represents a novel and powerful cell therapeutic treatment for ALF. | Yilin Xu Jinglin Wang Haozhen Ren Hao Dai Ying Zhou Xiongzhao Ren Yang Wang Sisi Feng Xiaogang Deng Jiaying Wu Tianlong Fu Tengfei Nie Haifeng He Tongkun Wei Bing Zhu Lijian Hui Bin Li Jing Wang Hongyan Wang Luonan Chen Xiaolei Shi Xin Cheng | 2023 | Cell Research2023，33，2： | 0 |
| 4 | Recognition for avian influenza virus proteins based on support vector machine and linear discriminant analysis显示文摘Total 200 properties related to structural characteristics were employed to represent structures of 400 HA coded proteins of influenza virus as training samples. Some recognition models for HA proteins of avian influenza virus (AIV) were developed using support vector machine (SVM) and linear discriminant analysis (LDA). The results obtained from LDA are as follows: the identification accuracy (Ria) for training samples is 99.8% and Ria by leave one out cross validation is 99.5%. Both Ria of 99.8% for training samples and Ria of 99.3% by leave one out cross validation are obtained using SVM model, respectively. External 200 HA proteins of influenza virus were used to validate the external predictive power of the resulting model. The external Ria for them is 95.5% by LDA and 96.5% by SVM, respectively, which shows that HA proteins of AIVs are preferably recognized by SVM and LDA, and the performances by SVM are superior to those by LDA. | LIANG GuiZhao CHEN ZeCong YANG ShanBin MEI Hu ZHOU Yuan YANG Li ZHOU Peng YANG ShengXi SHU Mao LIAO ChunYang WU ShiRong LI GenRong HE Liu GAO JianKun Gan MengYu LI DeJing CHEN GuoPing WANG GuiXue LONG Sha JING JuHua ZHENG XiaoLin ZENG Hui ZHANG QiaoXia ZHANG MengJun YANG Qi TIAN FeiFei TONG JianBo WANG JiaoNa LIU YongHong LI Bo QIU LiangJia CAI ShaoXi ZHAO Na YANG Yan SU XiaLi SONG Jian CHEN MeiXia ZHANG XueJiao SUN JiaYing LI JingWei CHEN GuoHua CHEN Gang DENG Jie PENG ChuanYou ZHU WanPing XU LuoNan WU YuQuan LIAO LiMin LI Zhi LI Jun LU DaJun SU QinLiang HUANG ZhengHu ZHOU Ping LI ZhiLiang | 2008 | Science China Chemistry2008，51，2： | 0 |
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