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| 1 | In vivo theranostics with near-infraredemitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration显示文摘Carbon dots that exhibit near-infrared fluorescence(NIR CDs)are considered emerging nanomaterials for advanced biomedical applications with low toxicity and superior photostability and targeting compared to currently used photoluminescence agents.Despite progress in the synthesis of NIR CDs,there remains a key obstacle to using them as an in vivo theranostic agent.This work demonstrates that the newly developed sulfur and nitrogen codoped NIR CDs are highly efficient in photothermal therapy(PTT)in mouse models(conversion efficiency of 59%)and can be readily visualized by photoluminescence and photoacoustic imaging.The real theranostic potential of NIR CDs is enhanced by their unique biodistribution and targeting.Contrary to all other nanomaterials that have been tested in biomedicine,they are excreted through the body’s renal filtration system.Moreover,after intravenous injection,NIR CDs are accumulated in tumor tissue via passive targeting,without any active species such as antibodies.Due to their accumulation in tumor tissue without the need for intratumor injection,high photothermal conversion,excellent optical and photoacoustic imaging performance,and renal excretion,the developed CDs are suitable for transfer to clinical biomedical practice. | Xin Bao Ye Yuan Jingqin Chen Bohan Zhang Di Li Ding Zhou Pengtao Jing Guiying Xu Yingli Wang Kateřina Holá Dezhen Shen Changfeng Wu Liang Song Chengbo Liu Radek Zbořil Songnan Qu | 2018 | Light(Science & Applications)2018，7，1： | 13 |
| 2 | Machine learning assisted design of γ′-strengthened Co-base superalloys with multi-performance optimization显示文摘Designing a material with multiple desired properties is a great challenge,especially in a complex material system.Here,we propose a material design strategy to simultaneously optimize multiple targeted properties of multi-component Co-base superalloys via machine learning.The microstructural stability,γ′solvus temperature,γ′volume fraction,density,processing window,freezing range,and oxidation resistance were simultaneously optimized. | Pei Liu Haiyou Huang Stoichko Antonov Cheng Wen Dezhen Xue Houwen Chen Longfei Li Qiang Feng Toshihiro Omori Yanjing Su | 2020 | npj Computational Materials2020，，1： | 8 |
| 3 | 显示文摘 | XIAO Shuqin LIU Dezhen LIU Yihua | 1999 | CHIN PHYS LETT (in China)1999，16，6： | 1 |
| 4 | Synthesis of a novel linear polyphosphazene-based epoxy resin and its application in halogen-free flame-resistant thermosetting systems显示文摘 | Huan Liu Xiaodong Wang Dezhen Wu | 2015 | Polymer Degradation and Stability2015，118，： | 1 |
| 5 | Structural and optical properties of MgxZn1-xO thin films prepared by the sol-gel method显示文摘 | Dongxu Zhao Yichun Liu Dezhen Shen | 2002 | Journal of Crystal Growth2002，234，： | 1 |
| 6 | Riguang Jin A methodology for the preparation of nanoporous polyimide films with low dielectric constants显示文摘 | Lizhong Jiang Jiugui Liu Dezhen Wu | 2006 | Thin Solid Films2006，510，： | 1 |
| 7 | An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk,local immunosuppression and tumor progression显示文摘Dissecting and understanding the cancer ecosystem,especially that around the tumor margins,which have strong implications for tumor cell infiltration and invasion,are essential for exploring the mechanisms of tumor metastasis and developing effective new treatments.Using a novel tumor border scanning and digitization model enabled by nanoscale resolution-SpaTial Enhanced REsolution Omics-sequencing(Stereo-seq),we identified a 500µm-wide zone centered around the tumor border in patients with liver cancer,referred to as“the invasive zone”.We detected strong immunosuppression,metabolic reprogramming,and severely damaged hepatocytes in this zone.We also identified a subpopulation of damaged hepatocytes with increased expression of serum amyloid A1 and A2(referred to collectively as SAAs)located close to the border on the paratumor side.Overexpression of CXCL6 in adjacent malignant cells could induce activation of the JAK-STAT3 pathway in nearby hepatocytes,which subsequently caused SAAs’overexpression in these hepatocytes.Furthermore,overexpression and secretion of SAAs by hepatocytes in the invasive zone could lead to the recruitment of macrophages and M2 polarization,further promoting local immunosuppression,potentially resulting in tumor progression.Clinical association analysis in additional five independent cohorts of patients with primary and secondary liver cancer(n=423)showed that patients with overexpression of SAAs in the invasive zone had a worse prognosis.Further in vivo experiments using mouse liver tumor models in situ confirmed that the knockdown of genes encoding SAAs in hepatocytes decreased macrophage accumulation around the tumor border and delayed tumor growth.The identification and characterization of a novel invasive zone in human cancer patients not only add an important layer of understanding regarding the mechanisms of tumor invasion and metastasis,but may also pave the way for developing novel therapeutic strategies for advanced liver cancer and other solid tumors. | Liang Wu Jiayan Yan Yinqi Bai Feiyu Chen Xuanxuan Zou Jiangshan Xu Ao Huang Liangzhen Hou Yu Zhong Zehua Jing Qichao Yu Xiaorui Zhou Zhifeng Jiang Chunqing Wang Mengnan Cheng Yuan Ji Yingyong Hou Rongkui Luo Qinqin Li Liang Wu Jianwen Cheng Pengxiang Wang Dezhen Guo Waidong Huang Junjie Lei Shang Liu Yizhen Yan Yiling Chen Sha Liao Yuxiang Li Haixiang Sun Na Yao Xiangyu Zhang Shiyu Zhang Xi Chen Yang Yu Yao Li Fengming Liu Zheng Wang Shaolai Zhou Huanming Yang Shuang Yang Xun Xu Longqi Liu Qiang Gao Zhaoyou Tang Xiangdong Wang Jian Wang Jia Fan Shiping Liu Xinrong Yang Ao Chen Jian Zhou | 2023 | Cell Research2023，33，8： | 1 |
| 8 | Photolu- minescence properties of MgxZn1- xO alloy thin films fabri- cated by the sol- gel deposition method 显示文摘 | Liu Yichun Shen Dezhen | 2001 | J Appl Phys2001，90，11： | 1 |
| 9 | A methodology for the preparation of nanoporous polyimide films with low dielectric constants 显示文摘 | Jiang Lizhong Liu Jiugui Wu Dezhen | 2006 | Thin Solid Films2006，，1： | 1 |
| 10 | Recycling combustibles from aged municipal solid wastes(MSW)to improve fresh MSW incineration in Shanghai:Investigation of necessity and feasibility显示文摘Aged municipal solid wastes(MSW)excavated from landfills and dumpsites were characterized to analyze their fraction composition,moisture content,and lower heat value(LHV).The necessity and feasibility of recycling combustibles from aged MSW to improve the incineration of fresh MSW were investigated.The results showed that combustibles in aged MSW were easily separated from other components and than LHV of the separated combustibles are higher than 11000 kJ/kg.The fresh MSW are of high moisture contents with average LHV below 6500 kJ/kg,making their stable combustion difficult to maintain in MSW incinerators.For both fresh MSW and aged MSW,plastics are the main contributor to their LHV.To improve incineration of fresh MSW that are characterized with low LHV,combustibles separated from aged MSW were made into refuse derived fuel(RDF)pellets and were then added to fresh MSW by 2%wt.–5%wt.LHV variation and air supply resistance change of the MSW layer on the incinerator grate caused by the addition of RDF was checked,and no significant changes were found.No obvious difference was observed for the‘burn-out time’between RDF pellets and fresh MSW either.RDF made from aged MSW combustibles is found to be a promising auxiliary fuel to improve the incineration of fresh MSW,and aged MSW from old landfill cells and dumpsites can be finally disposed of jointly with fresh MSW by recycling combustible from the former to be coincinerated with the latter in the incineration plants. | Dezhen CHEN Zhenzhen GUAN Guangyu LIU Gongming ZHOU Tong ZHU | 2010 | Frontiers of Environmental Science & Engineering2010，4，2： | 1 |
| 11 | A methodology for the preparation of nanoporous polyimide films with low dielectric constants显示文摘 | Jiang Lizhong Liu Jiugui Wu Dezhen | 2006 | Thin Solid Films2006，510，12： | 1 |
| 12 | A methodology for the preparation of nanoporous polyimide films with low dielec-tric constant显示文摘 | Jiang Lizhong Liu Jiugui wu Dezhen | 2006 | Thin Solid Films2006，510，12： | 1 |
| 13 | Methodology for the preparation of nanoporous polyimide films with low dielectric constants显示文摘 | Lizhong Jiang Jiugui Liu Dezhen Wu A | 2006 | Thin Solid Films2006，510，： | 1 |
| 14 | A Methodology for the Preparation of Nanoporous Polyimide Films with Low Dielectric Constants显示文摘 | Jiang Lizhong Liu Jiugui Wu Dezhen | 2006 | Thin Solid Films2006，510，12： | 1 |
| 15 | Fluorescence stability of 8-hydroxyquinoline aluminum 显示文摘 | Yu Gui Shen Dezhen Liu Yunqi Zhu Daoben | 2001 | Chemical Physics Letters2001，333，： | 1 |
| 16 | Photodegradation of 8-hydroxyquinolin aluminum 显示文摘 | Yu Gui Shen Dezhen Liu Yunqi Zhu Daoben | 2001 | Synthetic Metals2001，121，： | 1 |
| 17 | Molten waste plastic pyrolysis in a vertical falling film reactor and the influence of temperature on the pyrolysis products显示文摘Molten plastics are characterised with high viscosity and low thermal conductivity. Applying falling film pyrolysis reactor to deal with waste plastics can not only improve heat transfer efficiency, but also solve the flow problem.In this work, the pyrolysis process of molten polypropylene(PP) in a vertical falling film reactor is experimentally studied, and the influence of heating temperature on pyrolysis products is discussed. It has been found that with the temperature increases from 550 ℃ to 625 ℃, the yield of pyrolysis oil decreases from 74.4 wt%(± 2.2 wt%) to53.5 wt%(±1.3 wt%). The major compositions of the pyrolysis oil are C_9, C_(12) and C_(18), and β-scission reactions are predominant. The content of the light fraction C_6-C_(12) of pyrolysis oil is 69.7 wt%. Compared with other pyrolysis reactors, the yield of oil from vertical falling film pyrolysis reactor is slightly higher than that from tubular reactor,equal to that from rotary kiln reactor, and slightly lower than that in medium fluidised-bed reactor. | zechen jin dezhen chen lijie yin yuyan hu huangqing zhu liu hong | 2018 | Chinese Journal of Chemical Engineering2018，26，2： | 1 |
| 18 | Amplified Spontaneous Green Emission and Lasing Emission From Carbon Nanoparticles显示文摘 | Songnan Qu Xingyuan Liu Xiaoyang Guo Minghui Chu Ligong Zhang Dezhen Shen | 2014 | Adv Funct Mater2014，，18： | 1 |
| 19 | The dependence of emission spectra of rare earth ion on the band-gap energy of Mg x Zn 1? x O alloy显示文摘 | Dongxu Zhao Yichun Liu Dezhen Shen Jiying Zhang Youming Lu Xiwu Fan | 2002 | Journal of Crystal Growth2002，，1： | 1 |
| 20 | Advances in Diagnosis and Treatment of Neuropsychiatric Systemic Lupus Erythematosus显示文摘1 Introduction Neuropsychiatric systemic lupus erythematosus(NPSLE)is a serious complication of systemic lupus erythematosus(SLE),with an incidence of about 30%to 40%[1].No matter early or late SLE patients are prone to concurrent,so early diagnosis and treatment of NPSLE is extremely important. | Shufei Zeng Yangyang Zang Dezhen Chen Baozhang Guan Fanna Liu Mingming Ma Yu Mong Huiyuan Zheng Aiyun Cha Xiangnan Dong Huanhuan Liu Taksui Wong Shuang Cui Tong Liu Yongpin Lu Chen Yun Hongwei Hu B.Hocher W.Pommer Zuhui Chen Lianghong Yin | 2017 | 临床医学工程2017，24，S1： | 0 |
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