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| 1 | An Investigation of Oxidative DNA Damage in Pharmacy Technicians Exposed to Antineoplastic Drugs in Two Chinese Hospitals Using The Urinary 8-OHdG Assay显示文摘Objective To investigate oxidative DNA damage in pharmacy technicians preparing antineoplastic drugs at the PIVAS (Pharmacy Intravenous Admixture Service) in two Chinese hospitals.Methods Urinary 8-OHdG served as a biomarker.5-Fluorouracil (5-FU) concentrations in air,masks and gloves were determined.The spill exposure of each PIVAS technician to antineoplastic drugs was investigated.Eighty subjects were divided into exposed group I,II,and control group I,II.Results 5-FU concentration ratios for gloves and masks in exposed group I were significantly higher than those in exposed group II (P<0.05 or P<0.01).The average urinary 8-OHdG concentrations in exposed group I,control group I,exposed group II,and control group II were 14.69±0.93,10.68±1.07,10.57±0.55,and 11.96±0.73 ng/mg Cr,respectively.Urinary 8-OHdG concentration in exposed group I was significantly higher than that in control group I or that in exposed group II (P<0.01).There was a significant correlation between urinary 8-OHdG concentrations and spill frequencies per technician (P<0.01).Conclusion There was detectable oxidative DNA damage in PIVAS technicians exposed to antineoplastic drugs.This oxidative DNA damage may be associated with their spill exposure experience and contamination of their personal protective equipment. | HUANG Yu Wen JIAN Le ZHANG Mei Bian ZHOU Quan YAN Xiao Feng HUA Xu Dong ZHOU Ying HE Ji Liang | 2012 | Biomedical and Environmental Sciences2012，25，1： | 30 |
| 2 | Outbreak of Dengue Fever in Central China,2013显示文摘In 2013,the first dengue fever(DF) outbreak in central China was reported in the central of Henan province,northern temperate regions,although they have been sequentially recorded in Southern China.106 suspected DF cases were reported and 73 patients were confirmed dengue virus type 3(DEN-3) infections.62/392(15.8%) local health persons showed DEN antibodies positive.To this day Henan is the northernmost province in China which has been reported about outbreak of DF and what is important is that it warns us the endemic range of DF has been expanded geographically in China. | HUANG Xue Yong MA Hong Xia WANG Hai Feng DU Yan Hua SU Jia LI Xing Le TANG Xiao Yan MA Hong Peng ZU Bing Can ZHANG Qiao Hong CHEN Hao Min XU Bian Li | 2014 | Biomedical and Environmental Sciences2014，27，11： | 30 |
| 3 | The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. | Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao | 2016 | Translational Neurodegeneration2016，5，1： | 23 |
| 4 | Endothelial Nitric Oxide Synthase Gene Intron 4, 27 bp Repeat Polymorphism and Essential Hypertension in the Kazakh Chinese Population显示文摘为了调查在 27 bp 之间的关系,在内含子 4in 重复多型性 endothelial 在 KazakhChinese 人口的氮的氧化物合酶( eNOS4 )基因和必要高血压,有必要高血压和 138 个健康的人的 151 个病人在 Xinjiang uygur 从 Shawan 区域的 Boertonggu 农村被选择中国 in2006 的自治区域。在二个组的 eNOS 的多型性与聚合酶链反应试金被检测,在每个组的遗传型频率是计算的跟随 Hardy-Weinberg 法律。Fourand 27 bp 重复的五辆双人脚踏车是被指明一 and “ b' 分别地。b/b, b/a 和 eNOS4 基因的 a/a 遗传型的频率在控制组是 84.06% , 15.22% 和 0.72% ,这被发现,并且 81.46% , 15.89% 和 2.65% 分别地在高血压组织。基因的频率一 and “ b' 在控制组是 91.67% 和 8.33% , 89.40% 和 10.60% 分别地在高血压组织。血浆 eNOS 活动没与 eNOS 基因的遗传型和等位基因被联系,这被发现。在高血压组的血浆 eNOS 活动显著地与控制组(P<0.01 ) 相比被减少。结果建议 eNOS4 基因多型性是不大可能的是为在 Xinjiang 哈萨克人口的必要高血压的主要基因危险性因素。然而,在血浆 eNOS 活动之间的一个积极协会和必要高血压被揭示了。 | Fengmei DENG Qinghua HU Bin TANG Fang HE Shuxia GUO Jiang CHEN Feng LI Xuehua WU Jun ZHANG Huimin ZHANG Juan ZHAO Hua ZHONG Ling HE Jun LI Le ZHANG Shuren WANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，5： | 18 |
| 5 | Clinical Characteristics, Radiological Features and Gene Mutation in 10 Chinese Families with Spinocerebellar Ataxias显示文摘 | Jian-Wen Chen Li Zhao Feng Zhang Lan Li Yu-Hang Gu Jing-Yuan Zhou Hui Zhang Ming Meng Kai-Hua Zhang Wei-Dong Le Chun-Bo Dong | 2015 | Chinese Medical Journal2015，，13： | 14 |
| 6 | MicroRNA-dependent development revealed by RNA interference-mediated gene silencing of LmDicerl in the migratory locust显示文摘MicroRNAs (miRNAs ) 是小 noncoding RNA,它参予许多生物过程。在迁移的蝗虫的小 RNA transcriptome 被描绘了, 50 保存了, 185 个潜在的蝗虫特定的 miRNA 家庭候选人用高产量的定序被识别了 miRNA 家庭。然而,它是不清楚的是否 miRNAs 影响许多蝗虫生物进程,例如生长或开发。在昆虫, Dicer1 ribonuclease 把 miRNA 先锋转变成成熟 miRNAs。因此,使用全身的 RNA 干扰(RNAi ) 到沉默在迁移的蝗虫的 Dicer1 的表示,草之小穗 migratoria,我们在蝗虫减少了 miRNA 内容并且破坏了脱毛(nymphnymph,和 nymphadult ) 的二种类型。LmDicer1 的 RNAi 也在 L 导致了高死亡。migratora。我们的学习表明 LmDicer1 为 miRNA 规定和 L 的开发是必要的。migratoria。这些结果进一步支持我们 LmDicer1 能为为控制这个重要昆虫害虫开发新奇策略作为一个优秀目标服务的观点。 | Yan-Li Wang Mei-Ling Yang Feng Jiang Jian-Zhen Zhang Le Kang | 2013 | Insect Science2013，20，1： | 11 |
| 7 | SbHKT1;4, a member of the high‐affinity potassium transporter gene family from Sorghum bicolor, functions to maintain optimal Na^+/K^+ balance under Na^+ stress显示文摘In halophytic plants, the high‐affinity potassium transporter HKT gene family can selectively uptake Kt in the presence of toxic concentrations of Nat. This has so far not been well examined in glycophytic crops. Here, we report the characterization of SbHKT1;4, a member of the HKT gene family from Sorghum bicolor. Upon Nat stress, SbHKT1;4 expression was more strongly upregulated in salt‐tolerant sorghum accession, correlating with a better balanced Nat/ Kt ratio and enhanced plant growth. Heterogeneous expression analyses in mutants of Saccharomyces cerevisiae and Arabidopsis thaliana indicated that overexpressing SbHKT1;4 resulted in hypersensitivity to Nat stress, and such hypersensitivity could be alleviated with the supply of elevated levels of Kt, implicating that SbHKT1;4 may mediate Kt uptake in the presence of excessive Nat. Further electrophysiological evidence demonstrated that SbHKT1;4 could transport Nat and Kt when expressed in Xenopus laevis oocytes. The relevance of the finding that SbHKT1;4 functions to maintain optimal Nat/Kt balance under Nat stress to the breeding of salt‐tolerant glycophytic crops is discussed. | Tian‐Tian Wang Zhi‐Jie Ren Zhi‐Quan Liu Xue Feng Rui‐Qi Guo Bao‐Guo Li Le‐Gong Li Hai‐Chun Jing | 2014 | Journal of Integrative Plant Biology2014，56，3： | 11 |
| 8 | Catgut implantation at acupoints increases the expression of glutamate aspartate transporter and glial glutamate transporter-1 in the brain of rats with spasticity after stroke显示文摘Catgut implantation at acupoints has been shown to alleviate spasticity after stroke in rats.However,the underlying mechanisms are poorly understood.In this study,we used the rat middle cerebral artery occlusion model of stroke.Three days after surgery,absorbable surgical catgut sutures were implanted at Dazhui(GV14),Jizhong(GV6),Houhui,Guanyuan(CV4)and Zhongwan(CV12).The Zea Longa score was used to assess neurological function.The Modified Ashworth Scale was used to evaluate muscle tension.The 2,3,5-triphenyl-tetrazolium chloride assay was used to measure infarct volume.Immunohistochemical staining was performed for glutamate aspartate transporter(GLAST)and glial glutamate transporter-1(GLT-1)expression.Western blot assay was used to analyze the expression of GLAST and GLT-1.Reverse transcription and polymerase chain reaction were carried out to assess the expression of GLAST and GLT-1m RNAs.After catgut implantation at the acupoints,neurological function was substantially improved,muscle tension was decreased,and infarct volume was reduced in rats with spasticity after stroke.Furthermore,the expression of GLAST and GLT-1 m RNAs was increased on the injured(left)side.Our findings demonstrate that catgut implantation at acupoints alleviates spasticity after stroke,likely by increasing the expression of GLAST and GLT-1. | Rui-Qing Li Ming-Yue Wan Jing Shi Hui-Ling Wang Fei-Lai Liu Cheng-Mei Liu Jin Huang Ren-Chao Liu Le Ma Xiao-Dong Feng | 2018 | Neural Regeneration Research2018，13，6： | 10 |
| 9 | In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine显示文摘Berberrubine (BRB ) 是在 vivo 比 BBR 显示出更强壮的葡萄糖阴沉的效果的 berberine (BBR ) 的主要代谢物。在另一方面, BRB 快速并且广泛地被使产生代射变化进 berberrubine-9-O -- 在在口头的管理以后的老鼠的 D-glucuronide (BRBG ) 。在这研究,我们在老鼠比较了 BRB 和 BRBG 的 pharmacokinetic 性质,并且探索了位于他们的葡萄糖阴沉的活动下面的机制。有导致 HFD 的多糖症的 C57BL/6 老鼠被管理 BRB (50 mg 吗?? | Na YANG Run-bin SUN Xing-long CHEN Le ZHEN Chun GE Yu-qing ZHAO Jun HE Jian-liang GENG Jia-hua GUO Xiao-yi YU Fei FEI Si-qi FENG Xuan-xuan ZHU Hong-bo WANG Feng-hua FU Ji-ye AA Guang-ji WANG | 2017 | Acta Pharmacologica Sinica2017，38，3： | 9 |
| 10 | Design and experimental study of a practical Osculating Inward Cone Waverider Inlet显示文摘A design method based on tip to tail streamline tracing and osculating inward cone methods is discussed for designing the integrated Osculating Inward Cone Waverider Inlet(OICWI). A practical geometrical constrained experimental model of OICWI is designed based on the validated design method. It has a total contraction ratio of 4.61 and inner contraction ratio is 2.0. Wind-tunnel tests have been conducted for the OICWI model at free stream Mach number(Ma_∞) of 4.0, 3.5 and 3.0 respectively. The experimental results show that the OICWI has high flow capture ratio and compression abilities. It can self-start at Ma_∞= 3.5 and 4.0 and its flow capture ratio is 0.73 at Ma_∞= 4.0, and Angle of Attack(AOA) 0°. The research results show that the OICWI has advantages of inward cone waverider and streamline tracing inlet. Present OICWI is a novel approach for waverider inlet integration studies and it will promote the use of waverider inlet integration configuration in the studies of airbreathing hypersonic vehicles. | He Xuzhao Zhou Zheng Qin Si Wei Feng Le Jialing | 2016 | Chinese Journal of Aeronautics2016，29，6： | 8 |
| 11 | Protective effects of acupuncture and LGNHFD on expressions of vascular endothelial growth factor, basic fibroblast growth factor,and cluster of differentiation 34 in rats with cerebral ischemia-reperfusion injury显示文摘OBJECTIVE: To investigate the protective effects of electroacupuncture and LGNHFD on cerebral ischemia-reperfusion injury, and their effects on the expression of cluster of differentiation 34(CD 34), vascular endothelial growth factor(VEGF), and basic fibroblast growth factor(b FGF) in the peripheral tissue of the cerebral ischemic semi-dark zone in rats.The influence and mechanism of expression.METHODS: Healthy male Sprague-Dawley rats were randomly divided into the sham operation group, model group, Traditional Chinese Medicine (TCM) group, electroacupuncture group, and acupuncture group. The cerebral ischemia model was prepared by middle artery occlusion. The electroacupuncture and TCM groups received electroacupuncture at the 'Neiguan(PC6)', 'Baihui(GV20)', and 'Renzhong(GV26)' acupoints from 4 h after modeling, once daily for 14 d. After modeling,the acupuncture and TCM groups were administered LGNHFD once daily for 14 d. After treatment,the infarct volume and regional cerebral blood flow(r CBF) were measured in each group, the expression of CD34 in the surrounding ischemic penumbra was determined using immunohistochemistry,and the expression of angiogenesis-related factors in the ischemic hemisphere was detected by western blot.RESULTS: Compared with the sham operation group, r CBF was significantly decreased(P < 0.01)and cerebral infarction volume was significantly increased(P < 0.01) in the model group at four time points(5 min and 3, 7, and 14 d after modeling). At three postoperative time points(3, 7, and 14 d), the number of CD34 + cells in the model group were significantly increased(P < 0.01), and the relative expression levels of VEGF, b FGF, and CD34+ in the ischemic hemisphere were significantly increased(P < 0.01, P < 0.05). Compared with the model group, the r CBF of the acupuncture group was significantly increased at 3, 7, and 14 d after intervention(P < 0.01), while the r CBF of the electroacupuncture and TCM groups was significantly increased at 7 and 14 d after intervention(P < 0.01).After 3, 7, and 14 d of intervention, infarct volume was significantly reduced(P < 0.01), the number of CD34 + cells was significantly increased(P < 0.01,P < 0.05), and the relative expression levels of VEGF,b FGF, and CD34 in the ischemic hemisphere were significantly increased(P < 0.01, P < 0.05). Compared with the electroacupuncture and TCM groups, the r CBF of the acupuncture group was significantly increased(P < 0.01), the infarct volume was significantly reduced(P < 0.01), and the relative expression levels of VEGF, b FGF, and CD34 were significantly increased(P < 0.05, P < 0.01) after 3, 7,and 14 d of intervention.CONCLUSION: Acupuncture therapy is superior to simple drug and electroacupuncture therapy for reducing infarct volume, increasing r CBF and CD34 expression in cells, and promoting capillary regeneration in rats with cerebral ischemia. This may be related to the increased expression of VEGF, b FGF,and CD34 — which are related to cerebrovascular neovascularization — in the ischemic hemispheres of such rats. | YANG Le YANG Baocun ZHANG Caixia TONg Jie FENG Geli XIAO Gaiqin | 2021 | Journal of Traditional Chinese Medicine2021，41，3： | 8 |
| 12 | An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma显示文摘No clinically available biomarkers can predict pathological complete response(pCR)for esophageal squamous cell carcinomas(ESCCs)with neoadjuvant chemoradiotherapy(nCRT).Considering that antitumor immunity status is an important determinant for nCRT,we performed an integrative analysis of immune-related gene profiles from pretreatment biopsies and constructed the first individualized immune signature for pCR and outcome prediction of ESCCs through a multicenter analysis.During the discovery phase,14 differentially expressed immune-related genes(DEIGs)with greater than a twofold change between pCRs and less than pCRs( | Chaoqi Zhang Guochao Zhang Nan Sun Zhen Zhang Liyan Xue Zhihui Zhang Haijun Yang Yuejun Luo Xiaoli Zheng Yonglei Zhang Yufen Yuan Ruixue Lei Zhaoyang Yang Bo Zheng Le Wang Yun Che Feng Wang Sihui Wang Shugeng Gao Qi Xue Yi Zhang Jie He | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 13 | Whole-genome sequencing provides insights into the genetic diversity and domestication of bitter gourd(Momordica spp.)显示文摘Bitter gourd(Momordica charantia)is a popular cultivated vegetable in Asian and African countries.To reveal the characteristics of the genomic structure,evolutionary trajectory,and genetic basis underlying the domestication of bitter gourd,we performed whole-genome sequencing of the cultivar Dali-11 and the wild small-fruited line TR and resequencing of 187 bitter gourd germplasms from 16 countries.The major gene clusters(Bi clusters)for the biosynthesis of cucurbitane triterpenoids,which confer a bitter taste,are highly conserved in cucumber,melon,and watermelon.Comparative analysis among cucurbit genomes revealed that the Bi cluster involved in cucurbitane triterpenoid biosynthesis is absent in bitter gourd.Phylogenetic analysis revealed that the TR group,including 21 bitter gourd germplasms,may belong to a new species or subspecies independent from M.charantia.Furthermore,we found that the remaining 166 M.charantia germplasms are geographically differentiated,and we identified 710,412,and 290 candidate domestication genes in the South Asia,Southeast Asia,and China populations,respectively.This study provides new insights into bitter gourd genetic diversity and domestication and will facilitate the future genomics-enabled improvement of bitter gourd. | Junjie Cui Yan Yang Shaobo Luo Le Wang Rukui Huang Qingfang Wen Xiaoxia Han Nansheng Miao Jiaowen Cheng Ziji Liu Changyuan Zhang Chengcheng Feng Haisheng Zhu Jianwen Su Xinjian Wan Fang Hu Yu Niu Xiaoming Zheng Yulan Yang Dai Shan Zhensheng Dong Weiming He Narinder P.S.Dhillon Kailin Hu | 2020 | Horticulture Research2020，7，1： | 7 |
| 14 | Anatomical and functional outcomes after Densiron 68 heavy silicone oil tamponade for complicated retinal detachment in Chinese eyes显示文摘AIM:To evaluate the safety and efficacy of Densiron 68 heavy silicone oil (HSO) tamponade for complicated retinal detachment(RD)in Chinese eyes.METHODS:Twenty-one eyes of 21 patients with complicated RD were included in this retrospective study.All patients underwent pars plana vitrectomy with an internal tamponade using Densiron 68 HSO.Anatomical and functional results and complications were evaluated,including retinal status,visual acuity(VA),intraocular pressure(IOP),intraocular inflammation,lens opacity,and HSO emulsification.RESULTS:Allthepatients were followed up for 3mo to1y(5.8±1.16mo).Retinal reattachment was achieved in 19of 21 patients(90.5%).VA improved in 18 of 21 patients(85.7%),from 1.93 logMAR(±0.48)to 1.52 logMAR(±0.45)(P=0.001).Postoperative complications included early dispersion of HSO in 7 eyes(38.8%),cataract in 10 of 18phakic eyes(55.5%),moderate postoperative inflammation reaction in 10 eyes(47.6%),and elevated IOP in 5 eyes(23.8%),all of which were controlled by medication or by surgery.CONCLUSION:Highanatomical and functional success rates can be achieved with primary vitrectomy for complicated RD by using Densiron 68 HSO;however,it should not be ignored that Densiron 68 HSO can cause some complications in the eye. | Fang Liu Hui Li Le Feng Fang Wang | 2014 | International Journal of Ophthalmology(English edition)2014，7，3： | 7 |
| 15 | Preliminary study of a dot immunogold filtration assay for rapid detection of anti-HCV IgG显示文摘INTRODUCTIONHepatitisCisaworldwideepidemicdiseasestemmingfromthehepatitisCvirus(HCV).HCVisnotonlythepathogenicfactorofhepati... | XIAO Le Yi 1, YAN Xiao Jun 1, MI Ming Ren 2, HAN Feng Chan 1 and HOU Yu 1 | 1999 | World Journal of Gastroenterology1999，5，4： | 7 |
| 16 | 863 genomes reveal the origin and domestication of chicken显示文摘Despite the substantial role that chickens have played in human societies across the world,both the geographic and temporal origins of their domestication remain controversial.To address this issue,we analyzed 863 genomes from a worldwide sampling of chickens and representatives of all four species of wild jungle fowl and each of the five subspecies of red jungle fowl(RJF).Our study suggests that domestic chickens were initially derived from the RJF subspecies Gallus gallus spadiceus whose present-day distribution is predominantly in southwestern China,northern Thailand and Myanmar.Following their domestication,chickens were translocated across Southeast and South Asia where they interbred locally with both RJF subspecies and other jungle fowl species.In addition,our results show that the White Leghorn chicken breed possesses a mosaic of divergent ancestries inherited from other subspecies of RJF.Despite the strong episodic gene flow from geographically divergent lineages of jungle fowls,our analyses show that domestic chickens undergo genetic adaptations that underlie their unique behavioral,morphological and reproductive traits.Our study provides novel insights into the evolutionary history of domestic chickens and a valuable resource to facilitate ongoing genetic and functional investigations of the world's most numerous domestic animal. | Ming-Shan Wang Mukesh Thakur Min-Sheng Peng Yu Jiang Laurent Alain Francois Frantz Ming Li Jin-Jin Zhang Sheng Wang Joris Peters Newton Otieno Otecko Chatmongkon Suwannapoom Xing Guo Zhu-Qing Zheng Ali Esmailizadeh Nalini Yasoda Hirimuthugoda Hidayat Ashari Sri Suladari Moch Syamsul Arifin Zein Szilvia Kusza Saeed Sohrabi Hamed Kharrati-Koopaee Quan-Kuan Shen Lin Zeng Min-Min Yang Ya-Jiang Wu Xing-Yan Yang Xue-Mei Lu Xin-Zheng Jia Qing-Hua Nie Susan Joy Lamont Emiliano Lasagna Simone Ceccobelli Humpita Gamaralalage Thilini Nisanka Gunwardana Thilina Madusanka Senasige Shao-Hong Feng Jing-Fang Si Hao Zhang Jie-Qiong Jin Ming-Li Li Yan-Hu Liu Hong-Man Chen Cheng Ma Shan-Shan Dai Abul Kashem Fazlul Haque Bhuiyan Muhammad Sajjad Khan Gamamada Liyanage Lalanie Pradeepa Silva Thi-Thuy Le Okeyo Ally Mwai Mohamed Nawaz Mohamed Ibrahim Megan Supple Beth Shapiro Olivier Hanotte Guojie Zhang Greger Larson Jian-Lin Han Dong-Dong Wu Ya-Ping Zhang | 2020 | Cell Research2020，30，8： | 7 |
| 17 | Preparation of mulberry-like RuO_(2) electrode material for supercapacitors显示文摘As a newly emerging excellent energy storage device,supercapacitors have been widely studied due to their unique advantages.Electrode material is one of the key components that determine the performance of a supercapacitor.Among the various electrode materials of supercapacitors,RuO_(2) has attracted great attention in the scientific community due to its high theoretical energy storage capability and excellent stability.However,most RuO_(2) materials suffer the problem of low specific surface area,causing a much lower actual capacitance value compared to the theoretical performance of the material.In this work,a mulberry-like RuO_(2) electrode material with large specific surface area(159.4 m^(2)·g^(-1))was successfully synthesized by a facial hydrothermal method.The electrochemical characterization has shown that the RuO_(2) possesses a high specific capacitance of 400 F·g^(-1) at a current density of 0.2 A·g^(-1) and good capacitance retention rate of 84.7%after 6000 charge/discharge cycles under a current density of 10 A·g^(-1).The energy densities and power densities of the RuO_(2)-AC supercapacitor vary from25.0 to 11.7 Wh·kg^(-1) and 160 to 10,560 W·kg^(-1) at current density ranging from 0.2 to 10.0 A·g^(-1),respectively. | Feng Yu Le Pang Hong-Xia Wang | 2021 | Rare Metals2021，40，2： | 6 |
| 18 | Effect of Gd addition on mechanical and microstructural properties of Mg-xGd-2.6Nd-0.5Zn-0.5Zr cast alloys显示文摘The Mg-xGd-2.6Nd-0.5Zn-0.5Zr(x=0,3.0,4.5 and 6.0,wt.%)alloys were prepared by gravity casting and then T6 treatment.Microstructures of the alloy were observed using optical microscopy and scanning electron microscopy.Results show that the as-cast alloys contained network Mg3Gd phases,blocky and needle-like Mg12(Nd,Gd)phases.The a(Zr)particle inclusions in the a(Mg)matrix are also observed.Content of the secondary phases decreases as Gd content increases.Tensile test results show that the tensile and yield strengths of all the alloys increase as Gd content increases under the as-cast and T6 conditions,but the elongation exhibits the opposite trend.The blocky Mg12(Nd,Gd)phases appear and act as crack initiator and deteriorates the experimental alloys’ductility with the increase of Gd content,especially as Gd content increases to 6.0 wt.%,so the Mg-6.0Gd-2.6Nd-0.5Zn-0.5Zr alloy has the lowest elongation value compared to the other alloys studied.After T6 treatment,the Mg-4.5Gd-2.6Nd-0.5Zn-0.5Zr alloy exhibits the optimal mechanical properties both at room temperature and 250℃. | Liang Zhan Yi-zhi Le Zhi-jun Feng Yan-chun Lou Ming Ruan Hua-wen Li | 2020 | China Foundry2020，17，3： | 6 |
| 19 | Paeoniflorin-6′-0-benzene sulfonate alleviates collageninduced arthritis in mice by downregulating BAFF-TRAF2-NF-kB signaling: comparison with biological agents显示文摘Paeoniflorin-6′-0-benzene sulfonate (CP-25) is a new ester derivative of paeoniflorin with improved lipid solubility and oral bioavailability, as well as better anti-inflammatory activity than its parent compound. In this study we explored whether CP-25 exerted therapeutic effects in collagen-induced arthritis (CIA) mice through regulating B-cell activating factor (BAFF)-BAFF receptors-mediated signaling pathways. CIA mice were given CP-25 or injected with biological agents rituximab or etanercept for 40 days. In CIA mice, we found that T cells and B cells exhibited abnormal proliferation;the percentages of CD19^+ total B cells, CD19^+CD27^+-activated B cells, CD19^+BAFFR^+ and CD19^+TACI^+cells were significantly increased in PBMCs and spleen lymphocytes. CP-25 suppressed the indicators of arthritis, alleviated histopathology, accompanied by reduced BAFF and BAFF receptors expressions, inhibited serum immunoglobulin levels, decreased the Bell subsets percentages, and prevented the expressions of key molecules in NF-kB signaling. Furthermore, we showed that treatment with CP-25 reduced CD19+TRAF2^+ cell expressions stimulated by BAFF and decreased TRAF2 overexpression in HEK293 cells in vitro. Thus, CP-25 restored the abnormal T cells proliferation and B-cell percentages to the normal levels, and normalized the elevated levels of IgA, lgG2a and key proteins in NF-kB signaling. In comparison, rituximab and etanercept displayed stronger antiinflammatory activities than CP-25;they suppressed the elevated inflammatory indexes to below the normal levels in CIA mice. In summary, our results provide evidence that CP-25 alleviates CIA and regulates the functions of B cells through BAFF-TRAF2-NF-kB signaling. CP-25 would be a soft immunomodulatory drug with anti-inflammatory effect. | Jin-ling Shu Xian-zheng Zhang Le Han Feng Zhang Yu-jing Wu Xiao-yu Tang Chen Wang Yu Tai Qing-tong Wang Jing-yu Chen Yan Chang Hua-xun Wu Ling-ling Zhang Wei Wei | 2019 | Acta Pharmacologica Sinica2019，40，6： | 6 |
| 20 | New therapeutics beyond amyloid-βand tau for the treatment of Alzheimer’s disease显示文摘As the population ages,Alzheimer’s disease(AD),the most common neurodegenerative disease in elderly people,will impose social and economic burdens to the world.Currently approved drugs for the treatment of AD including cholinesterase inhibitors(donepezil,rivastigmine,and galantamine)and an N-methyl-D-aspartic acid receptor antagonist(memantine)are symptomatic but poorly affect the progression of the disease.In recent decades,the concept of amyloid-β(Aβ)cascade and tau hyperphosphorylation leading to AD has dominated AD drug development.However,pharmacotherapies targeting Aβand tau have limited success.It is generally believed that AD is caused by multiple pathological processes resulting from Aβabnormality,tau phosphorylation,neuroinflammation,neurotransmitter dysregulation,and oxidative stress.In this review we updated the recent development of new therapeutics that regulate neurotransmitters,inflammation,lipid metabolism,autophagy,microbiota,circadian rhythm,and disease-modified genes for AD in preclinical research and clinical trials.It is to emphasize the importance of early diagnosis and multiple-target intervention,which may provide a promising outcome for AD treatment. | Feng Zhang Ru-jia Zhong Cheng Cheng Song Li Wei-dong Le | 2021 | Acta Pharmacologica Sinica2021，42，9： | 5 |
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