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| 1 | Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman's syndrome显示文摘Asherman's syndrome(AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells(BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration. Finally, five patients achieved successful pregnancies and live births. Therefore, we conclude that ΔNp63 is a crucial therapeutic target for AS. This novel treatment significantly improves the outcome for the patients with severe AS. | Guangfeng Zhao Yun Cao Xianghong Zhu Xiaoqiu Tang Lijun Ding Haixiang Sun Juan Li Xinan Li Chenyan Dai Tong Ru Hui Zhu Jingjie Lu Caimei Lin Jingmei Wang Guijun Yan Huiyan Wang Lei Wang Yimin Dai Bin Wang Ruotian Li Jianwu Dai Yan Zhou Yali Hu | 2017 | Science China(Life Sciences)2017，60，4： | 39 |
| 2 | Bio-reduction of nitrate from groundwater using a hydrogen-based membrane biofilm reactor显示文摘A hydrogen-based membrane biofilm reactor(MBfR) using H2 as electron donor was investigated to remove nitrate from groundwater.When nitrate was first introduced to the MBfR,denitrification took place on the shell side of the membranes immediately,and the effluent concentration of nitrate continuously decreased with 100% removal rate on day 45 under the influent nitrate concentration of 5 mg NO3--N/L,which described the acclimating and enriching process of autohydrogenotrophic denitrification bacteria.A series of short-term experiments were applied to investigate the effects of hydrogen pressures and nitrate loadings on denitrification.The results showed that nitrate reduction rate improved as H2 pressure increasing,and over 97% of total nitrogen removal rate was achieved when the nitrate loading increased from 0.17 to 0.34 g NO3--N/(m2 ·day) without nitrite accumulation.The maximum denitrification rate was 384 g N/(m3 ·day).Partial sulfate reduction,which occurred in parallel to nitrate reduction,was inhibited by denitrififcation due to the competition for H2 .This research showed that MBfR is effective for removing nitrate from the contaminated groundwater. | Siqing Xia Fohua Zhong Yanhao Zhang Haixiang Li Xin Yang | 2010 | Journal of Environmental Sciences2010，22，2： | 23 |
| 3 | PIKA as an Adjuvant Enhances Specific Humoral and Cellular Immune Responses Following the Vaccination of Mice with HBsAg plus PIKA显示文摘An adjuvant is usually used to enhance the immune response induced by vaccines. The choice of adjuvant or immune enhancer determines the effectiveness of the immune response. Currently, aluminium (Alum, a generic term for salts of aluminium) is the only FDA-approved adjuvant. Alum predominantly induces the differentiation of Th2 cells and thus mediates an antibody immune response. Therefore, there is an urgent need for new adjuvants that enhance not only humoral but also cellular immune responses. In the present study, we demonstrates that PIKA (a stabilized dsRNA) as an adjuvant directly induces the activation and the proliferation of both B and NK cells in vitro. Injection of PIKA into mice results in the production of cytokines in vivo. In addition, the study demonstrates that PIKA promotes the maturation of bone marrow-derived dendritic cells (BMDCs) including up-regulation of the co-stimulatory molecules CD80, CD86 and CD40, and the induction of cytokines such as IL-12p70, IL-12p40 and IL-6. Importantly, after immunization of mice with HBsAg plus PIKA, the presence of PIKA enhances the titers of HBsAg-specific IgG and HBsAg-specific IFN-γ production. These results demonstrate that PIKA as an adjuvant can promote both humoral and cellular immune responses. These might have an implication in applying PIKA as an adjuvant to be used in the design and development of both therapeutic and preventive vaccines, and used in the clinical study. | Erxia Shen Li Li Lietao Li Lianqiang Feng Lin Lu Ziliang Yao Haixiang Lin Changyou Wu | 2007 | Cellular & Molecular Immunology2007，4，2： | 13 |
| 4 | Geochronology and Hf Isotope Study of Pegmatite in the Xiaoqinling Area of NW China: Implication for Petrogenesis and Regional Metamorphism显示文摘In this study, we carried out petrography, zircon U-Pb geochronology and Hf isotopic analyses on a granitic pegmatite dyke in the Xiaoqinling area in southern margin of the North China Craton(NCC). Our study suggests that the pegmatite dyke likely crystallized from a volatile-rich pegmatitic magma. Different from most other pegmatite elsewhere, zircon from this pegmatite dyke does not contain unusually high U and Th concentrations and suffered no evident radioactive damage, therefore we successfully obtained a zircon U-Pb dating using laser ablation-inductively coupled plasma-mass spectrometry(LA-ICP-MS), which yields an average 207Pb/206 Pb age of 1 814±6 Ma, representing the intrusive age of the granitic pegmatite dyke. Zircon εHf(t) values are between-8.3 and-3.0, corresponding to Hf depleted mantle model ages from 2 649 to 2 991 Ma with an average of 2 881 Ma. These data indicate that this granitic pegmatite dyke may have been derived from partial melting of Meso-Neoarchean metamorphic rocks from the Xiaoqinling basement. Granitic pegmatite magma may have emplaced within the Taihua Group wall rocks during the last stage of the middle to high grade metamorphism. Furthermore, according to the petrographic observation, the 1.81 Ga pegmatite dyke and the 1 800–1 750 Ma Xiong'er Group rocks were not undergone middle to high grade metamorphism, indicating 1.81 Ga as the termination of the latest regional metamorphism in the southern margin of the NCC. | Haixiang Zhao Shaoyong Jiang Baozhang Dai Liang Ma Jianwei Li | 2015 | Journal of Earth Science2015，26，3： | 5 |
| 5 | Apoptotic extracellular vesicles are metabolized regulators nurturing the skin and hair显示文摘Over 300 billion of cells die every day in the human body,producing a large number of endogenous apoptotic extracellular vesicles(apoEVs).Also,allogenic stem cell transplantation,a commonly used therapeutic approach in current clinical practice,generates exogenous apoEVs.It is well known that phagocytic cells engulf and digest apoEVs to maintain the body’s homeostasis.In this study,we show that a fraction of exogenous apoEVs is metabolized in the integumentary skin and hair follicles.Mechanistically,apoEVs activate the Wnt/β-catenin pathway to facilitate their metabolism in a wave-like pattern.The migration of apoEVs is enhanced by treadmill exercise and inhibited by tail suspension,which is associated with the mechanical force-regulated expression of DKK1 in circulation.Furthermore,we show that exogenous apoEVs promote wound healing and hair growth via activation of Wnt/β-catenin pathway in skin and hair follicle mesenchymal stem cells.This study reveals a previously unrecognized metabolic pathway of apoEVs and opens a new avenue for exploring apoEV-based therapy for skin and hair disorders. | Lan Ma Chider Chen Dawei Liu Zhiqing Huang Jiaqi Li Haixiang Liu Ryan Tsz Kin Kwok Benzhong Tang Bingdong Sui Xiao Zhang Jianxia Tang Xueli Mao Weiying Huang Songtao Shi Xiaoxing Kou | 2023 | Bioactive Materials2023，，1： | 3 |
| 6 | Challenges and strategies in high-accuracy manufacturing of the world’s largest SiC aspheric mirror显示文摘In the process of manufacturing the world’s largest silicon carbide(SiC)aspheric mirror,the primary difficulties are mirror blank preparation,asphere fabrication,and testing,as well as cladding and coating.Specifically,the challenges include the homogeneity of the complicated structure casting,accuracy and efficiency of the fabrication process,print-through effect,fidelity and precision of test procedure,stress and denseness of cladding process,the dynamic range of interferometric measurement,and air turbulence error due to the long optical path.To break through such a barrier of difficulties,we proposed the water-soluble room temperature vanishing mold and gel casting technology,homogeneous microstructure reaction-formed joint technology,nano-accuracy efficient compound fabrication,gravity unloading technology,high-denseness low-defect physical vapor deposition(PVD)Si-cladding technology,test data fusion method,and time-domain averaging method,etc.Based on the proposed technologies and methods,we have accomplished the world’s largest SiC aspheric mirror with a size of φ4.03 m.The impressive performance of the SiC aspheric mirror is validated by the characteristics of the fabricated SiC aspheric mirror.The aerial density of the SiC blank is less than 120 kg/m^(2),surface shape test accuracy is better than 6 nm RMS,thickness inhomogeneity of the cladding layer is less than 5%,and the final surface figure error and roughness are 15.2 nm RMS and 0.8 nm RMS,respectively. | Xuejun Zhang Haixiang Hu Xiaokun Wang Xiao Luo Ge Zhang Wenxing Zhao Xiaoyi Wang Zhenyu Liu Ling Xiong Erhui Qi Congcong Cui Yanchao Wang Yingjie Li Xu Wang Longxiang Li Yang Bai Qiang Cheng Zhiyu Zhang Ruigang Li Wa Tang Xuefeng Zeng Weijie Deng Feng Zhang | 2022 | Light(Science & Applications)2022，11，12： | 3 |
| 7 | VMStore: Distributed storage system for multiple virtual machines显示文摘Desktop virtualization is a very hot concept in both industry and academic communities. Since virtualized desktop system is based on multiple virtual machines (VM), it is necessary to design a distributed storage system to manage the VM images. In this paper, we design a distributed storage system, VMStore, by taking into account three important characteristics: high performance VM snapshot, booting optimization from multiple images and redundancy removal of images data. We adopt a direct index structure of blocks for VM snapshots to speed up VM booting performance significantly; provide a distribute storage structure with good bandwidth scalability by dynamically changing the number of storage nodes; and propose a data preprocessing strategy with intelligent object partitioning techniques, which would eliminate duplication more effectively. Performance analysis for VMStore focuses on two metrics: the speedup of VM booting and the overhead of de-duplication. Experimental results show the efficiency and effectiveness of VMStore. | LIAO XiaoFei LI He JIN Hai HOU HaiXiang JIANG Yue & LIU HaiKun | 2011 | Science China(Information Sciences)2011，54，6： | 3 |
| 8 | Enhanced electrocatalytic oxidation of dyes in aqueous solution using cobalt phthalocyanine modified activated carbon fiber anode显示文摘Cobalt tetra(2,4-dichloro-1,3,5-triazine)aminophthalocyanine(CoPc)was immobilized covalently on activated carbon fiber(ACF)felt to obtain CoPc-modified ACF(CoPc-ACF)catalyst,and an electrocatalytic oxidation system using CoPc-ACF as the anode was constructed.The electrocatalytic oxidation of Acid Red 1(AR1)was investigated in aqueous solution by an UV-vis spectrophotometer and UPLC.The results indicated that AR1 could be eliminated efficiently in this electrocatalytic oxidation system.In addition,the results of FTIR,TOC and GC-MS suggested that the electrocatalytic oxidation experienced the decoloration achieved by destroying the azo linkage and the further mineralization due to the cleavages of benzene ring and naphthalene ring.The intermediates were mainly small molecular compounds such as maleic acid and succinic acid,etc.Repetitive tests showed that CoPc-ACF can maintain high electrocatalytic activity over several cycles.The further EPR spin-trap experiments indicated that the hydroxyl radicals did not dominate the reaction in this electrocatalytic system,which was completely different from the traditional electro-Fenton system.Based on the non-radical reaction mechanism,the CoPc-modified ACF electrocatalyst has potential application in treating actual dyestuffs wastewaters,which are accompanied with high concentration of hydroxyl radical scavengers such as chlorine ions and additives in the textile printing and dyeing industry. | LI Nan DONG SuSu LV WangYang HUANG SanQing CHEN HaiXiang YAO YuYuan CHEN WenXing | 2013 | Science China Chemistry2013，56，12： | 2 |
| 9 | Borohydride ionic liquids and borane/ionic- liquid solutions as hypergolic fuels with superior low ignition-delay times显示文摘 | LI Songqing GAO Haixiang SHREEVE J M | 2014 | Angewandte Chemie International Edition2014，53，11： | 1 |
| 10 | Construction of cytopathic PK-15 cell model of classical swine fever virus显示文摘No cytopathic effect (CPE) can be observed on classical swine fever virus (CSFV) infected cell culture in vitro. This brings an obstacle to the researches on reciprocity between CSFV and host cells. Based on the construction of full-length genomic infectious Cdna clone of Chinese CSFV standard virulent Shimen strain, partial deletion is intro- duced into genomic Cdna to obtain a 7.5 kb subgenomic Cdna. A new subgenomic CSFV is derived from transfection with the subgenomic Cdna on PK-15 cells pre-infected by CSFV Shimen virus. Typical CPE induced by this subgenomic virus is observed on PK-15 cells. Coexistence of wild- type and subgenomic virus in cytopathic cell culture is dem- onstrated by RT-PCR detection in cytopathic cells. For conclusion, the construction of cytopathic cell model exploited a new way for researches on the molecular mechanism of CSFV pathogenesis. | WU Haixiang, ZHANG Chuyu, ZHENG Congyi, WANG Jiafu, PAN Zishu, LI Lei, CAO Shen & Yl GuanghuiInstitute of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, ChinaCorrespondence should be addressed to Zhang Chuyu (e-mail: avlab@ whu.edu.cn) | 2003 | Chinese Science Bulletin2003，48，9： | 1 |
| 11 | Enhanced hydrogen storage properties of NaBH_(4)–Mg(BH_(4))_(2) composites by NdF_(3) addition显示文摘As two important members of complex hydrides,Mg(BH_(4))2 and Na BH_(4) have a high gravimetric capacity(14.9 and10.8 wt%,respectively).In this study,the Mg(BH_(4))2 was synthesized by the ion exchange method.Afterwards,the Mg(BH_(4))_(2) and Na BH_(4) composites with different amounts(30,40 and 50 wt%)of NdF3 were prepared by mechanical milling.Effects of the Nd F3 on the microstructural evolution and hydrogen storage properties were investigated.The results show that Nd F3catalyst can significantly improve the dehydrogenation kinetics of the eutectic composites of Na BH_(4)–Mg(BH_(4))_(2).The onset hydrogen desorption temperature of the composites is about88.6C,which is about 110C lower than that of Mg(BH_(4))_(2)and Na BH_(4)composites.Mg(BH_(4))_(2)–Na BH_(4)-0.5NdF3composites can released 5.2 wt%H_(2)at 250C within 30 min,and the dehydrogenation capacity is significantly higher than that of Mg(BH_(4))_(2)–Na BH_(4)composites.The analysis of the dehydrogenation mechanism reveals that NdF3takes participate in the reaction to generate Na MgF3 to promote the dehydrogenation reaction process of the composites. | Jianguang Yuan Jinting Chen Haixiang Huang Yujie Lv Bogu Liu Zhongyu Li Bao Zhang Wei Lv Ying Wu | 2021 | Progress in Natural Science:Materials International2021，31，4： | 1 |
| 12 | An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk,local immunosuppression and tumor progression显示文摘Dissecting and understanding the cancer ecosystem,especially that around the tumor margins,which have strong implications for tumor cell infiltration and invasion,are essential for exploring the mechanisms of tumor metastasis and developing effective new treatments.Using a novel tumor border scanning and digitization model enabled by nanoscale resolution-SpaTial Enhanced REsolution Omics-sequencing(Stereo-seq),we identified a 500µm-wide zone centered around the tumor border in patients with liver cancer,referred to as“the invasive zone”.We detected strong immunosuppression,metabolic reprogramming,and severely damaged hepatocytes in this zone.We also identified a subpopulation of damaged hepatocytes with increased expression of serum amyloid A1 and A2(referred to collectively as SAAs)located close to the border on the paratumor side.Overexpression of CXCL6 in adjacent malignant cells could induce activation of the JAK-STAT3 pathway in nearby hepatocytes,which subsequently caused SAAs’overexpression in these hepatocytes.Furthermore,overexpression and secretion of SAAs by hepatocytes in the invasive zone could lead to the recruitment of macrophages and M2 polarization,further promoting local immunosuppression,potentially resulting in tumor progression.Clinical association analysis in additional five independent cohorts of patients with primary and secondary liver cancer(n=423)showed that patients with overexpression of SAAs in the invasive zone had a worse prognosis.Further in vivo experiments using mouse liver tumor models in situ confirmed that the knockdown of genes encoding SAAs in hepatocytes decreased macrophage accumulation around the tumor border and delayed tumor growth.The identification and characterization of a novel invasive zone in human cancer patients not only add an important layer of understanding regarding the mechanisms of tumor invasion and metastasis,but may also pave the way for developing novel therapeutic strategies for advanced liver cancer and other solid tumors. | Liang Wu Jiayan Yan Yinqi Bai Feiyu Chen Xuanxuan Zou Jiangshan Xu Ao Huang Liangzhen Hou Yu Zhong Zehua Jing Qichao Yu Xiaorui Zhou Zhifeng Jiang Chunqing Wang Mengnan Cheng Yuan Ji Yingyong Hou Rongkui Luo Qinqin Li Liang Wu Jianwen Cheng Pengxiang Wang Dezhen Guo Waidong Huang Junjie Lei Shang Liu Yizhen Yan Yiling Chen Sha Liao Yuxiang Li Haixiang Sun Na Yao Xiangyu Zhang Shiyu Zhang Xi Chen Yang Yu Yao Li Fengming Liu Zheng Wang Shaolai Zhou Huanming Yang Shuang Yang Xun Xu Longqi Liu Qiang Gao Zhaoyou Tang Xiangdong Wang Jian Wang Jia Fan Shiping Liu Xinrong Yang Ao Chen Jian Zhou | 2023 | Cell Research2023，33，8： | 1 |
| 13 | How do inundation provoke the release of phosphorus in soil-originated sediment due to nitrogen reduction after reclaiming lake from polder显示文摘Different N and P fractions inmicrocosm incubation experiment was measured using highresolution in-situ Peeper and DGT techniques combining with sequential extraction procedure.The results showed the synchronous desorption and release of PO_(4)^(3-),S^(2-)and Fe^(2+)from the solid soil-originated sediment.This trend indicated that the significant reduction of Fe-P and SO_(4)^(2-) occurred in the pore water during the inundation.The concentrations of PO_(4)^(3-) in the overlying water and pore water increased to more than 0.1 and 0.2 mg/L at the beginning of the incubation experiment.Decreased NO_(3)^(-) concentrations from more than 1.5 mg/L to less than 0.5 mg/L combining with increasing NH^(4+) concentrations from less than 1mg/L tomore than 5 mg/L suggested the remarkable NO_(3)-reduction via dissimilatory nitrate reduction to ammonia(DNRA)pathway over time.High NH^(4+) concentrations in the pore water aggravated the release of Fe^(2+) through reduction of Fe(Ⅲ)-P as electric acceptors under anaerobic conditions.This process further stimulated the remarkable releasing of labile PO_(4)^(3-) from the solid phase to the solution and potential diffusion into overlying water.Additionally,high S^(2-) concentration at deeper layer indicated the reduction and releasing of S^(2-)from oxidation states,which can stimulated the NO_(3)^(-)reduction and the accumulation of NH^(4+)in the pore water.This process can also provoke the reduction of Fe-P as electric acceptors following the release of labile PO_(4)^(3-)into pore water.Generally,inundation potentially facilitate the desorption of labile P and attention should be paid during the reclaiming lake from polder. | Hezhong Yuan Bingchan Jia JuanWu Haixiang Wang Jianghua Yu Yiwei Cai Enfeng Liu Qiang Li Qingfei Zeng | 2022 | Journal of Environmental Sciences2022，34，8： | 1 |
| 14 | Small molecule gas sorption and diffusion in coal: molecular simulation 显示文摘 | Hu Haixiang Li Xiaochun Fang Zhiming Wei Ning Li Qianshu | 2010 | Energy2010，35，： | 1 |
| 15 | Transmission of Point-line Meshing Gear显示文摘 | Luo Qihan Li Haixiang Wang Junrong | 2007 | The International Journal of Advanced Manufacturing Technology2007，33，10： | 1 |
| 16 | Transmission of point - line meshing gear显示文摘 | Luo Qihan Li Haixiang Wang Junrong | 2007 | Aduanced Manufacturing Technology2007，33，910： | 1 |
| 17 | Delay-induced inward and outward spiral waves in oscillatory medium显示文摘 | HU Haixiang JI Lin LI Shuqian | 2008 | J ChemPhys2008，128，04： | 1 |
| 18 | A smooth non-parametric estimation framework for safety-first port-folio optimization显示文摘 | Yao Haixiang Li Yong Benson K | 2014 | Quantitative Finance2014，15，11： | 1 |
| 19 | Mean -CVaR portfolio selection: A nonparametric estimationframework 显示文摘 | Yao Haixiang Li Zhongfei Lai Yongzeng | 2013 | Computers Operations Research2013，40，4： | 1 |
| 20 | In vivo target protein degradation induced by PROTACs based on E3 ligase DCAF15显示文摘Dear Editor,As an emerging drug discovery paradigm,Proteolysis targeting chimeras(PROTACs)facilitate ubiquitination and degradation of the targets by cellular endogenous proteasome system.Compared with traditional small molecular inhibitors,PROTACs work like enzymes and can operate with or without functional inhibition of the targets,which endows this strategy to degrade drug targets,especially useful for“undruggable”ones. | Liang Li Dazhao Mi Haixiang Pei Qiuhui Duan Xinyue Wang Wenbo Zhou Jianping Jin Dali Li Mingyao Liu Yihua Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
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