|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury显示文摘The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan,Hubei province,and rapidly spread to many provinces in China as well as other countries.Here we report the epidemiological,clinical,laboratory,and radiological characteristics,as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen,China.All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS).The most common laboratory abnormalities were hypoalbuminemia,lymphopenia,decreased percentage of lymphocytes (LYM) and neutrophils (NEU),elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH),and decreased CD8 count.The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity.ALB,LYM,LYM (%),LDH,NEU (%),and CRP were highly correlated to the acute lung injury.Age,viral load,lung injury score,and blood biochemistry indexes,albumin (ALB),CRP,LDH,LYM (%),LYM,and NEU (%),may be predictors of disease severity.Moreover,the Angiotensin Ⅱlevel in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury.Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection. | Yingxia Liu Yang Yang Cong Zhang Fengming Huang Fuxiang Wang Jing Yuan Zhaoqin Wang Jinxiu Li Jianming Li Cheng Feng Zheng Zhang Lifei Wang Ling Peng Li Chen Yuhao Qin Dandan Zhao Shuguang Tan Lu Yin Jun Xu Congzhao Zhou Chengyu Jiang Lei Liu | 2020 | Science China(Life Sciences)2020，63，3： | 157 |
| 2 | A huge oceanic-type UHP metamorphic belt in southwestern Tianshan, China: Peak metamorphic age and P-T path显示文摘Recent progress in the study of the UHP metamorphic belt in southwestern Tianshan,China,is summarized in this paper.This about 80-km-long and over 10-km-wide UHP belt has been recognized by the discovery of coesite,coesite pseudomorphs and other UHP minerals.It is the largest oceanic-type UHP metamorphic belt reported so far.It has formed due to northward subduction of the Tianshan Paleo-Ocean.U-Pb dating of metamorphic rims of zircons from a coesite-bearing garnet-phengite schist yields a peak UHP metamorphic ages of 320±3.7 Ma.Combined with ages of 233–226 Ma obtained from rims of zircons from retrograded eclogites,a long retrograde metamorphic evolution(>70 Ma)has been revealed.According to phase equilibria modeling,the P-T paths of both coesite-bearing eclogites and garnet-phengite schists are characterized by thermal relaxation,i.e.,the metamorphic temperature peak lags behind the pressure peak,indicating that the UHP rocks experienced slow and long heating and decompression during exhumation in the subduction channel.On the basis of the field observation that a small amount of eclogite lenses is wrapped in large volumes of metapelites,and the similar P-T paths of both rock types,we propose that the exhumation of the UHP eclogites from southwestern Tianshan,China,may have resulted from the exhumation of large volumes of low-density metapelites,which carried the denser eclogites to the Earth’s surface. | ZHANG LiFei DU JinXue Lü Zeng YANG Xin GOU LongLong XIA Bin CHEN ZhenYu WEI ChunJing SONG ShuGuang | 2013 | Chinese Science Bulletin2013，58，35： | 19 |
| 3 | Modulation of IL-37 expression by triptolide and triptonide in THP-1 cells显示文摘IL-37 是仅仅最近被识别的反煽动性的 cytokine,并且它高度与煽动性、自体免疫的疾病从病人在纸巾被表示。煽动性的 cytokines 和煽动性的刺激能导致 IL-37 的 upregulation。然而,反煽动性的药是否导致 IL-37 的表示,没被报导。在这个工作,第一次,我们揭开了那主要 bioactive 二个部件, triptolide 和 triptonide,从植物 Tripterygium wilfordii 钩 f。(TwHF ) ,它拥有反煽动性的活动, upregulate IL-37 的表示,和这表情被 ERK1/2 和 p38 MAPK 禁止者压制。总的来说,第一次,我们的研究表明了那反煽动性的活跃部件(triptolide 和 triptonide ) upregulated 经由 ERK1/2 和 p38 MAPK 小径的激活最可能的 IL-37 的表示。 | Lingge He Zhuangyan Liang Fuqian Zhao Lifei Peng Zhangquan Chen | 2015 | Cellular & Molecular Immunology2015，12，4： | 14 |
| 4 | Experimental investigation on thermal conductivity and viscosity of aluminum nitride nanofluid显示文摘Aluminum nitride nanoparticles (AlNs) have been found to be a good additive for enhancing the thermal conductivity of traditional heat exchange fluids.At a volume fraction of 0.1,the thermal conductivity enhancement ratios are 38.71% and 40.2%,respectively,for ethylene glycol and propylene glycol as the base fluids.Temperature does not have much influence on the enhanced thermal conductivity ratios of the nanofluids,though a volume fraction of 5.0% appears to signify a critical concentration for rheology:for<5.0 vol% for Newtonian behavior,and for >5.0 vol% for obvious shear-shinning behavior,for both ethylene glycol and propylene glycol. | Wei Yu Huaqing Xie Yang Li Lifei Chen | 2011 | Particuology2011，9，2： | 9 |
| 5 | Effect of Short-term Forest Bathing in Urban Parks on Perceived Anxiety of Young-adults: A Pilot Study in Guiyang, Southwest China显示文摘Forest can be taken as a natural therapy to alleviate perceived anxiety of visitors. Given the geographical difference between urban and rural forest environments, little is known about the urban forest therapy effect of anxiety alleviation with reference to the rural forest. In this study, forty-three university students(aged from 19 to 23) were recruited as participants to visit the forest parks at urban and rural areas of Guiyang City on 21 and 23 December 2016. The forest experience was separated by four sceneries. Participants were asked to complete questionnaires by self-evaluating specific anxiety change from 12 questions with scores from 1 to 10 at both entrance and exit of the parks. The Wilcoxon signed-rank test and paired t-test were used to compare the change of anti-anxiety scores during forest bathing and between urban and rural forests, respectively. Results revealed that forest bathing in the urban park can alleviate the anxiety from financial state(P = 0.0028), exam-pass pressure(P = 0.0040) and love-affair relationship(P = 0.0286). Although rural forest bathing can also alleviate the anxiety from financial state(P = 0.0222), meanwhile, it maintained the anxiety about campus life(P < 0.0001). Forest tree richness tended to be higher in the rural forest park than in the urban one, which in contrast decreased the anxiety alleviation from inter-communication in the rural forest park(P = 0.0487). Principle component analysis indicated that participants tended to perceive more decline of anxiety from social contact in the urban forest. In conclusion, university students were recommended to pay a short visit to the urban forest with partners if they felt anxious about personal affairs and felt necessary to talk with others. For general people's visiting, urban forest trees can be controlled in diversity to some extent to look orderly and alleviate perceived anxiety. | ZHOU Changwei YAN Lingbin YU Lifei WEI Hongxu GUAN Haoming SHANG Chongfei CHEN Feiyu BAO Junzhou | 2019 | Chinese Geographical Science2019，29，1： | 5 |
| 6 | Tissue distribution and tumor uptake of folate receptor–targeted epothilone folate conjugate,BMS-753493,in CD2F1 mice after systemic administration显示文摘To assess targeting of an epothilone folate conjugate(BMS-753493) to the folate receptor(FR)-overexpressed tumor in mice bearing both FRt and FR– tumors,a series of experiments were conducted by quantitative whole-body autoradiography(QWBA) and LC–MS/MS following i.v.administration of BMS-753493 or its active moiety,BMS-748285 in mice bearing FRt(98M109) and FR–(M109) tumors.QWBA showed [3H]BMS-753493–derived radioactivity was extensively distributed to various tissues.The FR over-expressing 98M109 tumors showed consistently higher level of radioactivity than FR-negative tumors(i.e.,M109 tumors) up to 48 h post dose of [3H]BMS-753493,despite the magnitude of difference between the tumors is relatively small(generally 3 5-fold).The radioactivity level in 98M109 tumors was 2 12-fold of normal tissues except intestine/content at 48 h post dose.No selective radioactivity uptake into 98M109 tumors over M109 or normal tissues was observed after i.v.administration of the active epothilone,[3H]BMS-748285.LC–MS/MS measurements demonstrated that the concentrations of BMS-748285,presumably from hydrolysis of the folate conjugate,in 98M109 tumors were greater than those in M109 tumors after i.v.administration of BMS-753493(2–3-fold) whereas no differential uptake in the tumors following BMS-748285 administration.Those data were consistent with radioactivity determinations.Those results demonstrated that the folate conjugation in BMS-753493 enabled moderately preferential distribution of the active epothilone to FR overexpressing 98M109 tumors,thereby supporting targeted delivery of cytotoxics through the folate receptor. | Hong Shen Lifei Wang Weiqi Chen Krista Menard Yang Hong Yuan Tian Samuel J.Bonacorsi W.Griffith Humphreys Francis Y.Lee Jinping Gan | 2016 | Acta Pharmaceutica Sinica B2016，6，5： | 3 |
| 7 | Progress in octahedral spherical hohlraum study显示文摘In this paper,we give a review of our theoretical and experimental progress in octahedral spherical hohlraum study.From our theoretical study,the octahedral spherical hohlraums with 6 Laser Entrance Holes(LEHs)of octahedral symmetry have robust high symmetry during the capsule implosion at hohlraum-to-capsule radius ratio larger than 3.7.In addition,the octahedral spherical hohlraums also have potential superiority on low backscattering without supplementary technology.We studied the laser arrangement and constraints of the octahedral spherical hohlraums,and gave a design on the laser arrangement for ignition octahedral hohlraums.As a result,the injection angle of laser beams of 50°-60°was proposed as the optimum candidate range for the octahedral spherical hohlraums.We proposed a novel octahedral spherical hohlraum with cylindrical LEHs and LEH shields,in order to increase the laser coupling efficiency and improve the capsule symmetry and to mitigate the influence of the wall blowoff on laser transport.We studied on the sensitivity of the octahedral spherical hohlraums to random errors and compared the sensitivity among the octahedral spherical hohlraums,the rugby hohlraums and the cylindrical hohlraums,and the results show that the octahedral spherical hohlraums are robust to these random errors while the cylindrical hohlraums are the most sensitive.Up till to now,we have carried out three experiments on the spherical hohlraum with 2 LEHs on Shenguang(SG)laser facilities,including demonstration of improving laser transport by using the cylindrical LEHs in the spherical hohlraums,spherical hohlraum energetics on the SGIII prototype laser facility,and comparisons of laser plasma instabilities between the spherical hohlraums and the cylindrical hohlraums on the SGIII laser facility. | Ke Lan Jie Liu Zhichao Li Xufei Xie Wenyi Huo Yaohua Chen Guoli Ren Chunyang Zheng Dong Yang Sanwei Li Zhiwen Yang Liang Guo Shu Li Mingyu Zhang Xiaoying Han Chuanlei Zhai Lifei Hou Yukun Li Keli Deng Zheng Yuan Xiayu Zhan Feng Wang Guanghui Yuan Haijun Zhang Bobin Jiang Lizhen Huang Wei Zhang Kai Du Runchang Zhao Ping Li Wei Wang Jingqin Su Xuewei Deng Dongxia Hu Wei Zhou Huaiting Jia Yongkun Ding Wanguo Zheng Xiantu He | 2016 | Matter and Radiation at Extremes2016，1，1： | 2 |
| 8 | Developmental toxicity of TCBPA on the nervous and cardiovascular systems of zebrafish (Danio rerio): A combination of transcriptomic and metabolomics显示文摘Tetrachlorobisphenol A(TCBPA),a widely used halogenated flame retardant,is frequently detected in environmental compartments and human samples.However,unknown developmental toxicity and mechanisms limit the entire understanding of its effects.In this study,zebrafish(Danio rerio)embryos were exposed to various concentrations of TCBPA while a combination of transcriptomics,behavioral and biochemical analyzes as well as metabolomics were applied to decipher its toxic effects and the potential mechanisms.We found that TCBPA could interfere with nervous and cardiovascular development through focal adhesion and extracellular matrix-receptor(ECM-receptor)interaction pathways through transcriptomic analysis.Behavioral and biochemical analysis results indicated abnormal swimming behavior of zebrafish larvae.Morphological observations revealed that TCBPA could cause the loss of head blood vessels.Metabolomic analysis showed that arginine-related metabolic pathways were one of the main pathways leading to TCBPA developmental toxicity.Our study demonstrated that by using omics,TCBPA was shown to have neurological and cardiovascular developmental toxicity and the underlying mechanisms were uncovered and major pathways identified. | Wentao Liu Yifan Pan Lu Yang Yun Xie Xuanyue Chen Jing Chang Weiyu Hao Lifei Zhu Bin Wan | 2023 | Journal of Environmental Sciences2023，，5： | 2 |
| 9 | Metallic and ferromagnetic MoS2 nanobelts with vertically aligned edges显示文摘Edge effects are predicted to significantly impact the properties of low dimensional materials with layered structures. The synthesis of low dimensional materials with copious edges is desired for exploring the effects of edges on the band structure and properties of these materials. Here we developed an approach for synthesizing MoS2 nanobelts terminated with vertically aligned edges by sulfurizing hydrothermally synthesized MoO3 nanobelts in the gas phase through a kinetically driven process; we then investigated the electrical and magnetic properties of these metastable materials. These edge-terminated MoS2 nanobelts were found to be metallic and ferromagnetic, and thus dramatically different from the semiconducting and nonmagnetic two-dimensional (2D) and three-dimensional (3D) 2H-MoS2 materials. The transitions in electrical and magnetic properties elucidate the fact that edges can tune the properties of low dimensional materials. The unique structure and properties of this one-dimensional (1D) MoS2 material will enable its applications in electronics, spintronics, and catalysis. | Guanchen Xu Xinsheng Wang Yupeng Sun Xiao Chen Jingying Zheng Lifei Sun Liying Jiao Jinghong Li | 2015 | Nano Research2015，8，9： | 2 |
| 10 | A probabilistic framework for optimizing projected clusters with categorical attributes显示文摘The ability to discover projected clusters in high-dimensional data is essential for many machine learning applications. Projective clustering of categorical data is currently a challenge due to the difficulties in learning adaptive weights for categorical attributes coordinating with clusters optimization. In this paper,a probability-based learning framework is proposed, which allows both the attribute weights and the centerbased clusters to be optimized by kernel density estimation on categorical attributes. A novel algorithm is then derived for projective clustering on categorical data, based on the new learning approach for the kernel bandwidth selection problem. We show that the attribute weight substantially connects to the kernel bandwidth, while the optimized cluster center corresponds to the normalized frequency estimator of the categorical attributes.Experimental results on synthesis and real-world data show outstanding performance of the proposed method,which significantly outperforms state-of-the-art algorithms. | CHEN LiFei | 2015 | Science China(Information Sciences)2015，58，7： | 2 |
| 11 | Surface chemical modification of muhiwalled carbon nanotubes by a wet- mechanochemical reaction显示文摘 | Chen Lifei Xie Huaqing Li yang | 2008 | Journal of Nanomaterials2008，2008，1200： | 1 |
| 12 | Regenerative potential of allopregnanolone显示文摘 | Jun Ming Wang Lifei Liu Ronald W. Irwin Shuhua Chen Roberta Diaz Brinton | 2007 | Brain Research Reviews2007，，2： | 1 |
| 13 | Binding of Puerarin to Human Serum Albumin: A Spectroscopic Analysis and Molecular Docking显示文摘 | Yang He Yiwei Wang Lifei Tang Hui Liu Wei Chen Zhongliang Zheng Guolin Zou | 2008 | Journal of Fluorescence2008，，2： | 1 |
| 14 | Model-based method for projective clustering显示文摘 | Chen Lifei Jiang Qingshan Wang Shengrui | 2012 | IEEE Transactions on Knowledge and Data Engineering2012，24，7： | 1 |
| 15 | Effect of the spacer group of cationic gemini surfactant on microemulsion phase behavior显示文摘 | Chen Lifei Shang Yazhuo Liu Honglai | | 0，，02： | 1 |
| 16 | Model-based method for projective clustering显示文摘 | Chen Lifei Jiang Qingshan Wang Shengrui | 2012 | IEEE Transactions on Knowledge and Data Engineering2012，24，7： | 1 |
| 17 | Investigation of Thermal Conductivity and Viscosity of Ethylene Glycol Base ZnO Nanofluid 显示文摘 | YU Wei XIE Huaqing CHEN Lifei | 2009 | Thermochimica Acta2009，491，： | 1 |
| 18 | Petrology of rodingite derived from eclogite in western Tianshan,China显示文摘 | Li Xuping Zhang Lifei Wei Chunjing Ai Yongliang Chen Jing | | 0，，03： | 1 |
| 19 | Investigation on the thermal transport properties of ethylene glycol-based nanofluids containing copper nanoparticles显示文摘 | Wei Yu Huaqing Xie Lifei Chen Yang Li | 2009 | Powder Technology2009，，3： | 1 |
| 20 | Effect of the spacer group of cationic gemini surfactant on microemulsion phase behavior 显示文摘 | Lifei Chen Yazhuo Shang Honglai Liu | 2006 | Journal of Colloid and Interface Science2006，301，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员