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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Comparison of Long-term Outcomes in Patients with Premature Triple-vessel Coronary Disease Undergoing Three Different Treatment Strategies: A Prospective Cohort Study显示文摘 | Jing-Jing Xu Yin Zhang Lin Jiang Jian Tian Lei Song Zhan Gao Xin-Xing Feng Xue-Yan Zhao Yan-Yan Zhao Dong Wang Kai Sun Lian-Jun Xu Ru Liu Run-Lin Gao Bo Xu Lei Song Jin-Qing Yuan | 2018 | Chinese Medical Journal2018，，1： | 10 |
| 3 | Efficacy and safety of Shenyankangfu Tablet,a Chinese patent medicine,for primary glomerulonephritis:A multicenter randomized controlled trial显示文摘Background:Shenyankangfu Tablet(SYKFT)is a Chinese patent medicine that has been used widely to decrease proteinuria and the progression of chronic kidney disease.Objective:This trial compared the efficacy and safety of SYKFT,for the control of proteinuria in primary glomerulonephritis patients,against the standard drug,losartan potassium.Design,setting,participants and intervention:This was a multicenter,double-blind,randomized,controlled clinical trial.Primary glomerulonephritis patients,aged 18-70 years,with blood pressure≤140/90 mmHg,estimated glomerular filtration rate(eGFR)>45 mL/min per 1.73 ㎡,and 24-hour proteinuria level of 0.5-3.0 g,were recruited in 41 hospitals across 19 provinces in China and were randomly divided into five groups:SYKFT,losartan potassium 50 mg or 100 mg,SYKFT plus losartan potassium 50 mg or 100 mg.Main outcome measu res:The primary outcome was change in the 24-hour proteinuria level,after 48 weeks of treatment.Results:A total of 735 participants were enrolled.The percent decline of urine protein quantification in the SYKFT group after 48 weeks was 8.78%±2.56%(P=0.006)more than that in the losartan 50 mg group,which was 0.51%±2.54%(P=1.000)less than that in the losartan 100 mg group.Compared with the losartan potassium 50 mg group,the SYKFT plus losartan potassium 50 mg group had a 13.39%±2.49%(P<0.001)greater reduction in urine protein level.Compared with the losartan potassium 100 mg group,the SYKFT plus losartan potassium 100 mg group had a 9.77%±2.52%(P=0.001)greater reduction in urine protein.With a superiority threshold of 15%,neither was statistically significant.eGFR,serum creatinine and serum albumin from the baseline did not change statistically significant.The average change in TCM syndrome score between the patients who took SYKFT(-3.00[-6.00,-2.00])and who did not take SYKFT(-2.00[-5.00,0])was statistically significant(P=0.003).No obvious adverse reactions were observed in any group.Conclusion:SYKFT decreased the proteinuria and improved the TCM syndrome scores of primary glomerulonephritis patients,with no change in the rate of decrease in the eGFR.SYKFT plus losartan potassium therapy decreased proteinuria more than losartan potassium therapy alone.Trial registration number:NCT02063100 on ClinicalTrials.gov. | Jie Wu Shu-wei Duan Hong-tao Yang Yue-yi Deng Wei Li Ya-ni He Zhao-hui Ni Yong-li Zhan Shan Lin Zhi-yong Guo Jun Zhu Jing-ai Fang Xu-sheng Liu Li-hua Wang Rong Wang Nian-song Wang Xiao-hong Cheng Li-qun He Ping Luo Shi-ren Sun Ji-feng Sun Ai-ping Yin Geng-ru Jiang Hong-yu Chen Wen-hu Liu Hong-li Lin Meng Liang Lu Ma Ming Chen Li-qun Song Jian Chen Qing Zhu Chang-ying Xing Yun Li Ji-ning Gao Rong-shan Li Ying Li Hao Zhang Ying Lu Qiao-ling Zhou Jun-zhou Fu Qiang He Guang-yan Cai Xiang-mei Chen | 2021 | Journal of Integrative Medicine2021，19，2： | 8 |
| 4 | Relationship between fibrinogen levels and cardiovascular events in patients receiving percutaneous coronary intervention:a large single-center study显示文摘Background:It is currently unclear if fibrinogen is a risk factor for adverse events in patients receiving percutaneous coronary intervention(PCI)or merely serves as a marker of pre-existing comorbidities and other causal factors.We therefore investigated the association between fibrinogen levels and 2-year all-cause mortality,and compared the additional predictive value of adding fibrinogen to a basic model including traditional risk factors in patients receiving contemporary PCI.Methods:A total of 6293 patients undergoing PCI with measured baseline fibrinogen levels were enrolied from January to December 2013 in Fuwai Hospital.Patients were divided into three groups according to tertiles of baseline fibrinogen levels:low fibrinogen,<2.98 g/L;medium fibrinogen,2.98 to 3.58 g/L;and high fibrinogen,≥3.58 g/L.Independent predictors of 2-year clinical outcomes were determined by multivariate Cox proportional hazards regression modeling.The increased discriminative value of fibrinogen for predicting all-cause mortality was assessed using the C-statistic and integrated discrimination improvement(IDI).Results:The 2-year all-cause mortality rate was 1.2%.It was significantly higher in the high fibrinogen compared with the low and medium fibrinogen groups according to Kaplan-Meier analyses(1.7%vs.0.9%and 1.7%vs.1.0%,respectively;log-rank,P=0.022).Fibrinogen was significantly associated with all-cause mortality according to multivariate Cox regression(hazard ratio 1.339,95%confidence interval:1.109-1.763,P=0.005),together with traditional risk factors including age,sex,diabetes mellitus,left ventricular ejection fraction,creatinine clearance,and low-density lipoprotein cholesterol.The area under the curve for all-cause mortality in the basic model including traditional risk factors was 0.776,and this value increased to 0.787 when fibrinogen was added to the model(IDI=0.003,Z=0.140,P=0.889).Conclusions:Fibrinogen is associated with 2-year all-cause mortality in patients receiving PCI,but provides no additional information over a model including traditional risk factors. | Ping Jiang Zhan Gao Wei Zhao Ying Song Xiao-Fang Tang Jing-Jing Xu Huan-Huan Wang Lin Jiang Jue Chen Shu-Bin Qiao Yue-Jin Yang Run-Lin Gao Bo Xu Jin-Qing Yuan | 2019 | Chinese Medical Journal2019，，8： | 7 |
| 5 | Prognostic Value of NT-proBNP in Stable Coronary Artery Disease in Chinese Patients after Percutaneous Coronary Intervention in the Drug-eluting Stent Era显示文摘Objective The predictive value of N-terminal pro-brain natriuretic peptide(NT-proBNP) in patients with stable coronary artery disease(SCAD) in the drug-eluting stent era is not yet clear. We aimed to evaluate the prognostic value of NT-proBNP in SCAD patients after percutaneous coronary intervention(PCI). Methods We examined 4,293 consecutive SCAD patients who underwent PCI between January 2013 and December 2013 in Fuwai Hospital, China. The primary endpoint was all-cause death. NT-proBNP levels were measured before PCI using Elisa kits(Biomedica, Austria). The indication for PCI was based on the degree of coronary stenosis and evidence of ischemia. Results Among 3,187 SCAD patients with NT-proBNP data, after a 2-year follow-up, NT-proBNP levels were predictive for all-cause death in the SCAD population [area under the receiver operating characteristic curve, 0.768; 95% confidence interval(CI), 0.687-0.849; P < 0.001]. At the optimum cutoff point of 732 pg/mL, the sensitivity and specificity of death was 75.0% and 72.3%, respectively. In a multivariable Cox regression model, the death hazard ratio was 6.43(95% CI, 2.99-13.82; P < 0.001) for patients with NT-proBNP levels ≥ 732 pg/mL, compared with < 732 pg/mL. Conclusion NT-proBNP is a strong predictor of 2-year death with SCAD after PCI in the drug-eluting stent era. | ZHAO Xue Yan LI Jian Xin TANG Xiao Fang XU Jing Jing SONG Ying JIANG Lin CHEN Jue SONG Lei GAO Li Jian GAO Zhan QIAO Shu Bin YANG Yue Jin GAO Run Lin XU Bo YUAN Jin Qing | 2018 | Biomedical and Environmental Sciences2018，31，12： | 5 |
| 6 | Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors显示文摘Novel therapies are urgently needed to improve global treatment of SARS-CoV-2 infection.Herein,we briefly provide a concise report on the medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors with representative examples in different strategies from the medicinal chemistry perspective. | Shenghua Gao Tianguang Huang Letian Song Shujing Xu Yusen Cheng Srinivasulu Cherukupalli Dongwei Kang Tong Zhao Lin Sun Jian Zhang Peng Zhan Xinyong Liu | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 5 |
| 7 | Evaluation of CRUSADE and ACUITY-HORIZONS Scores for Predicting Long-term Out-of-Hospital Bleeding after Percutaneous Coronary Interventions显示文摘 | Xue-Yan Zhao Jian-Xin Li Xiao-Fang Tang Ying Xian Jing-Jing Xu Ying Song Lin Jiang Lian-Jun Xu Jue Chen Yin Zhang Lei Song Li-Jian Gao Zhan Gao Jun Zhang Yuan Wu Shu-Bin Qiao Yue-Jin Yang Run-Lin Gao Bo Xu Jin-Qing Yuan | 2018 | Chinese Medical Journal2018，，3： | 4 |
| 8 | Validation of Predictive Value of Patterns of Nonadherence to Antiplatelet Regimen in Stented Patients Thrombotic Risk Score in Chinese Population Undergoing Percutaneous Coronary Intervention:A Prospective Observational Study显示文摘Background:The patterns of nonadherence to antiplatelet regimen in stented patients (PARIS)thrombotic risk score are a novel score for predicting the risk of coronary thrombotic events (CTEs)after percutaneous coronary intervention (PCI)with drug-eluting stents. However,the prognostic value of this score has not been fully evaluated in non-Euro-American PCI populations. Methods:We performed a prospective,observational study of 10,724 patients who underwent PCI in Fuwai hospital,China and evaluated the PARIS thrombotic risk score's predictive value of CTEs in the PCI population.The area under the receiver operating characteristic curve (AUROC)was used to assess the predictive value of the PARIS score for CTE. Results:Among 9782 patients without in-hospital events,a total of 95 CTEs occurred during the 2-year follow-up.The PARIS score was significantly higher in patients with CTEs (3.384-2.04)compared with patients without events (2.53±1.70,P <0.001). According to the risk stratification of the PARIS thrombotic score,the risk of CTEs in the high-risk group was 3.14 times higher than that in the low-risk group (hazard ratio [HR],3.14;95% confidence interval [CI],1.92-5.13;P <0.001).However,the risk of CTEs in the intermediate-risk and low-risk groups was not significant (HR,1.39;95% CI,[0.86-2.24];P =0.184).The PARIS score showed prognostic value in evaluating CTEs in the overall population (AUROC,0.621;95% CI,0.561-0.681),the acute coronary syndrome (ACS)population (AUROC,0.617;95% CI,0.534-0.700;P =0.003),and the non-ACS population (AUROC,0.647;95% CI,0.558-0.736;P =0.001). Conclusions:In a real-world Chinese population,the PARIS thrombotic risk score shows a modest prognostic value for CTEs in patients after PCI.This score also has a predictive value for CTEs in the ACS and non-ACS subgroup populations. | Xue-Yan Zhao Jian-Xin Li Xiao-Fang Tang Jing-Jing Xu Ying Song Lin Jiang Jue Chen Lei Song Li-Jian Gao Zhan Gao Shu-Bin Qiao Yue-Jin Yang Run-Lin Gao Ro Xu Jin-Qing Yuan | 2018 | Chinese Medical Journal2018，，22： | 4 |
| 9 | Association of CDKN2B-AS1 Polymorphisms with Premature Triple-vessel Coronary Disease and Their Sex Specificity in the Chinese Population显示文摘Objective The aim of this study is to establish whether cyclin-dependent kinase inhibitor 2B antisense RNA 1(CDKN2 B-AS1) gene polymorphisms are associated with premature triple-vessel disease(PTVD). Methods Nine single-nucleotide polymorphisms(rs1063192, rs10757274, rs1333042, rs1333049, rs2285327, rs3217986, rs3217992, rs4977574, and rs9632884) were genotyped in 884 PTVD patients and 907 control subjects(males ≤ 50 years old and females ≤ 60 years old) using the improved multiplex ligase detection reaction method. Results The allele frequencies of rs10757274 G, rs1333049 C, rs4977574 G(all P < 0.001), and rs3217986 G(P = 0.040) were significantly higher in the PTVD group than in the control group, but those of rs1063192 A, rs1333042 G, and rs9632884 C(all P < 0.001) were significantly lower in the former than in the latter. Logistic regression analysis revealed that homozygote AA of rs1333042 is associated with decreased risk for PTVD(OR = 0.42, 95% CI: 0.22-0.82, P = 0.011). In addition, the allele frequencies observed differed between genders. The G allele of rs3217986 was associated with increased risk for PTVD in male patients only(OR = 2.94, 95% CI: 1.27-6.80, P = 0.012) in the dominant model, and no positively mutated allele was found in female patients. Conclusion Polymorphisms of the CDKN2 B-AS1 gene are associated with the incidence of PTVD in the Chinese population. Furthermore, the frequencies of mutated alleles differed between genders. | XU Jing Jing JIANG Lin XU Lian Jun GAO Zhan ZHAO Xue Yan ZHANG Yin SONG Ying LIU Ru SUN Kai GAO Run Lin XU Bo SONG Lei YUAN Jin Qing | 2018 | Biomedical and Environmental Sciences2018，31，11： | 3 |
| 10 | Evaluation of the Patterns of Non-Adherence to Anti-Platelet Regimens in Stented Patients Bleeding Score for Predicting the Long-term Out-of-hospital Bleeding Risk in Chinese Patients after Percutaneous Coronary Intervention显示文摘 | Xue-Yan Zhao Jian-Xin Li Xiao-Fang Tang Jing-Jing Xu Ying Song Lin Jiang Jue Chen Lei Song Li-Jian Gao Zhan Gao Shu-Bin Qiao Yue-Jin Yang Run-Lin Gao Bo Xu Jin-Qing Yuan | 2018 | Chinese Medical Journal2018，，12： | 2 |
| 11 | Relationships between body weight and other morphological traits in young sea cucumbers Apostichopus japonicas显示文摘Correlation, multiple regression, and path analyses were used to investigate the relationships between body weight and three other morphological traits in juvenile Japanese sea cucumbers Apostichopus japonicus . We measured live body weight (BW), body length (BL), numbers of papillae (NP), and numbers of tube feet (NF) at 60, 80, 100, and 130 days post-hatching (dph). We calculated path correlation coefficients, correlation indices ( R 2 ), and coefficients of determination with BW as the dependent variable and the other morphological traits as independent variables. The coefficient of variation for BW was high across all age groups, and all measured morphological traits were significantly correlated ( P < 0.01). BL had the greatest direct eff ect on BW across all age groups (60 dph, 0.526;80 dph, 0.404;100 dph, 0.620;and 130 dph, 0.681), while NF had the greatest indirect eff ect on BW across all age groups (60 dph, 0.528;80 dph, 0.452;100 dph, 0.666;and 130 dph, 0.603). Regression analyses between morphological traits and BW indicated that R 2 was greater than 0.85 only in the 100-dph specimens. The indirect eff ects of the other measured morphological traits on BW were age-dependent. The optimal regression equations, as determined with stepwise regression, were, for 60-dph specimens: BW 60 =10 (-3.04+0.092BL+0.014NP+0.014NF)( R 2 =0.632);for 80-dph specimens: BW 80 =10 (- 3.035+0.056BL+0.017NP+0.02NF)( R 2 =0.686);for 100-dph specimens: BW 100 =10 (- 3.742+0.069BL+0. 633 · lg (NP)+0. 464 · lg (NF))( R 2 =0.893);and for 130-dph specimens: BW 130 =10 (- 2.472+0.065BL+0.012NP)( R 2 =0.774). Our work clarified the correlation between various morphological traits and body weight of a commercially-important sea cucumber species ( A . japonicus ). Our predictive models for body weight might be useful for the aquaculture and selective breeding of A . japonicus . These models might also provide theoretical support for the indirect selection of traits that are difficult to select directly. | ZHAN Yaoyao ZHANG Weijie GE Chen LIN Kai LI Guang SONG Jian CHANG Yaqing | 2019 | Journal of Oceanology and Limnology2019，37，2： | 2 |
| 12 | Effects of metabolic syndrome on onset age and long-term outcomes in patients with acute coronary syndrome显示文摘BACKGROUND: We aim to investigate effects of metabolic syndrome on onset age and long-termoutcomes in patients with acute coronary syndrome (ACS).METHODS: Patients with ACS (n=6,431) who underwent percutaneous coronary interventionfrom January to December 2013 were enrolled. After excluding patients with previous coronary arterydisease, 1,558 patients were diagnosed with early-onset ACS (men aged ≤50 years;women aged≤60 years) and 3,044 patients with late-onset ACS. Baseline characteristics and five-year clinicaloutcomes were measured.RESULTS: Body mass index, triglyceride, low-density lipoprotein cholesterol, and uric acidconcentrations were significantly higher, while the high-density lipoprotein cholesterol (HDL-C)concentration was lower in the early-onset ACS group (P<0.001). Multivariate logistic regression revealedobesity (odds ratio [OR] 1.590, 95% confi dence interval [CI] 1.345–1.881), hypertriglyceridemia (OR 1.403,95% CI 1.185–1.660), and low HDL-C (OR 1.464, 95% CI 1.231–1.742) as independent risk factorsfor early-onset ACS (all P<0.001). The fi ve-year follow-up showed that the incidences of all cause death(1.5% vs. 3.8%, P<0.001), cardiac death (1.1% vs. 2.0%, P=0.023), and recurrent stroke (2.2% vs. 4.2%,P<0.001) were lower, while bleeding events were more frequent in the early-onset ACS group. A subgroupanalysis showed higher incidences of recurrent myocardial infarction (MI) and revascularization in patientswith early-onset ACS and metabolic syndrome.CONCLUSIONS: Obesity, hypertriglyceridemia, and lower HDL-C level are independent riskfactors for early-onset ACS, recurrent MI, and revascularization. The control of metabolic syndromemay reduce the incidence of early-onset ACS and improve the long-term prognosis. | Jing-jing Xu Ying Song Ping Jiang Lin Jiang Xue-yan Zhao Zhan Gao Jian-xin Li Shu-bin Qiao Run-lin Gao Yue-jin Yang Yin Zhang Bo Xu Jin-qing Yuan | 2021 | World Journal of Emergency Medicine2021，12，1： | 1 |
| 13 | Recent developments in the medicinal chemistry of single boron atom-containing compounds显示文摘Various boron-containing drugs have been approved for clinical use over the past two decades,and more are currently in clinical trials.The increasing interest in boron-containing compounds is due to their unique binding properties to biological targets;for example,boron substitution can be used to modulate biological activity,pharmacokinetic properties,and drug resistance.In this perspective,we aim to comprehensively review the current status of boron compounds in drug discovery,focusing especially on progress from 2015 to December 2020.We classify these compounds into groups showing anticancer,antibacterial,antiviral,antiparasitic and other activities,and discuss the biological targets associated with each activity,as well as potential future developments. | Shu Song Ping Gao Lin Sun Dongwei Kang Jacob Kongsted Vasanthanathan Poongavanam Peng Zhan Xinyong Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 1 |
| 14 | 食管鳞状细胞癌中的基因改变显示文摘2014年5月,《自然》杂志发表了由中国医学科学院肿瘤医院分子肿瘤学国家重点实验室主任詹启敏院士团队与华大基因、汕头大学医学院等合作取得的一项科学成果。食管癌是最为常见的恶性肿瘤之一,也是全世界癌症死亡率第六的肿瘤。全球约70%的食管癌发生在中国,90%以上食管癌的病理为食管鳞状细胞癌(ESCC)。目前,尚缺乏食管鳞状细胞癌的早期诊断和治疗的临床方法,导致患者5年生存率仅为10%。 | 曹守强 Song Y Li L Ou Y Gao Z Li E Li X Zhang W Wang J Xu L Zhou Y Ma X Liu L Zhao Z Huang X Fan J Dong L Chen G Ma L Yang J Chen L He M Li M Zhuang X Huang K Qiu K Yin G Guo G Feng Q Chen P Wu Z Wu J Zhao J Luo L Fu M Xu B Chen B Li Y Tong T Wang M Liu Z Lin D Zhang X Yang H Zhan Q | 2015 | 中国胸心血管外科临床杂志2015，22，1： | 1 |
| 15 | Isolation of a New PAK1 Gene from Sea Cucumber(Apostichopus japonicus) and Its Expression Analysis and Function Characterization显示文摘The p21-activated kinase 1(PAK1)is a downstream serine/threonine kinase effector of Rac1/Cdc42 that regulates various biological processes including those associating with pathological inflammation.To investigate the function of PAK1 in echinoderms,we isolated a new PAK1 from sea cucumber Apostichopus japonicus(AjPAK1)by transcriptome database mining and with rapid amplification of cDNA ends(RACE).The full-length cDNA AjPAK1 was 2303 bp in length,containing a 1587 bp ORF encoding 528 amino acid residues.The deduced AjPAK1 contained a p21-Rho-binding domain(PBD)and a serine/threonine protein kinase catalytic domain(S_TKc),which was similar to the PAK1 of crown-of-thorns starfish Acanthaster planci and other eukaryotes.AjPAK1 expressed in all tissues of adult A.japonicus analyzed with the highest transcript anumdance detected in coelomocytes.Significant change in AjPAK1 abundance was observed at 4,24,48 and 72 h after Vibrio splendidus infection.Silencing AjPAK1 induced a significant reduction of lysozyme content in coelomic fluid and relative transcript abundances of AjRac1 and AjMKK3/6 in A.japonicus coelomocytes.These results should aid to characterize PAK1 of sea cucumber and decipher its immune function. | REN Liyuan LI Kaiquan ZHAN Yaoyao WANG Yi YU Yao CHEN Yang LIN Kai SONG Jian CHANG Yaqing | 2019 | Journal of Ocean University of China2019，18，5： | 1 |
| 16 | Superlong High-Quality Tellurium N anotubes: Synthesis, Characterization, and Optical Property显示文摘 | J M Song Y Z Lin Y J Zhan | 2008 | Crystal Growth & Design2008，8，6： | 1 |
| 17 | Prognostic Value of Vascular Endothelial Growth Factor Expression in Patients with Lung Cancer: A Systematic Review with Meta-Analysis显示文摘 | Ping Zhan Jing Wang Xiao-jing Lv Qin Wang Li-xin Qiu Xin-qing Lin Li-ke Yu Yong Song | 2009 | Journal of Thoracic Oncology2009，，9： | 1 |
| 18 | Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity显示文摘STING,an endoplasmic reticulum(ER)transmembrane protein,mediates innate immune activation upon cGAMP stimulation and is degraded through autophagy.Here,we report that activated STING could be transferred between cells to promote antitumor immunity,a process triggered by RAB22A-mediated non-canonical autophagy.Mechanistically,RAB22A engages PI4K2A to generate PI4P that recruits the Atg12–Atg5–Atg16L1 complex,inducing the formation of ER-derived RAB22A-mediated non-canonical autophagosome,in which STING activated by agonists or chemoradiotherapy is packaged.This RAB22A-induced autophagosome fuses with RAB22A-positive early endosome,generating a new organelle that we name Rafeesome(RAB22A-mediated non-canonical autophagosome fused with early endosome).Meanwhile,RAB22A inactivates RAB7 to suppress the fusion of Rafeesome with lysosome,thereby enabling the secretion of the inner vesicle of the autophagosome bearing activated STING as a new type of extracellular vesicle that we define as R-EV(RAB22A-induced extracellular vesicle).Activated STING-containing R-EVs induce IFNβrelease from recipient cells to the tumor microenvironment,promoting antitumor immunity.Consistently,RAB22A enhances the antitumor effect of the STING agonist diABZI in mice,and a high RAB22A level predicts good survival in nasopharyngeal cancer patients treated with chemoradiotherapy.Our findings reveal that Rafeesome regulates the intercellular transfer of activated STING to trigger and spread antitumor immunity,and that the inner vesicle of non-canonical autophagosome originated from ER is secreted as R-EV,providing a new perspective for understanding the intercellular communication of organelle membrane proteins. | Ying Gao Xueping Zheng Boyang Chang Yujie Lin Xiaodan Huang Wen Wang Shirong Ding Weixiang Zhan Shang Wang Beibei Xiao Lanqing Huo Youhui Yu Yilin Chen Run Gong Yuanzhong Wu Ruhua Zhang Li Zhong Xin Wang Qiuyan Chen Song Gao Zhengfan Jiang Denghui Wei Tiebang Kang | 2022 | Cell Research2022，32，12： | 1 |
| 19 | Preparation of Mo_2C nanoparticles dispersion-strengthened copper-based composite by EB-PVD显示文摘In this research, a nano-Mo2 C particle dispersion-strengthened copper alloy was prepared by a novel method, i.e., electron beam physical vapor deposition(EBPVD) which has advantages of simple technical process and low cost compared with the conventional mechanical alloying method. And the microstructure and properties of the material were investigated. The results show that the copper matrix is composed of columnar crystals with the average width of 7 lm, and the size of Mo2 C dispersoid is1–7 nm. The ultimate tensile strength of the material is486 MPa, and the electrical conductivity is 82 % IACS. As the temperature increases from 293 to 573 K, the material becomes more brittle. | Xiao Li Guang-Ping Song Fan-Yu Bu Bin Xu Bai-Yang Lou Zhan Lin | 2014 | Rare Metals2014，33，5： | 1 |
| 20 | Superlong high-quality tellurium nanotubes:Synthesis,characterization,and optical property显示文摘 | SONG J M LIN Y Z ZHAN Y J | 2008 | Cryst Growth Des2008，8，： | 1 |
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