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| 1 | Petroleum hydrocarbons and their effects on fishery species in the Bohai Sea, North China显示文摘Systematic studies on the changes in concentrations of petroleum hydrocarbons (PHs) and their effects on fishery species in the Bohai Sea during 1974-2004 are presented. Changes in PHs concentrations were closely related to Yellow River runoff. Concentrations of PHs accumulated in fish and shrimp increased by about 0.712 mg/kg dry weight when trophic level of fish and shrimps increased by 1. Attention should also be paid to the high PHs concentrations in mollusks along the coastal waters of the Bohai Sea. Average concentration of PHs in the adjacent coastal waters of Tianjin City during 1996-2005 decreased the population growth rates of fish, crustaceans and mollusks in the Bohai Sea by 2.58%, 6.59% and 2.33%, respectively. Therefore, PHs have significantly contributed to the decline in fisheries in the Bohai Sea, and they must be reduced to realize the sustainable fisheries. | Sisi Xu Jinming Song Huamao Yuan Xuegang Li Ning Li Liqin Duan Yu Yu | 2011 | Journal of Environmental Sciences2011，23，4： | 15 |
| 2 | Environmental significance of biogenic elements in surface sediments of the Changjiang Estuary and its adjacent areas显示文摘Biogenic elements and six phosphorus(P) fractions in surface sediments from the Changjiang Estuary and adjacent waters were determined to investigate the governing factors of these elements, and further to discuss their potential uses as paleo-environment proxies and risks of P release from sediment. Total organic carbon(TOC) and leachable organic P(Lea-OP) showed high concentrations in the estuary, Zhejiang coast and ofshore upwelling area. They came from both the Changjiang River and marine biological input.Biogenic silicon(BSi) exhibited a high concentration band between 123 and 124°E. BSi mainly came from diatom production and its concentration in the inshore area was diluted by river sediment. Total nitrogen(TN) was primarily of marine biogenic origin. Seaward decreasing trends of Fe-bound P and Al-bound P revealed their terrestrial origins. Influenced by old Huanghe sediment delivered by the Jiangsu coastal current, the maximum concentration of detrital P(Det-P) was observed in the area north of the estuary. Similar high concentrations of carbonate fluorapatite(CFA-P) and CaCO3 in the southern study area suggested marine calcium-organism sources of CFA-P. TOC, TN and non-apatite P were enriched in fine sediment, and Det-P partially exhibited coarse-grain enrichment, but BSi had no correlation with sediment grain size. Diferent sources and governing factors made biogenic elements and P species have distinct potential uses in indicating environmental conditions. Transferable P accounted for 14%-46% of total P. In an aerobic environment,there was low risk of P release from sediment, attributed to excess Fe oxides in sediments. | Yu Yu Jinming Song Xuegang Li Huamao Yuan Ning Li Liqin Duan | 2013 | Journal of Environmental Sciences2013，25，11： | 9 |
| 3 | Effects of substrate type and material-substrate bonding on high-temperature behavior of monolayer WS2显示文摘这研究表明在 2D 材料和它的底层之间的相互作用能显著地修改它的电子、光的性质,并且能因此被用作一个工具优化这些性质。高温度(25500 灭獯瑩 ? 慭牴硩 ? 桔 ? 楤' 湛?慣慰楣楴獥漠 ? 桴 ? 潍 ? ??? 猯'T?? 潣灭獯瑩 ? | Liqin Su Yifei Yu Linyou Cao Yong Zhang | 2015 | Nano Research2015，8，8： | 7 |
| 4 | Development and experimental verification of a mathematical expression for the discharge rate of a semi-circular open channel显示文摘Semi-circular open channel plays an important role in various applications and the measurement of its discharge is of interests.In this study,theoretical formulae for free overflow in a semi-circular channel are developed and presented for the discharge and wetted area relationship.The traditional discharge formulation and available experimental data are used to verify and validate the proposed relationships.The discharges calculated by using the proposed relationship show very good agreement with the experimental data sets.The results from this study supply the basis for circular weir development. | Qu Liqin Yu Xinxiao Xiao Juan Lei Tingwu | 2010 | International Journal of Agricultural and Biological Engineering2010，3，3： | 2 |
| 5 | Temperature-sensitive polymeric nanogels encapsulating withβ-cyclodextrin and ICG complex for high-resolution deep-tissue ultrasound-switchable fluorescence imaging显示文摘One of the thorny problems currently impeding the applications of the fluorescence imaging technique is the poor spatial resolution in deep tissue.Ultrasound-switchable fluorescence(USF)imaging is a novel imaging tool that has recently been explored to possibly surmount the above-mentioned bottleneck.Herein,αβ-cyclodextrin/indocyanine green(ICG)complex-encapsulated poly(N-isopropylacrylamide)(PNIPAM)nanogel was synthesized and studied for ex vivo/in vivo deep tissue/high-resolution near infrared USF(NIR-USF)imaging.To be specific,our results revealed that the average diameter of the as-prepared nanogels was significantly decreased to-32 nm from-335 nm compared to the reported ICG-PNIPAM nanoparticles.Additionally,the excitation/emission characteristics of the ICG itself in present nanogels were almost completely retained,and the resultant nanogel exhibited high physiological stability and positive biocompatibility.In particular,the signal-to-noise ratio of the USF image for the PNIPAM/P-cyclodextrin/ICG nanogel(33.01±2.42 dB)was prominently higher than that of the ICG-PNIPAM nanoparticles(18.73±0.33 dB)in 1.5-cm-thick chicken breast tissues.The NIR-USF imaging in 3.5-cm-thick chicken breast tissues was achieved using this new probe.The e x v iv o NIR-USF imaging of the mouse liver was also successfully obtained.Animal experiments showed that the present nanogels were able to be effectively accumulated into U87 tumor-bearing mice via enhanced permeability and retention effects,and the high-resolution NIR-USF imaging of in v ivo tumor was efficiently acquired.The metabolism and in vivo biodistribution of the nanogels were evaluated.Overall,the results suggest that the current nanogel is a highly promising NIR-USF probe for deep tissue and high-resolution USF imaging. | Ruilin Liu Tingfeng Yao Yang Liu Shuai Yu Liqin Ren Yi Hong Kytai T.Nguyen Baohong Yuan | 2020 | Nano Research2020，13，4： | 1 |
| 6 | Active canopy sensor-based precision N management strategy for rice显示文摘 | Yinkun Yao Yuxin Miao Shanyu Huang Lei Gao Xiaobo Ma Guangming Zhao Rongfeng Jiang Xinping Chen Fusuo Zhang Kang Yu Martin Gnyp Georg Bareth Cheng Liu Liqin Zhao Wen Yang Huamin Zhu | 2012 | Agronomy for Sustainable Development2012，，4： | 1 |
| 7 | Bioconcentration and metabolism of decabromodiphenyl ether (BDE-209) result in thyroid endocrine disruption in zebrafish larvae显示文摘 | Qi Chen Liqin Yu Lihua Yang Bingsheng Zhou | 2012 | Aquatic Toxicology2012，，： | 1 |
| 8 | Truncated glycoprotein E of varicella-zoster virus is an ideal immunogen for Escherichia coli-based vaccine design显示文摘Varicella-zoster virus(VZV)is a highly infectious agent responsible for both varicella and herpes zoster disease.Despite high efficacy,there remain safety and accessibility concerns with the licensed vaccines.Here,we sought to produce a VZV g E immunogen using an E.coli expression system.We found that the soluble expression and yield of g E protein could be enhanced via C-terminal truncations to the protein,thereby facilitating a robust and scalable purification process for the purpose of vaccine manufacturing.The lead truncated g E(aa 31–358),hereafter referred to as tg E,was a homogenous monomer in solution and showed excellent antigenicity.Finally,we assessed and compared the immunogenicity of tg E with commercial v Oka LAV and Shingrix vaccine.We found that aluminum-adjuvanted tg E was immunogenic as compared with v Oka LAV.When adjuvanted with AS01B,a two-dose immunization of tg E showed comparable or better potency in antibody responses and cell-mediated immunity with those of the Shingrix vaccine at the same dosage,especially in terms of the proportion of IFN-γ-expressing CD4^(+)T cells.In conclusion,this method of E.coli-mediate tg E expression offers a cost-effective and scalable strategy to generate an ideal VZV g E immunogen for the development of both varicella and zoster vaccines. | Tingting Chen Jie Sun Sibo Zhang Tingting Li Liqin Liu Wenhui Xue Lizhi Zhou Siting Liang Zhili Yu Qingbing Zheng Hai Yu Tong Cheng Jun Zhang Ying Gu Shaowei Li Ningshao Xia | 2023 | Science China(Life Sciences)2023，66，4： | 1 |
| 9 | Exposure to DE-71 alters thyroid hormone levels and gene transcription in the hypothalamic–pituitary–thyroid axis of zebrafish larvae显示文摘 | Liqin Yu Jun Deng Xiongjie Shi Chunsheng Liu Ke Yu Bingsheng Zhou | 2009 | Aquatic Toxicology2009，，3： | 1 |
| 10 | ROS is essential for initiation of energy deprivation-induced autophagy显示文摘Autophagy is a highly conserved degradation process in which intracellular components are engulfed into a double membrane structure,known as the autophagosomes,and then delivered to lysosomes/vacuoles for degradation(Ohsumi,2014).Recently,autophagy has been found to be responsible for maintaining glucose homeostasis in adult animals(Karsli-Uzunbas et al.,2014).However,the molecular mechanism underlying energy deprivation-induced autophagy remains relatively unclear. | Choufei Wu Yixing Li Shu Zhong Yingcong Chen Yu Xie Yuyao Feng Weijing Yao Suping Fu Yanlan Zhu Liefeng Wang Yuting Chen Liqin Zhang Jingjing Tong Cong Yi | 2021 | Journal of Genetics and Genomics2021，48，6： | 1 |
| 11 | Antitumor and immuno- modulatory activity of polysaccharides from Sargassum fusiforme 显示文摘 | Xiaoming Chen Wenjian Nie Guoqing Yu Yali Li Yun- shuang Hu Jianxin Lu Liqin Jin | 2012 | Food and Chemical Toxicology2012，50，34： | 1 |
| 12 | A review on the effects of PBDEs on thyroid and reproduction systems in fish 显示文摘 | YU Liqin HAN Zhihua LIU Chunsheng | 2015 | General and Comparative Endocrinology2015，219，： | 1 |
| 13 | High impact of vehicle and solvent emission on the ambient volatile organic compounds in a major city of northwest China显示文摘Monitoring of ambient volatile organic compounds(VOCs)was conducted within typical residentialcommercial area in the city of Xi’an in northwest China during typical ozone(O_(3))episodes,to investigate the major contributors to the characteristic of ambient VOCs and their impact on O_(3) production.In the residential-commercial area,diurnal variation of VOCs was highly impacted by vehicle exhaust,fuel evaporation,and local solvent use.Relative higher contributions(up to 60%)of VOCs from solvent use to the ozone formation potential were found.The present findings highlight the urgent need for restrictions on the emission of VOCs from solvent use and non-vehicle-traffic-related sources,such as oil storage. | Yonggang Xue Liqin Wang Suixin Liu Yu Huang Long Chen Long Cui Yan Cheng Junji Cao | 2022 | Chinese Chemical Letters2022，33，5： | 1 |
| 14 | Sintering and properties of low-firing non-ohmic SrTiO3 ceramics显示文摘 | Liqin Zhou Changkui Yu | 1994 | Journal of Materials Science1994，，22： | 1 |
| 15 | Clinical practice guideline for body composition assessment based on upper abdominal magnetic resonance images annotated using artificial intelligence显示文摘Introduction Upper abdominal magnetic resonance(MR)imaging is appropriate for body composition analysis.111 Especially for individuals with obesity,it is of great value to quantify the hepatic proton density fat fraction(PDFF)and the amount of abdominal adipose tissue during clinical evaluation and for research on obesity-related risks.Analytical results may be used to determine the optimal choice of surgical procedure and evaluate treatment outcomes.Multiple artificial intelligence(Al)algorithms and systems have been developed for the automated measurement of body composition.The basis of Al development and application is to have uniform standards for clinical data acquisition and management.The uneven quality ofMR images is one ofthe major obstacles to Al system development and analytical results.A standardized process of MR scanning and clinical data management is urgently needed. | Han Lv Mengyi Li Zhenchang Wang Dawei Yang Hui Xu Juan Li Yang Liu Di Cao Yawen Liu Xinru Wu He Jin Peng Zhang Liqin Zhao Rixing Bai Yunlong Yue Bin Li Nengwei Zhang Mingzhu Zou Jinghai Song Weibin Yu Pin Zhang Weijun Tang Qiyuan Yao Liheng Liu Hui Yang Zhenghan Yang Zhongtao Zhang National Clinical Research Center for Digestive Diseases in Beijing Friendship Hospital,Capital Medical University Beijing Quality Control and Improvement Center of Medical Imaging National Health Commission Capacity Building and Continuing Education Center,Chinese College of Metabolic and Bariatric Surgeons Beijing Quality Control and Improvement Center of Metabolic and Bariatric Surgery | 2022 | Chinese Medical Journal2022，，6： | 1 |
| 16 | Thinking on the Development of 'Carbon Finance' in Commercial Banks of China显示文摘 | ZOU Fan YANG Hui YU Liqin | 2011 | Energy Procedia2011，5，： | 1 |
| 17 | Antitumor and immunomodulatory activity of polysaccharides from Sargassum fusiforme显示文摘 | Xiaoming Chen Wenjian Nie Guoqing Yu Yali Li Yunshuang Hu Jianxin Lu Liqin Jin | 2011 | Food and Chemical Toxicology (-)2011，，3： | 1 |
| 18 | Bone morphogenetic protein 4 (BMP4) promotes hepatic glycogen accumulation and reduces glucose level in hepatocytes through mTORC2 signaling pathway显示文摘Liver is an important organ for regulating glucose and lipid metabolism.Recent studies have shown that bone morphogenetic proteins(BMPs)may play important roles in regu-lating glucose and lipid metabolism.Inour previous studies,we demonstrated that BMP4 signif-icantly inhibits hepatic steatosis and lowers serum triglycerides,playing a protective role against the progression of non-alcoholic fatty liver disease(NAFLD).However,the direct impact of BMP4 on hepatic glucose metabolism is poorly understood.Here,we investigated the regulatory roles of BMP4 in hepatic glucose metabolism.Through a comprehensive analysis of the 14 types of BMPs,we found that BMP4 was one of the most potent BMPs in promoting hepatic glycogen accumulation,reducing the level of glucose in hepatocytes and effecting the expression of genes related to glucose metabolism.Mechanistically,we demonstrated that BMP4 reduced the hepatic glucose lewels through the activation of mTORC2 signaling pathway in vitro and in wivo.Collectively,our findings strongly suggest that BMP4 may play an essential role in regulating hepatic glucose metabolism.This knowledge should aid us to understand the molecular pathogenesis of NAFLD,and may lead to the development of novel therapeutics by exploiting the inhibitory effects of BMPs on hepatic glucose and lipid metabolism. | Liqin An Qiong Shi Ying Zhu Hao Wang Qi Peng Jinghong Wu Yu Cheng Wei Zhang Yanyu Yi Zihao Bao Hui Zhang Yetao Luo Jiaming Fan | 2021 | Genes & Diseases2021，8，4： | 1 |
| 19 | Sustainable all-weather CO 2 utilization by mimicking natural photosynthesis in a single material显示文摘Solar-driven CO_(2)conversion into hydrocarbon fuels is a sustainable approach to synchronously alleviating the energy crisis and achieving net CO_(2)emissions.However,the dependence of the conversion process on solar illumination hinders its practical application due to the intermittent availability of sunlight at night and on cloudy or rainy days.Here,we report a model material of Pt-loaded hexagonal tungsten trioxide(Pt/h-WO3)for decoupling light and dark reaction processes,demonstrating the sustainable CO_(2)conversion under dark conditions for the first time.In such a material system,hydrogen atoms can be produced by photocatalytic water splitting under solar illumination,stored together with electrons in the h-WO_(3)through the transition of W^(6+)to W^(5+)and spontaneously released to trigger catalytic CO_(2)reduction under dark conditions.Furthermore,we demonstrate using natural light that CH4 production can persist at night and on rainy days,proving the accomplishment of all-weather CO_(2)conversion via a sustainable way. | Xianjin Shi Yu Huang Ran Long Zhenyu Wang Liqin Wang Junji Cao Gangqiang Zhu Yujie Xiong | 2024 | National Science Review2024，11，2： | 0 |
| 20 | Abrin P2 suppresses proliferation and induces apoptosis of colon cancer cells via mitochondrial membrane depolarization and caspase activation显示文摘在人的结肠癌 HCT-8 房间上探索 abrin P2 的细胞毒素的机制, abrin P2 从 Abrus precatorius L 的种子被孤立。abrin P2 向 12 根不同人的癌症房间线展出了 cytotoxicity,这被发现。我们的结果证明 abrin P2 压制了人的结肠癌房间(HCT-8 房间) 的增长并且在 S 和 G2/M 阶段导致了房间周期拘捕。abrin P2 由禁止了房间增长的机制经由 cyclin B1 的下面规定,增殖房间原子抗原和 Ki67,以及 P21 的起来规定。另外, abrin P2 处于 HCT-8 房间 apoptosis 的率导致了剂量依赖者和时间依赖者增加。有 Z-VAD-FMK,一个用途广泛的 caspase 禁止者,和 abrin P2 的治疗证明 abrin P2 经由 caspases 的激活导致了 HCT-8 房间 apoptosis。一起,我们的结果揭示了那 abrin 在 HCT-8 房间的导致 P2 的 apoptosis 与 caspases-3/-8/-9,在 Bcl-2/Bax 比率的减小, mitochondrial 膜潜力的损失,和细胞色素 c 的增加的激活被联系版本。我们进一步证明 abrin P2 管理有效地在裸体老鼠压制了结肠癌异种皮移植的生长。这是 abrin P2 有效地由压制增长并且导致 apoptosis 在 vivo 并且在 vitro 禁止结肠癌细胞生长的第一份报告。 | Ying Yu Runmei Yang Xiuyun Zhao Dandan Qin Zhaoyang Liu Fang Liu Xin Song Liqin Li Renqing Feng Nannan Gao | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 0 |
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