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| 1 | Study on the Application of UHVDC Hierarchical Connection Mode to Multi-infeed HVDC System显示文摘随着我国特高压交直流技术的广泛应用,多馈入直流集中落入受端负荷中心将是未来我国电网发展所面临的重要问题。为从电网结构上有效解决多馈入直流系统的问题,提出一种特高压直流分层接入交流电网的方式。研究分层接入方式直流多馈入短路比计算方法的适用性,从理论上对比特高压直流不同接入方式下多馈入直流电网的系统特性,证明特高压直流分层接入方式有助于提高多馈入直流系统的电压支撑能力,引导潮流在1000kV与500kV层级间合理分布。结合国家电网规划,仿真验证了特高压直流分层接入方式的优势。 | LIU Zhenya QIN Xiaohui ZHAO Liang ZHAO Qingbo | 2013 | 中国电机工程学报2013，33，10： | 80 |
| 2 | Geological Features and Reservoiring Mode of Shale Gas Reservoirs in Longmaxi Formation of the Jiaoshiba Area显示文摘This study is based on the sedimentation conditions, organic geochemistry, storage spaces, physical properties, lithology and gas content of the shale gas reservoirs in Longmaxi Formation of the Jiaoshiba area and the gas accumulation mode is summarized and then compared with that in northern America. The shale gas reservoirs in the Longmaxi Formation in Jiaoshiba have good geological conditions, great thickness of quality shales, high organic content, high gas content, good physical properties, suitable depth, good preservation conditions and good reservoir types. The quality shales at the bottom of the deep shelf are the main target interval for shale gas exploration and development. Shale gas in the Longmaxi Formation has undergone three main reservoiring stages:the early stage of hydrocarbon generation and compaction when shale gas reservoirs were first formed; the middle stage of deep burial and large-scale hydrocarbon generation, which caused the enrichment of reservoirs with shale gas; the late stage of uplift, erosion and fracture development when shale gas reservoirs were finally formed. | GUO Xusheng HU Dongfeng LI Yuping LIU Ruobing WANG Qingbo | 2014 | Acta Geologica Sinica(English Edition)2014，88，6： | 28 |
| 3 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 4 | Selection of optimal window length using STFT for quantitative SNR analysis of LFM signal显示文摘An adaptive approach to select analysis window parameters for linear frequency modulated(LFM) signals is proposed to obtain the optimal 3 dB signal-to-noise ratio(SNR) in the shorttime Fourier transform(STFT) domain.After analyzing the instantaneous frequency and instantaneous bandwidth to deduce the relation between the window length and deviation of the Gaussian window,high-order statistics is used to select the appropriate window length for STFT and get the optimal SNR with the right time-frequency resolution according to the signal characteristic under a fixed sampling rate.Computer simulations have verified the effectiveness of the new method. | Qingbo Yin Liran Shen Mingyu Lu Xiangyang Wang Zhi Liu | 2013 | Journal of Systems Engineering and Electronics2013，24，1： | 11 |
| 5 | Snail and Slug mediate tamoxifen resistance in breast cancer cells through activation of EGFR-ERK independent of epithelial-mesenchymal transition显示文摘 | Yan Jian Xiaotong Zhao Qian Xiao Qingbo Liu Keshuo Ding Fei Yu Rui Zhang Tao Zhu Gaoxiang Ge | 2014 | Journal of Molecular Cell Biology2014，8，4： | 11 |
| 6 | b-DAZL:A novel gene in bovine spermatogenesis显示文摘DAZL 基因在 gametogenesis 起一个重要作用。这基因的 Microdeletion 和变化经常在脊椎动物和无脊椎动物与绝育被联系了。这里,包含 DAZL 基因的完全的开的读物框架的 cDNA,它编码通常认为的 RRM RNA 有约束力的蛋白质,被 RT-PCR 从牛的纸巾孤立。孤立的基因被叫作 b-DAZL。基于计算机的地点分析证明 b-DAZL 在染色体 1 的结束附近被定位。b-DAZL 基因和它的脊椎动物相当或相同事物分享了高核苷酸类似(90 94%) 在编码区域并且在 genomic 组织,每由 10 前 ons 和 9 introns 组成。他们的蛋白质产品包含了一个高度保存的 RNA 有约束力的主题,一次唯一的 DAZ 重复,和 PUM2 和 PABP 交往领域。RT-PCR 试金表明 b-DAZL 在睾丸和卵巢被表示。然而,没有信号在无菌的雄的牛牦牛的睾丸被检测。不育的男性的睾丸的微观结构显示出很少的 spermatocytes 但是主要体的房间。这些观察与有有缺点的 DAZL 表示的睾丸的典型显型一致。随后的基因察觉研究显示那抄写拘捕可能在牛牦牛的睾丸导致一个 b-DAZL 抄本缺点。我们的结果建议 b-DAZL 可以涉及精子发生,并且基因的那抄写拘捕在牛牦牛与男绝育被联系。 | Qingbo Zhang Qifa Li Jiahuang Li Xinfu Li Zhenshan Liu Dawei Song Zhuang Xie | 2008 | Progress in Natural Science:Materials International2008，18，10： | 6 |
| 7 | Analysis of IGF2 mRNA expression and its methylation status between cattle yaks and their parents显示文摘Cattle yaks are an F1 hybrid between cattle and yaks and exhibit significant hybrid vigor. However, cattle yaks are sterile males. To study the epigenetic aspects of this reproductive isolation, IGF2 mRNA expression in cattle yaks and their parents and the patterns of the IGF2 differentially methylated regions (DMR) were examined in blood and testes. The results showed that IGF2 expression in cattle yaks' testes was lower than in their parents (P < 0.01). The IGF2 DMR was highly methylated (above 90%) in blood and testes of cattle yaks, yaks and cattle, with the highest level in cattle yaks (P > 0.05). Our study showed that IGF2 plays an important role in bovine spermato-genesis and might be involved in cattle-yak male sterility. The methylation level of the IGF2 DMR was irrelevant to the lower expression of IGF2 in cattle yaks; other factors perhaps play roles in its expression. | Zhenshan Liu Qifa Li Qingbo Zhang Xuguang Qu Liyan Dong Chamba Yang-zom Zhuang Xie Honglin Liu | 2009 | Progress in Natural Science:Materials International2009，19，9： | 5 |
| 8 | 120 mm Single-crystalline perovskite and wafers: towards viable applications显示文摘As the large single-crystalline silicon wafers have revolutionized many industries including electronics and solar cells, it is envisioned that the availability of large single-crystalline perovskite crystals and wafers will revolutionize its broad applications in photovoltaics, optoelectronics, lasers, photodetectors, light emitting diodes(LEDs), etc. Here we report a method to grow large single-crystalline perovskites including single-halide crystals: CH3NH3PbX3(X=I, Br, Cl), and dual-halide ones:CH3NH3Pb(ClxBr1.x)3 and CH3NH3Pb(BrxI1.x)3, with the largest crystal being 120 mm in length. Meanwhile, we have advanced a process to slice the large perovskite crystals into thin wafers. It is found that the wafers exhibit remarkable features:(1)its trap-state density is a million times smaller than that in the microcrystalline perovskite thin films(MPTF);(2) its carrier mobility is 410 times higher than its most popular organic counterpart P3HT;(3) its optical absorption is expanded to as high as910 nm comparing to 797 nm for the MPTF;(4) while MPTF decomposes at 150 °C, the wafer is stable at high temperature up to270 °C;(5) when exposed to high humidity(75% RH), MPTF decomposes in 5 h while the wafer shows no change for overnight;(6) its photocurrent response is 250 times higher than its MPTF counterpart. A few electronic devices have been fabricated using the crystalline wafers. Among them, the Hall test gives low carrier concentration with high mobility. The trap-state density is measured much lower than common semiconductors. Moreover, the large SC-wafer is found particularly useful for mass production of integrated circuits. By adjusting the halide composition, both the optical absorption and the light emission can be fine-tuned across the entire visible spectrum from 400 nm to 800 nm. It is envisioned that a range of visible lasers and LEDs may be developed using the dual-halide perovskites. With fewer trap states, high mobility, broader absorption, and humidity resistance, it is expected that solar cells with high stable efficiency maybe attainable using the crystalline wafers. | Yucheng Liu Xiaodong Ren Jing Zhang Zhou Yang Dong Yang Fengyang Yu Jiankun Sun Changming Zhao Zhun Yao Bo Wang Qingbo Wei Fengwei Xiao Haibo Fan Hao Deng Liangping Deng Shengzhong (Frank) Liu | 2017 | Science China Chemistry2017，60，10： | 5 |
| 9 | Hybrid nano-scale Au with ITO structure for a high-performance near-infrared silicon-based photodetector with ultralow dark current显示文摘An internal photoemission-based silicon photodetector detects light below the silicon bandgap at room temperature and can exhibit spectrally broad behavior,making it potentially suited to meet the need for a near-infrared pure Si photodetector.In this work,the implementation of a thin Au insertion layer into an ITO/n-Si Schottky photodetector can profoundly affect the barrier height and significantly improve the device performance.By fabricating a nanoscale thin Au layer and an ITO electrode on a silicon substrate,we achieve a well-behaved ITO/Au/n-Si Schottky diode with a record dark current density of 3.7×10^(−7) A/cm^(2) at−1 V and a high rectification ratio of 1.5×10^(8) at±1 V.Furthermore,the responsivity has been obviously improved without sacrificing the dark current performance of the device by decreasing the Au thickness.Such a silicon-based photodetector with an enhanced performance could be a promising strategy for the realization of a monolithic integrated pure silicon photodetector in optical communication. | Xinxin Li Zhen Deng Jun Li Yangfeng Li Linbao Guo Yang Jiang Ziguang Ma Lu Wang Chunhua Du Ying Wang Qingbo Meng Haiqiang Jia Wenxin Wang Wuming Liu Hong Chen | 2020 | Photonics Research2020，8，11： | 4 |
| 10 | Light doping of tungsten into copper-platinum nanoalloys for boosting their electrocatalytic performance in methanol oxidation显示文摘Coupling the bi-functional mechanism with compressive lattice strain might be an effective way to boost the electrocatalysis of platinum(Pt)-based nanoparticles for methanol oxidation reaction(MOR).This strategy weakens the chemisorption of poisoning CO-like intermediates generated during MOR on the active Pt sites by lowering their d-band center.In this context,we herein report the synthesis of ternary copper-tungsten-platinum(CuWPt)nanoalloys with light doping of W element by simply co-reducing their precursors at elevated temperature.In this ternary alloy system,the presence of only small amount of W element not only weakens the chemisorption of CO-like intermediates by lowering the Pt d-band center through compressive lattice strain,but also cleans the active Pt sites by“hydrogen spillover effect”,endowing the as-prepared CuWPt nanoalloys at an appropriate Cu/W/Pt ratio with good activity for MOR.In specific,the ternary CuWPt alloy nanoparticles at a Cu/W/Pt molar ratio of 21/4/75 show a specific activity of 2.5 mA·cm^(−2)and a mass activity of 2.11 A·mg^(−1)with a better durability,outperforming those ternary CuWPt alloy nanoparticles at other Cu/W/Pt ratios,binary CuPt alloys and commercial Pt/C catalyst as well as a large number of reported Pt-based electrocatalysts.In addition,a single direct methanol fuel cell(DMFC)assembled using ternary CuWPt nanoalloys as anodic catalysts shows a power density of 24.3 mW·cm^(−2)and an open-circle voltage of 0.6 V,also much higher than those of the single DMFC assembled from commercial Pt/C catalysts. | Danye Liu Qing Zeng Chaoquan Hu Dong Chen Hui Liu Yongsheng Han Lin Xu Qingbo Zhang Jun Yang | 2022 | Nano Research Energy2022，1，2： | 4 |
| 11 | Lysyl oxidase promotes bleomycin-induced lung fibrosis through modulating inflammation显示文摘包括 lysyl oxidase (哈鱼) ,涉及骨胶原生合成的酶为自发的肺的纤维变性作为潜在的治疗学的目标被建议了。哈鱼表示是显著地,在 bleomycin (BLM ) 的 upregulated 导致了肺纤维变性,并且哈鱼表示或哈鱼活动的抑制击倒减轻肺纤维变性。出人意料地,有在煽动性的阶段的哈鱼禁止者的鼠标的治疗,然而并非 fibrogenic 阶段,高效地减少骨胶原免职并且使肺建筑学正常化。哈鱼的抑制损害煽动性的房间渗入,发信号的 TGF- ,和 myofibroblast 累积。而且,哈鱼的宫外的表示敏化纤维变性抵抗的 Balb/c 老鼠到导致 BLM 的发炎和肺纤维变性。这些结果建议那条哈鱼为由在肺损害以后加重煽动性的反应和随后的纤维变性过程的导致 BLM 的试验性的肺纤维变性的前进是不可缺少的。 | Tao Cheng Qingbo Liu Rui Zhang Ying Zhang Jianfeng Chen Ronghuan Yu Gaoxiang Ge | 2014 | Journal of Molecular Cell Biology2014，8，6： | 3 |
| 12 | Recent progress in perovskite solar cells:material science显示文摘Perovskite solar cells represent a promising third-generation photovoltaic technology with low fabrication cost and high power conversion efficiency.In light of the rapid development of perovskite materials and devices,a systematic survey on the latest advancements covering a broad range of related work is urgently needed.This review summarizes the recent major advances in the research of perovskite solar cells from a material science perspective.The discussed topics include the devices based on different type of perovskites(organic-inorganic hybrid,all-inorganic,and lead-free perovskite and perovskite quantum dots),the properties of perovskite defects,different type of charge transport materials(organic,polymeric,and inorganic hole transport materials and inorganic and organic electron transport materials),counter electrodes,and interfacial materials used to improve the efficiency and stability of devices.Most discussions focus on the key progresses reported within the recent five years.Meanwhile,the major issues limiting the production of perovskite solar cells and the prospects for the future development of related materials are discussed. | Jiang-Yang Shao Dongmei Li Jiangjian Shi Chuang Ma Yousheng Wang Xiaomin Liu Xianyuan Jiang Mengmeng Hao Luozheng Zhang Chang Liu Yiting Jiang Zhenhan Wang Yu-Wu Zhong Shengzhong(Frank)Liu Yaohua Mai Yongsheng Liu Yixin Zhao Zhijun Ning Lianzhou Wang Baomin Xu Lei Meng Zuqiang Bian Ziyi Ge Xiaowei Zhan Jingbi You Yongfang Li Qingbo Meng | 2023 | Science China Chemistry2023，66，1： | 3 |
| 13 | Improved perovskite solar cell efficiency by tuning the colloidal size and free ion concentration in precursor solution using formic acid additive显示文摘Improving the quality of the perovskite active layer is crucial to obtaining high performance perovskite solar cells(PSCs). In this work, by introducing formic acid into the formamidinium lead iodide(FAPbI3)precursor solution, we managed to achieve reduced colloidal size in the solution, leading to more uniform deposition of FAPbI3 film with lower trap state density and higher carrier mobility. The solar cells based on the FAPbI3 absorber layer modified with formic acid show significantly better photovoltaic performance than that on the reference FAPbI3 film without formic acid. The device performance shows a close correlation with the colloidal size. Within the range studied from 6.7 to 1.0 nm, the smaller the colloidal size is, the higher the solar cell efficiency. More specifically, the cell efficiency is improved from17.82% for the control cell without formic acid to 19.81% when 0.764 M formic acid was used. Formic acid has also been added into a CH3NH3PbI3(MAPbI3) precursor solution, which exhibits a similar effect on the resulting MAPb I3 films and solar cells, with efficiency improved from 16.07% to 17.00%. | Lina Meng Qingbo Wei Zhou Yang Dong Yang Jiangshan Feng Xiaodong Ren Yucheng Liu Shengzhong(Frank)Liu | 2020 | Journal of Energy Chemistry2020，29，2： | 2 |
| 14 | Heterostructured ZnFe_2O_4/Fe_2TiO_5/TiO_2 Composite Nanotube Arrays with an Improved Photocatalysis Degradation Efficiency Under Simulated Sunlight Irradiation显示文摘To improve the visible light absorption and photocatalytic activity of titanium dioxide nanotube arrays(TONTAs), ZnFe_2O_4(ZFO) nanocrystals were perfused into pristine TONTA pipelines using a novel bias voltageassisted perfusion method. ZFO nanocrystals were well anchored on the inner walls of the pristine TONTAs when the ZFO suspensions(0.025 mg m L^(-1)) were kept under a60 V bias voltage for 1 h. After annealing at 750 °C for2 h, the heterostructured ZFO/Fe_2 TiO_5(FTO)/TiO_2 composite nanotube arrays were successfully obtained. Furthermore, Fe^(3+)was reduced to Fe^(2+)when solid solution reactions occurred at the interface of ZFO and the pristine TONTAs. Introducing ZFO significantly enhanced thevisible light absorption of the ZFO/FTO/TONTAs relative to that of the annealed TONTAs. The coexistence of type I and staggered type II band alignment in the ZFO/FTO/TONTAs facilitated the separation of photogenerated electrons and holes, thereby improving the efficiency of the ZFO/FTO/TONTAs for photocatalytic degradation of methylene blue when irradiated with simulated sunlight. | Kun Xiong Kunzhou Wang Lin Chen Xinqing Wang Qingbo Fan Jérémie Courtois Yuliang Liu Xianguo Tuo Minhao Yan | 2018 | Nano-Micro Letters2018，10，1： | 2 |
| 15 | ADAMTS-7 Mediates Vascular Smooth Muscle Cell Migration and Neointima Formation in Balloon-Injured Rat Arteries显示文摘 | Li Wang Jingang Zheng Xue Bai Bo Liu Chuan-ju Liu Qingbo Xu Yi Zhu Nanping Wang Wei Kong Xian Wang | 2009 | Circulation Research2009，，5： | 2 |
| 16 | A time domain correction method for Doppler-distortion signal from acoustic moving source显示文摘Doppler effect widely exists in the signal from the moving acoustic source.In order to solve such problems as frequency shift and frequency band expansion,a time domain correction method is presented in this paper.First,the discrete time vector for interpolation and the amplitude restoration formula is derived based on the moving relationship and the Morse acoustic theory,then the amplitude weights are corrected and the distortion signal is interpolated.Every point of the discrete signal is operated separately in time domain.Compared with the existing frequency domain methods,this method does not need to know the characteristic frequency beforehand and would not be influenced by the blending of the frequency band.Hence,this method can be employed to correct multiple frequency signals and it is also a simple and effective Doppler effect reduction method. | LIU Fang HE Qingbo SHEN Changqing HU Fei ZHANG Ao KONG Fanrang | 2014 | Chinese Journal of Acoustics2014，33，1： | 2 |
| 17 | Effective shape-controlled synthesis of gallium selenide nanosheets by vapor phase deposition显示文摘The controlled synthesis of large and uniform gallium selenide(GaSe)crystals is crucial for its various applications based on the attractive properties of this emerging material.In this work,vapor phase growth of high-quality monolayer GaSe nanosheets with multiple shape and size is achieved by tuning the Ga/GaSe ratio in the precursor.A theoretical model based on density functional theory calculations and kinetic Wulff construction theory describe the observed shape evolution of the GaSe nanosheets.Results show that the Ga/Se ratio plays a critical role in the evolution of the domain shape and size.Moreover,the as-grown GaSe nanosheets show improved performance with photoresponse time less than 0.7 ms and responsibility up to 3,000 AW.This study presents a previously unexplored strategy for the controlled growth of two-dimensional(2D)GaSe nanosheets for promising applications in next-generation optoelectronics. | Lilan Tan Qingbo Liu Yufeng Ding Xiaogang Lin Wei Hu Meng-Qiu Cai Hong Zhou | 2020 | Nano Research2020，13，2： | 2 |
| 18 | α 1 -Adrenergic receptors mediate combined signals initiated by mechanical stretch stress and norepinephrine leading to accelerated mouse vein graft atherosclerosis显示文摘 | Shuying Liu Yuhuang Li Zhengyu Zhang Fukang Xie Qingbo Xu Xi Huang Jintao Huang Chaohong Li | 2013 | Journal of Vascular Surgery2013，，6： | 2 |
| 19 | Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury显示文摘Compelling evidence has revealed that biased activation of G protein-coupled receptor(GPCR)signaling,including angiotensin II(AngII)receptor type 1(AT1)signaling,plays pivotal roles in vascular homeostasis and injury,but whether a clinically relevant endogenous biased antagonism of AT1 signaling exists under physiological and pathophysiological conditions has not been clearly elucidated.Here,we show that an extracellular matrix protein,cartilage oligomeric matrix protein(COMP),acts as an endogenous allosteric biased modulator of the AT1 receptor and its deficiency is clinically associated with abdominal aortic aneurysm(AAA)development.COMP directly interacts with the extracellular N-terminus of the AT1 via its EGF domain and inhibits AT1-β-arrestin-2 signaling,but not Gq or Gi signaling,in a selective manner through allosteric regulation of AT1 intracellular conformational states.COMP deficiency results in activation of AT1a-β-arrestin-2 signaling and subsequent exclusive AAA formation in response to AngII infusion.AAAs in COMP–/–or ApoE–/–mice are rescued by AT1a orβ-arrestin-2 deficiency,or the application of a peptidomimetic mimicking the AT1-binding motif of COMP.Explorations of the endogenous biased antagonism of AT1 receptor or other GPCRs may reveal novel therapeutic strategies for cardiovascular diseases. | Yi Fu Yaqian Huang Zhao Yang Yufei Chen Jingang Zheng Chenfeng Mao Zhiqing Li Zhixin Liu Bing Yu Tuoyi Li Meili Wang Chanjuan Xu Yiwei Zhou Guizhen Zhao Yiting Jia Wei Guo Xin Jia Tao Zhang Li Li Ziyi Liu Shengchao Guo Mingliang Ma Heng Zhang Bo Liu Junbao Du Wengong Wang Chaoshu Tang Pei Gao Qingbo Xu Xian Wang Jianfeng Liu Jinpeng Sun Wei Kong | 2021 | Cell Research2021，31，7： | 2 |
| 20 | Pattern characteristics in patients with primary liver cancer in different clinical stages显示文摘OBJECTIVE: To explore the characteristics of primary liver cancer in terms of Traditional Chinese Medicine(TCM) by analyzing the variations of the patterns along with the clinical stages.METHODS: The patients who were hospitalized in the Changhai Hospital of Traditional Chinese Medicine dated from March 1999 to December 2008 were included in this retrospective study. The patients were grouped according to their cancer stages, and their patterns were judged and quantified according to the 'Standard diagnosis and quantitative criteria of the common patterns in primary liv-er cancer' formulated by the Changhai Hospital of Traditional Chinese Medicine. Statistics methods included ANOVA and nonparametric test, among others.RESULTS: The data of the 398 newly diagnosed patients showed that Qi Stagnation, Blood Stasis, and Dampness patterns were more frequent than the other basic patterns with relatively high scores; patterns of Liver Qi Stagnation, Liver Blood Stasis, and Dampness Heat were more than the other complex patterns and scored relatively high. Scores of Dampness and Liver Qi Stagnation patterns varied among the groups at different stages and the differences were statistically significant(PDampness= 0.002,PLiver Qi Stagnation= 0.020). The highest scores of Dampness pattern and Liver Qi Stagnation pattern corresponded with Stage Ⅲb, and Stage equency wⅢ a, respectively. Dampness pattern fras higher(P =0.001) in the Stage Ⅲb group than in other groups.CONCLUSION: Pattern characteristics in patients with primary liver cancer of different clinical stages might manifest in the variations of the Dampness pattern along the process of the disease and the major pathogenic factor of primary liver cancer might be Dampness. | Qin Liping Meng Jing Lang Qingbo Liu Long Li Bai | 2015 | Journal of Traditional Chinese Medicine2015，35，1： | 2 |
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