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| 1 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 2 | TPX2 knockdown suppressed hepatocellular carcinoma cell invasion via inactivating AKT signaling and inhibiting MMP2 and MMP9 expression显示文摘Objective: Targeting protein for Xenopus kinesin-like protein 2(TPX2) is a nuclear proliferation-related protein that plays a critical role in the formation of mitotic spindle. High expression of TPX2 has been observed in several types of tumors. However, the role of TPX2 in hepatocellular carcinoma(HCC) remains unclear. Our study aimed to investigate the effect of TPX2 on HCC cell invasion.Methods: The immortalized normal human liver cell line L02 and six HCC cell lines including SMMC-7721, BEL-7402, Huh-7, HepG2, Hep3 B and SKHep1 were subjected to qRT-PCR and western blot for TPX2 mRNA and protein, respectively. Furthermore, TPX2 small interfering RNA(siRNA) was used to knock down TPX2 expression in SMMC-7721 and HepG2 cells. Cell proliferation and invasion were determined by MTT and transwell assays. Otherwise, expression of p-AKT, MMP2 and MMP9 were evaluated by western blot in SMMC-7721 cells.Results: The expression of TPX2 in HCC cell lines was markedly higher than that in normal human liver cell line. TPX2 knockdown using a specific TPX2-siRNA reduced the number of invaded cells and inhibited cell proliferation in SMMC-7721 and HepG2 cells. Furthermore, TPX2 knockdown resulted in inactivation of AKT signaling and down-regulation of MMP2 and MMP9 expression in SMMC-7721 cells.Conclusions: Our study identified that TPX2 might contribute to tumor cell invasion through activating AKT signaling and subsequently increasing MMP2 and MMP9 in HCC. | Qingquan Liu Pinghua Yang Kangsheng Tu Hongyong Zhang Xin Zheng Yingmin Yao Qingguang Liu | 2014 | Chinese Journal of Cancer Research2014，26，4： | 11 |
| 3 | Optimization of a new animal glue binder system cured by CO_2 for use in foundry显示文摘A new sand binder system cured by CO2 was prepared based on the animal bone glue.To overcome the disadvantages of animal glue such as agglomeration at room temperature,high energy consumption and low efficiency,an alkaline decomposition process was selected,and certain modifier was used to modify the performance of the animal glue binder.For the alkaline decomposition,NaOH was used as the catalyst with an addition of 4wt.% to the animal glue.A modifier was determined through the orthogonal experiment with a weight ratio of glycerin:glycol:dextrin:animal glue = 9:16:15:100,and the optimal modification reaction should be performed at 75 ℃ with a reaction time of 90 min.Ca(OH)2 was used as a promoter;the optimal CO2 gas flux blowing into the sand was 0.7 m3.h-1 for a duration of 60s under the experimental conditions.Results show that an original strength above 0.7 MPa and a final strength about 4.2 MPa can be achieved,which could meet the requirement of rapid moulding and core-making for foundry.The new binder was characterized and analyzed by means of IR,and the modification and CO2-cured mechanisms of this animal glue binder were also discussed. | Liu Weihua Zhang Yilin Li Yingmin Liu Xiuling | 2012 | China Foundry2012，9，4： | 5 |
| 4 | Response of MG63 Osteoblast Cells to Surface Modification of Ti-6Al-4V Implant Alloy by Laser Interference Lithography显示文摘 | Qi Liu Wenjun Li Liang Cao Jiajia Wang Yingmin Qu Xinyue Wang Rongxian Qiu Xu Di Zuobin Wang Bojian Liang | 2017 | Journal of Bionic Engineering2017，14，3： | 4 |
| 5 | Short wave diathermy for small spontaneouspneumothorax显示文摘 | Ma Yingmin Li Jihua Liu Youning | 1997 | Thorax1997，52，： | 1 |
| 6 | Association between the Apolipoprotein E4 and Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Intravenous Anesthesia and Inhalation Anesthesia显示文摘 | Yingmin Cai Haitao Hu Pengbin Liu Gaifeng Feng Weijiang Dong Bing Yu Yulin Zhu Jinxin Song Minggang Zhao | 2012 | Anesthesiology2012，，1： | 1 |
| 7 | Stabilities,mechanical and thermodynamic properties of Al-RE intermetallics:A first-principles study显示文摘Stabilities,mechanical and thermodynamic properties of 87 intermetallics in Al-RE binary system were studied by first-principles based on density functional theory(DFT).The results show that the calculated stabilities at T=0 K are in good agreement with experimental values.Al2 RE intermetallics exhibit the best stability in Al-RE binary compounds;and the stabilities in descending order are Al2 RE,Al3 RE,AlRE,Al11RE_(3),AlRE2 and AlRE_(3).The calculated Al-RE intermetallics possess mechanical stabilities.The hardness and strength of the most Al-RE intermetallics are greater than pure aluminum except AlCe,AlPr,AlEu and AlYb.The hardness and strength in descending order are Al11RE_(3),Al3 RE,Al2 RE and AIRE.Part of AlRE intermetallics exhibit ductility;the others are brittle.The heat capacities of Al-RE intermetallics in ascending order are Al-Sc,Al-Y,Al-lanthanides.On the contrary,the coefficient of thermal expansion(CTE)in ascending order is Al-lanthanides,Al-Y and Al-Sc. | Tongyu Liu Tianyu Ma Yingmin Li Yuyan Ren Weihua Liu | 2022 | Journal of Rare Earths2022，40，2： | 1 |
| 8 | Prognostic significance of miR-218 in human hepatocellular carcinomaand its role in cell growth显示文摘 | Kangsheng Tu Chao Li Xin Zheng Wei Yang Yingmin Yao Qingguang Liu | 2014 | Oncology Reports2014，，4： | 1 |
| 9 | Evaluation of Fbxw7 expression and its correlation with expression ofSREBP-1 in a mouse model of NAFLD显示文摘 | Kangsheng Tu Xin Zheng Guozhi Yin Xianfeng Zan Yingmin Yao Qingguang Liu | 2012 | Molecular Medicine Reports2012，，3： | 1 |
| 10 | Evaluation of Fbxw7 expression and its correlation with the expression of c‐Myc, cyclin E and p53 in human hepatocellular carcinoma显示文摘 | Kangsheng Tu Xin Zheng Xianfeng Zan Shaoshan Han Yingmin Yao Qingguang Liu | 2012 | Hepatology Research2012，，9： | 1 |
| 11 | An iterative learning approach to formation control of multi-agent systems显示文摘 | Yang Liu Yingmin Jia | 2011 | Systems & Control Letters2011，，1： | 1 |
| 12 | An iterative learning approach to formation control of multi-agent systems 显示文摘 | Liu Yang Jia Yingmin | 2012 | Systems & Control Letters2012，61，1： | 1 |
| 13 | Experimental study on the dust collection mechanisms of wet fiber grid 显示文摘 | Gong Lihong(宫丽虹) Wang Yingmin(王英敏) and Liu Kun(刘鲲) | 2001 | Journal of Liaoning Technical University Natural Science Edition (辽宁工程技术大学学报)2001，17，1： | 1 |
| 14 | Study on the slope break belts in the Jurassic down-warped lacustrine basin in westem- margin area, Junggar Basin, northwestern China显示文摘 | Liu Hao Wang Yingmin Xin Renchen | 2006 | Marine and Pe- troleum Geology2006，23，910： | 1 |
| 15 | Optimal set integer programming algorithm for multiple maneuvering targets tracking in clutter显示文摘The aim of this paper is to solve the problems of multitarget tracking in clutter. Firstly, the data association of measurement-to-target is formulated as an integer programming problem. Through using the linear programming (LP) based branchand-bound method and adjusting the constraint conditions, an optimal set integer programming (OSIP) algorithm is then proposed for tracking multiple non-maneuvering targets in clutter. For the case of maneuvering targets, this paper introduces the OSIP algorithm into the filtering step of the interacting multiple model (IMM) algorithm resulting in the IMM based on OSIP algorithm. Extensive Monte Carlo simulations show that the presented algorithms can obtain superior estimations even in the case of high density noises. | Xiaoyan Fu Yingmin Jia Xiaohe Liu | 2013 | Journal of Systems Engineering and Electronics2013，24，4： | 1 |
| 16 | Wettability characteristic of PTFE and glass surface irradiated by keV ions显示文摘 | Chen Yan Zhao Ziqiang Liu Yingmin | 2008 | Appl Surf Sci2008，254，17： | 1 |
| 17 | Electrocatalytic reduction of NO to NH_(3) in ionic liquids by P-doped TiO_(2) nanotubes显示文摘Designing advanced and cost-effective electrocatalytic system for nitric oxide(NO)reduction reaction(NORR)is vital for sustainable NH_(3) production and NO removal,yet it is a challenging task.Herein,it is shown that phosphorus(P)-doped titania(TiO_(2))nanotubes can be adopted as highly efficient catalyst for NORR.The catalyst demonstrates impressive performance in ionic liquid(IL)-based electrolyte with a remarkable high Faradaic efficiency of 89%and NH3 yield rate of 425μg·h^(−1)·mg_(cat).^(−1),being close to the best-reported results.Noteworthy,the obtained performance metrics are significantly larger than those for N_(2) reduction reaction.It also shows good durability with negligible activity decay even after 10 cycles.Theoretical simulations reveal that the introduction of P dopants tunes the electronic structure of Ti active sites,thereby enhancing the NO adsorption and facilitating the desorption of ^(*)NH_(3).Moreover,the utilization of IL further suppresses the competitive hydrogen evolution reaction.This study highlights the advantage of the catalyst−electrolyte engineering strategy for producing NH_(3) at a high efficiency and rate. | Shangcong Zhang Qian Liu Xinyue Tang Zhiming Zhou Tieyan Fan Yingmin You Qingcheng Zhang Shusheng Zhang Jun Luo Xijun Liu | 2023 | Frontiers of Chemical Science and Engineering2023，17，6： | 1 |
| 18 | Parenting Style and Shyness of Late Adolescence Students in China: The Mediating Effect of Parent-Child Attachment显示文摘 | Chen YingMin Liu XiaoRan Yu LiNa Wu YunPeng Han Xue | 2015 | Psychology Research2015，5，7： | 0 |
| 19 | Annotation and Joint Extraction of Scientific Entities and Relationships in NSFC Project Texts显示文摘Aiming at the lack of classification and good standard corpus in the task of joint entity and relationship extraction in the current Chinese academic field, this paper builds a dataset in management science that can be used for joint entity and relationship extraction, and establishes a deep learning model to extract entity and relationship information from scientific texts. With the definition of entity and relation classification, we build a Chinese scientific text corpus dataset based on the abstract texts of projects funded by the National Natural Science Foundation of China(NSFC) in 2018–2019. By combining the word2vec features with the clue word feature which is a kind of special style in scientific documents, we establish a joint entity relationship extraction model based on the Bi LSTM-CNN-CRF model for scientific information extraction. The dataset we constructed contains 13060 entities(not duplicated) and 9728 entity relation labels. In terms of entity prediction effect, the accuracy rate of the constructed model reaches 69.15%, the recall rate reaches 61.03%, and the F1 value reaches 64.83%. In terms of relationship prediction effect, the accuracy rate is higher than that of entity prediction, which reflects the effectiveness of the input mixed features and the integration of local features with CNN layer in the model. | Zhiyuan GE Xiaoxi QI Fei WANG Tingli LIU Jun GUAN Xiaohong HUANG Yong SHAO Yingmin WU | 2023 | Journal of Systems Science and Information2023，11，4： | 0 |
| 20 | Simulated annealing algorithm for ill-posed or ill-conditioning deconvolution problem显示文摘A simulated annealing deconvolution technique dealing with the ill-posed and ill-Conditioning problems is presented. Following a survey about direct and iterative deconvolution techniques, the simulated annealing approach for ill-posed and ill-conditioning decon volution is introduced. With comparison to some deconvolution techniques the new approach is described in details. A specific ill-posed and ill-Conditioning deconvolution example is consid ered and the deconvolution results using the simulated annealing approach and some conventional techniques such as clipped inverse filtering, reblurring, multiple-operator, constrained iteration, etc., are given. It has shown that the simulated annealing approach fights against the ill-posed and ill-conditioning successfully. | WANG Yingmin MA Yuanliang LIU Jianmin and Philip R. Atkins (Institute of Acoustic Engineering, Northwestern Polytechnical University Xi’an 710072) (School of Electronic & Electrical Engineering The University of Birnimgham, Birmingham B15 2TT, U.K.) | 1996 | Chinese Journal of Acoustics1996，15，2： | 0 |
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