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| 1 | Spatial and Temporal Changes of Arable Land Driven by Urbanization and Ecological Restoration in China显示文摘Since the industrial revolution, human activities have both expanded and intensified across the globe resulting in accelerated land use change. Land use change driven by China’s development has put pressure on the limited arable land resources, which has affected grain production. Competing land use interests are a potential threat to food security in China. Therefore, studying arable land use changes is critical for ensuring future food security and maintaining the sustainable development of arable land. Based on data from several major sources, we analyzed the spatio-temporal differences of arable land among different agricultural regions in China from 2000 to 2010 and identified the drivers of arable land expansion and loss. The results revealed that arable land decreased by 5.92 million ha or 3.31%. Arable land increased in the north and decreased in the south of China. Urbanization and ecological restoration programs were the main drivers of arable land loss, while the reclamation of other land cover types(e.g., forest, grassland, and wetland) was the primary source of the increased arable land. The majority of arable land expansion occurred in the Northwest, but the centroid for grain production moved to northeast, which indicated that new arable land was of poor quality and did not significantly contribute to the grain production capacity. When combined with the current ‘Red Line of Arable Land Policy’(RAL) and ‘Ecological Redline Policy’(EPR), this study can provide effective information for arable land policymaking and help guide the sustainable development of arable land. | WANG Liyan ANNA Herzberger ZHANG Liyun XIAO Yi WANG Yaqing XIAO Yang LIU Jianguo OUYANG Zhiyun | 2019 | Chinese Geographical Science2019，29，5： | 9 |
| 2 | An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma显示文摘No clinically available biomarkers can predict pathological complete response(pCR)for esophageal squamous cell carcinomas(ESCCs)with neoadjuvant chemoradiotherapy(nCRT).Considering that antitumor immunity status is an important determinant for nCRT,we performed an integrative analysis of immune-related gene profiles from pretreatment biopsies and constructed the first individualized immune signature for pCR and outcome prediction of ESCCs through a multicenter analysis.During the discovery phase,14 differentially expressed immune-related genes(DEIGs)with greater than a twofold change between pCRs and less than pCRs( | Chaoqi Zhang Guochao Zhang Nan Sun Zhen Zhang Liyan Xue Zhihui Zhang Haijun Yang Yuejun Luo Xiaoli Zheng Yonglei Zhang Yufen Yuan Ruixue Lei Zhaoyang Yang Bo Zheng Le Wang Yun Che Feng Wang Sihui Wang Shugeng Gao Qi Xue Yi Zhang Jie He | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 3 | A scalable sulfuration of WS2 to improve cyclability and capability of lithium-ion batteries显示文摘二维的转变金属 dichalcogenides (WS 2 和 SnS 2) 最近加入了精力存储材料的家庭(为锂离子电池和 supercapacitors ) 由于他们的有利离子置闰。到目前为止,在阶段纯的 WS 2, 的合成的挑战严重地在 WS 2 nanosheets,低电子传导性,和 WS 2, 的易碎的性质之间重新叠限制它的使用 Li 离子电池申请。此处,我们开发灵巧的低温度解决方案硫化进程戏剧性地改进电池性能。硫化过程被表明在把 WO 3 杂质变换成 WS 2, 并且在修理硫空缺有效,到改进 cyclability 和率能力。锂离子电池大小证明 WS 2 阳极的稳定的能力能被 48.4% 经由硫化 reprocessing 提高,即,从在 0.8 的相对高的当前的密度的 381.7 ~ 566.8 mAh/g,在 50 以后的 A/g 骑车。我们进一步证明硫化进程能乐意地被扩大到另外的 dichalcogenides,并且可以为锂离子电池向万用的电极材料的一个类提供改进电气化学的特征。 | Liyan Zhou Shancheng Yan Lijia Pan Xinran Wang Yuqiao Wang Yi Shi | 2016 | Nano Research2016，9，3： | 7 |
| 4 | Radiolabeling and Biodistribution of a Nasopharyngeal Carcinoma-targeting Peptide Identified by in vivo Phage Display显示文摘指向 CEN-1 人的鼻咽的癌(NPC ) 的 dodecapeptide EDIKPKTSLAFR 配体被识别由在 vivo 噬菌体显示。二 tridecapeptides 和他们的衍生物,命名 YR13 ( YEDIKPKTSLAFR ), EY13 ( EDIKPKTSLAFRY ), EY13-NH_2 ( EDIKPKTSLAFRY-NH_2 ) andFmoc-YR13 ( Fmoc-YEDIKPKTSLAFR ),被综合,无线电用^( 131 )标记 I.The 稳定性 invitro ,在忍受 NPC 肿瘤的老鼠的选择噬菌体粒子的简历分发和织物分发被决定,并且无线电的血浆代谢物分析把肽标记被带 out.AlthoughFmoc 和 NH_2 组能保护肽免受 deiodination 的伤害,仅仅 Fmoc 组禁止了 Fmoc-YR13 的绑定到 NPC 肿瘤。复合 EY13-NH_2 ,肽 EY13 的C终端酰胺,有最大的浆液稳定性,最少的 deiodination ,并且证明有利肿瘤/血 ratios.Theselected 噬菌体粒子(噬菌体 3 或噬菌体 5 )是比控制噬菌体(起始的噬菌体显示器肽图书馆)在 NPC 肿瘤集中的更多 .EY13 能也禁止选择噬菌体粒子的绑定到肿瘤。结果显示 EDIKPKTSLAFR 是在诊断、治疗学的 NPC 的一个好候选人。 | Liyan SUN Taiwei CHU Yi WANG Xiangyun WANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，8： | 5 |
| 5 | Prospective, naturalistic study of open-label OROS methylphenidate treatment in Chinese school-aged children with attention-deficit/hyperactivity disorder显示文摘背景注意赤字活动过度混乱( ADHD )在童年期间是最普通的心理混乱之一,由活动过度, impulsivity 和疏忽的核心症状描绘了并且自己把大负担放在孩子上,他们的家庭和 society.Osmotic 释放口头的系统 methylphenidate (OROS哩/时)开发克服一些限制的一次每日的控制版本明确的表达与立即版本的 methylphenidate (红外哩/时)被联系 .It | ZHENG Yi WANG Yu-feng QIN Jiong WANG Li-wen ZOU Li-ping J IN Xing-ming XU Tong WANG Yi OI Yuan-li GONG Mei-en YIN Qing-yun MAI Jian-ning JING Jin LUO Xiang-yang MA Hong-wei LI Hai-bo XIE Ling LIYan Kuang Gui-fang YI Ming-ji WANG Feng ZHU Xiao-hua YAO Yan-bin | 2011 | Chinese Medical Journal2011，，20： | 2 |
| 6 | Change of Ecological Footprint and Analysis of Ecological Sustainability——Taking Zhangjiakou City as an Example显示文摘This paper researches the ecological sustainability of Zhangjiakou City, Hebei Province, China, using the ecological footprint model. According to the study we find that Zhangjiakou City was in the situation of ecological deficit from 1990 to 2000 and the deficit had the enlarging tendency. In 1990 the per capita ecological footprint was 0.964 and the per capita ecological capacity was 0.518, thus it can be calculated that the per capita ecological deficit was –0.446. However in 2000, the per capita ecological footprint increased to 1.068, at the same time the per capita eco- logical capacity decreased to 0.471, then the per capita ecological deficit in 2000 was –0.597. Furthermore, this paper studies the ecological sustainability of the city from the changes of the ecological footprint of per 10,000 yuan GDP and the productivity of ecological system. Finally the authors point out the shortage of the model and the way to improve it. | WANG Liyan LIU Yi CHEN Tian | 2007 | Chinese Geographical Science2007，17，1： | 2 |
| 7 | Protective humoral immunity in SARS-CoV-2 infected pediatric patients显示文摘After the rapid spread of SARS-CoV-2 in Wuhan,China,at the beginning of 2020,about 1.5 million confirmed cases and over 80,000 deaths have been reported around 200 countries and territories all over the world and the number continues to increase.However,we still have limited knowledge of this new coronavirus,especially the interaction between SARS-CoV-2 and our immune system. | Yaguang Zhang Jin Xu Ran Jia Chunyan Yi Wangpeng Gu Pengcheng Liu Xinran Dong Hao Zhou Bo Shang Shipeng Cheng Xiaoyu Sun Jing Ye Xuezhen Li Jia Zhang Zhiyang Ling Liyan Ma Bingbing Wu Mei Zeng Wenhao Zhou Bing Sun | 2020 | Cellular & Molecular Immunology2020，17，7： | 2 |
| 8 | Efficient procedure for isolating methylated catechins from green tea and effective simultaneous analysis of ten catechins, three purine alkaloids, and gallic acid in tea by high-performance liquid chromatography with diode array detection显示文摘 | Bing Hu Lin Wang Bei Zhou Xin Zhang Yi Sun Hong Ye Liyan Zhao Qiuhui Hu Guoxiang Wang Xiaoxiong Zeng | 2009 | Journal of Chromatography A2009，，15： | 2 |
| 9 | Preparation and In Vitro Evaluation of Liposoreal Chloroquine Diphosphate Loaded by a Transmembrane pH- gradient Method 显示文摘 | Liyan Q Na J Yi J | 2008 | International Journal of Pharmaeeutics2008，，361： | 1 |
| 10 | Vitamin B6 regulates IL-33 homeostasis to alleviate type 2 inflammation显示文摘Interleukin-33(IL-33)is a crucial nuclear cytokine that induces the type 2 immune response and maintains immune homeostasis.The fine-tuned regulation of IL-33 in tissue cells is critical to control of the type 2 immune response in airway inflammation,but the mechanism is still unclear.Here,we found that healthy individuals had higher phosphate-pyridoxal(PLP,an active form of vitamin B6)concentrations in the serum than asthma patients.Lower serum PLP concentrations in asthma patients were strongly associated with worse lung function and inflammation.In a mouse model of lung inflammation,we revealed that PLP alleviated the type 2 immune response and that this inhibitory effect relied on the activity of IL-33.A mechanistic study showed that in vivo,pyridoxal(PL)needed to be converted into PLP,which inhibited the type 2 response by regulating IL-33 stability.In mice heterozygous for pyridoxal kinase(PDXK),the conversion of PL to PLP was limited,and IL-33 levels were increased in the lungs,aggravating type 2 inflammation.Furthermore,we found that the mouse double minute 2 homolog(MDM2)protein,an E3 ubiquitin-protein ligase,could ubiquitinate the N-terminus of IL-33 and sustain IL-33 stability in epithelial cells.PLP reduced MDM2-mediated IL-33 polyubiquitination and decreased the level of IL-33 through the proteasome pathway.In addition,inhalation of PLP alleviated asthma-related effects in mouse models.In summary,our data indicate that vitamin B6 regulates MDM2-mediated IL-33 stability to constrain the type 2 response,which might help develop a potential preventive and therapeutic agent for allergy-related diseases. | Songling Zhu Shufen Zhong Kebin Cheng Li-Sha Zhang Jiu-wu Bai Zu Cao Su Wang Wen Chen Shipeng Cheng Liyan Ma Zhiyang Ling Yuying Huang Wangpeng Gu Xiaoyu Sun Chunyan Yi Meng Zhao Shuo Liang Jin-Fu Xu Bing Sun Yaguang Zhang | 2023 | Cellular & Molecular Immunology2023，20，7： | 1 |
| 11 | Chinese consensus guidelines for therapeutic drug monitoring of polymyxin B,endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society显示文摘Polymyxin B,which is a last-line antibiotic for extensively drug-resistant Gram-negative bacterial infections,became available in China in Dec.2017.As dose adjustments are based solely on clinical experience of risk toxicity,treatment failure,and emergence of resistance,there is an urgent clinical need to perform therapeutic drug monitoring(TDM)to optimize the use of polymyxin B.It is thus necessary to standardize operating procedures to ensure the accuracy of TDM and provide evidence for their rational use.We report a consensus on TDM guidelines for polymyxin B,as endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society.The consensus panel was composed of clinicians,pharmacists,and microbiologists from different provinces in China and Australia who made recommendations regarding target concentrations,sample collection,reporting,and explanation of TDM results.The guidelines provide the first-ever consensus on conducting TDM of polymyxin B,and are intended to guide optimal clinical use. | XIAOFEN LIU CHENRONG HUANG PHILLIP JBERGEN JIAN LI JINGJING ZHANG YIJIAN CHEN YONGCHUAN CHEN BEINING GUO FUPIN HU JINFANG HU LINLIN HU XIN LI HONGQIANG QIU HUA SHAO TONGWEN SUN YU WANG PING XU JING YANG YONG YANG ZHENWEI YU BIKUI ZHANG HUAIJUN ZHU XIAOCONG ZUO YI ZHANG LIYAN MIAO JING ZHANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，2： | 1 |
| 12 | Progress in use of surfactant in nearly static conditions in natural gas hydrate formation显示文摘Natural gas hydrate is an alternative energy source with a great potential for development.The addition of surfactants has been found to have practical implications on the acceleration of hydrate formation in the industrial sector.In this paper,the mechanisms of different surfactants that have been reported to promote hydrate formation are summarized.Besides,the factors influencing surfactant-promoted hydrate formation,including the type,concentration,and structure of the surfactant,are also described.Moreover,the effects of surfactants on the formation of hydrate in pure water,brine,porous media,and systems containing multiple surfactants are discussed.The synergistic or inhibitory effects of the combinations of these additives are also analyzed.Furthermore,the process of establishing kinetic and thermodynamic models to simulate the factors affecting the formation of hydrate in surfactant-containing solutions is illustrated and summarized. | Zhen PAN Yi WU Liyan SHANG Li ZHOU Zhien ZHANG | 2020 | Frontiers in Energy2020，14，3： | 1 |
| 13 | Damage repair effect of He Ne laser on wheat exposed to enhanced ultraviolet B radiation显示文摘 | Yang Liyan Han Rong Sun Yi | 2012 | Plant Physiology and Biochemistry2012，57，： | 1 |
| 14 | Efficient procedure for isolating methylated catechins from green tea and effective simultaneous analysis of ten catechins, three purine alkaloids, and gallic acid in tea by high-performance liquid chromatography with diode array detection显示文摘 | Bing Hu Lin Wang Bei Zhou Xin Zhang Yi Sun Hong Ye Liyan Zhao Qiuhui Hu Guoxiang Wang Xiaoxiong Zeng | 2009 | Journal of Chromatography A2009，，15： | 1 |
| 15 | AC impedance characteristics of a 2kW PEM fuel cell stack under different operating conditions and load changes显示文摘 | Xiqiang Yan Ming Hou Liyan Sun Dong Liang Qiang Shen Hongfei Xu Pingwen Ming Baolian Yi | 2007 | International Journal of Hydrogen Energy2007，，17： | 1 |
| 16 | Thermal degradation and thermal mechanical properties of two high-performance aromatic polyimide fibers显示文摘 | Huang Liyan Shi Yi | 1999 | J Macromol Sci Phys1999，38，： | 1 |
| 17 | Thermal degradation of organo-soluble polyimides显示文摘 | Shi Yi Jin Xigao | 1999 | Sci in China1999，42，： | 1 |
| 18 | Damage repair effect of He- Ne laser on wheat exposed to enhanced ultraviolet-B radiation 显示文摘 | YANG Liyan HAN Rong SUN Yi | 2012 | Plant Physiology and Biochemistry2012，57，： | 1 |
| 19 | Paclitaxel liposome for injection (Lipusu) plus cisplatin versus gemcitabine plus cisplatin in the first-line treatment of locally advanced or metastatic lung squamous cell carcinoma: A multicenter, randomized, open-label, parallel controlled clinical study显示文摘Background:Lipusu is the first commercialized liposomal formulation of pacli-taxel and has demonstrated promising efficacy against locally advanced lung squamous cell carcinoma(LSCC)in a small-scale study.Here,we conducted a multicenter,randomized,phase 3 study to compare the efficacy and safety of cis-platin plus Lipusu(LP)versus cisplatin plus gemcitabine(GP)as first-line treat-ment in locally advanced or metastatic LSCC.Methods:Patients enrolled were aged between 18 to 75 years,had locally advanced(clinical stage IIIB,ineligible for concurrent chemoradiation or surgery)or metastatic(Stage IV)LSCC,had no previous systemic chemother-apy and at least one measurable lesion as per the Response Evaluation Criteria in Solid Tumors(version 1.1)before administration of the trial drug.The primary endpoint was progression-free survival(PFS).The secondary endpoints included objective response rate(ORR),disease control rate(DCR),overall survival(OS),and safety profiles.To explore the possible predictive value of plasma cytokines for LP treatment,plasma samples were collected from the LP group at baseline and first efficacy evaluation time and were then subjected to analysis by 45-Plex ProcartaPlex Panel 1 to detect the presence of 45 cytokines using the Luminex xMAP technology.The correlation between treatment outcomes and dynamic changes in the levels of cytokines were evaluated in preliminary analyses.Results:The median duration of follow-up was 15.4 months.237 patients in the LP group and 253 patients in the GP group were included in the per protocol set(PPS).In the PPS,the median PFS was 5.2 months versus 5.5 months in the LP and GP group(hazard rtio[HR]:1.03,P=0.742)respectively.The median OS was 14.6 months versus 12.5 months in the LP and GP group(HR:0.83,P=0.215).The ORR(41.8%versus 45.9%,P=0.412)and DCR(90.3%versus 88.1%,P=0.443)were also similar between the LP and GP group.A significantly lower proportion of patients in the LP group experienced adverse events(AEs)leading to treatment interruptions(10.9%versus 26.4%,P<0.001)or treatment termination(14.3%versus 23.1%,P=0.011).The analysis of cytokine levels in the LP group showed that low baseline levels of 27 cytokines were associated with an increased ORR,and 15 cytokines were associated with improved PFS,with 14 cytokines,including TNF-a,IFN-y,IL-6,and IL-8,demonstrating an overlapping trend.Conclusion:The LP regimen demonstrated similar PFS,OS,ORR and DCR as the GP regimen for patients with locally advanced or metastatic LSCC but had more favorable toxicity profiles.The study also identified a spectrum of different cytokines that could be potentially associated with the clinical benefit in patients who received the LP regimen. | Jie Zhang Yueyin Pan Qin Shi Guojun Zhang Liyan Jiang Xiaorong Dong Kangsheng Gu Huijuan Wang Xiaochun Zhang Nong Yang Yuping Li Jianping Xiong Tienan Yi Min Peng Yong Song Yun Fan Jiuwei Cui Gongyan Chen Wei Tan Aimin Zang Qisen Guo Guangqiang Zhao Ziping Wang Jianxing He Wenxiu Yao Xiaohong Wu Kai Chen Xiaohua Hu Chunhong Hu Lu Yue Da Jiang Guangfa Wang Junfeng Liu Guohua Yu Junling Li Jianling Bai Wenmin Xie Weihong Zhao Lihong Wu Caicun Zhou | 2022 | Cancer Communications2022，42，1： | 1 |
| 20 | A SARS-CoV-2 antibody retains potent neutralization against Omicron by targeting conserved RBM residues显示文摘The newly emerged Omicron(B.1.1.529)variant of SARS-CoV-2 is quickly overtaking the Delta variant and becoming the dominant strain around the world due to its enhanced transmissibility and high immune escape potential[1,2].Compared to the Wuhan strain,the Omicron variant carries 37 spike mutations,of which 15 are within the receptor-binding domain(RBD)(Fig.1A).A high mutation rate is associated with remarkable resistance to current vaccines and RBD-specific antibody therapeutics[2,3,4]. | Chunyan Yi Zhiyang Ling Xiao Lu Yadong Fu Zhuo Yang Sonam Wangmo Shuangfeng Chen Yaguang Zhang Liyan Ma Wangpeng Gu Hongzhou Lu Xiaoyu Sun Bing Sun | 2022 | Cellular & Molecular Immunology2022，19，5： | 1 |
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