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| 1 | Safety,tolerability,and pharmacokinetics of BAT8001 in patients with HER2-positive breast cancer:An open-label,dose-escalation,phase I study显示文摘Background:The introductions of anti-human epidermal growth factor receptor-2(HER2)agents have significantly improved the treatment outcome of patients with HER2-positive breast cancer.BAT8001 is a novel antibodydrug conjugate targeting human epidermal growth factor receptor-2(HER2)-expressing cells composed of a trastuzumab biosimilar linked to the drug-linker Batansine.This dose-escalation,phase I study was designed to assess the safety,tolerability,pharmacokinetics,and preliminary anti-tumor activity of BAT8001 in patients with HER2-positive locally advanced or metastatic breast cancer.Methods:This trial was conducted in subjects with histologically confirmed HER2-positive breast cancer(having evaluable lesions and an Eastern Cooperative Oncology Group performance status of 0 or 1)using a 3+3 design of escalating BAT8001 doses.Patients received BAT8001 intravenously in a 21-day cycle,with dose escalation in 5 cohorts:1.2,2.4,3.6,4.8,and 6.0 mg/kg.The primary objective was to evaluate the safety and tolerability of BAT8001.Preliminary activity of BAT8001 was also assessed as a secondary objective.Results:Between March 2017 to May 2018,29 HER2-positive breast cancer patients were enrolled.The observed dose-limiting toxicities were grade 4 thrombocytopenia and grade 3 elevated transaminase.The maximum tolerated dose was determined to be 3.6 mg/kg.Grade 3 or greater adverse events(AEs)occurred in 14(48.3%)of 29 patients,including thrombocytopenia in 12(41.4%)patients,aspartate aminotransferase increased in 4(13.8%)patients,γ-glutamyl transferase increased in 2(6.9%)patients,alanine aminotransferase increased in 2(6.9%)patients,diarrhea in 2(6.9%)patients.Objective response was observed in 12(41.4%,95%confidence interval[CI]=23.5%-61.1%)and disease control(including patients achieving objective response and stable disease)was observed in 24(82.8%,95%CI=64.2%-94.2%)patients.Conclusions:BAT8001 demonstrated favorable safety profiles,with promising anti-tumor activity in patients with HER2-positive locally advanced or metastatic breast cancer.BAT8001 has the potential to provide a new therapeutic option in patients with metastatic HER2-positive breast cancer. | Ruoxi Hong Wen Xia Liye Wang Kaping Lee Qianyi Lu Kuikui Jiang Shengfeng Li Jinquan Yu Jin Wei Weijia Tang Danyang Zhou Xin An Jiajia Huang Cong Xue Xiwen Bi Yanxia Shi Zhongyu Yuan Fei Xu Shusen Wang | 2021 | Cancer Communications2021，41，2： | 2 |
| 2 | TSPAN1 functions as an oncogene in gastric cancer and is downregulated by miR-573显示文摘 | Zhengmao Lu Tianhang Luo Mingming Nie Tao Pang Xin Zhang Xiaojun Shen Liye Ma Jianwei Bi Guo Wei Guoen Fang Xuchao Xue | 2015 | FEBS Letters2015，，： | 1 |
| 3 | The draft genome of the fast-growing non-timber forest species moso bamboo (PhyUostachys heterocycla) 显示文摘 | Peng Z H Lu Y Li L Zhao Q Feng Q Gao Z M Lu H Y Hu T YAO N Liu K Y LiY FanDL GuoYL LiW J LuY Q Weng Q J Zhou C C Zhang L Huang T Zhu C R Liu X G Yang X W Wang T Miao K Zhuang C Y Cao X L Tang W L Liu G S Liu Y L Chen J Liu Z J Yuan L C Liu Z H Huang X H LuT T Fei B H Ning Z M Han B Jiang Z H | 2013 | Nature Genetics2013，45，4： | 1 |
| 4 | Cr(Ⅵ) reduction at rutilecatalyzed cathode in microbial fuel cells 显示文摘 | LiY Lu A H Ding H R | 2009 | Electrochemistry Communications2009，11，7： | 1 |
| 5 | Molecular characterization and serodiagnosis analysis of a novel lysophospholipase from Clonorchis sinensis显示文摘 | MaC HuX HuF LiY ChenX ZhouZ Lu F XuJ Wu Z Yu X | 2007 | Parasitol Res2007，02，： | 1 |
| 6 | Laparoscopic Radical Correction Combined With Extensive Lymphadenectomy and Pelvic Autonomic Nerve Preservation for Mid-to-Low Rectal Cancer显示文摘 | Tao Liu Chao Zhang PeiWu Yu Jun Chen Dongzhu Zeng Lu Gan Wei Lv LiYe Liu Xiaochu Yan | 2011 | Clinical Colorectal Cancer2011，，3： | 1 |
| 7 | Iterative receiver for space time block coded OFDM systems in dispersive fading channels 显示文摘 | LU Ben WANG Xiao Dong LIYe | 2002 | IEEE Transactions on Wireless Communication2002，1，2： | 1 |
| 8 | Is isolated nocturnal hypertension a novel clinical entity?Finding from a Chinese population study显示文摘 | Liy Staessen JA Lu L | 2007 | Hypertension2007，50，2： | 1 |
| 9 | Cold storage duration affects litchi fruit quali-ty,membrane permeability,enzyme activities and energy chargeduring shelf time at ambient temperature显示文摘 | LIU H SONG L YOU Y LIY DUAN X JIANG Y JOYCE DC ASHRAF M LU W | 2011 | Postharvest Biology andTechnology2011，60，： | 1 |
| 10 | Follistatin Improves Skeletal Muscle Healing after Injury and Disease through an Interaction with Muscle Regeneration, Angiogenesis, and Fibrosis显示文摘 | ZHU J H LIY LU A P | 2011 | Am l Pathol2011，179，2： | 1 |
| 11 | Chemical Composition of Special Glutinous Rice and Its Effect on the Quality of Brewed Wine显示文摘The chemical composition of 8 different special glutinous rice varieties was analyzed,and its effects on the physical and chemical properties of the wines brewed were investigated. The correlations between major chemical constituents and quality of glutinous rice were analyzed. The results show that the contents of the major chemical constituents in the special glutinous rice varieties were not much different,and they all ranked as starch’s > protein’s > fat’s. After 4-8 weeks of fermentation,the total acidity decreased with time( excepting Heixiangnuo),the total residual sugar reduced significantly,and the alcohol content increased significantly. The correlations between starch content of glutinous rice and physical and chemical indices and sensory quality of its brewed wine were not significant. There are positive correlations between protein content and various indices,and the correlation with total acidity reached the significant level. Fat content was negatively correlated with alcohol content,and positively correlated with sensory quality. | Jiayong XIANG Yuanyuan PENG Liye LU LU XIE Qinxin XIE Guiyuan MENG Rong XIAO | 2019 | Asian Agricultural Research2019，11，12： | 1 |
| 12 | Reduced Glass Transition Temperature and Glass Forming Ability of Bulk Glass Forming Alloys显示文摘 | Lu ZP LiY Ng SC | 2000 | Journal of Non-Crystalline Solids2000，270，123： | 1 |
| 13 | Was Wuhan the early epicenter of the COVID-19 pandemic?——a critique显示文摘Recently, Worobey et al.(2022) published a report entitled ‘The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic' that succinctly summarizes their study [1]. A pre-print version of this study had earlier elicited a series of highprofile media coverages [2,3]. All these reports deliver a social-political message that the Huanan market is the epicenter of COVID-19. | Yanan Cao Lingling Chen Hua Chen Yupeng Cun Xiaofeng Dai Hongli Du Feng Gao Fengbiao Guo Yalong Guo Pei Hao Shunmin He Shunping He XiongLei He Zheng Hu Boon-Peng Hoh Xin Jin Qian Jiang Qinghua Jiang Asifullah Khan Hong-Zhi Kong Jinchen Li Shuai Cheng Li Ying Li Qiang Lin Jianquan Liu Qi Liu Jian Lu Xuemei Lu Shujin Luo Qinghua Nie Zilong Qiu Tieliu Shi Xiaofeng Song Jianzhong Su Sheng-ce Tao Chaolong Wang Chuan-Chao Wang Guo-Dong Wang Jiguang Wang Qi Wu Shaoyuan Wu Shuhua Xu Yu Xue Wenjun Yang Zhaohui Yang Kai Ye Yuan-Nong Ye Li Yu Fangqing Zhao Yiqiang Zhao Weiwei Zhai Dandan Zhang Liye Zhang Houfeng Zheng Qi Zhou Tianqi Zhu Ya-ping Zhang | 2023 | National Science Review2023，10，4： | 0 |
| 14 | Effects of Health Qigong Exercise on Depression and Anxiety in Patients with Parkinson’s Disease显示文摘Objective: This study explored the effects of Health Qigong exercise on depression and anxiety in patients withParkinson’s disease (PD). Methods: A total of 42 volunteers who met the inclusion criteria were recruited andrandomly allocated into the experimental group and the control group. The experimental group carried out60-minute sessions of Health Qigong exercise five times a week for 12 weeks while the control group did not performany regular physical exercise. Data on cognitive impairment, psychomotor retardation, somatic anxiety,weight loss and sleep disorders, the sum score of the 17-item Hamilton Depression Rating Scale (HDRS-17), stateanxiety, trait anxiety as well as the sum score of the State-Trait Anxiety Inventory (STAI) were collected for threerepeated measurements (baseline, 6, and 12 weeks). Results: Significant differences were observed in depression,state anxiety, trait anxiety, cognitive impairment and psychomotor retardation in the experimental group but nodifference in somatic anxiety, weight loss and sleep disorders. Conclusion: Health Qigong exercise can pose positivepsychological effects and alleviate the depression and anxiety in patients with Parkinson’s disease. It can beapplied as an accessible supplement to the existent drug treatment for PD. | Xiying Li Alyx Taylor Jinming Li Ting Wang Jing Kuang Zhihao Zhang Xiaolei Liu Tingting Liu Xia Qin Shenghua Lu Liye Zou | 2022 | International Journal of Mental Health Promotion2022，24，6： | 0 |
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