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| 1 | Celastrus orbiculatus extract induces mitochondrial-mediated apoptosis in human hepatocellular carcinoma cells显示文摘OBJECTIVE:To investigate the apoptotic effects and underlying molecular mechanisms of Celastrus orbiculatus(C.orbiculatus) extract in human hepatocellular carcinoma cells.METHODS:Human hepatocellular carcinoma cells(HCCLM6) were treated with C.orbiculatus extract(COE) at different nontoxic concentrations(10,20,40,80,and 160 μg/mL).The effect of COE on HC-CLM6 viability was examined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT) assays.Cellular apoptosis following COE treatment was assessed by flow cytometry and western blot analysis.RESULTS:COE significantly inhibited cell viability and induced apoptosis of HCCLM6 cells in a dose-dependent manner.Apoptosis was accompanied by increased Bax expression and decreased Bcl-2 expression.In addition,COE treatment led to the release of cytochrome c,activation of caspase-3,and cleavage of poly(ADP-ribose) polymerase(PARP).Furthermore,activation of extracellular signal-regulated kinase(ERK),p38 kinase,and c-Jun N-terminal kinase(JNK) phosphorylation,and down-regulation of Akt phosphorylation was observed.CONCLUSION:COE induces mitochondrial-mediated,caspase-dependent apoptosis in HCCLM6 cells,which might be attributed to the activation of mitogen-activated protein kinase(MAPK) and inhibition of Akt signaling pathways.These data suggest that COE may be a potential treatment for human hepatocellular carcinoma. | Hua Zhang Yayun Qian Yanqing Liu Guoqing Li Pingfang Cui Yaodong Zhu Hui Ma Xue Ji Shiyu Guo Hisamits Tadashi | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 18 |
| 2 | 秸秆处理技术的最新进展:挑战与解决方案显示文摘秸秆作为一种农业副产品已被认为是一种潜在生物质资源。然而,露天焚烧秸秆仍是世界许多地区的主要手段,这造成资源浪费和空气污染。近年来已经开发了许多用于从秸秆中回收能源和资源的技术,由于其经济可行性和生态友好性质,该生物学方法引起了越来越多的研究兴趣。然而,在生物加工过程之前对秸秆进行预处理是必不可少的,并且在很大程度上决定了过程的可行性、经济可行性和环境可持续性。因此,本综述试图对当前的秸秆预处理技术和管理实践进行重要而全面的分析。主要提出了结合微生物降解和酶促水解的综合生物过程,并阐述了其与未来大规模秸秆处理相关的潜在利益、局限性和挑战,并展望了前景和方向。 | Yingqun Ma Yanqing Shen Yu Liu | 2020 | 中国农机化学报2020，41，11： | 18 |
| 3 | PepperHub, an Informatics Hub for the Chili Pepper Research Community显示文摘 | Feng Liu Huiyang Vu Yingtian Deng Jingyuan Zheng Minglei Liu Lijun Ou Bozhi Yang Xiongze Dai Yanqing Ma Shengyu Feng Shuang He Xuefeng Li Zhuqing Zhang Wenchao Chen Shudong Zhou Rong Chen Minmin Liu Sha Yang Ruimin Wei Huadong Li Feng Li Bo Ouyang Xuexiao Zou | 2017 | Molecular Plant2017，10，8： | 13 |
| 4 | Adsorption of lead on multi-walled carbon nanotubes with different outer diameters and oxygen contents: Kinetics, isotherms and thermodynamics显示文摘The effects of different outer diameters and surface oxygen contents on the adsorption of heavy metals onto six types of multi-walled carbon nanotubes (MWCNTs) were investigated in an aqueous solution and lead was chosen as a model metal ion. The results indicated that the percentage removal and adsorption capacity of lead remarkably increased with decreasing outer diameter due to larger specific surface area (SSA). The SSA-normalized maximum adsorption capacity (qm /SSA) and SSA-normalized adsorption coefficient (Kd /SSA) were strongly positively correlated with surface oxygen content, implying that lead adsorption onto MWCNTs significantly increases with the rise of oxygen content and decreases with decreasing SSA. The calculated thermodynamic parameters indicated that adsorption of lead on MWCNTs was endothermic and spontaneous. When the oxygen content of MWCNTs increased from 2.0% to 5.9%, the standard free energy (△ G0 ) became more negative, which implied that the oxygenated functional groups increased the adsorption affinity of MWCNTs for lead. Through calculation of enthalpy (△ H0 ), G0 and free energy of adsorption (Ea ), lead adsorption onto MWCNTs was recognized as a chemisorption process. The chemical interaction between lead and the phenolic groups of MWCNTs could be one of the main adsorption mechanisms due to highly positive correlations between the phenolic groups and K d /SSA or q m /SSA. | Fei Yu Yanqing Wu Jie Ma Chi Zhang | 2013 | Journal of Environmental Sciences2013，25，1： | 11 |
| 5 | Heterogeneously integrated,superconducting silicon-photonic platform for measurementdevice-independent quantum key distribution显示文摘Integrated photonics provides a route to both miniaturization of quantum key distribution(QKD)devices and enhancing their performance.A key element for achieving discrete-variable QKD is a singlephoton detector.It is highly desirable to integrate detectors onto a photonic chip to enable the realization of practical and scalable quantum networks.We realize a heterogeneously integrated,superconducting silicon-photonic chip.Harnessing the unique high-speed feature of our optical waveguide-integrated superconducting detector,we perform the first optimal Bell-state measurement(BSM)of time-bin encoded qubits generated from two independent lasers.The optimal BSM enables an increased key rate of measurement-device-independent QKD(MDI-QKD),which is immune to all attacks against the detection system and hence provides the basis for a QKD network with untrusted relays.Together with the timemultiplexed technique,we have enhanced the sifted key rate by almost one order of magnitude.With a 125-MHz clock rate,we obtain a secure key rate of 6.166 kbps over 24.0 dB loss,which is comparable to the state-of-the-art MDI-QKD experimental results with a GHz clock rate.Combined with integrated QKD transmitters,a scalable,chip-based,and cost-effective QKD network should become realizable in the near future. | Xiaodong Zheng Peiyu Zhang Renyou Ge Liangliang Lu Guanglong He Qi Chen Fangchao Qu Labao Zhang Xinlun Cai Yanqing Lu Shining Zhu Peiheng Wu Xiao-Song Ma | 2021 | Advanced Photonics2021，3，5： | 5 |
| 6 | Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome显示文摘To unravel the genetic mechanisms of disease and physiological traits,it requires comprehensive sequencing analysis of large sample size in Chinese populations.Here,we report the primary results of the Chinese Academy of Sciences Precision Medicine Initiative(CASPMI)project launched by the Chinese Academy of Sciences,including the de novo assembly of a northern Han reference genome(NH1.0)and whole genome analyses of 597 healthy people coming from most areas in China.Given the two existing reference genomes for Han Chinese(YH and HX1)were both from the south,we constructed NH1.0,a new reference genome from a northern individual,by combining the sequencing strategies of PacBio,10×Genomics,and Bionano mapping.Using this integrated approach,we obtained an N50 scaffold size of 46.63 Mb for the NH1.0 genome and performed a comparative genome analysis of NH1.0 with YH and HX1.In order to generate a genomic variation map of Chinese populations,we performed the whole-genome sequencing of 597 participants and identified 24.85 million(M)single nucleotide variants(SNVs),3.85 M small indels,and 106,382 structural variations.In the association analysis with collected phenotypes,we found that the T allele of rs1549293 in KAT8 significantly correlated with the waist circumference in northern Han males.Moreover,significant genetic diversity in MTHFR,TCN2,FADS1,and FADS2,which associate with circulating folate,vitamin B12,or lipid metabolism,was observed between northerners and southerners.Especially,for the homocysteine-increasing allele of rs1801133(MTHFR 677T),we hypothesize that there exists a “comfort”zone for a high frequency of 677T between latitudes of 35–45 degree North.Taken together,our results provide a high-quality northern Han reference genome and novel population-specific data sets of genetic variants for use in the personalized and precision medicine. | Zhenglin Du Liang Ma Hongzhu Qu Wei Chen Bing Zhang Xi Lu Weibo Zhai Xin Sheng Yongqiao Sun Wenjie Li Meng Lei Qiuhui Qi Na Yuan Shuo Shi Jingyao Zeng Jinyue Wang Yadong Yang Qi Liu Yaqiang Hong Lili Dong Zhewen Zhang Dong Zou Yanqing Wang Shuhui Song Fan Liu Xiangdong Fang Hua Chen Xin Liu Jingfa Xiao Changqing Zeng | 2019 | Genomics, Proteomics & Bioinformatics2019，17，3： | 4 |
| 7 | Optimization and Effects of Catalytic Ozonation of Actual Phenolic Wastewater by CuO/Al2O3显示文摘In order to improve the ability of ozone to catalyze the degradation of phenolic pollutants in wastewater,the CuO/Al2O3 catalysts was prepared by the impregnation precipitation method and an ozone catalytic oxidation system was constructed.The actual phenolic sewage was used as the treatment object.And the reaction conditions of the system were optimized,and the treatment effect was determined,while the non-catalytic system was used as a control group.At the same time,the influence of salt and ammonia nitrogen related water quality on the system was studied.The optimal reaction conditions for the treatment of phenolic wastewater covered:a catalyst dosage of 30 g/L,an ozone flow rate of 0.3 m3/h,a pH value of 8.80,and a reaction time of 15 minutes.Under these conditions,the phenol and COD removal rates of the system reached 98.7%and 49.4%,respectively,which were by 31.3 percentage points and 16.2 percentage points higher than that of the ozonation system alone.The salt and ammonia nitrogen in the sewage can reduce the oxidation effect of the system.When the salinity reached 10%and the ammonia nitrogen content reached 13 000 mg/L,the removal rate of phenol could be reduced by about 20%.The results of this paper have a reference value for phenol wastewater treatment engineering. | Ma Rui Liu Guangmin Feng Sihui Qiu Xiaoyu Zhang Yanqing Xia Shumei Xue Jianliang | 2019 | China Petroleum Processing & Petrochemical Technology2019，21，3： | 3 |
| 8 | Daily SPEI Reveals Long-term Change in Drought Characteristics in Southwest China显示文摘Drought is the most widespread and insidious natural hazard, presenting serious challenges to ecosystems and human society. The daily Standardized Precipitation Evapotranspiration Index(SPEI) has been developed to identify the regional spatiotemporal characteristics of drought conditions from 1960 to 2016, revealing the variability in drought characteristics across Southwest China. Daily data from142 meteorological stations across the region were used to calculate the daily SPEI at the annual and seasonal time scale. The Mann-Kendall test and the trend statistics were then applied to quantify the significance of drought trends, with the following results. 1) The regionally averaged intensity and duration of all-drought and severe drought showed increasing trends, while the intensity and duration of extreme drought exhibited decreasing trends. 2) Mixed(increasing/decreasing) trends were detected, in terms of intensity and duration, in the three types of drought events. In general, no evidence of significant trends(P < 0.05) was detected in the drought intensity and duration over the last 55 years at the annual timescale. Seasonally, spring was characterized by a severe drought trend for all drought and severe drought conditions, while extreme drought events in spring and summer were very severe. All drought intensities and durations showed an increasing trend across most regions, except in the northwestern parts of Sichuan Province. However, the areal extent of regions suffering increasing trends in severe and extreme drought became relatively smaller. 3) We identified the following drought hotspots: Guangxi Zhuang Autonomous Region from the 1960 s to the 1990 s, respectively. Guangxi Zhuang Autonomous Region and Guizhou Province in the 1970 s and 1980 s, and Yunnan Province in the 2000 s. Finally, this paper can benefit operational drought characterization with a day-to-day drought monitoring index, enabling a more risk-based drought management strategy in the context of global warming. | JIA Yanqing ZHANG Bo MA Bin | 2018 | Chinese Geographical Science2018，28，4： | 3 |
| 9 | Recognition of Early Paleozoic Magmatisms in the Supposed Proterozoic Basements of Zhalantun, Great Xing’an Range, NE China显示文摘The Zhalantun terrane from the Xing’an massif, northeast China, was used to be considered as Proterozoic basements. However, amounts of detrital zircon ages from the meta-sedimentary rocks deny the existence of Precambrian basements recently. Notably, magmatic rocks were barely reported to limit the exact ages of the Zhalantun basements. In this study, we collected rhyolite, gabbro and quartz diorite for zircon in-situ U-Pb isotopic dating, which yield crystallization ages of ~505 Ma, ~447 Ma and ~125 Ma, respectively. Muscovite schist and siltstone define maximum depositional ages of ~499 Ma and ~489 Ma, respectively. Additionally, these dated supracrustal rocks and plutons also yield ancient detrital/xenocryst zircon ages of ~600-1000 Ma, ~1600-2220 Ma, ~2400 Ma, ~2600-2860 Ma. Based on the whole-rock major and trace element compositions, the ~505 Ma rhyolites display high SiO2 and alkaline contents, low Fe2O3T, TiO2 and Al2O3, and relatively high Mg O and Mg#, which exhibit calc-alkaline characteristics. These rhyolites yield fractionated REE patterns and negative Nb, Ta, Ti, Sr, P and Eu anomalies and positive Zr anomalies. The geochemistry, petrology and Lu-Hf isotopes imply that rhyolites were derived from the partial melting of continental basalt induced by upwelling of sub-arc mantle magmas, and then experienced fractional crystallization of plagioclase, which points to a continental arc regime. The ~447 Ma gabbros exhibit low Si O2 and alkaline contents, high Fe2 O3 T, Ti O2, Mg O and Mg#. They show minor depletions of La and Ce, flat MREE and HREE patterns, and negative Nb, Ta, Zr and Hf anomalies. Both sub-arc mantle and N-MORB-like mantle were involved in the formation of the gabbros, indicative of a probable back-arc basin tectonic setting. Given that, the previously believed Proterozoic supracrustal rocks and several plutons from the Zhalantun Precambrian basements were proved to be Paleozoic to Mesozoic rocks, among which these Paleozoic magmatic rocks were generally related to subduction regime. So far, none Proterozoic rocks have been identified from the Zhalantun Precambrian basement, though some ~600-3210 Ma ancient detrital/xenocryst zircons were reported. Combined with ancient zircon ages and newly reported ~2.5 Ga and ~1.8 Ga granites from the south of the Zhalantun, therefore, the Precambrian rocks probably once exposed in the Zhalantun while they were re-worked and consumed during later long tectonic evolutionary history, resulting in absence of Precambrian rocks in the Zhalantun. | QIN Tao GUO Rongrong ZANG Yanqing QIAN Cheng WANG Yan SI Qiuliang SUN Wei MA Yongfei | 2019 | Acta Geologica Sinica(English Edition)2019，93，5： | 3 |
| 10 | Chatter free sliding mode control of a chaotic coal mine power grid with small energy inputs显示文摘An augmented proportional-integral sliding surface was designed for a sliding mode controller.A chatter free sliding mode control strategy for a chaotic coal mine power grid was developed.The stability of the control strategy was proven by Lyapunov stability theorem.The proposed sliding mode control strategy eliminated the chattering phenomenon by replacing the sign function with a saturation function,and by replacing the constant coefficients in the reaching law with adaptive ones.An immune genetic algorithm was used to optimize the parameters in the improved reaching law.The cut-in time of the controllers was optimized to reduce the peak energy of their output.Simulations showed that the proposed sliding mode controller has good,chatter free performance. | Xu Yanqing Jia Feng Ma Caoyuan Mao Jiasong Zhang Shaowei | 2012 | International Journal of Mining Science and Technology2012，22，4： | 2 |
| 11 | Submicrosecond electro-optical switching of one-dimensional soft photonic crystals显示文摘Soft photonic crystals are appealing due to their self-assembly ability,wide tunability,and multistimuli-responsiveness.However,their response time is relatively slow,ranging from milliseconds to minutes.Here,we report submicrosecond switching of chiral liquid crystals(LCs)with 1D photonic microstructures,where electric fields modify the orientational order of molecules and quench their fluctuations,rather than altering the orientation.Thus,the adjusted refractive indices result in a fast shift of the photonic bandgap,on the order of 100 ns,which is four orders of magnitude faster than conventional electro-optic switching in cholesterics.This work offers tremendous opportunities for soft photonic applications. | Lingling Ma Chaoyi Li Luyao Sun Zhenpeng Song Yanqing Lu Bingxiang Li | 2022 | Photonics Research2022，10，3： | 2 |
| 12 | Adsorption of toluene, ethylbenzene and xylene isomers on multi-walled carbon nanotubes oxidized by different concentration of NaOCI显示文摘 | Fei YU Jie MA Yanqing WU | 2012 | Frontiers of Environmental Science & Engineering2012，6，3： | 2 |
| 13 | Sedimentary Age of the Baoligaomiao Formation in the Zhanlantun Area, Inner Mongolia:Constraints by Fossil Assemblage and Zircon Geochronology显示文摘The Baoligaomiao Formation is widely distributed fromthe East Wuqi to Zhanlantun area in the Xing'anMongolian orogenic belt (Tian Shugang et al., 2016; Weiet al., 2017). This formation contains abundant Angarabiological fossils which exhibit diachronismcharacteristics and are mostly incomplete. Therefore, thoseAngara fossils reported are unable to limit the exactsedimentary age of the Baoligaomiao Formation. | QIN Tao QIAN Cheng LI Linchuan JIANG Bin SUN Wei NA Fuchao SI Qiuliang MA Yongfei ZANG Yanqing | 2018 | Acta Geologica Sinica(English Edition)2018，92，3： | 1 |
| 14 | Investigation on process mechanism of a novel energy-saving synthesis for high performance Li_(4)Ti_(5)O_(12) anode material显示文摘Li_(4)Ti_(5)O_(12)(LTO) anode material demonstrates superior cycling performance due to its stable spinel structure and high lithiation/de-lithiation potential.Herein,a novel energy-saving solid-phase synthesis route for LTO has been successfully designed,employing the cheap industrial intermediate product of metatitanic acid (HTO) as titanium source.Through the in-situ Fourier transform infrared spectroscopy (FTIR)and ex-situ X-ray diffraction (XRD),it is revealed for the first time that the amorphous crystal structure of HTO is more conducive for the Li+insertion,making it possible to prepare LTO at a relatively lower sintering temperature.Utilizing the dehydration carbonization reaction between glucose and sulfuric acid,an ingenious strategy of glucose pre-coating is adopted to avoid the generation of Li_(2)SO_(4) impurity caused by the residual sulfuric acid on the surface of HTO,which meanwhile enhances the conductivity and inhibits the particle growth of LTO.The obtained ALTO@C anode material consequently exhibits excellent electrochemical performance that 132.0 m Ah g^(-1)is remained even at 20 C,and ultra low decay rate of 0.015% per cycle is achieved during 1000 cycles at 2 C.Remarkably,LiCoO_(2)//ALTO@C full cell delivers conspicuous low-temperature property (130.7 m Ah g^(-1)at 0.5 C and almost no attenuation after 300 cycles under-20℃). | Guochuan Wang Hongmei Wang Guangqiang Ma Xinhe Du Liyu Du Peng Jing Yanqing Wang Kaipeng Wu Hao Wu Qian Wang Yun Zhang | 2022 | Journal of Energy Chemistry2022，31，7： | 1 |
| 15 | The effect of matrix creep property on the consolidation process of SiC/Ti–6Al–4V composite显示文摘 | Ma Zhijun Yang Yanqing Lü Xianghong Luo Xian Chen Yan | 2006 | Materials Science & Engineering A2006，，： | 1 |
| 16 | Microstructures and mechanical properties of hot-pressed MoSi2-matrix composites reinforced with SiC and ZrO2 particles显示文摘 | Qin Ma Yanqing yang Mokuang kang | 2001 | Composites Science and Technology2001，，61： | 1 |
| 17 | The Dynamic Adjustments of Factor Inputs in China~ Major Wheat Producing Areas显示文摘 | CHEN SHUZHANG OXLEY L XU ZHENG WANG YANQING MA HENGYUN | 2013 | Economic Modeling2013，33，1： | 1 |
| 18 | The Preparation of Malefic Anhydride Modified Polyethylene via in-situ Chlorinating Graft Copolymerization显示文摘 | Yanqing Ma Li Zhang Zhuang Du Jiruo Zhao Ying Feng Jinghua Yin | 2009 | Polymer-Plastics Technology and Engineering2009，，1： | 1 |
| 19 | The effect of magnetron sputter parameter on fiber coating character 显示文摘 | Ma Zhijun Yang Yanqing Du Jiang | 2004 | Materials Letters2004，58，： | 1 |
| 20 | Non degenerating Dehn fillings on genus two Heegaard splittings of knots' complements显示文摘It is Thurston's result that for a hyperbolic knot K in S^3, almost all Dehn fillings on its complement result in hyperbolic 3-manifolds except some exceptional cases. So almost all produced 3-manifolds have the same geometry. It is known that its complement in S^3, denoted by E(K), admits a Heegaard splitting. Then it is expected that there is a similar result on Heegaard distance for Dehn fillings. In this paper, Dehn fillings on genus two Heegaard splittings are studied. More precisely, we prove that if the distance of a given genus two Heegaard splitting of E(K) is at least 3, then for any two degenerating slopes on ?E(K), there is a universal bound of their distance in the curve complex of ?E(K). | Jiming Ma Ruifeng Qiu Yanqing Zou | 2018 | Science China Mathematics2018，61，6： | 1 |
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