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| 1 | Can Cadmium Uptake by Chinese Cabbage be Reduced After Growing Cd-Accumulating Rapeseed?显示文摘Rapeseed (Brassica campestris L.), a Cd-accumulating crop, is effective in reducing plant-available Cd from soil. A pot experiment was conducted to test the hypothesis that the Cd uptake by Chinese cabbage (Brassica pekinensis Rupr.) grown in rotation with rapeseed would be reduced due to the efficient removal of bioavailable Cd from soil solution by the rapeseed crops. The Cd removal by shoot for the rapeseed cultivar Zhucang Huazi ranged from 0.24% to 0.99% in natural Cd-contaminated soil (soil A) and from 0.63% to 1.23% in artificial Cd-contaminated soil (soil B) during the growth period of 4–7 weeks; whereas that for the rapeseed cultivar Chuanyou II-93 ranged from 0.25% to 0.66% and from 0.38% to 1.02%, respectively. Chinese cabbage grown in the pots with soil A for five weeks after harvesting rapeseed exhibited a significantly lower Cd concentration compared to that grown in the control pots (uncropped with rapeseed). However, the rotation of rapeseed did not lower the Cd concentration of Chinese cabbage on soil B. Although an increase of Cd uptake was observed in the rapeseed cultivars with growth time, and the decrease of soil NH 4 OAc-extractable Cd was found only in the natural rather than artificial Cd-contaminated soil. | SU De-Chun , JIAO Wei-Ping, ZHOU Man and CHEN Xia College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193 (China) | 2010 | Pedosphere2010，20，1： | 9 |
| 2 | 多维对数正态作答时间模型:对潜在加工速度多维性的探究显示文摘在心理与教育测量中,潜在加工速度反映学生运用潜在能力解决问题的效率。为在多维测验中探究潜在加工速度的多维性并实现参数估计,本研究提出多维对数正态作答时间模型。实证数据分析及模拟研究结果表明:(1)潜在加工速度具有与潜在能力相匹配的多维结构;(2)新模型可精确估计个体水平的多维潜在加工速度及与作答时间有关的题目参数;(3)冗余指定潜在加工速度具有多维性带来的负面影响低于忽略其多维性所带来的。 | 詹沛达 Hong Jiao Kaiwen Man | 2020 | 心理学报2020，52，9： | 8 |
| 3 | NOD2 和 TLR2 ligands 由在遗传性过敏症的像皮炎的皮肤发炎与真皮的成纤维细胞交往触发 basophils 和嗜曙红血球的激活显示文摘有遗传性过敏症的皮炎(广告) 的病人的皮肤由葡萄球菌 aureus 为殖民有唯一的倾向(S。aureus ) ,它贡献发炎和广告的冷酷的预后。尽管位于 S 下面的机制。不清楚的、最近的研究在在 S 调整煽动性的回答为模式识别受体发现了一个枢轴的角色的广告遗体的导致 aureus 的恶化。aureus 感染。在现在的学习,我们使用了像广告的皮肤发炎的一个典型老鼠模型并且发现了那 S。联系 aureus 的核苷酸绑定 oligomerization 包含域的蛋白质 2 (NOD2 ) 并且像使用费的受体 2 (TLR2 ) ligands 加重了像广告的症状,它进一步被败坏由在里面 basophils 和嗜曙红血球的 vivo 扩大。随后的组织学的分析表明真皮的成纤维细胞在像广告的皮肤损害是弥漫的。有 basophils 和嗜曙红血球的人的真皮的成纤维细胞的合作文化在真皮的成纤维细胞上导致了对 NOD2/TLR2 ligands 和细胞间的粘附 molecule-1 的提高的表示的精力旺盛的 cytokine/chemokine 回答。Basophils 和嗜曙红血球为在合作文化的广告相关的 cytokine/chemokine 表示主要负责。直接细胞间的接触为在 basophils 和真皮的成纤维细胞之间的串音是必要的,当可溶的调停人是足够的调停时嗜曙红血球成纤维细胞相互作用。而且,细胞内部的 p38 激活 mitogen 的蛋白质 kinase,细胞外的调整信号的 kinase,和表明小径的原子 factor-kappa B 为在广告相关的发炎的 basophils,嗜曙红血球,和真皮的成纤维细胞的 NOD2/TLR2 调停 ligand 的激活是必要的。这研究通过天生的有免疫力的房间的激活提供广告的 NOD2/TLR2-mediated 恶化的证据因此使一条新奇机械学的小径由清楚些哪个 S。aureus 贡献广告的 pathophysiology。 | Delong Jiao Chun-Kwok Wong Huai-Na Qiu Jie Dong Zhe Cai Man Chu Kam-Lun Hon Miranda Sin-Man Tsang Christopher Wai-Kei Lam | 2016 | Cellular & Molecular Immunology2016，13，4： | 8 |
| 4 | 2,3,7,8-Tetrachlorodibenzo-p-dioxin Promotes Proliferation of Astrocyte Cells via the Akt/STAT3/Cyclin D1 Pathway显示文摘Objective The compound 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD), a persistent organic pollutant, is harmful to the nervous system, but its effects on the brain are still unclear. This study aimed to investigate the effects of TCDD on astrocytes proliferation and underlying molecular mechanism. Methods The cell proliferation was measured by EdU-based proliferation assay and PI staining by flow cytometry. Protein expression levels were detected by Western blotting. Immunofluorescence, cytoplasmic and nuclear fractions separation were used to assess the distribution of signal transducer and activator of transcription 3(STAT3). Results C6 cells treated with 10 and 50 nmol/L TCDD for 24 h showed significant promotion of the proliferation of. The exposure to TCDD resulted in the upregulation in the expression levels of phosphorylated protein kinase B(p-Akt), phosphorylated STAT3, and cyclin D1 in a dose-and time-dependent manner. The inhibition of Akt expression with LY294002 or STAT3 expression with AG490 abolished the TCDD-induced cyclin D1 upregulation and cell proliferation. Furthermore, LY294002 suppressed the activation of STAT3. Finally, TCDD promoted the translocation of STAT3 from the cytoplasm to the nucleus, and LY294002 treatment blocked this effect. Conclusion TCDD exposure promotes the proliferation of astrocyte cells via the Akt/STAT3/cyclin D1 pathway, leading to astrogliosis. | WU Chang Yue YIN Kai Zhi ZHANG Yan JIAO Man ZHAO Xin Yuan WU Qi Yun | 2019 | Biomedical and Environmental Sciences2019，32，4： | 5 |
| 5 | Magnetic resonance imaging of the extraocular muscles and corresponding cranial nerves in patients with special forms of strabismus显示文摘有技术进展的背景,磁性的回声成像(MRI ) 现在是足够敏感的检测从生活题目的 brainstem 和轨道产生的眼睛的马达神经的微妙的结构的畸形。这研究被设计描出在有有斜视的特殊形式的 29 个病人全部的 strabismus.Methods A 的特殊形式的病人的 MRI 特征经历了轨道并且 intracalvarium MRI。在 brainstem 的眼睛的马达神经的成像在用采用不变的获得(3D 节日) 的三维的快成像的飞机定序的 0.8 公里厚度图象被执行。到眼睛外面的肌肉( EOM )的神经, EOM 和他们的联系结缔组织被双阶段的卷在有眼睛外面的肌肉的先天的纤维变性的厚 planes.Results 病人展出了的 2.0 公里以内在tri平面的扫描与 T1 weighting 想象发育不全动眼( CN3 ),外展肌肉( CN6 ),软骨轮( CN4 )神经,和 EOM ;在 brainstem 和到侧面的权利的 CN3 的劣等的部门的一个额外的分支的 CN6 的发育不全是 Duane 的收回症候群的最普通然而并非唯一的演讲。CN6,美容(CN7 ) 和舌下神经(CN12 ) 神经的发育不全与 M (o) bius 症候群在病人被揭示。在双边的 synergistic 集中和分叉的稀罕诉讼中,到中间的权利的 CN3 的一个扩大分支和到劣等的权利的 CN3 的一个可疑分支双边地是 found.Conclusion MRI 能揭示眼睛的马达神经和他们的相应 EOM 的微妙的结构。这能在斜视的一些特殊形式关于致病提供珍贵信息。 | JIAO Yong-hong ZHAO Kan-xing WANG Zhen-chang QIAN Xue-han WU Xiao MAN Feng-yuan LU Wei SHE Hai-cheng | 2009 | Chinese Medical Journal2009，，24： | 4 |
| 6 | Could saline irrigation clear all residual common bile duct stones after lithotripsy?A self-controlled prospective cohort study显示文摘BACKGROUND A previous study showed that irrigation with 100 mL saline reduced residual common bile duct(CBD)stones,which potentially cause recurrent stones after endoscopic retrograde cholangiopancreatography.AIM To determine whether saline irrigation can improve CBD clearance after lithotripsy.METHODS This prospective self-controlled study enrolled patients receiving mechanical lithotripsy for large(>1.2 cm)CBD stones.After occlusion cholangiography confirmed CBD stone clearance,peroral cholangioscopy(POC)was performed to determine clearance scores based on the number of residual stones.The amounts of residual stones spotted via POC were graded on a 5-point scale(score 1,worst;score 5,best).Scores were documented after only stone removal(control)and after irrigation with 50 mL and 100 mL saline,respectively.The stone composition was analyzed using infrared spectroscopy.RESULTS Between October 2018 and January 2020,47 patients had CBD clearance scores of 2.4±1.1 without saline irrigation,3.5±0.7 with 50 mL irrigation,and 4.6±0.6 with 100 mL irrigation(P<0.001).Multivariate analysis showed that CBD diameter>15 mm[odds ratio(OR)=0.08,95%confidence interval(CI):0.01-0.49;P=0.007]and periampullary diverticula(PAD)(OR=6.51,95%CI:1.08-39.21;P=0.041)were independent risk factors for residual stones.Bilirubin pigment stones constituted the main residual stones found in patients with PAD(P=0.004).CONCLUSION Irrigation with 100 mL of saline may not clear all residual CBD stones after lithotripsy,especially in patients with PAD and/or a dilated(>15 mm)CBD.Pigment residual stones are soft and commonly found in patients with PAD.Additional saline irrigation may be required to remove retained stones. | Yan-Yan Lin Yu-Dong Wang Ping Yue Xian-Zhuo Zhang Joseph W Leung Pan-Pan Jiao Man Yang Hai-Ping Wang Bing Bai Ying Liu Jin-Duo Zhang Hong-Bo Chen Wen-Bo Meng Xun Li | 2021 | World Journal of Gastroenterology2021，27，4： | 4 |
| 7 | Differential Analysis of ARX Block Ciphers Based on an Improved Genetic Algorithm显示文摘Differential cryptanalysis is one of the most critical analysis methods to evaluate the security strength of cryptographic algorithms.This paper first applies the genetic algorithm to search for differential characteristics in differential cryptanalysis.A new algorithm is proposed as the fitness function to generate a high-probability differential characteristic from a given input difference.Based on the differential of the differential characteristic found by genetic algorithm,Boolean satisfiability(SAT)is used to search all its differential characteristics to calculate the exact differential probability.In addition,a penalty-like function is also proposed to guide the search direction for the application of the stochastic algorithm to differential cryptanalysis.Our new automated cryptanalysis method is applied to SPECK32 and SPECK48.As a result,the 10-round differential probability of SPECK32 is improved to 2^(−30.34),and a 12-round differential of SPECK48 with differential probability 2−46.78 is achieved.Furthermore,the corresponding differential attacks are also performed.The experimental results show our method’s validity and outstanding performance in differential cryptanalysis. | KANG Man LI Yongqiang JIAO Lin WANG Mingsheng | 2023 | Chinese Journal of Electronics2023，32，2： | 3 |
| 8 | Plant multiscale networks:charting plant connectivity by multi-level analysis and imaging techniques显示文摘In multicellular and even single-celled organisms,individual components are interconnected at multiscale levels to produce enormously complex biological networks that help these systems maintain homeostasis for development and environmental adaptation.Systems biology studies initially adopted network analysis to explore how relationships between individual components give rise to complex biological processes.Network analysis has been applied to dissect the complex connectivity of mammalian brains across different scales in time and space in The Human Brain Project.In plant science,network analysis has similarly been applied to study the connectivity of plant components at the molecular,subcellular,cellular,organic,and organism levels.Analysis of these multiscale networks contributes to our understanding of how genotype determines phenotype.In this review,we summarized the theoretical framework of plant multiscale networks and introduced studies investigating plant networks by various experimental and computational modalities.We next discussed the currently available analytic methodologies and multi-level imaging techniques used to map multiscale networks in plants.Finally,we highlighted some of the technical challenges and key questions remaining to be addressed in this emerging field. | Xi Zhang Yi Man Xiaohong Zhuang Jinbo Shen Yi Zhang Yaning Cui Meng Yu Jingjing Xing Guangchao Wang Na Lian Zijian Hu Lingyu Ma Weiwei Shen Shunyao Yang Huimin Xu Jiahui Bian Yanping Jing Xiaojuan Li Ruili Li Tonglin Mao Yuling Jiao Sodmergen Haiyun Ren Jinxing Lin | 2021 | Science China(Life Sciences)2021，64，9： | 3 |
| 9 | Either transepidermal water loss rates or stratum corneum hydration levels can predict quality of life in children with atopic dermatitis显示文摘Importance:Patients with atopic dermatitis(AD)display compromised epidermal barrier and suffer from poor quality of life.We hypothesized that quality of life could reflect in the changes in the epidermal barrier function.Objective:To determine whether the epidermal barrier function correlates with the severity of pruritus and/or life quality in children with AD.Methods:A total of 120 children,aged 0-12 years,with moderate AD were enrolled.Children were topically treated with topical corticosteroids(TCS)and an emollient for 2 weeks.The Eczema Area and Severity Index(EASI),visual analogue scale(VAS)for pruritus severity,the Infant’s Dermatitis Quality of Life Index(IDQOL)and the Children’s Dermatology Life Quality Index(CDLQI)were evaluated.Transepidermal water loss(TEWL)rates,stratum corneum(SC)hydration,and skin surface pH were measured.Correlations of epidermal barrier function with pruritus,life quality,and EASI were determined.Results:Following 2-week treatments,significant improvements were observed in EASI,TEWL,SC hydration,the VAS of pruritus,as well as DQOL(P<0.001 for all).TEWL positively,while SC hydration negatively correlated with VAS pruritus,DQOL,and EASI(P<0.001).Interpretation:Both TEWL and SC hydration levels can serve as indicators of the severity of pruritus and quality of life in children with AD. | Shan Wang Chunping Shen Mutong Zhao Lei Jiao Jing Tian Yang Wang Lin Ma Mao-Qiang Mao-Qiang Man | 2021 | Pediatric Investigation2021，5，4： | 1 |
| 10 | Hepatic fibrosis 显示文摘 | JIAO J FRIEI)MAN S L ALOMAN C | 2009 | Curt Opin Gastroenterol2009，25，3： | 1 |
| 11 | Nuclear Factor-κB Signaling Mediates Antimony-induced Astrocyte Activation显示文摘Objective Antimony(Sb)has recently been identified as a novel nerve poison,although the cellular and molecular mechanisms underlying its neurotoxicity remain unclear.This study aimed to assess the effects of the nuclear factor kappa B(NF-κB)signaling pathway on antimony-induced astrocyte activation.Methods Protein expression levels were detected by Western blotting.Immunofluorescence,cytoplasmic and nuclear fractions separation were used to assess the distribution of p65.The expression of protein in brain tissue sections was detected by immunohistochemistry.The levels of mRNAs were detected by Quantitative real-time polymerase chain reaction(qRT-PCR)and reverse transcriptionpolymerase chain reaction(RT-PCR).Results Antimony exposure triggered astrocyte proliferation and increased the expression of two critical protein markers of reactive astrogliosis,inducible nitric oxide synthase(iNOS)and glial fibrillary acidic protein(GFAP),indicating that antimony induced astrocyte activation in vivo and in vitro.Antimony exposure consistently upregulated the expression of inflammatory factors.Moreover,it induced the NF-κB signaling,indicated by increased p65 phosphorylation and translocation to the nucleus.NF-κB inhibition effectively attenuated antimony-induced astrocyte activation.Furthermore,antimony phosphorylated TGF-β-activated kinase 1(TAK1),while TAK1 inhibition alleviated antimonyinduced p65 phosphorylation and subsequent astrocyte activation.Conclusion Antimony activated astrocytes by activating the NF-κB signaling pathway. | ZHANG Tao ZHENG Yu Dan JIAO Man ZH Ye XU Shen Ya ZHU Piao Yu ZHAO Xin Yuan WU Qi Yun | 2021 | Biomedical and Environmental Sciences2021，34，1： | 1 |
| 12 | A 2.09 Mb fragment translocation on chromosome 6 causes abnormalities during meiosis and leads to less seed watermelon显示文摘Seedlessness is a valuable agronomic trait in watermelon(Citrullus lanatus)breeding.Conventional less seed watermelons are mainly triploid,which has many disadvantages due to unbalanced genome content.Less seed watermelon can be achieved at the diploid level when certain reproductive genes are mutated or by chromosome translocation,which leads to defects during meiosis.However,the formation mechanism of diploid less seed watermelons remains largely unknown.Here,we identified a spontaneous mutant line,watermelon line“148”,which can set seeds normally when self-pollinated.A total of 148×JM F_(1) hybrid plants exhibited seed number reductions to 50.3%and 47.3%of those of the two parental lines,respectively,which are considered to be less seed.Examination of pollen viability and hybridization experiments revealed that F 1 hybrids produce semisterile pollen and ovules.Further cytological observations indicated that semisterility was a result of a reciprocal translocation of chromosomes,which exhibited one quadrivalent ring of four chromosomes at prometaphase I during meiosis.RT-qPCR analysis indirectly confirmed that the semisterile phenotype is caused by chromosome translocation rather than disruption of specific meiotic gene expression.F 2 population genetic analysis indicated that the“148”watermelon line is a homozygous translocation and that the less seed phenotype of the F_(1) hybrid is prompted by one chromosome fragment translocation.The translocated fragment was further fine mapped to a 2.09 Mb region on chromosome 6 by whole-genome resequencing and genetic map cloning procedures.Our work revealed that a 2.09Mb chromosome fragment translocation on chromosome 6,causing meiotic defects at metaphase I during meiosis,leads to diploid less seed watermelon.Our findings provide a new promising method for less seed watermelon breeding at the diploid level,as well as a fragment size reference for breeding less seed watermelon through artificially induced chromosome translocation. | Shujuan Tian Jie Ge Gongli Ai Jiao Jiang Qiyan Liu Xiner Chen Man Liu Jianqiang Yang Xian Zhang Li Yuan | 2021 | Horticulture Research2021，8，1： | 1 |
| 13 | Biology of Ageing and Role of Dietary Antioxidants显示文摘 | Cheng Peng Xiaobo Wang Jingnan Chen Rui Jiao Lijun Wang Yuk Man Li Yuanyuan Zuo Yuwei Liu Lin Lei Ka Ying Ma Yu Huang Zhen-Yu Chen Dina Bellizzi | 2014 | BioMed Research International2014，，： | 1 |
| 14 | Protein surface recognition of the novel tetra-carboxylphenyl calix[4]arene to cytochrome c显示文摘新奇 tetra-carboxylphenyl 杯的相互作用[4 ] 有牛的心细胞色素 c (Cc ) 的 arene (TCPC ) 被荧光光谱学和分子的建模方法首先调查。稳定的 1:1 建筑群的形成被荧光滴定监视,并且它的有约束力的常数是 1.916 脳 107 L 摩尔 ? 1。分子的建模揭示 TCPC 的识别机制到 Cc 表面,也就是说,静电的相互作用驾驶 TCPC 到 Cc 表面,并且货车 der Waals 相互作用面向 TCPC 平行到 Cc 劈开。 | Wen Ting An Yong Jiao Xiao Hua Sun Chuan Dong Shao Min Shuang Ping Fang Xia Man Shing Wong | 2008 | Chinese Chemical Letters2008，19，11： | 0 |
| 15 | New constraints on exotic spin-dependent interactions with an ensemble-NV-diamond magnetometer显示文摘Laboratory search of exotic interactions is crucial for exploring physics beyond the standard model.We report new experimental constraints on two exotic spin-dependent interactions at the micrometer scale based on ensembles of nitrogen-vacancy(NV)centers in diamond.A thin layer of NV ele ctronic spin ensembles is synthesized as the solid-state spin quantum sensor,and a lead sphere is taken as the interacting nucleon source.Our result establishes new bounds for two types of exotic spin interactions at the micrometer scale.For an exotic parity-odd spin-and velocity-dependent interaction,improved bounds are set within the force range from 5 to 500μm.The upper limit of the corresponding coupling constant g_A~eg_V~N at 330μm is more than 1000-fold more stringent than the previous constraint.For the P,T-violating scalar-pseudoscalar nucleon-electron interaction,improved constraints are established within the force range from 6 to 45μm.The limit of the corresponding coupling constant g_S~Ng_P~e is improved by more than one order of magnitude at 30μm.This work demonstrates that a solid-state NV ensemble can be a powerful platform for probing exotic spin-dependent interactions. | Hang Liang Man Jiao Yue Huang Pei Yu Xiangyu Ye Ya Wang Yijin Xie Yi-Fu Cai Xing Rong Jiangfeng Du | 2023 | National Science Review2023，10，7： | 0 |
| 16 | Effect of cooling rate on the magnetic properties of Fe_(53)Nd_(37)Al_(10) alloy显示文摘The effect of cooling rate on the magnetic properties of the Fe53Nd37Al10 alloy prepared by different methods, i.e., suction casting and melt spinning at different rates, was investigated. The Fe53Nd37Al10 ribbon at the wheel speed of 5m·s-1 exhibits the highest coercivity in the samples. Two hard magnetic phases are detected from the hysteresis loops of the 5m·s-1 ribbon at all temperatures below room temperature. Their appearance is associated with different exchange coupling interactions, which are between the two kinds of hard magnetic phases or between the hard magnetic phase and the soft magnetic phase. | Qin Bai Yan-fei Hao Jiao Wang Hua Man Yong-jun Tang Hui Xu Shuang Xia | 2013 | International Journal of Minerals,Metallurgy and Materials2013，20，5： | 0 |
| 17 | Transportation of citrinin is regulated by the CtnC gene in the medicinal fungus Monascus purpureus显示文摘Monascus is one of the most essential microbial resources in China,with thousands of years of history.Modern science has proved that Monascus can produce pigment,ergosterol,monacolin K,-aminobutyric acid,and other functionally active substances.Currently,Monascus is used to produce a variety of foods,health products,and pharmaceuticals,and its pigments are widely used as food additives.However,Monascus also makes a harmful polyketide component called citrinin in the fermentation process;citrinin has toxic effects on the kidneys such as teratogenicity,carcinogenicity,and mutagenicity(Gong et al.,2019).The presence of citrinin renders Monascus and its products potentially hazardous,which has led many countries to set limits and standards on citrinin content. | Yanling GUI Guangfu TANG Haiqiao MAN Jiao WANG Jie HAN Jiehong ZHAO | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，6： | 0 |
| 18 | Magnetic resonance imaging of unilateral vertical retraction syndrome with atypical strabismus显示文摘我们与单方的垂直收回症候群报导二个病人。二个案例的轨道的磁性的回声成像(MRI ) 显示出轨道的结构的类似的尺寸和地点,但是与戏剧性地不同的斜视类型。轨道的 MRI sagittal 重建建议反常肌肉组织从劣等的权利产生了,它可能与收回被联系并且也眼睑的裂缝和不正常的斜视变窄。 | ZHANG Cheng-yue MAN Feng-yuan WANG Zhen-chang YU Gang WU Qian JIAO Yong-hongand ZHAO Kan-xing | 2011 | Chinese Medical Journal2011，，19： | 0 |
| 19 | RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis显示文摘Cellular senescence provides a protective barrier against tumorigenesis in precancerous or normal tissues upon distinct stressors.However,the detailed mechanisms by which tumor cells evade premature senescence to malignant progression remain largely elusive.Here we reported that RBM4 adversely impacted cellular senescence to favor glutamine-dependent survival of esophageal squamous cell carcinoma(ESCC)cells by dictating the activity of LKB1,a critical governor of cancer metabolism.The level of RBM4 was specifically elevated in ESCC compared to normal tissues,and RBM4 overexpression promoted the malignant phenotype.RBM4 contributed to overcome H-RAS-or doxorubicin-induced senescence,while its depletion caused P27-dependent senescence and proliferation arrest by activating LKB1-AMPK-mTOR cascade.Mechanistically,RBM4 competitively bound LKB1 to disrupt the LKB1/STRAD/MO25 heterotrimeric complex,subsequently recruiting the E3 ligase TRIM26 to LKB1,promoting LKB1 ubiquitination and degradation in nucleus.Therefore,such molecular process leads to bypassing senescence and sustaining cell proliferation through the activation of glutamine metabolism.Clinically,the ESCC patients with high RBM4 and low LKB1 have significantly worse overall survival than those with low RBM4 and high LKB1.The RBM4 high/LKB1 low expression confers increased sensitivity of ESCC cells to glutaminase inhibitor CB-839,providing a novel insight into mechanisms underlying the glutamine-dependency to improve the efficacy of glutamine inhibitors in ESCC therapeutics. | Lei Chen Wenjing Zhang Dan Chen Quan Yang Siwen Sun Zhenwei Dai Zhengzheng Li Xuemei Liang Chaoqun Chen Yuexia Jiao Lili Zhi Lianmei Zhao Jinrui Zhang Xuefeng Liu Jinyao Zhao Man Li Yang Wang Yangfan Qi | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 0 |
| 20 | Vertical deviation and A pattern of type Ⅲ Duane retraction syndrome显示文摘 | SHE Hai-cheng MAN Feng-yuan WANG Zhen-chang WANG Jing-hui JIAO Yong-hong ZHAO Kan-xing | 2012 | Chinese Medical Journal2012，，16： | 0 |
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