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| 1 | 国际糖尿病足工作组:糖尿病足感染诊断与治疗指南——《国际糖尿病足工作组:糖尿病足防治国际指南(2019)》的一部分显示文摘国际糖尿病足工作组(IWGDF)从1999年开始发布糖尿病足病防治指南。本指南是有关糖尿病足感染的诊断和治疗的指南,是在2015年糖尿病足感染指南基础上更新的。糖尿病足感染指南编辑委员会基于患者-干预-比较-结局(PICO)原则,整合内部与外部专家顾问的建议,并对2016年以后有关糖尿病足感染和处治的文献进行系统评价后,提出了27条推荐要点。这些推荐要点涵盖了软组织与骨组织感染的诊断,包括感染的严重性分级。这是IWGDF15年以来第一次对这个分级表进行更新。此外,指南还评估了糖尿病足感染的微生物学,包括如何收集标本及如何识别致病菌。最后,指南讨论了治疗糖尿病足感染的方法,包括经验性抗生素的选择、软组织和骨组织感染的抗微生物治疗、何时和如何进行外科处理以及各种辅助治疗对糖尿病足感染的有效性。本版指南在原指南的基础上更新了4个表格和1个图。我们认为该指南可以为糖尿病足感染的临床诊断和治疗提供更好的帮助。 | Benjamin A.Lipsky Eric Senneville Zulfqarali G.Abbas Javier Aragón-Sánchez Mathew Diggle John M.Embil Shigeo Kono Lawrence A.Lavery Matthew Malone Suzanne A.van Asten Vilma Urbancic-Rovan Edgar J.G.Peters 无 徐俊(译) 许樟荣(审校) | 2019 | 感染.炎症.修复2019，20，4： | 18 |
| 2 | 胆固醇结石病人肝脏脂质代谢异常的分子生物学研究显示文摘目的:研究导致胆石病人胆汁胆固醇过饱和的肝脏胆固醇和胆汁酸代谢途径中的分子生物学改变。方法:收集22例胆石病人和13例无胆石病的对照病人肝脏活检组织、胆囊胆汁和血浆。采用实时定量PCR检测肝脏基因表达,采用Western印迹法测定蛋白含量。结果:胆石病人较对照组ABCG5/ABCG8和LXRα基因的mRNA表达水平分别增加51%、59%和102%。肝脏SRBI的mRNA和蛋白含量均增加。结论:胆石病人ABCG5/ABCG8基因表达上调,可能与LXRα表达增加促进相关,这些异常是导致胆汁胆固醇过饱和的原因。此外,胆汁中过多的胆固醇可能来源于经肝脏高密度脂蛋白受体SRBI的摄取,而不是由于肝脏合成和酯化的异常。 | 蒋兆彦 姜翀弋 胡海 所广军 Paolo Parini Gsta Eggertsen Matthew A Davis Lawrence L Rudel Curt Einarsson 韩天权 张圣道 | 2007 | 外科理论与实践2007，12，5： | 4 |
| 3 | Early surgery in Crohn's disease a benefit in selected cases显示文摘AIM: To compare the outcomes of a cohort of Crohn's disease(CD) patients undergoing early surgery(ES) to those undergoing initial medical therapy(IMT).METHODS: We performed a review of a prospective database CD patients managed at a single tertiary institution. Inclusion criteria were all patients with ileal or ileocolonic CD between 1995-2014. Patients with incomplete data, isolated colonic or perianal CD were excluded. Primary endpoints included the need for, and time to subsequent surgery. Secondary endpoints included the number and duration of hospital admissions, and medical therapy. RESULTS: Forty-two patients underwent ES and 115 underwent IMT. The operative intervention rate at 5 years in the ES group was 14.2% vs IMT 31.3%(HR = 0.41, 95%CI: 0.23-0.72, P = 0.041). The ES group had fewer hospital admissions per patient [median 1 vs 3(P = 0.012)] and fewer patients required anti-TNF therapy than IMT(33.3% vs 57%, P = 0.003). A subgroup analysis of 62 IMT patients who had undergone surgery were compared to ES patients, and showed similar 5 year(from index surgery) re-operation rates 16.1% vs 14.3%. In this subset, a significant difference was still found in median number of hospital admissions favouring ES, 1 vs 2(P = 0.002).CONCLUSION: Our data supports other recent studies suggesting that patients with ileocolonic CD may have a more benign disease course if undergoing early surgical intervention, with fewer admissions to hospital and atrend to reduced overall operation rates. | Vinna An Lauren Cohen Matthew Lawrence Michelle Thomas Jane Andrews James Moore | 2016 | World Journal of Gastrointestinal Surgery2016，8，7： | 3 |
| 4 | Defining Surgical Quality in Gastric Cancer: A RAND/UCLA Appropriateness Study显示文摘 | Savtaj Brar Calvin Law Robin McLeod Lucy Helyer Carol Swallow Lawrence Paszat Rajini Seevaratnam Roberta Cardoso Matthew Dixon Alyson Mahar Laercio G. Lourenco Lavanya Yohanathan Alina Bocicariu Tanios Bekaii-Saab Ian Chau Neal Church Daniel Coit Christop | 2013 | Journal of the American College of Surgeons2013，，2： | 3 |
| 5 | Phase-II Study of Gemcitabine and Cisplatin in Patients with Metastatic Biliary and Gallbladder Cancer显示文摘 | Jeffrey A. Meyerhardt Andrew X. Zhu Keith Stuart David P. Ryan Lawrence Blaszkowsky Nicole Lehman Craig C. Earle Matthew H. Kulke Pankaj Bhargava Charles S. Fuchs | 2008 | Digestive Diseases and Sciences2008，，2： | 2 |
| 6 | Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA , IDH1 , EGFR , and NF1显示文摘 | Roel G.W. Verhaak Katherine A. Hoadley Elizabeth Purdom Victoria Wang Yuan Qi Matthew D. Wilkerson C. Ryan Miller Li Ding Todd Golub Jill P. Mesirov Gabriele Alexe Michael Lawrence Michael O'Kelly Pablo Tamayo Barbara A. Weir Stacey Gabriel Wendy Winckler | 2010 | Cancer Cell2010，，1： | 2 |
| 7 | SCCT guidelines for the interpretation and reporting of coronary computed tomographic angiography显示文摘 | Gilbert L. Raff Chair Aiden Abidov Stephan Achenbach Daniel S. Berman Lawrence M. Boxt Matthew J. Budoff Victor Cheng Tony DeFrance Jeffrey C. Hellinger Ronald P. Karlsberg | 2009 | Journal of Cardiovascular Computed Tomography2009，，： | 1 |
| 8 | High-Quality Video View Interpolation Using a Layered Representation显示文摘 | Sing Bing Kang Matthew Uyttendaele Simon Winder Richard Szeliski | 2004 | ACM Transactions on Graphics (S0730-0301)2004，23，3： | 1 |
| 9 | Intensity-Modulated Radiotherapy in the Treatment of Oropharyngeal Cancer: An Update of the Memorial Sloan-Kettering Cancer Center Experience显示文摘 | Jeremy Setton Nicola Caria Jonathan Romanyshyn Lawrence Koutcher Suzanne L. Wolden Michael J. Zelefsky Nicholas Rowan Eric J. Sherman Matthew G. Fury David G. Pfister Richard J. Wong Jatin P. Shah Dennis H. Kraus Weiji Shi Zhigang Zhang Karen D. Schupak D | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，： | 1 |
| 10 | Evidence-Based Approach to Lingering Hydration Questions显示文摘 | Matthew S. Ganio Douglas J. Casa Lawrence E. Armstrong Carl M. Maresh | 2007 | Clinics in Sports Medicine2007，，1： | 1 |
| 11 | Prevention of Child Behavior Problems Through Universal Implementation of a Group Behavioral Family Intervention显示文摘 | Stephen R. Zubrick Kristine A. Ward Sven R. Silburn David Lawrence Anwen A. Williams Eve Blair Deborah Robertson Matthew R. Sanders | 2005 | Prevention Science2005，，4： | 1 |
| 12 | A multicenter, randomized, phase 2 clinical trial to evaluate the efficacy and safety of combination docetaxel and carboplatin and sequential therapy with docetaxel then carboplatin in patients with recurrent platinum‐sensitive ovarian cancer显示文摘 | Angeles Alvarez Secord Andrew Berchuck Robert V. Higgins Lawrence R. Nycum Matthew F. Kohler Larry E. Puls Robert W. Holloway George S. Lewandowski Fidel A. Valea Laura J. Havrilesky | 2011 | Cancer2011，，13： | 1 |
| 13 | Asso-ciations between HIV infection and subclinical coronary athero-sclerosis显示文摘 | WendyS Post Matthew Budoff Lawrence Kingsley | 2014 | Annals of internal medicine2014，160，7： | 1 |
| 14 | The Outcome of Laparoscopic Heller Myotomy for Achalasia is Not Influenced by the Degree of Esophageal Dilatation显示文摘 | Matthew P. Sweet Ian Nipomnick Warren J. Gasper Karen Bagatelos James W. Ostroff Piero M. Fisichella Lawrence W. Way Marco G. Patti | 2008 | Journal of Gastrointestinal Surgery2008，，1： | 1 |
| 15 | The expression of a naturally occurring, truncated allele of an α-SNAP gene suppresses plant parasitic nematode infection显示文摘 | Prachi Matsye Gary Lawrence Reham Youssef Kyung-Hwan Kim Katheryn Lawrence Benjamin Matthews Vincent Klink | 2012 | Plant Molecular Biology2012，，2： | 1 |
| 16 | MRI segmentation using fuzzy clustering techniques显示文摘 | Clark Matthew C Hall Lawrence O | 1994 | IEEE Engineering in Medicine and Biology1994，13，5： | 1 |
| 17 | Automatic Tumor Segmentation Using knowledge-Based Technique显示文摘 | Clark Matthew C Hall Lawrence O | 1998 | IEEE Transactions on Medical Imaging1998，17，2： | 1 |
| 18 | Use of peak troponin value differentiate myocardial infarction from reversible nerogenic left ventricular dysfunction associated with aneurysmal subarachnoid hemorrhage显示文摘 | Ketan R Matthew J Lawrence Liao | 2003 | J Neurosurg2003，98，： | 1 |
| 19 | Effects of dynamic exercise intensity on the activation of hormone-sensitive lipase in human skeletal muscle显示文摘 | MATTHEW J WATT GEORGE J F HEIGENHAUSER LAWRENCE L | 2003 | J Physiol2003，547，1： | 1 |
| 20 | Severe combined immunodeficiency (SCID) and attention deficit hyperactivity disorder (ADHD) associated with a coronin-1A mutation and a chromosome 16p11.2 deletion显示文摘 | Lawrence R. Shiow Kenneth Paris Matthew C. Akana Jason G. Cyster Ricardo U. Sorensen Jennifer M. Puck | 2008 | Clinical Immunology2008，，1： | 1 |
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