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| 1 | Increased hepcidin expression in colorectal carcinogenesis显示文摘AIM:To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anae- mia and whether it might have a role in colorectal car- cinogenesis. METHODS: Mass spectrometry (MALDI-TOF MS and SELDI-TOF MS) was employed to measure hepcidin in urine collected from 56 patients with colorectal cancer. Quantitative Real Time RT-PCR was utilised to determine hepcidin mRNA expression in colorectal cancer tissue. Hepcidin cellular localisation was determined using im- munohistochemistry. RESULTS: We demonstrate that whilst urinary hepcidin expression was not correlated with anaemia it was posi- tively associated with increasing T-stage of colorectal cancer (P < 0.05). Furthermore, we report that hepcidin mRNA is expressed in 34% of colorectal cancer tissue specimens and was correlated with ferroportin repres- sion. This was supported by hepcidin immunoreactivity in colorectal cancer tissue. CONCLUSION: We demonstrate that systemic hepcidin expression is unlikely to be the cause of the systemic anaemia associated with colorectal cancer. However, we demonstrate for the first time that hepcidin is expressed by colorectal cancer tissue and that this may represent a novel oncogenic signalling mechanism. | Douglas G Ward Keith Roberts Matthew J Brookes Howard Joy Ashley Martin Tariq Ismail Robert Spychal Tariq Iqbal Chris Tselepis | 2008 | World Journal of Gastroenterology2008，14，9： | 12 |
| 2 | Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice显示文摘BACKGROUND Type 1 diabetes(T1D) is associated with major chronic microvascular complications which contribute significantly to diabetes associated morbidity.The protein primarily responsible for glucose reabsorption in the kidney is sodium glucose co-transporter 2(SGLT2). Presently, SGLT2 inhibitors are widely used in diabetic patients to improve blood glucose levels and prevent cardiovascular and renal complications. Given the broad therapeutic application of SGLT2 inhibitors, we hypothesised that SGLT2 inhibition may exert its protective effects via alterations of the gut microbiome and tested this in a type 1 diabetic mouse model of diabetic retinopathy.AIM To determine whether the treatment with two independent SGLT2 inhibitors affects gut health in a type 1 diabetic mouse model.METHODS The SGLT2 inhibitors empagliflozin or dapagliflozin(25 mg/kg/d) or vehicle dimethylsulfoxide(DMSO) were administered to C57 BL/6 J, Akita, Kimba and Akimba mice at 10 wk of age for 8 wk via their drinking water. Serum samples were collected and the concentration of succinate and the short chain fatty acid(SCFA) butyric acid was measured using gas chromatography-mass spectrometry. Enzyme-linked immunosorbent assay(ELISA) was performed to determine the concentration of insulin and leptin. Furthermore, the norepinephrine content in kidney tissue was determined using ELISA. Pancreatic tissue was collected and stained with haematoxylin and eosin and analysed using brightfield microscopy.RESULTS Due to the presence of the Akita allele, both Akita and Akimba mice showed a reduction in insulin production compared to C57 BL/6 J and Kimba mice.Furthermore, Akita mice also showed the presence of apoptotic bodies within the pancreatic islets. The acinar cells of Akita and Akimba mice showed swelling which is indicative of acute injury or pancreatitis. After 8 wk of SGLT2 inhibition with dapagliflozin, the intermediate metabolite of gut metabolism known as succinate was significantly reduced in Akimba mice when compared to DMSO treated mice. In addition, empagliflozin resulted in suppression of succinate levels in Akimba mice. The beneficial SCFA known as butyric acid was significantly increased in Akita mice after treatment with dapagliflozin when compared to vehicle treated mice. The norepinephrine content in the kidney was significantly reduced with both dapagliflozin and empagliflozin therapy in Akita mice and was significantly reduced in Akimba mice treated with empagliflozin.In non-diabetic C57 BL/6 J and Kimba mice, serum leptin levels were significantly reduced after dapagliflozin therapy.CONCLUSION The inhibition of SGLT2 reduces the intermediate metabolite succinate, increases SCFA butyric acid levels and reduces norepinephrine content in mouse models of T1 D. Collectively, these improvements may represent an important mechanism underlying the potential benefits of SGLT2 inhibition in T1 D and its complications. | Lakshini Y Herat Natalie C Ward Aaron L Magno Elizabeth P Rakoczy Marcio G Kiuchi Markus P Schlaich Vance B Matthews | 2020 | World Journal of Gastroenterology2020，26，23： | 3 |
| 3 | Is iron overload in alcohol-related cirrhosis mediated by hepcidin?显示文摘In this case report we describe the relationship between ferritin levels and hepcidin in a patient with alcohol-related spur cell anemia who underwent liver transplantation.We demonstrate a reciprocal relation-ship between serum or urinary hepcidin and serum ferritin,which indicates that inadequate hepcidin production by the diseased liver is associated with elevated serum ferritin.The ferritin level falls with increasing hepcidin production after transplantation.Neither inflammatory indices(IL6)nor erythropoietin appear to be related to hepcidin expression in this case.We suggest that inappropriately low hepcidin production by the cirrhotic liver may contribute substantially to elevated tissue iron stores in cirrhosis and speculate that hepcidin replacement in these patients may be of therapeutic benefi t in the future. | Tariq Iqbal Azzam Diab Douglas G Ward Matthew J Brookes Chris Tselepis Jim Murray Elwyn Elias | 2009 | World Journal of Gastroenterology2009，15，46： | 2 |
| 4 | Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp.显示文摘 | Neil Woodford Matthew J. Ellington Juliana M. Coelho Jane F. Turton M. Elaina Ward Susan Brown Sebastian G.B. Amyes David M. Livermore | 2006 | International Journal of Antimicrobial Agents2006，，4： | 2 |
| 5 | Cytotoxic,nuclear and growth inhibitory effects of photodynamic drugs on pancreatic carcinoma cells显示文摘 | Ward AJ Matthews EK | 1990 | Cancer Lett1990，102，： | 1 |
| 6 | Prevention of Child Behavior Problems Through Universal Implementation of a Group Behavioral Family Intervention显示文摘 | Stephen R. Zubrick Kristine A. Ward Sven R. Silburn David Lawrence Anwen A. Williams Eve Blair Deborah Robertson Matthew R. Sanders | 2005 | Prevention Science2005，，4： | 1 |
| 7 | Blood Pressure Measurement:Conditions,Invasive Blood Pressure Monitoring显示文摘 | Matthew Ward Jeremy A Langton | 2007 | Cont Edu Anaesth Crit Care& Pain2007，7，4： | 1 |
| 8 | Hemodynamics for brain--computer interfaces 显示文摘 | Matthews F Pearlmutter B A Ward T E | 2008 | Signal Processing Magazine IEEE2008，25，1： | 1 |
| 9 | Cytotoxic nuclear and growth inhibitory effects of photodynamic drugs on pancreatic carcinoma cells显示文摘 | WARD A J MATTHEWS E K | 1990 | Cancer Letters1990，102，： | 1 |
| 10 | LIN28 Expression in Malignant Germ Cell Tumors Downregulates let-7 and Increases Oncogene Levels显示文摘 | Matthew J. Murray Harpreet K. Saini Charlotte A. Siegler Jennifer E. Hanning Emily M. Barker Stijn van Dongen Dawn M. Ward Katie L. Raby Ian J. Groves Cinzia G. Scarpini Mark R. Pett Claire M. Thornton Anton J. Enright James C. Nicholson Nicholas Coleman | 2013 | Cancer Research2013，，15： | 1 |
| 11 | Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription显示文摘 | Matthew P Coghlan Ainsley A Culbert Darren AE Cross Stacey L Corcoran John W Yates Nigel J Pearce Oliver L Rausch Gregory J Murphy Paul S Carter Lynne Roxbee Cox David Mills Murray J Brown David Haigh Robert W Ward David G Smith Kenneth J Murray Alastair | 2000 | Chemistry & Biology2000，，10： | 1 |
| 12 | Crystal structure analysis of recombinant human uteroglobin and molecular modeling of ligand binding显示文摘 | Pattabiraman N Matthews JH Ward KB | 2000 | Ann NY Acad Sci2000，923，： | 1 |
| 13 | Sperling, et ak Biomarker Changes During Acute Heart Failure Treatment 显示文摘 | Brent Boyer MS Kimberly Ward Hart MA Matthew I | 2012 | Congest Heart Fail2012，18，2： | 1 |
| 14 | Circulating Tumor Cells as a Window on Metastasis Biology in Lung Cancer显示文摘 | Jian-Mei Hou Matthew Krebs Tim Ward Robert Sloane Lynsey Priest Andrew Hughes Glen Clack Malcolm Ranson Fiona Blackhall Caroline Dive | 2011 | The American Journal of Pathology2011，，3： | 1 |
| 15 | A Concept for Extending the Applicability of Constraint-Induced Movement Therapy through Motor Cortex Activity Feedback Using a Neural Prosthesis显示文摘 | Ward TE Soraghan C J Matthews F | 2007 | Comput Intell Neurosci2007，，： | 1 |
| 16 | The Biaxial Drawing Behaviour of Poly(Ethylene Terephthalate)显示文摘 | Duckett R A Ward I M | 1997 | Polymer1997，38，19： | 1 |
| 17 | Long-Term Results of a Phase II Trial of Neoadjuvant Chemotherapy Followed by Esophagectomy for Locally Advanced Esophageal Neoplasm显示文摘 | Arjun Pennathur James D. Luketich Rodney J. Landreneau Julie Ward Neil A. Christie Michael K. Gibson Matthew Schuchert Kristi Cooper Stephanie R. Land Chandra P. Belani | 2008 | The Annals of Thoracic Surgery2008，，： | 1 |
| 18 | MAP2 and synaptophysin protein expression following motor learning suggests dynamic regulation and distinct alterations coinciding with synaptogenesis显示文摘 | Matthew J. Derksen Nicole L. Ward Kelly D. Hartle Tammy L. Ivanco | 2006 | Neurobiology of Learning and Memory2006，，3： | 1 |
| 19 | Systematic meta-analysis of individual selective serotonin reuptake inhibitor medications and congenital malformations显示文摘 | Nicholas Myles Hannah Newall Harvey Ward Matthew Large | 2013 | Australian & New Zealand Journal of Psychiatry2013，，11： | 1 |
| 20 | Disruption of the disulfide bonds of recombinant murine interleukin-6 induces formation of a partially unfolded state显示文摘 | Zhang J G Matthews J M Ward L D et a1 | 1997 | Biochemistry1997，36，9： | 1 |
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