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| 1 | Correlation of burial organic carbon and paleoproductivity in the Mesoproterozoic Hongshuizhuang Formation, northern North China显示文摘In general, total organic carbon (TOC) is directly used as a proxy for paleoproductivity, however, it is not only affected by paleoproductivity, but also controlled by redox conditions and terrigenous detrital matter influx. Major and trace elements were analysed with the purpose of investigating the redox potential and paleoproductivity during deposition of the Hongshuizhuang Formation. In the present study, C-S relationship, V/Cr ratio and Mo concentration indicate that the dolomites were deposited in oxic environments, however, most of the black shales were accumulated in euxinic environments. P/Ti values in the Hongshuizhuang samples can be compared with those in the Japanese Ubara Permian-Triassic section which were regarded to be deposited under a moderate to high paleoproductivity. Ba/Al values are slightly lower than that of the laminated sediments from the continental margins of Central California (CCAL) which were thought to be accumulated under a high paleoproductivity. These results indicate that the paleoproductivity was moderate to high during deposition of the Hongshuizhuang Formation. Burial organic carbon shows positive correlations with V/Cr and Mo, but shows only weakly or no correlation with P/Ti and Ba/Al, respectively, suggesting that although the paleoproductivity was moderate to high during deposition of the Hongshuizhuang Formation, its organic-rich sediments were predominantly controlled by redox conditions and had no direct relationship with paleoproductivity. | LUO QingYong ZHONG NingNing ZHU Lei WANG YanNian QIN Jing QI Lin ZHANG Yi MA Yong | 2013 | Chinese Science Bulletin2013，58，11： | 17 |
| 2 | New progress and future prospects of CBM exploration and development in China显示文摘Efforts to speed up China's coal bed methane (CBM) exploration developments related to production safety, optimization of energy structures, prevention of energy waste and reduction of greenhouse gas emissions are all of great significance. In order to strengthen CBM exploration and development in China and to encourage increased growth in the CBM industry, we firstly give a general overview of the recent technological innovations and other developments in CBM exploration in the U.S., Canada and other countries. Using this background information as the starting point, we further present observations and analyses of CBM exploration and development, preferential policies, technical support and implications of R&D for CBM development in China. The results show that the problems related to CBM exploration technology development and lack of a complete set of management policies are still the major issues slowing down the growth of domestic CBM industry. Development of resource exploration and technology, R&D and establishment of favorable government policy to support the industry and the creation of a relevant information platform, etc. are finally recommended. | Vun Jian Xu Fengyin Liu Lin Zhong Ningning Wu Xiaobin | 2012 | International Journal of Mining Science and Technology2012，22，3： | 11 |
| 3 | Large-area high quality PtSe2 thin film with versatile polarity显示文摘Two-dimensional(2D)materials have attracted increasing attention for their outstanding structural and electrical properties.However,for mass-production of field effect transistors(FETs)and potential applications in integrated circuits,large-area and uniform 2D thin films with high mobility,large on-off ratio,and desired polarity are needed to synthesize firstly.Here,a transfer-free growth method for platinum diselenide(PtSe2)films has been developed.The PtSe2 films have been synthesized with various thicknesses in centimeter-sized scale.Typical FET made from a few layer PtSe2 show p-type unipolar,with a high field-effect hole mobility of 6.2 cm^(2) V^(−1) s^(−1) and an on-off ratio of 5×10^(3).The versatile semimetal-unipolar-ambipolar transition in synthesized PtSe2 films is also firstly observed as the thickness thinning.This work realizes the large-scale preparation of PtSe2 with prominent electrical properties and provides a new strategy for polarity's modulation. | Wei Jiang Xudong Wang Yan Chen Guangjian Wu Kun Ba Ningning Xuan Yangye Sun Peng Gong Jingxian Bao Hong Shen Tie Lin Xiangjian Meng Jianlu Wang Zhengzong Sun | 2019 | InfoMat2019，1，2： | 5 |
| 4 | Integrated single-cell RNA sequencing analysis reveals distinct cellular and transcriptional modules associated with survival in lung cancer显示文摘Lung adenocarcinoma(LUAD)and squamous carcinoma(LUSC)are two major subtypes of non-small cell lung cancer with distinct pathologic features and treatment paradigms.The heterogeneity can be attributed to genetic,transcriptional,and epigenetic parameters.Here,we established a multi-omics atlas,integrating 52 single-cell RNA sequencing and 2342 public bulk RNA sequencing.We investigated their differences in genetic amplification,cellular compositions,and expression modules.We revealed that LUAD and LUSC contained amplifications occurring selectively in subclusters of AT2 and basal cells,and had distinct cellular composition modules associated with poor survival of lung cancer.Malignant and stage-specific gene analyses further uncovered critical transcription factors and genes in tumor progression.Moreover,we identified subclusters with proliferating and differentiating properties in AT2 and basal cells.Overexpression assays of ten genes,including sub-cluster markers AQP5 and KPNA2,further indicated their functional roles,providing potential targets for early diagnosis and treatment in lung cancer. | Li Zhang Yiming Zhang Chengdi Wang Ying Yang Yinyun Ni Zhoufeng Wang Tingting Song Menglin Yao Zhiqiang Liu Ningning Chao Yongfeng Yang Jun Shao Zhidan Li Ran Zhou Li Chen Dan Zhang Yuancun Zhao Wei Liu Yupeng Li Ping He Jing-wen Lin Yuan Wang Kang Zhang Lu Chen Weimin Li | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 2 |
| 5 | DEM simulation of particle flow and separation in a vibrating flip-flow screen显示文摘Vibrating flip-flow screens(VFFS)with stretchable polyurethane sieve mats have been widely used in screening fine-grained materials in recent years.In this work,the discrete element method(DEM)is used to study the screening process in VFFS to explain particle flow and separation behavior at the particle scale.Unlike traditional vibrating screens,for VFFS,the amplitude response of each point on the elastic sieve mat is different everywhere.This study measures the kinematics of the elastic sieve mat under different conditions such as different stretched lengths and material loads.To establish the elastic sieve mat model in a DEM simulation,the continuous elastic sieve mat is discretized into multiple units,and the displacement signal of each unit tested is analyzed by Fourier series.The Fourier series analysis results of each unit are used as the setting parameters for motion.In this way,the movement of the elastic sieve mat is approximately simulated,and a DEM model of VFFS is produced.Through the simulation,the flow and separation of different-sized particles in VFFS are studied,and the reasonability of the simulation is verified by a pilot-scale screening experiment.The present study demonstrates the potential of the DEM method for the analysis of screening processes in VFFS. | Chi Yu Dongdong Lin Ningning Xu Xinwen Wang Kunwei Pu Zhenghao Wang Guofeng Zhao Runhui Geng Sanpeng Gong | 2023 | Particuology2023，，2： | 2 |
| 6 | Experimental investigation on the distribution uniformity and pressure drop of perforated plate distributors for the innovative spray-type packed bed thermal storage显示文摘As an innovative thermal energy technology,the spray-type packed bed has advantages of high efficiency and low cost.A liquid distributor is the key component for the spray-type packed bed for scattering heat-transfer liquid drops evenly.In this study,the distribution performance and pressure drop of the perforated plate distributors of different orifice diameters were studied experimentally.The experimental results indicate that orifice diameter has a greater effect on the distribution performance compared to flow rate.With an increase in flow rate,the flow pattern through the distributor changes from the uncovered drop to the covered drop and then to the jet flow.The covered drop pattern shows the best performance with a good distribution and a small pressure drop simultaneously,which is the design and optimization principle of the distributor for a spray-type packed bed. | Lin Lin Liang Wang Xipeng Lin Ningning Xie Haisheng Chen | 2022 | Particuology2022，20，2： | 2 |
| 7 | Structural analysis of the promoter of tomato 1-aminocyclopropane-1-carboxylate synthase 6 gene(Le-ACS6)显示文摘Ethylene plays an important role in the regulation of many growth and developmental processes of higher plants. In tomato,Le-ACS6,a member of the ACC synthase multigene family involved in system 1 ethylene biosynthesis during fruit ripening,is subject to negative feedback regulation by ethylene. To identify the cis-elements that are responsible for the negative feedback control,we established an in vitro transient assay system employing particle bombardment on mature-green tomato fruit pericarp to examine the expression of a luciferase(LUC) reporter gene driven by a 5′-serially deleted Le-ACS6 promoter. The results localized putative cis-elements required for negative ethylene-response between -347 and -266 upstream from the translational start site ATG. Several lines of stable transformation of the Le-ACS6 promoter and GUS reporter fusion gene containing internal deletion from -347 to -266 were generated. The expression pattern of the GUS reporter showed that removal of the nucleotides from -347 to -266 completely eliminated the response of the Le-ACS6 promoter to exogenous ethylene. | LIN JingYu FAN Rong WAN XiaoRong CHARNG Yee-yung WANG NingNing | 2007 | Chinese Science Bulletin2007，52，9： | 1 |
| 8 | Label-free and sequence-specific DNA detection down to a picomolar level with carbon nanotubes as support for probe DNA显示文摘 | Ningning Zhu Yuqing Lin Ping Yu | 2009 | Analytica Chimica Acta2009，650，： | 1 |
| 9 | METHODS FOR IMPROVING APPROXIMATE ACCURACY FOR HYPERBOLIC INTEGRODIFFERENTIAL EQUATIONS显示文摘In this paper we study the higher accuracy methods-the extrapolation and defect correction for the semidiscrete Galerkin approximations to the solutions of hyperbolicintegrodifferential equations. The global extrapolation and the correction approximationsof third order, rather than the pointwise extrapolation results, are derived. | LIN Qun ZHANG Shuhua YAN Ningning(Institute of Systems Science, Academia Sinica, Beijing 100080, China) | 1997 | Systems Science and Mathematical Sciences1997，10，3： | 1 |
| 10 | Overexpression of UDP-glucose pyrophosphorylase from Larix gmelinii enhances vegetative growth in transgenic Arabidopsis thaliana显示文摘 | Ningning Li Li Wang Wenbo Zhang Katsuaki Takechi Hiroyishi Takano Xiaofei Lin | 2014 | Plant Cell Reports2014，，5： | 1 |
| 11 | Down-staging depth score could be a survival predictor for locally advanced gastric cancer patients after preoperative chemoradiotherapy显示文摘Objective:The predictive effect of preoperative chemoradiotherapy(CRT)is low and difficult in guiding individualized treatment.We examined a surrogate endpoint for long-term outcomes in locally advanced gastric cancer patients after preoperative CRT.Methods:From April 2012 to April 2019,95 patients with locally advanced gastric cancer who received preoperative concurrent CRT and who were enrolled in three prospective studies were included.All patients were stage T_(3/4) N_(+).Local control,distant metastasis-free survival(DMFS),disease-free survival(DFS)and overall survival(OS)were evaluated.Clinicopathological factors related to long-term prognosis were analyzed using univariate and multivariate analyses.The down-staging depth score(DDS),which is a novel method of evaluating CRT response,was used to predict long-term outcomes.Results:The median follow-up period for survivors was 30 months.The area under the curve(AUC)of the receiver operating characteristic(ROC)curve predicted by the DDS was 0.728,which was better than the pathological complete response(pCR),histological response and ypN0.Decision curve analysis further affirmed that DDS had the largest net benefit.The DDS cut-off value was 4.pCR and ypN0 were associated with OS(P=0.026 and 0.049).Surgery and DDS are correlated with DMFS,DFS and OS(surgery:P=0.001,<0.001 and<0.001,respectively;and DDS:P=0.009,0.013 and 0.032,respectively).Multivariate analysis showed that DDS was an independent prognostic factor of DFS(P=0.021).Conclusions:DDS is a simple,short-term indicator that was a better surrogate endpoint than pCR,histological response and ypN0 for DFS. | Ning Li Xin Wang Yuan Tang Dongbin Zhao Yihebali Chi Lin Yang Liming Jiang Jun Jiang Jinming Shi Wenyang Liu Hua Ren Hui Fang Yu Tang Bo Chen Ningning Lu Hao Jing Shunan Qi Shulian Wang Yueping Liu Yongwen Song Yexiong Li Jing Jin | 2021 | Chinese Journal of Cancer Research2021，33，4： | 1 |
| 12 | Geochemistry of source rocks in the Es_3 and Es_4 members in the Shahejie Formation of the Western Depression, Liaohe Oilfield, China显示文摘The Western Depression of the Liaohe Basin is the major exploration area of the Liaohe Oilfield, and its main source rocks consist of the third and fourth members of the Shahejie Formation (Es3 and Es4). These source rocks are widely distributed in the depression, with semi-deep lake and fan delta as the main sedimentary facies, brown oil shale and black gray-dark gray mudstone as the main rocks, and a total thickness of 270-1450 m. The kerogens are mainly of the types I and IIA, and partly of the type IIB and least of the type III. The Ro values range from 0.4%-0.8%, indicating an evolution stage from immature to mature. The maturity of Es4 source rocks is rela-tively high, reaching the early mature stage, but their distribution and thickness are lower than those of Es3. Besides, according to biomarker analysis, it is thought that the source rocks of Es3 and Es4 are characterized by mixed input, and most of the source rocks were formed in the brackish water-saline and strongly oxygen-free environment. Fur-thermore, the Qingshui, Niuxintuo and Chenjia sags are believed to possess greater potential for hydrocarbon gen-eration and expulsion, for they are source rocks with a larger thickness, have higher organic carbon contents, belong to better organic matter types and possess higher maturities. | WANG Weili LIU Luofu JIANG Zhenxue ZHONG Ningning WANG Ying WANG Ping WU Lin MENG Jianghui ZHOU Jieli GUO Yongqiang | 2011 | Chinese Journal Of Geochemistry2011，30，4： | 1 |
| 13 | DNMT3A inhibits E2F1-induced arterial marker expression and impairs angiogenesis in human umbilical artery endothelial cells显示文摘Arterial marker genes EphrinB2 and HEY2 are essential for cardiovascular development and post-natal neovascularization.Our previous study confirmed.that E2F1 could activate the transcription of EphrinB2 and HEY2 in human mesenchymal stem cells;however,the detailed mechanism has not been resolved yet.In this study,we focused on the interaction between E2F1 and DNMT3A,a de novo DNA methyltransferase,on regulating the expression of EphrinB2 and HEY2,and explored the potential mechanisms.Gain-and loss-of-function experiments implicated the positive effect of E2F1 on the expression of EphrinB2 and HEY2 and tube formation in human umbilical artery endothelial cells.Accumulation of DNMT3A decreased the levels of EphrinB2 and HEY2,and impaired tube formation induced by E2F1,while inhibiting DNMT3A by RNA interference aug-mented their expression and angiogenesis in E2F 1-trasfected cells.We then asked whether the low expressions of EphrinB2 and HEY2 induced by DNMT3A are related to the methylation status of their promoters.Surprisingly,the methylation status of the CpG islands in the promoter region was not significantly affected by overexpression of exogenous DNMT3A.Furthermore,the inter-action between E2F1 and DNMT3A was confirmed by co-immunoprecipitation.DNMT3A could inhibit the transcription of EphrinB2 and HEY2 promoters by affecting the binding of E2F1 to its recognition sequences as revealed by luciferase reporter assay and chromatin immunoprecipita-tion.These results identified a novel mechanism underlying the cooperation of DNMT3A with E2F1 on regulating target gene expression,and revealed their roles in the angiogenic process. | Kaiyue Su Ningning Lin Shouqiang Xie Yabo Han Zaiming Yang Hongmin Zhang Hongpeng He Sa Zhou Wenjian Ma Tongcun Zhang Nan Wang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，11： | 1 |
| 14 | A mechanistic study of selective propane dehydrogenations on MoS_(2) supported single Fe atoms显示文摘On-purpose propane dehydrogenation(PDH) has emerged as a profitable alternative to the traditional cracking of oil products for propylene production. By means of density functional theory(DFT) calculations, the present work demonstrates that Fe atoms may atomically disperse on MoS_(2)(Fe_(1)/MoS_(2)) and serve as a promising single-atom catalyst(SAC) for PDH. The catalytic activity of Fe_(1)/MoS_(2)is attributed to the highly exposed d orbitals of single Fe atoms, while the propylene selectivity is originated from the kinetic inhibition of propylene dehydrogenation resulting from fast propenyl hydrogenation. The unique catalytic selectivity of Fe_(1)/MoS_(2)may inspire further investigations of on-purpose dehydrogenations of propane on SACs. | Yingke Yang Ruru Song Xing Fan Yunxia Liu Ningning Kong Haiping Lin Youyong Li | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
| 15 | Study on the P2P Cloud Storage Architecture Based on Semantic Hypergraph显示文摘Cloud storage has the characteristics of distributed and virtual, and it makes the ownership rights and management rights of users data separated. The master-slave architecture of cloud storage has a problem of single point failure. In this paper, we provide a cloud storage architecture model based on Semantic equivalence. According to semantic matching degree, this architecture divides the nodes into node cluster by creating semantic tree and maintains system routing through semantic hypergraph. Through simulation experiments show that dividing network into semantic can enhance scalability and flexibility of the system, and it can improve the efficiency of network organization and the security of cloud storage system, at the same time, it can also reduce the cloud data storage and the delay of reading time. | SONG Ningning LIN Ruijie AN Xingshuo GONG Chao YAO Zhiyong | 2015 | China Communications2015，12，S2： | 0 |
| 16 | Construction of apricot variety search engine based on deep learning显示文摘Apricot has a long history of cultivation and has many varieties and types. The traditional variety identification methods are timeconsuming and labor-consuming, posing grand challenges to apricot resource management. Tool development in this regard will help researchers quickly identify variety information. This study photographed apricot fruits outdoors and indoors and constructed a dataset that can precisely classify the fruits using a U-net model (F-score:99%), which helps to obtain the fruit's size, shape, and color features. Meanwhile, a variety search engine was constructed, which can search and identify variety from the database according to the above features. Besides, a mobile and web application (ApricotView) was developed, and the construction mode can be also applied to other varieties of fruit trees.Additionally, we have collected four difficult-to-identify seed datasets and used the VGG16 model for training, with an accuracy of 97%, which provided an important basis for ApricotView. To address the difficulties in data collection bottlenecking apricot phenomics research, we developed the first apricot database platform of its kind (ApricotDIAP, http://gffzz2a5b87b2dfb54266hpxnk96onc65q6cck.ffgz.tsg.suse.edu.cn/) to accumulate, manage, and publicize scientific data of apricot. | Chen Chen Lin Wang Huimin Liu Jing Liu Wanyu Xu Mengzhen Huang Ningning Gou Chu Wang Haikun Bai Gengjie Jia Tana Wuyun | 2024 | Horticultural Plant Journal2024，10，2： | 0 |
| 17 | Hypoxia-inducible factor upregulation by roxadustat attenuates drug reward by altering brain iron homoeostasis显示文摘Substance use disorder remains a major challenge,with an enduring need to identify and evaluate new,translational targets for effective treatment.Here,we report the upregulation of Hypoxia-inducible factor-1α(HIF-1α)expression by roxadustat(Rox),a drug developed for renal anemia that inhibits HIF prolyl hydroxylase to prevent degradation of HIF-1α,administered either systemically or locally into selected brain regions,suppressed morphine(Mor)-induced conditioned place preference(CPP). | Pengju Yan Ningning Li Ming Ma Zhaoli Liu Huicui Yang Jinnan Li Chunlei Wan Shuliu Gao Shuai Li Longtai Zheng John LWaddington Lin Xu Xuechu Zhen | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 18 | Self-assembly of anisotropic tobacco mosaic virus nanoparticles on gold substrate显示文摘A facile approach to assembled virus film with tunable structure is presented.Rod-like tobacco mosaic virus (TMV) was selected as the prototype in this study for its anisotropic structural feature.TMV can either 'lie down' or 'stand up' on gold substrate by tuning the solution pH.A quartz crystal microbalance with dissipation monitoring was used to monitor the pH-dependent self-assembly behavior of TMV nanoparticles,and atomic force microscopy and single molecule force spectroscopy further confirmed the different assembly structures. | PENG Bo LIU NingNing LIN Yuan WANG LiMing ZHANG WenKe NIU ZhongWei WANG Qian SU ZhaoHui | 2011 | Science China Chemistry2011，54，1： | 0 |
| 19 | Impairment of rigidity sensing caused by mutant TP53 gain of function in osteosarcoma显示文摘Osteosarcoma(OS)is the most common primary malignant pediatric bone tumor and is characterized by high heterogeneity.Studies have revealed a wide range of phenotypic differences among OS cell lines in terms of their in vivo tumorigenicity and in vitro colony-forming abilities.However,the underlying molecular mechanism of these discrepancies remains unclear.The potential role of mechanotransduction in tumorigenicity is of particular interest.To this end,we tested the tumorigenicity and anoikis resistance of OS cell lines both in vitro and in vivo.We utilized a sphere culture model,a soft agar assay,and soft and rigid hydrogel surface culture models to investigate the function of rigidity sensing in the tumorigenicity of OS cells.Additionally,we quantified the expression of sensor proteins,including four kinases and seven cytoskeletal proteins,in OS cell lines.The upstream core transcription factors of rigidity-sensing proteins were further investigated.We detected anoikis resistance in transformed OS cells.The mechanosensing function of transformed OS cells was also impaired,with general downregulation of rigidity-sensing components.We identified toggling between normal and transformed growth based on the expression pattern of rigidity-sensing proteins in OS cells.We further uncovered a novel TP53 mutation(R156P)in transformed OS cells,which acquired gain of function to inhibit rigidity sensing,thus sustaining transformed growth.Our findings suggest a fundamental role of rigidity-sensing components in OS tumorigenicity as mechanotransduction elements through which cells can sense their physical microenvironment.In addition,the gain of function of mutant TP53 appears to serve as an executor for such malignant programs. | Ming Luo Mingyang Huang Ningning Yang Yufan Zhu Peng Huang Zhujun Xu Wengang Wang Lin Cai | 2023 | Bone Research2023，11，2： | 0 |
| 20 | PARALLEL COMPUTATION AND DOMAIN DECOMPOSITION FOR A CLASS OF HYPERBOLIC PROBLEMS显示文摘PARALLELCOMPUTATIONANDDOMAINDECOMPOSITIONFORACLASSOFHYPERBOLICPROBLEMSLINQun;YANNingning;ZHOUAihui(InstituteofSystemsScience,... | LIN Qun YAN Ningning ZHOU Aihui(Institute of Systems Science, Academia Sinica,Beijing 100080,China) | 1995 | Systems Science and Mathematical Sciences1995，8，2： | 0 |
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