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| 1 | RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings显示文摘在有前列腺癌症的不同赛跑的病人之中有显著不同;然而,位于这差别下面的机制仍然保持不清楚。这里,我们在场 transcriptome 的一处全面风景用 RNA-seq,越过关于基因熔化的前列腺癌症 transcriptomes 的揭示巨大的差异,长 noncoding RNA (长 ncRNA ) ,其他的拼接和体的变化从中国人口 14 主要前列腺癌症和他们的配对的正常对应物介绍。14 个肿瘤(21.4%) 中的三个在中国病人怀有 TMPRSS2 尔格熔化,和这熔化的低流行进一步在一个另外的肿瘤集合(10/54=18.5%) 被证实。尤其是,二新奇基因熔化, CTAGE5-KHDRBS3 (20/54=37%) 和 USP9Y-TTTY15 (19/54=35.2%) ,在我们的耐心的队经常发生了。介绍的进一步系统的 transcriptional 识别了是在肿瘤表示的差别的众多的长 ncRNAs。在长 ncRNA 和基因的表示之间的关联的分析建议长 ncRNAs 可以在 transcriptional 规定以外有功能。这研究在中国人口产出新卓见进前列腺癌症的致病。 | Shancheng Ren Zhiyu Peng Jian-Hua Mao Yongwei Yu Changjun Yin Xin Gao Zilian Cui Jibin Zhang Kang Yi Weidong Xu Chao Chen Fubo Wang Xinwu Guo Ji Lu Jun Yang Min Wei Zhijian Tian Yinghui Guan Liang Tang Chuanliang Xu Linhui Wang Xu Gao Wei Tian Jian Wang Huanming Yang Jun Wang Yinghao Sun | 2012 | Cell Research2012，22，5： | 66 |
| 2 | Two soybean bHLH factors regulate response to iron deficiency显示文摘Iron is an indispensable micronutrient for plant growth and development. Limited bioavailability of Fe in the soil leads to iron deficiency chlorosis in plants and yield loss. In this study, two soybean basic helix-loophelix transcription factors, Gmb HLH57 and Gmb HLH300,were identified in response to Fe-deficiency. Both transcription factors are expressed in roots and nodules,and are induced by Fe deficiency; these patterns were confirmed in transgenic hairy roots expressing constructs of the endogenous promoters fused to a GUS reporter gene. Bimolecular fluorescence complementation, yeast two-hybrid and coimmunoprecipitation(co-IP) assays indicated a physical interaction between Gmb HLH57 and Gmb HLH300. Studies on transgenic soybeans Reseoverexpressing Gmb HLH57 and Gmb HLH300 revealed that overexpression of each transcription factor, alone,results in no change of the responses to Fe deficiency,whereas overexpression of both transcription factors upregulated the downstream Fe uptake genes and increased the Fe content in these transgenic plants.Compared to wild type, these double overexpression transgenic plants were more tolerant to Fe deficiency.Taken together, our findings establish that Gmb HLH57 and Gmb HLH300 are important transcription factors involved in Fe homeostasis in soybean. | Lin Li Wenwen Gao Qi Peng Bin Zhou Qihui Kong Yinghui Ying Huixia Shou | 2018 | Journal of Integrative Plant Biology2018，60，7： | 10 |
| 3 | A refined coherent point drift(CPD)algorithm for point set registration显示文摘The coherent point drift (CPD) algorithm is a powerful approach for point set registration. However, it suffers from a serious problem-there is a weight parameter w that reflects the assumption about the amount of noise and number of outliers in the Gaussian mixture model, and its value has an influence on the point set registration performance In the original CPD algorithm, the value of w is set manually, and hence an improper value will lead to poor registration results. To solve this problem, a fully automatic algorithm for the selection of an optimal weight parameter is proposed using a hybrid optimization scheme that combines the genetic algorithm with the Nelder-Mead simplex method. The experiments show that the refined CPD algorithm is more effective and extends the original CPD algorithm in its methodology and applications. | WANG Peng WANG Ping QU ZhiGuo GAO YingHui SHEN ZhenKang | 2011 | Science China(Information Sciences)2011，54，12： | 9 |
| 4 | Physiological effects of weightlessness: countermeasure system development for a long-term Chinese manned spaceflight显示文摘The Chinese space station will be built around 2020. As a national space laboratory, it will offer unique opportunities for studying the physiological effects of weightlessness and the efficacy of the countermeasures against such effects. In this paper, we described the development of countermeasure systems in the Chinese space program. To emphasize the need of the Chinese space program to implement its own program for developing countermeasures, we reviewed the literature on the negative physiological effects of weightlessness, the challenges of completing missions, the development of countermeasure devices, the establishment of countermeasure programs, and the efficacy of the countermeasure techniques in American and Russian manned spaceflights. In addition, a brief overview was provided on the Chinese research and development on countermeasures to discuss the current status and goals of the development of countermeasures against physiological problems associated with weightlessness. | Linjie Wang Zhili Li Cheng Tan Shujuan Liu Jianfeng Zhang Siyang He Peng Zou Weibo Liu Yinghui Li | 2019 | Frontiers of Medicine2019，13，2： | 9 |
| 5 | Distributed regression estimation with incomplete data in multi-agent networks显示文摘In this paper, distributed regression estimation problem with incomplete data in a time-varying multi-agent network is investigated. Regression estimation is carried out based on local agent information with incomplete in the non-ignorable mechanism. By virtue of gradient-based design and adaptive filter, a distributed algorithm is proposed to deal with a regression estimation problem with incomplete data. With the help of convex analysis and stochastic approximation techniques, the exact convergence is obtained for the proposed algorithm with incomplete data and a jointly-connected multi-agent topology. Moreover, online regret analysis is also given for real-time learning. Then, simulations for the proposed algorithm are also given to demonstrate how it can solve the estimation problem in a distributed way, even when the network configuration is time-varying. | Yinghui WANG Peng LIN Yiguang HONG | 2018 | Science China(Information Sciences)2018，61，9： | 7 |
| 6 | Clinical phenotype network: the underlying mechanism for perso- nalized diagnosis and treatment of traditional Chinese medicine显示文摘繁体中文药(TCM ) 在个性化的药的一个典型纲要调查临床的诊断和治疗整齐,它意味着有一样的疾病的个性化的病人将从不同 TCM 医生获得不同诊断和最佳的治疗。这个原则被 TCM 临床的专业人员认出并且粘住几千年了。然而,个性化的药不是的 TCM 的内在的机制到目前为止充分调查了并且仍然保持未知。这份报纸讨论 TCM 的框架在经典文学并且在真实世界的临床的背景的个性化的药,并且调查 TCM 的内在的机制从网络药的观点的个性化的药。在失眠上基于 246 个设计得好的门诊病人记录,由评估表明观察的个人偏爱和植物药方的偏爱,我们注意了每张植物药方的重要类似和每相遇的症状类似。为了调查 TCM 的内在的机制,个性化药,我们构造了一个临床的显型网络(CPN ) ,在哪个临床的显型实体喜欢症状并且诊断作为连接表现为在这些实体之间的节点和关联。这 CPN 被用来调查症候群和症状的同现的混杂的边界。小世界的拓扑的特征与高聚类结构在 CPN 被注意,它在 TCM 的合理性上提供卓见个性化的诊断和处理。这个网络上的调查将帮助我们在 TCM 的内在的机制上获得理解个性化的药并且将为 TCM 的精炼建议一个新观点个性化的临床的技巧。 | Xuezhong Zhou Yubing Li Yonghong Peng Jingqing HU Runshun Zhang Liyun He Yinghui Wang Lijie Jiang Shiyan Yan Peng Li Qi Xie Baoyan Liu | 2014 | Frontiers of Medicine2014，8，3： | 7 |
| 7 | Modulation of expression of P16 and Her2 in rat breast tissues of mammary hyperplasia model by external use of Rupifang Extract显示文摘OBJECTIVE:To observe the effect of Rupifang Extract in external use on expression of proto-oncogenes her2 and tumor suppression genes p16 in rat breast tissues of mammary hyperplasia model.To explore the mechanisms of Rupifang Extract in external use for preventing and treating mammary hyperplasia.METHODS:Thirty virginal female Wistar rats were randomized into 5 groups,6 in each,A:blank control group;B:model group;C:the low dose group of Rupifang;D:the middle dose group of Rupifang;and E:The high dose group of Rupifang.The mammary hyperplasia rat models were produced by injecting estradiol benzoate and progesterone and irritating by tail nipping.Drug intervention was also launched during the model formation.After 30 days,the expression of her2 and p16 in breast tissues of rats in each group were detected by the SP immunohistochemical method.RESULTS:Compared with Blank control group,the expression of her2 in breast tissues in Model group was higher,and the expression of p16 was lower(P<0.05 or P<0.01).After intervention with Rupifang Extract,compared with Model group,the expression of her2 in breast tissues in Rupifang groups was lower,and the expression of p16 higher(P<0.05 or P<0.01).CONCLUSION:The mechanisms of Rupifang Extract in external application for preventing and treating mammary hyperplasia may be reducing the expression of proto-oncogenes her2 and increasing the expression of tumor suppression genes p16. | Guijuan Zhang Dehui Li Hui Guo Rui Liao Bizhu Tan Suyi Zhang Yubin Liu Min Ma Xiaoting Zeng Zhuolong Peng Si Huang Yinghui Zheng Yi Ma | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 6 |
| 8 | A study on dynamic shear strength on frozen soil-concrete interface显示文摘Using newly developed dynamic shearing devices, the dynamic shearing strength of frozen soil-concrete interface was studied experimentally. By placing concrete blocks in the lower half of the shear box and frozen soil sample in the upper part, a series of dynamic shear tests on their interfaces were carried out. The obtained results are summarized and the main influencing factors are revealed. | Peng Lv JianKun Liu YingHui Cui | 2013 | Research in Cold and Arid Regions2013，5，4： | 5 |
| 9 | Biological applications of copper-containing materials显示文摘Copper is an indispensable trace metal element in the human body,which is mainly absorbed in the stomach and small intestine and excreted into the bile.Copper is an important component and catalytic agent of many enzymes and proteins in the body,so it can influence human health through multiple mechanisms.Based on the biological functions and benefits of copper,an increasing number of researchers in the field of biomaterials have focused on developing novel copper-containing biomaterials,which exhibit unique properties in protecting the cardiovascular system,promoting bone fracture healing,and exerting antibacterial effects.Copper can also be used in promoting incisional wounds healing,killing cancer cells,Positron Emission Tomography(PET)imaging,radioimmunological tracing and radiotherapy of cancer.In the present review,the biological functions of copper in the human body are presented,along with an overview of recent progress in our understanding of the biological applications and development of copper-containing materials.Furthermore,this review also provides the prospective on the challenges of those novel biomaterials for future clinical applications. | Peng Wang Yonghui Yuan Ke Xu Hongshan Zhong Yinghui Yang Shiyu Jin Ke Yang Xun Qi | 2021 | Bioactive Materials2021，6，4： | 5 |
| 10 | Distributed Consensus-Based K-Means Algorithm in Switching Multi-Agent Networks显示文摘 | LIN Peng WANG Yinghui QI Hongsheng HONG Yiguang | 2018 | Journal of Systems Science & Complexity2018，31，5： | 3 |
| 11 | Integrating global socio-economic influences into a regional land use change model for China显示文摘与快速的经济开发和都市化,在中国的陆地使用在最近的年里经历了巨大的变化;并且这以后将可能继续。在中国的陆地使用问题是迫切的并且需要推进学习。快速的陆地使用变化和经济开发为综合陆地使用变化研究使中国成为一个理想的区域,特别地多重因素的考试和在全球经济集成的上下文的全球地区性的相互作用。这份报纸论述一条综合建模途径在使用在地区性的规模改变的土地上检验全球社会经济的过程的影响。我们由联合一个简单全球社会经济的模型(GLOBFOOD ) 和地区性的空间分配模型(线索) 开发一个综合模型系统。模型系统用一个应用程序被说明在中国打使用。为一个给定的气候变化,人口生长,和各种各样的社会经济的状况,一个全球社会经济的模型在陆地使用上模仿全球市场和经济的影响,并且确定不同土地的变化使用类型。空间分发模型决定的陆地使用在由采用一个加权的适用性索引的每个空间格子很适当的陆地使用的类型,源于生态系统国家和地点条件的专家知识。一系列模型模拟将被进行并且分析了表明综合模型的能力与使用在中国改变的地区性的土地连接全球社会经济的因素。结果在中国允许陆地使用和风景的未来动力学的探索[出版摘要] | Xia XU Qiong GAO Changhui PENG Xuefeng CUI Yinghui LIU Li JIANG | 2014 | Frontiers of Earth Science2014，8，1： | 2 |
| 12 | Contour detection improved by frequency domain filtering of gradient image显示文摘We propose an intermediate computational step,frequency domain filtering of gradient image,to improve contour detection performance of gradient-based edge detectors.This step is inspired by analyzing the spectrum distribution of object contours and texture edges in the frequency domain of gradient image.We illustrate the principle and efect of this step by adding it to the Canny edge detector.The resulting operator can selectively retain object contours and region boundaries,and meanwhile can dramatically reduce non-meaningful elements caused by textured background.We use several types of images to compare the proposed method and other related methods qualitatively and quantitatively.Experimental results show that the proposed method can efectively enhance the contour detection of Canny edge detector and achieves similar detection performance to two other related methods but runs faster. | QU ZhiGuo GAO YingHui WANG Ping WANG Peng TAN XianSi SHEN ZhenKang | 2014 | Science China(Information Sciences)2014，57，1： | 2 |
| 13 | Four COVID-19 Cases of New Variant B.1.351 First Emerging in South Africa in Chinese Passengers on Same Flight-Shenzhen,China,January 2021显示文摘At 04∶50 on January 1,2021,a 36-year-old Chinese project manager(Case A),a 29-year-old Chinese worker(Case B),and a 53-year-old Chinese businessman(Case C)returned from Africa(Case A and B from South Africa and Case C from Lesotho)on the same flight and tested coronavirus disease 2019(COVID-19)RNA positive by real-time polymerase chain reaction(PCR)by Baoan District People’s Hospital.Shenzhen CDC received their oral nasopharyngeal swabs packages from the hospital and retested COVID-19 RNA positive at 09∶50.Meanwhile,Case D. | Cong Cheng Lei Wang Ziquan Lyu Bo Peng Yinghui Li Dongfeng Kong Le Zuo Xiaomin Zhang Chao Yang Weiwen Liu Jia Wan Yijun Tang Junjia He Ying Wen Shule Xu Weihua Wu Ying Chen Guangnan Liu Junjie Xia Xuan Zou Renli Zhang Qinghua Hu Shujiang Mei Tiejian Feng | 2021 | China CDC weekly2021，3，8： | 2 |
| 14 | Electronic structures and optical properties of two anthracene derivatives显示文摘The electronic structures and the optical properties of two anthracene derivatives, DBMA and DAA, are investigated by both experimental tech- niques and quantum chemical calculations. The cy- clic voltammetry and differential pulse polarograph measurement revealed that the introduction of ben- zol-imidazol and pyrrolo-pyridine group on the an- thracene block can affect the electrochemical be- havior of DBMA and DAA. Both UV/visible absorption and emission spectra of DBMA and DAA are red-shifted in contrast to the unsubstituted anthra- cene, so that the anthracene derivatives emit at blue-green region and the luminescence yields are remarkably elevated (over 90%). The B3LYP/6-31G theoretical calculations explored that the electronic structures of the anthracene derivatives are per- turbed by the side substitutes on the anthracene block, and the slight variation of the electronic struc- tures results in the enhanced electron accepting abil- ity and the decrease of the HOMO-LUMO energy gap, which is the origin of the emission to be shifted to blue-green region. The non-planar geometry struc- tures of DBMA and DAA are responsible for the ex- cellent luminescence yields. | ZHANG Peng XIA Baohui SUN Yinghui YANG Bing TIAN Wenjing WANG Yue ZHANG Guo | 2006 | Chinese Science Bulletin2006，51，20： | 1 |
| 15 | Plasmonic Ag@Oxide Nanoprisms for Enhanced Performance of Organic Solar Cells显示文摘 | Peng Du Pengtao Jing Di Li Yinghui Cao Zhenyu Liu Zaicheng Sun | 2015 | Small2015，，20： | 1 |
| 16 | Rate Metal Materials and Engineering显示文摘 | Zhao Yinghui Ge Peng Zhao Yongqing | 2009 | 38(1):462009，38，1： | 1 |
| 17 | Gravity affects the responsiveness of Runx2 to 1, 25-dihydroxyvitamin D3 (VD3)显示文摘 | Feima Guo Zhongquan Dai Feng Wu Zhaoxia Liu Yingjun Tan Yumin Wan Peng Shang Yinghui Li | 2013 | Acta Astronautica2013，，： | 1 |
| 18 | Depressed mitochondrial biogenesis and dynamic remodeling in mouse tibialis anterior and gastrocnemius induced by 4‐week hindlimb unloading显示文摘 | Jing Liu Yunhua Peng Zhiwei Cui Zhiming Wu Airong Qian Peng Shang Lina Qu Yinghui Li Jiankang Liu Jiangang Long | 2012 | IUBMB Life2012，，11： | 1 |
| 19 | Enhanced oral bioavailability of silybin by a supersaturatable self-emulsifying drug delivery system (S-SEDDS)显示文摘 | Yinghui Wei Xiaoli Ye Xiaoguang Shang Xuan Peng Qiang Bao Minchen Liu Manman Guo Fanzhu Li | 2011 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2011，，： | 1 |
| 20 | 妊娠109d母猪背膘过厚导致脂毒性胎盘环境且使繁殖性能下降显示文摘研究探讨了妊娠109日龄母猪背膘厚对母猪和仔猪生产性能的影响。从种猪场收集了846头3~5胎次的经产大白母猪的相关数据。根据妊娠109 d时母猪的背膘厚(≤16,17~18,19~20,21~22,23~24和≥25 mm)分为6组。对母猪繁殖性能的评价包括窝产仔数、初生窝重和21日龄断奶窝重、分娩胎盘重、胎盘效率和母猪泌乳日采食量。测量与血脂和胎盘脂质浓度相关的参数,对数据进行分析,以确定背膘厚、胎盘脂质和仔猪性能之间的关系。各组间的出生仔猪数、产活仔猪数、寄养仔猪数和断奶仔猪数差异不显著(P> 0.05)。初生窝重和断奶窝重、仔猪初生重、断奶重、胎盘效率以及出生体重<800 g的仔猪数量和比例与背膘厚呈显著的二次效应(P> 0.05)。在泌乳期,母猪的日采食量在妊娠109 d时随背膘厚度的增加而线性降低(P> 0.05)。虽然甘油三酯和低密度脂蛋白胆固醇(LDL-C)无显著差异,但随着母猪背膘厚的增加,母猪和脐带血中胆固醇、高密度脂蛋白胆固醇(HDL-C)和游离脂肪酸(FFA)浓度均显著升高(P <0.05)。随着母猪背膘厚的增加,胎盘脂质浓度也显著增加(P <0.05)。此外,背膘厚和胎盘脂质浓度与体重<800 g的仔猪数呈正相关(P <0.01),而与初生重、窝产仔重和断奶仔猪重呈负相关(P <0.01)。综上所述,妊娠末期母猪背膘厚与仔猪出生和断奶体重相关。胎盘异位脂质堆积引起的脂毒性可能是造成这种相关性的原因。 | 孙义姗 Yuanfei Zhou Tao Xu Anle Cai Yinghui Wu Hongkui Wei Siwen Jiang Jian Peng | 2019 | 猪业科学2019，36，11： | 1 |
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