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| 1 | Two soybean bHLH factors regulate response to iron deficiency显示文摘Iron is an indispensable micronutrient for plant growth and development. Limited bioavailability of Fe in the soil leads to iron deficiency chlorosis in plants and yield loss. In this study, two soybean basic helix-loophelix transcription factors, Gmb HLH57 and Gmb HLH300,were identified in response to Fe-deficiency. Both transcription factors are expressed in roots and nodules,and are induced by Fe deficiency; these patterns were confirmed in transgenic hairy roots expressing constructs of the endogenous promoters fused to a GUS reporter gene. Bimolecular fluorescence complementation, yeast two-hybrid and coimmunoprecipitation(co-IP) assays indicated a physical interaction between Gmb HLH57 and Gmb HLH300. Studies on transgenic soybeans Reseoverexpressing Gmb HLH57 and Gmb HLH300 revealed that overexpression of each transcription factor, alone,results in no change of the responses to Fe deficiency,whereas overexpression of both transcription factors upregulated the downstream Fe uptake genes and increased the Fe content in these transgenic plants.Compared to wild type, these double overexpression transgenic plants were more tolerant to Fe deficiency.Taken together, our findings establish that Gmb HLH57 and Gmb HLH300 are important transcription factors involved in Fe homeostasis in soybean. | Lin Li Wenwen Gao Qi Peng Bin Zhou Qihui Kong Yinghui Ying Huixia Shou | 2018 | Journal of Integrative Plant Biology2018，60，7： | 10 |
| 2 | Development and utilization of a new chemically-induced soybean library with a high mutation density显示文摘Mutagenized populations have provided important materials for introducing variation and identifying gene function in plants. In this study, an ethyl methanesulfonate(EMS)-induced soybean(Glycine max) population,consisting of 21,600 independent M_2 lines, was developed.Over 1,000 M_(4(5))families, with diverse abnormal phenotypes for seed composition, seed shape, plant morphology and maturity that are stably expressed across different environments and generations were identified. Phenotypic analysis of the population led to the identification of a yellow pigmentation mutant, gyl, that displayed significantly decreased chlorophyll(Chl) content and abnormal chloroplast development. Sequence analysis showed that gyl is allelic to Minn Gold, where a different single nucleotide polymorphism variation in the Mg-chelatase subunit gene(ChlI1a) results in golden yellow leaves. A cleaved amplified polymorphic sequence marker was developed and may be applied to marker-assisted selection for the golden yellow phenotype in soybean breeding. We show that the newly developed soybean EMS mutant population has potential for functional genomics research and genetic improvement in soybean. | Zhongfeng Li Lingxue Jiang Yansong Ma Zhongyan Wei Huilong Hong Zhangxiong Liu Jinhui Lei Ying Liu Rongxia Guan Yong Guo Longguo Jin Lijuan Zhang Yinghui Li Yulong Ren Wei He Ming Liu Nang Myint Phyu Sin Htwe Lin Liu Bingfu Guo Jian Song Bing Tan Guifeng Liu Maiquan Li Xianli Zhang Bo Liu Xuehui Shi Sining Han Sunan Hua Fulai Zhou Lili Yu Yanfei Li Shuang Wang Jun Wang Ruzhen Chang Lijuan Qiu | 2017 | Journal of Integrative Plant Biology2017，59，1： | 6 |
| 3 | Boosting Chemodynamic Therapy by the Synergistic Effect of Co‑Catalyze and Photothermal Effect Triggered by the Second Near‑Infrared Light显示文摘In spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction(i.e.,chemodynamic therapy,CDT)has been attracted more attentions in recent years,the limited Fenton reaction efficiency is the important obstacle to further application in clinic.Herein,we synthesized novel FeO/MoS2 nanocomposites modified by bovine serum albumin(FeO/MoS2-BSA)with boosted Fenton reaction efficiency by the synergistic effect of co-catalyze and photothermal effect of MoS2 nanosheets triggered by the second near-infrared(NIR II)light.In the tumor microenvironments,the MoS2 nanosheets not only can accelerate the conversion of Fe3+ions to Fe2+ions by Mo4+ions on their surface to improve Fenton reaction efficiency,but also endow FeO/MoS2-BSA with good photothermal performances for photothermal-enhanced CDT and photothermal therapy(PTT).Consequently,benefiting from the synergetic-enhanced CDT/PTT,the tumors are eradicated completely in vivo.This work provides innovative synergistic strategy for constructing nanocomposites for highly efficient CDT. | Songtao Zhang Longhai Jin Jianhua Liu Yang Liu Tianqi Zhang Ying Zhao Na Yin Rui Niu Xiaoqing Li Dongzhi Xue Shuyan Song Yinghui Wang Hongjie Zhang | 2020 | Nano-Micro Letters2020，12，12： | 2 |
| 4 | Four COVID-19 Cases of New Variant B.1.351 First Emerging in South Africa in Chinese Passengers on Same Flight-Shenzhen,China,January 2021显示文摘At 04∶50 on January 1,2021,a 36-year-old Chinese project manager(Case A),a 29-year-old Chinese worker(Case B),and a 53-year-old Chinese businessman(Case C)returned from Africa(Case A and B from South Africa and Case C from Lesotho)on the same flight and tested coronavirus disease 2019(COVID-19)RNA positive by real-time polymerase chain reaction(PCR)by Baoan District People’s Hospital.Shenzhen CDC received their oral nasopharyngeal swabs packages from the hospital and retested COVID-19 RNA positive at 09∶50.Meanwhile,Case D. | Cong Cheng Lei Wang Ziquan Lyu Bo Peng Yinghui Li Dongfeng Kong Le Zuo Xiaomin Zhang Chao Yang Weiwen Liu Jia Wan Yijun Tang Junjia He Ying Wen Shule Xu Weihua Wu Ying Chen Guangnan Liu Junjie Xia Xuan Zou Renli Zhang Qinghua Hu Shujiang Mei Tiejian Feng | 2021 | China CDC weekly2021，3，8： | 2 |
| 5 | Increased prediction value of biomarker combinations for the conversion of mild cognitive impairment to Alzheimer's dementia显示文摘Background:Progression of mild cognitive impairment(MCI)to Alzheimer's disease(AD)dementia can be predicted by clinical features and a combination of biomarkers may increase the predictive power.In the present study,we investigated whether the combination of olfactory function and plasma neuronal-derived exosome(NDE)Aβ1-42 can best predict progression to AD dementia.Methods:Eighty-seven MCI patients were enrolled and received cognitive assessment at 2-year and 3-year follow-up to reevaluate cognition.In the meanwhile,80 healthy controls and 88 AD dementia patients were enrolled at baseline as well to evaluate the diagnose value in cross-section.Olfactory function was evaluated with the sniffin sticks(SS-16)and Aβ142 levels in NDES were determined by ELISA.Logistic regression was performed to evaluate the risk factors for cognitive decline in MCI at 2-year and 3-year revisits.Results:In the cross cohort,lower SS-16 scores and higher AB142 levels in NDES were found in MCI and AD dementia compared to healthy controls.For the longitudinal set,8 MCI individuals developed AD dementia within 2 years,and 16 MCI individuals developed AD dementia within 3 years.The two-parameter combination of SS-16 scores and Aβ1-42 level in NDEs showed better prediction in the conversion of MCI to AD dementia at 2-year and 3-year revisits.Moreover,after a 3-year follow-up,SS-16 scores also significantly predicted the conversion to AD dementia,where lower scores were associated with a 10-fold increased risk of developing AD dementia(p=0.006).Similarly,higher AB1-42 levels in NDES in patients with MCI increased the risk of developing AD dementia by 8.5-fold(p=0.002).Conclusion:A combination of two biomarkers NDE AB1-42 and SS-16 predicted the conversion of MCI to AD dementia more accurately.These findings have critical implications for understanding the pathophysiology of AD dementia and for developing preventative treatments for cognitive decline. | Aonan Zhao Yuanyuan Li Yi Yan Yinghui Qiu Binyin Li Wei Xu Ying Wang Jun Liu Yulei Deng | 2020 | Translational Neurodegeneration2020，9，3： | 2 |
| 6 | Functional characterization of the rice SPX‐MFS family reveals a key role of OsSPX‐MFS1 in controlling phosphate homeostasis in leaves显示文摘 | Chuang Wang Wei Huang Yinghui Ying Shuai Li David Secco Steve Tyerman James Whelan Huixia Shou | 2012 | New Phytologist2012，，1： | 1 |
| 7 | Pattern Detection in Airborne LiDAR Data Using Laplacian of Gaussian Filter显示文摘Methods for feature detection in laser scanning data have been studied for decades ever since the emergence of the technology.However,it is still one of the unsolved problems in LiDAR data processing due to difficulty of texture and structure information extraction in unevenly sampled points.The paper analyzes the characteristics of Laplacian of Gaussian(LoG) Filter and its potential use for structure detection in LiDAR data.A feature detection method based on LoG filtering is presented and ex-perimented on the unstructured points.The method filters the elevation value(namely,z coordinate value) of each point by convo-lution using LoG kernel within its local area and derives patterns suggesting the existence of certain types of ground ob-jects/features.The experiments are carried on a point cloud dataset acquired from a neighborhood area.The results demonstrate patterns detected at different scales and the relationship between standard deviation that defines LoG kernel and neighborhood size,which specifies the local area that is analyzed. | ZHAN Qingming LIANG Yubin CAI Ying XIAO Yinghui | 2011 | Geo-Spatial Information Science2011，14，3： | 1 |
| 8 | Novel multifunctional theranostic nanoagents based on Ho^(3+) for CT/MRI dual-modality imaging-guided photothermal therapy显示文摘Because of the intrinsic defects of traditional treatment of cancer,it is quite needed to construct novel theranostic nanoagents that can not only improve the accuracy of imaging diagnosis but also achieve highly efficient therapy of cancer.Herein,we fabricated polydopamine-functionalized ammonium holmium fluoride nanocomposites(AHF@PDA)for dual-modality bioimaging(magnetic resonance imaging(MRI)and computed tomography(CT))owing to the high X-ray attenuation feature and magnetic property of Ho^(3+).Moreover,PDA shell endows AHF@PDA with excellent photothermal conversion performances and robust biocompatibility,leading to good treatment effect in vitro and in vivo.All above positive results certify that AHF@PDA have good potential as theranostic agents for clinical application in the future. | Dongzhi Xue Yang Liu Longhai Jin Yinghui Wang Fengzhi Cui Jianhua Liu Xiaoqing Li Songtao Zhang Ying Zhao Na Yin Rui Niu Daguang Wang Hongjie Zhang | 2021 | Science China Chemistry2021，64，4： | 1 |
| 9 | U6 is not a suitable endogenous control for the quantification of circulating microRNAs显示文摘 | Mengqin Xiang Ying Zeng Ruirui Yang Haifan Xu Zhuo Chen Jing Zhong Hailong Xie Yinghui Xu Xi Zeng | 2014 | Biochemical and Biophysical Research Communications2014，，： | 1 |
| 10 | Small intestinal tumors: diagnostic accuracy of enhanced multi-detector CT virtual endoscopy显示文摘 | Xuejuan Su Yinghui Ge Baosong Liang Minghui Wu Ying Guo Bo Ma Jianying Li | 2012 | Abdominal Imaging2012，，3： | 1 |
| 11 | A facile method for electrospinning of Ag nanopartieles/poly (vinyl alcohol )/carboxymethyl-chitosan nanofibers 显示文摘 | ZHAO Yinghui ZHOU Ying WU Xiaomian | 2012 | Applied Surface Science2012，258，22： | 1 |
| 12 | Phosphate-dependent regulation of vacuolar trafficking of OsSPX-MFSs is critical for maintaining intracellular phosphate homeostasis in rice显示文摘Vacuolar storage of inorganic phosphate(Pi)is essential for Pi homeostasis in plants.The SPX-MFS family proteins have been demonstrated to be vacuolar Pi transporters in many plant species.Transcriptional regulation of the predominant transporter among rice SPX-MFSs,OsSPX-MFS3,was only moderately suppressed by Pi starvation.Thus,post-transcriptional mechanisms were hypothesized to regulate the activity of OsSPX-MFS3.In this study,we found that the tonoplast localization of OsSPX-MFSs is inhibited under Pi-depleted conditions,resulting in their retention in the pre-vacuolar compartments(PVCs).A yeast two-hybrid screen identified that two SNARE proteins,OsSYP21 and OsSYP22,interact with the MFS domain of OsSPX-MFS3.Further genetic and cytological analyses indicate that OsSYP21 and OsSYP22 facilitate trafficking of OsSPX-MFS3 from PVCs to the tonoplast.Although a homozygous frameshift mutation in OsSYP22 appeared to be lethal,tonoplast localization of OsSPX-MFS3 was significantly inhibited in transgenic plants expressing a negative-dominant form of OsSYP22(OsSYP22-ND),resulting in reduced vacuolar Pi concentrations in OsSYP22-ND plants.Under Pi-depleted conditions,the interaction between OsSYP22 and OsSPX-MFS3 was disrupted,and this process depended on the presence of the SPX domain.Deleting the SPX domains of OsSPX-MFSs resulted in their tonoplast localization under both Pi-depleted and Pi-replete conditions.Complementation of the osspx-mfs1/2/3 triple mutants with the MFS domain or the SPX domain of OsSPX-MFS3 confirmed that the MFS and SPX domains are responsive to Pi transport activity and Pi-dependent regulation,respectively.These data indicated that the SPX domains of OsSPX-MFSs sense cellular Pi(InsP)levels and,under Pi-depleted conditions,inhibit the interaction between OsSPX-MFSs and OsSYP21/22 and subsequent trafficking of OsSPX-MFSs from PVCs to the tonoplast. | Runze Guo Qi Zhang Kun Qian Yinghui Ying Wenying Liao Lening Gan Chuanzao Mao Yong Wang James Whelan Huixia Shou | 2023 | Molecular Plant2023，16，8： | 0 |
| 13 | Immediate and long-term outcomes after treat-all among people living with HIV in China:an interrupted time series analysis显示文摘Background In 2003,China implemented free antiretroviral therapy(ART)for people living with HIV(PLHIV),establishing an eligibility threshold of CD4<200 cells/μl.Subsequently,the entry criteria were revised in 2012(eligibility threshold:CD4≤350 cells/μl),2014(CD4≤500 cells/μl),and 2016(treat-all).However,the impact of treat-all policy on HIV care and treatment indicators in China is unknown.We aimed to elucidate the immediate and long-term impact of the implementation of treat-all policy in China.Methods Anonymized programmatic data on ART initiation and collection in PLHIV who newly started ART were retrieved between 1 January 2015 and 31 December 2019,from two provincial and municipal Centers for Disease Control and Prevention and ten major infectious disease hospitals specialized in HIV care in China.We used Poisson and quasi-Poisson segmented regression models to estimate the immediate and long-term impact of treat-all on three key indicators:monthly proportion of 30-day ART initiation,mean CD4 counts(cells/μl)at ART initiation,and mean estimated time from infection to diagnosis(year).We built separate models according to gender,age,route of transmission and region.Results Monthly data on ART initiation and collection were available for 75,516 individuals[gender:83.8%males;age:median 39 years,interquartile range(IQR):28-53;region:18.5%Northern China,10.9%Northeastern China,17.5%Southern China,49.2%Southwestern China].In the first month of treat-all,compared with the contemporaneous counterfactual,there was a significant increase in proportion of 30-day ART initiation[+12.6%,incidence rate ratio(IRR)=1.126,95%CI:1.033-1.229;P=0.007]and mean estimated time from infection to diagnosis(+7.0%,IRR=1.070,95%CI:1.021-1.120;P=0.004),while there was no significant change in mean CD4 at ART initiation(IRR=0.990,95%CI:0.956-1.026;P=0.585).By December 2019,the three outcomes were not significantly different from expected levels.In the stratified analysis,compared with the contemporaneous counterfactual,mean CD4 at ART initiation showed significant increases in Northern China(+3.3%,IRR=1.033,95%CI:1.001-1.065;P=0.041)and Northeastern China(+8.0%,IRR=1.080,95%CI:1.003-1.164;P=0.042)in the first month of treat-all;mean estimated time from infection to diagnosis showed significant increases in male(+5.6%,IRR=1.056,95%CI:1.010-1.104;P=0.016),female(+14.8%,IRR=1.148,95%CI:1.062-1.240;P<0.001),aged 26-35(+5.3%,IRR=1.053,95%CI:1.001-1.109;P=0.048)and>50(+7.8%,IRR=1.078,95%CI:1.000-1.161;P=0.046),heterosexual transmission(+12.4%,IRR=1.124,95%CI:1.042-1.213;P=0.002)and Southwestern China(+12.9%,IRR=1.129,95%CI:1.055-1.208;P<0.001)in the first month of treat-all.Conclusions The implementation of treat-all policy in China was associated with a positive effect on HIV care and treatment outcomes.To advance the work of rapid ART,efforts should be made to streamline the testing and ART initiation process,provide comprehensive support services,and address the issue of uneven distribution of medical resources. | Xinsheng Wu Guohui Wu Ping Ma Rugang Wang Linghua Li Yinghui Sun Junjie Xu Yuwei Li Tong Zhang Quanmin Li Yuecheng Yang Lijing Wang Xiaoli Xin Ying Qiao Bingxue Fang Zhen Lu Xinyi Zhou Yuanyi Chen Qi Liu Gengfeng Fu Hongxia Wei Xiaojie Huang Bin Su Hui Wang Huachun Zou | 2023 | Infectious Diseases of Poverty2023，12，4： | 0 |
| 14 | Effects of Replacement on the Optical Properties of Narrow Bandgap Polymers:Comparing the Difference Between Thieno[3,2-b]thiophene Units and Thiophene Units显示文摘The effects of replacement on the optical properties of diketopyrrolopyrrole(DPP)-based polymers were discussed through replacing the thieno[3,2-b]thiophene units by thiophene units.It is easy to see that the role of replacement would lead to blue shift of steady-state absorption spectrum when thieno[3,2-b]thiophene units is replaced by thiophene units.Meanwhile,the transient absorption data indicate that the role of replacement would not change the relaxation mechanism of polymer,but is able to adjust the photo-excitation relaxation rate of polymer.Their intensity-dependent dynamic curves show that the exciton-exciton annihilation(EEA)would participate in the relaxation process when the polymer is in the aggregation.Through comparing the EEA data between the polymers,it is found that the role of replacement would change the spatial distribution of exciton. | CHEN Ying WANG Wenyan SUI Ning WANG Yinghui CHI Xiaochun KANG Zhihui ZHANG Hanzhuang NI Moucui | 2019 | Chemical Research in Chinese Universities2019，35，1： | 0 |
| 15 | Dynamic Mechanism of Relaxation Paths Occurring in TPA-DCPP: Roles of Solvent and Temperature显示文摘 | ZHONG Qiulin CHEN Ying WANG Yinghui CHI Xiaochun WANG Yue NI Moueui ZHANG Hanzhuang | 2017 | Chemical Research in Chinese Universities2017，33，3： | 0 |
| 16 | Screening of DNA Barcode of Quarantine Phytophthora显示文摘Phytophtkora is genus of plant-damaging Oomycetes,whose member species are capable of causing enormous economic losses on crops worldwide.In the present study,four candidate genes ITS,CO1,EF-1α and β-tubulin were tested using 123 strains of 80 species of Phytophthora to investigate the feasibility of serving as DNA barcoding markers.The results showed that among the four candidate genes,ITS and CO1 had the highest success rate of PCR amplification and sequencing,up to 100%and 96.7%.There were obvious barcode gaps in ITS,CO1 and β-tubulin,but their frequency distributions of intra-and interspecific genetic distances were slightly overlapped.Wilcoxon rank sum test on intraspecific genetic distances of the four genes showed ITS = CO1 = β-tubulin = EF-1α,indicating they had the same effect on intraspecific discrimination,while the test on interspecific genetic distances of the four genes showed ITS > CO1 > β-tubulin > EF-1α.In summary,ITS and CO1 should be used in combination as the primary barcodes,β-tubulin as the complementary barcode for the identification of 11 quarantine Phytophthora species. | Ruifang GAO Yinghui CHENG Ying WANG Ying WANG Liyun GUO Guiming ZHANG | 2017 | Agricultural Biotechnology2017，6，1： | 0 |
| 17 | mvPPT:A Highly Efficient and Sensitive Pathogenicity Prediction Tool for Missense Variants显示文摘Next-generation sequencing technologies both boost the discovery of variants in the human genome and exacerbate the challenges of pathogenic variant identification.In this study,we developed Pathogenicity Prediction Tool for missense variants(mvPPT),a highly sensitive and accurate missense variant classifier based on gradient boosting.mvPPT adopts high-confidence training sets with a wide spectrum of variant profiles,and extracts three categories of features,including scores from existing prediction tools,frequencies(allele frequencies,amino acid frequencies,and genotype frequencies),and genomic context.Compared with established predictors,mvPPT achieves superior performance in all test sets,regardless of data source.In addition,our study also provides guidance for training set and feature selection strategies,as well as reveals highly relevant features,which may further provide biological insights into variant pathogenicity. | Shi-Yuan Tong Ke Fan Zai-Wei Zhou Lin-Yun Liu Shu-Qing Zhang Yinghui Fu Guang-Zhong Wang Ying Zhu Yong-Chun Yu | 2023 | Genomics, Proteomics & Bioinformatics2023，21，2： | 0 |
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