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| 1 | Polymorphism of p16INK4a gene and rare mutation of p15INK4b gene exon2 in primary hepatocarcinoma显示文摘INTRODUCTION Hepatocellular carcinoma(HCC)is the mostcommon cause of death from cancer in China.Themechanisms of hepatocarcinogenesis are not yetknown clearly,p16INK4a gene,the multiple tumorsuppressor gene 1(MTS1),encodes P16 protein,which acts as an inhibitor by binding directly toCDK4 and CDK6 and preventing its association | Yang Qin Bo Li Yong Shu Tan Zhi Lin Sun Feng Qiong Zuo Ze Fang Sun Institute of Biochemistry and Molecular Biology,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China Department of General Surgery,The First Affiliated Hospital,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China Department of Pathology,The First Affiliated Hospital,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China | 2000 | World Journal of Gastroenterology2000，6，3： | 30 |
| 2 | Synthesis and characterization of lower generation broom molecules显示文摘与亢奋的分支被迈克尔增加与 dodecylamine 和甲基压克力在甲醇综合的十二烷基组一起的树枝状的分子作为原料吃了。这新型的树枝状的分子生动地被叫“在这的扫帚分子”报导。扫帚分子的水溶液的表面张力解雇了氨基的组被使用落下卷方法测量。为油 / 水(O/W ) 的扫帚分子的反乳化表演模仿了原油乳状液被检验。试验性的结果揭示了那,作为一表面活化剂新型,扫帚分子解雇了为 O/W 给反乳化看的氨基的组模仿的原油乳状液。 | Jun Wang Cui Qin Li Shu Yan Zhang Fang Sun Teng Jie Ge | 2008 | Chinese Chemical Letters2008，19，1： | 13 |
| 3 | The analysis of γ-glutamyl transpeptidase gene in different type liver tissues显示文摘AIM: To probe the value of γ-glutamyl transpeptidase (GGT)messenger RNA in monitoring canceration of liver cells andfor early diagnosis of hepatocellular carcinoma (HCC), byresearching the types of GGT messenger RNA (GGTmRNA)in liver tissues and peripheral blood of different hepatopathy.METHODS: The three types of GGTmRNA (A, B, C) in livertissues and peripheral blood from the patients with HCC,noncancerous hepatopathy, hepatic benign tumor, secondarycarcinoma of liver, and healthy persons were detected byreverse-transcription polymerase chain reaction (RT-PCR).RESULTS: (1) In normal liver tissues, type A waspredominantly found (100.00 %), type B was not found,type C was found occasionally (25.00 %). (2) The distributionof types of GGTmRNA in liver tissues with acute hepatitis,chronic hepatitis, cirrhosis, alcoholic hepatopathy was similaras in normal liver tissues (P>0.05), but type B was found in3 of 18 patients with chronic hepatitis (16.67 %), and alsoin 3 of 11 patients with cirrhosis (27.27 %). (3) There wasno significant difference of types of GGTmRNA between livertissues with hepatic benign tumor, secondary carcinoma ofliver and normal liver tissues (P>0.05). (4) Type B waspredominant in cancerous tissues with HCC (87.5 %), theprevalence of type B in cancerous tissues was significantlyhigher than that in normal liver tissues (0/12) (P<0.05), butthe prevalence of type A in cancerous tissues (46.88 %)was significantly lower than that in normal liver tissues(100.00 %) (P<0.05), and the prevalence of type C (6.25 %)in cancerous was the same as that in normal liver tissues(25.00 %) (P>0.05). In noncancerous tissues of livers withHCC, the main types were type A and type B, the prevalenceof type A (85.71%, 90.48 %) and type C (14.29 %, 9.52 %)in noncancerous tissues of liver with HCC was similar asthat in normal liver tissues (A: 100.00 %; C: 25.00 %)(P>0.05), but the prevalence of type B (80.95 %, 76.19 %)in noncancerous tissues of livers with HCC was significantlyhigher than that in normal liver tissues (0/12) (P<0.05). (5)The prevalence of type B (37.5 %) in peripheral blood withHCC was higher than that in normal person (0/12) (P<0.05).In peripheral blood, type B was found in 4 of 11 cases ofHCC with serum AFP negative.CONCLUSION: The shift of types of GGTmRNA from A toB in liver tissues may be closely related to the developmentof HCC, and the analysis of GGT gene may provide a usefultool for early diagnosis of HCC. | Guo-Qing Han Cheng-Yong Qin Rong-Hua Shu The Center of Liver Diseases, Shandong Provincial Hospital, Clinical Medical College of Shandong University, Jinan 250021, China | 2003 | World Journal of Gastroenterology2003，9，2： | 11 |
| 4 | Expression of the Tribolium castaneum (Coleoptera: Tenebrionidae) hsp83 gene and its relation to oogenesis during ovarian maturation显示文摘Heat shock proteins (HSP) can protect organisms and cells from thermal damage. In this study, we cloned the full length cDNA encoding the HSP83 protein (the homologue of HSP90) of Tribolium castaneum (red flour beetle). The isolated cDNA contains the full coding sequence, a partial 5′ untranslated region of 55 bp and the complete 3′ untranslated region. We found the hsp83 gene is located on chromosome 5 of the T. castaneum genome. The predicted HSP83 protein sequence has a high similarity (on average 86.77%) with that of other insect species. The expression of the hsp83 gene in the whole body and in the ovary could be induced with heat stress (40°C for 1 h) in newly hatched (within 3 h post emergence) and mature (10 days post emergence) beetles. Under normal conditions, the hsp83 expression in the ovary is about 3-fold higher than in the whole body at both stages. No significant difference in hsp83 expression was observed between the two ovarian developmental stages regardless if the beetles were treated with heat shock or not. The expression of the HSP83 protein in the whole body could also be induced with heat stress in newly hatched and mature beetles. However, in the ovary, HSP83 was only expressed in the follicle cells of mature beetles and not in newly hatched beetles, regardless if the beetles were treated with heat shock or not. Furthermore, the females were not able to produce mature oocytes after knock-down of the hsp83 expression by injecting dsRNA. These results suggest that the HSP83 protein is involved in protection against heat stress and could be involved in oogenesis during ovarian maturation of T. castaneum. | Jingjing Xu 1, Juan Shu 1, Qin Zhang Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China | 2010 | Journal of Genetics and Genomics2010，37，8： | 9 |
| 5 | Effect of Huangshukuihua(Flos Abelmoschi Manihot) on diabetic nephropathy:a Meta-analysis显示文摘OBJECTIVE: To assess the efficacy of Huangshukuihua(Flos Abelmoschi Manihot) on diabetic nephropathy(DN).METHODS: Articles were retrieved from Pub Med,EMBASE, the Cochrane Central Register of Controlled Trials, Web of Science, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure Database, Chinese Evidence-Based Medicine Database, and Wanfang Database. Two reviewers independently reviewed the article. Only randomized controlled trials were included and 27 were identified involving 2239 patients(1143 in the treatment group and 1096 in the control group).RESULTS: Huangshukuihua(Flos Abelmoschi Manihot) had a significant effect on renal function by improving blood urea nitrogen and serum creatinine,reducing urine protein(24-h urine protein, and urinary albumin excretion rate), and improving serum albumin level, compared with the control group.CONCLUSION: Our findings suggest that, although the bioactive ingredients and mechanism underlying renal protection are unknown, the role of Huangshukuihua(Flos Abelmoschi Manihot) in the treatment of DN deserves further investigation. | Sun Qin Yang Gangyi Zhang Min Zhang Min Chen Shu Chen Pin | 2015 | Journal of Traditional Chinese Medicine2015，35，1： | 9 |
| 6 | Microstructures and mechanical properties of Nb-alloyed CoCrCuFeNi high-entropy alloys显示文摘Nb has a positive effect on improving the mechanical properties of metal materials, and it is expected to strengthen CoCrCuFeNi high-entropy alloys(HEAs) with outstanding ductility and relatively weak strength. In this paper, the alloying effects of Nb on the microstructural evolution and the mechanical properties of the(CoCrCuFeNi)_(100-x)Nb_xHEA were investigated systematically. The result shows that Nb promotes the phase transition from FCC(face-centered cubic) to Laves phase, and the volume fractions of Laves phase increase from 0% to 58.2% as the Nb content increases. Compressive testing shows that the addition of Nb has a positive effect on improving the strength of CoCrCuFeNi HEA. The compressive yield strength of(CoCrCuFeNi)_(100-x)Nb_xHEAs increases from 338 MPa to 1322 MPa and the fracture strain gradually reduces from 60.0%(no fracture) to 8.1% as the Nb content increases from 0 to 16 at.%. The volume fraction increase of hard Laves phase is the key factor for the strength increase, and the reduction of the VEC(valence electron concentration) value induced by the addition of Nb is beneficial for the increase of the Laves phase content in these alloys. | Gang Qin Shu Wang Ruirun Chen Xue Gong Liang Wang Yanqing Su Jingjie Guo Hengzhi Fu | 2018 | Journal of Materials Science & Technology2018，34，2： | 8 |
| 7 | Bevacizumab plus capecitabine and cisplatin in Chinese patients with inoperable locally advanced or metastatic gastric or gastroesophageal junction cancer: randomized, double-blind, phase III study (AVATAR study)显示文摘 | Lin Shen Jin Li Jianming Xu Hongming Pan Guanghai Dai Shukui Qin Liwei Wang Jinwan Wang Zhenzhou Yang Yongqian Shu Ruihua Xu Lei Chen Yunpeng Liu Shiying Yu Lilian Bu Yongzhe Piao | 2015 | Gastric Cancer2015，，1： | 7 |
| 8 | Environmental benefits of underground coal gasification显示文摘Environmental benefits of underground coal gasification are evaluated. The results showed that through underground coal gasification, gangue discharge is eliminated, sulfur emission is reduced, and the amount of ash, mercury, and tar discharge are decreased. Moreover, effect of underground gasification on underground water is analyzed and CO 2 disposal method is put forward. | LIU Shu qin, LIU Jun hua, YU LI (China University of Mining & Technology, Beijing 100083, China. | 2002 | Journal of Environmental Sciences2002，14，2： | 7 |
| 9 | A Variant Constrained Genetic Algorithm for Solving Conditional Nonlinear Optimal Perturbations显示文摘A variant constrained genetic algorithm(VCGA) for effective tracking of conditional nonlinear optimal perturbations(CNOPs) is presented. Compared with traditional constraint handling methods, the treatment of the constraint condition in VCGA is relatively easy to implement. Moreover, it does not require adjustments to indefinite parameters. Using a hybrid crossover operator and the newly developed multi-ply mutation operator, VCGA improves the performance of GAs. To demonstrate the capability of VCGA to catch CNOPS in non-smooth cases, a partial differential equation, which has 'onoff' switches in its forcing term, is employed as the nonlinear model. To search global CNOPs of the nonlinear model, numerical experiments using VCGA, the traditional gradient descent algorithm based on the adjoint method(ADJ), and a GA using tournament selection operation and the niching technique(GA-DEB) were performed. The results with various initial reference states showed that, in smooth cases, all three optimization methods are able to catch global CNOPs. Nevertheless, in non-smooth situations, a large proportion of CNOPs captured by the ADJ are local. Compared with ADJ, the performance of GA-DEB shows considerable improvement, but it is far below VCGA. Further, the impacts of population sizes on both VCGA and GA-DEB were investigated. The results were used to estimate the computation time of VCGA and GA-DEB in obtaining CNOPs. The computational costs for VCGA, GA-DEB and ADJ to catch CNOPs of the nonlinear model are also compared. | ZHENG Qin SHA Jianxin SHU Hang LU Xiaoqing | 2014 | Advances in Atmospheric Sciences2014，31，1： | 6 |
| 10 | Protein expression and fucosylated glycans of the serum haptoglobin-β subunit in hepatitis B virus-based liver diseases显示文摘Glycosylation,调整 glycoproteins 的配置和功能,是最重要的 translational 以后修正。学习是在 glycan 和浆液 haptoglobin- 子单元(Hp-) 的蛋白质部分观察微分模式的这的目的与肝炎 B 从病人净化了病毒(HBV ) 感染,肝肝硬化(LC ) ,或 hepatocellular 癌(HCC ) 。2-D 胶化电气泳动和多路的 proteomics 染色技术被采用调查 Hp- glycan 水平是否与蛋白质水平成正比。Multi-lectin 污点,高效的液体层析(HPLC ) ,和西方的污点分析被执行识别 Hp- 份量上的 glycoform。我们的实验证明到 Hp- 的 glycosylated 形式的全部的浆液 Hp- 的比率与不同的肝疾病在病人之中变化了。全部的 Hp- 蛋白质表示水平比 LC 在 HCC 是高得多的,当 fucosylated Hp- 的一个增长比例也在 HBV 和健康控制与那相比在 LC 和 HCC 病人被观察时。微分 fucosylation 被 HPLC 和反人的 SialylLewis X 抗体进一步作为路易斯十世结构识别。在结论, Hp- glycan 和全部的蛋白质表示的异常引申可以是为早 hepatocarcinogenesis 的有希望的 biomarker。 | Hong Shu Shu Zhang Xiaonan Kang Shan Li Xue Qin Chun Sun Haojie Lu Yinkun Liu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，7： | 6 |
| 11 | Intra-abdominal inflammatory myofibroblastic tumor:Spontaneous regression显示文摘Inflammatory myofibroblastic tumors are usually treated by surgical resection. We herein report two cases of intra-abdominal inflammatory myofibroblastic tumors that were unresectable and underwent spontaneous regression without any treatment. Our case report and literature review show that regression is more common in the middle-aged and older male populations. Abdominal discomfort and fever were the most common symptoms, but the majority of patients had no obvious physical signs. There was no specific indicator for diagnosis. The majority of the lesions regressed within3 mo and nearly all of the masses completely resolved within 1 year. We conclude that the clinical characteristics of inflammatory myofibroblastic tumors are variable and, accordingly, the disease needs to be subdivided and treated on an individual basis. Surgery is always the first-line treatment; however, for those masses assessed as unresectable, conservative therapy with in-tense follow-up should be considered. | Jun-Jie Zhao Jia-Qian Ling Yong Fang Xiao-Dong Gao Ping Shu Kun-Tang Shen Jing Qin Yi-Hong Sun Xin-Yu Qin | 2014 | World Journal of Gastroenterology2014，20，37： | 6 |
| 12 | Purification and Characterization of a Low-temperature Hydroxylamine Oxidase from Heterotrophic Nitrifier Acinetobacter sp.Y16显示文摘Objective To purify a low-temperature hydroxylamine oxidase(HAO) from a heterotrophic nitrifying bacterium Acinetobacter sp.Y16 and investigate the enzyme property.Methods A HAO was purified by an anion-exchange and gel-filtration chromatography from strain Y16.The purity and molecular mass were determined by RP-HPLC and SDS-PAGE.The HAO activity was detected by monitoring the reduction of potassium ferricyanide using hydroxylamine as substrate and ferricyanide as electron acceptor.The partial amino acid sequence was determined by mass spectrometry.Results The low-temperature HAO with a molecular mass of 61 kDa was purified from strain Y16 by an anion-exchange and gel-filtration chromatography.The enzyme exhibited an ability to oxidize hydroxylamine in wide temperature range(4-40 ℃) in vitro using hydroxylamine as substrate and ferricyanide as electron acceptor.It was stable in the temperature range of 4 to 15 ℃ and pH range of6.0 to 8.5 with less than 30%change in its activity.The optimal temperature and pH were 15 ℃ and 7.5,respectively.Three peptides were determined by mass spectrometry which were shown to be not identical to other reported HAOs.Conclusion This is the first study to purify a low-temperature HAO from a heterotrophic nitrifier Acinetobacter sp.It differs from other reported HAOs in molecular mass and enzyme properties.The findings of the present study have suggested that the strain Y16 passes through a hydroxylamine-oxidizing process catalyzed by a low-temperature HAO for ammonium removal. | ZHANG Shu Mei LI Wei Guang ZHANG Duo Ying HUANG Xiao Fei QIN Wen SHA Chang Qing | 2014 | Biomedical and Environmental Sciences2014，27，7： | 6 |
| 13 | Prevalence and Risk Factors Associated with Adverse Drug Reactions among Previously Treated Tuberculosis Patients in China显示文摘我们与 anti-TB 药估计了不利的药反应(ADR ) 的发生并且为在中国在以前对待的肺结核病人开发 ADR 评估了风险因素。所有病人是由国家指南推荐了收到了首要的 anti-TB 政体(2HREZS/6HRE ) 。临床并且实验室评估一个月被执行一次。从 354 个参加者,(74.0%) 262 经历了象 hyperuricemia 那样的 ADR (65.0% , 230/354 ) , hepatotoxicity (6.2% , 22/354 ) 并且听觉骚乱(4.8% , 17/354 ) 。ADR 显著地与糖尿病 mellitus 被联系[或(95% CI ) :15.5 (2.07-115.87 )] ;然而,重量超过 50 kg [或(95% CI ) :0.41 (0.22-0.85 )] 是为 ADR 的出现的一个保护的因素。Hyperuricemia 是最普通的不利事件但是,有 hyperuricemia 的大多数病人为高尿的酸层次显示出增加的忍耐。低身体重量和糖尿病 mellitus 在 anti-TB 治疗期间增加了 ADR 的出现的风险。 | HAN Xi Qin PANG Yu MA Yan LIU Yu Hong GUO Ru SHU Wei HUANG Xue Rui GE Qi Ping DU Jian GAO Wei Wei | 2017 | Biomedical and Environmental Sciences2017，30，2： | 5 |
| 14 | Discovery and implications of catenary-bead subaqueous dunes显示文摘Measurements of topography at the segment of bifurcation between the South Channel and North Channel in the Yangtze Estuary were conducted, and a new type of subaqueous dune was discovered. This structure, newly defined as a catenary-bead dune, consists of a catenary dune and its associated elliptical pit bedform. Based on this finding, the nomenclature of 'morphology of dune associated with accompanying bedform' is first proposed. The measured data indicate a mean height and wavelength of 1.29 m and 31.89 m, respectively; wavelength/height ratio(L/H) of 14 to 56; and elliptical pits of mean and maximum depth 0.98 m and 1.98 m, respectively. Flow information was obtained using an Acoustic Doppler Current Profile(ADCP), and the bed material components were gathered with a bottom sampler. The results show mean flood and ebb velocities of 0.27 and 0.78 m s?1, respectively, with shorter duration of flood tide than ebb tide. The silt, very fine sand, and fine sand fractions were within the ranges 21.6–23.4%, 28.2–32.2%, and 39.7–41.6%, respectively, revealing complex bed material composition. Water depth at the study site varies from 13 to 17 m. This finding will enrich the study of dunes and provide important data for geomorphological research. Moreover, the results are significant for engineering applications to estuaries. | ZHENG Shu Wei CHENG He Qin WU Shuai Hu LIU Gao Wei LU XueJun XU WenXiao | 2016 | Science China Earth Sciences2016，59，3： | 5 |
| 15 | Incorporation of NLR into NIH stratificationsystem increases predictive accuracy for surgically resected gastrointestinal stromal tumors显示文摘以前的研究报导了那外科手术前的 neutrophil-to-lymphocyte (NLR ) , platelet-to-lymphocyte 比率为癌症的各种各样的类型是预示的。这研究的目的是与胃肠的 stromal 肿瘤(大意) 在病人调查外科手术前的外部血计数的预兆的实用程序。我们注册了为主要、局部性的大意经历了外科的 510 个连续、以前未经治疗的病人。在没有复发的幸存和结果变量之间的关系被 univariate 和 multivariate 分析估计,当 NLR 的 clinicopathologic 关联用 Chi 平方测试是坚定的时。外科手术前的 NLR 2 在为主要、局部性的大意经历手术的病人与差的预后被联系。它在是分类的病人仅仅是一个独立预言者 ? 健康高风险然而并非在全部人口的国家研究所。外科手术前的 NLR 是帮助为集中的辅助治疗和经常的监视识别病人的可行、可再现的外部 biomarker。 | Anwei Xue Xiaodong Gao Yong Fang Ping Shu Jiaqian Ling Kuntang Shen Yihong Sun Jing Qin Xinyu Qin Yingyong Hou | 2017 | Acta Biochimica et Biophysica Sinica2017，49，2： | 4 |
| 16 | Targeted disruption of tyrosinase causes melanin reduction in Carassius auratus cuvieri and its hybrid progeny显示文摘The white crucian carp(Carassius auratus cuvieri,WCC) not only is one of the most economically important fish in Asia,characterized by strong reproductive ability and rapid growth rates,but also represents a good germplasm to produce hybrid progenies with heterosis.Gene knockout technique provides a safe and acceptant way for fish breeding.Achieving gene knockout in WCC and its hybrid progeny will be of great importance for both genetic studies and hybridization breeding.Tyrosinase(TYR) is a key enzyme in melanin synthesis.Depletion of tyr in zebrafish and mice results in mosaic pigmentation or total albinism.Here,we successfully used CRISPR-Cas9 to target tyr in WCC and its hybrid progeny(WR) derived from the cross of WCC(♀) and red crucian carp(Carassius auratus red var.,RCC,♂).The level of TYR protein was significantly reduced in mutant WCC.Both the mutant WCC and the mutant WR showed different degrees of melanin reduction compared with the wild-type sibling control fish,resulting from different mutation efficiency ranging from 60% to 90%.In addition,the transcriptional expression profiles of a series of pivotal pigment synthesis genes,i.e.tyrp1,mitfa,mitfb,dct and sox10,were down-regulated in tyr-CRISPR WCC,which ultimately caused a reduction in melanin synthesis.These results demonstrated that tyr plays a key role in melanin synthesis in WCC and WR,and CRISPR-Cas9 is an effective tool for modifying the genome of economical fish.Furthermore,the tyr-CRISPR models could be valuable in understanding fundamental mechanisms of pigment formation in non-model fish. | Qingfeng Liu Yanhua Qi Qiuli Liang Jia Song Junmei Liu Wuhui Li Yuqin Shu Min Tao Chun Zhang Qinbo Qin Jing Wang Shaojun Liu | 2019 | Science China(Life Sciences)2019，62，9： | 4 |
| 17 | Experimental study of transient pressure wave in the behind armor blunt trauma induced by different rifle bullets显示文摘Pressure wave plays an important role in the occurrence of behind armor blunt trauma(BABT),and ballistic gelatin is widely used as a surrogate of biological tissue in the research of BABT.Comparison of pressure wave in the gelatin behind armor for different rifle bullets is lacking.The aim of this study was to observe dynamic changes in pressure wave induced by ballistic blunt impact on the armored gelatin block and to compare the effects of bullet type on the parameters of the transient pressure wave.The gelatin blocks protected with National Institute of Justice(NIJ) class III bulletproof armor were shot by three types of rifle bullet with the same level of impact energy.The transient pressure signals at five locations were recorded with pressure sensors and three parameters(maximum pressure,maximum pressure impulse,and the duration of the first positive phase) were determined and discussed.The results indicated that the waveform and the twin peak of transient pressure wave were not related to the bullet type.However,the values of pressure wave's parameters were significantly affected by bullet type.Additionally,the attenuation of pressure amplitude followed the similar law for the three ammunitions.These findings may be helpful to get some insight in the BABT and improve the structure design of bullet. | Rui-guo Han Yong-jie Qu Wen-min Yan Bin Qin Shu Wang Jian-zhong Wang | 2020 | Defence Technology(防务技术)2020，16，4： | 4 |
| 18 | Analysis on Genetic Similarity of Japonica Rice Variety from Different Origins of Geography in the World显示文摘The genetic similarity and genetic difference among improved japonica rice varieties from different countries (or regions and organizations) were detected. The aim is to provide genetic basis to the breeding of japonica rice varieties. The genetic similarity and cluster of 313 improved japonica varieties from 20 countries (or regions and organizations) were analyzed using the SSR marker. With 34 SSR primers which were polymorphic and uniformly distributed in rice genome, totally 198 alleles were detected among these improved varieties with the average number of alleles per pair of primers of 5.8235. RM320, RM531, RM1, RM21, and RM336 located more alleles, which were 16, 13, 12, 10, and 10 respectively. RM320, RM336, RM286, RM531, and RM21 showed higher genetic diversity indexes, which were 2.3668, 2.0041, 1.9684, 1.9508, and 1.7203, respectively. The genetic similarity for improved japonica varieties among different countries (or regions and organizations) were ranged from 0.279 to 0.918, and the mean value was 0.653. The rice varieties from countries whose latitude and geography position were all nearer were clustered together with higher genetic similarity indexes. The rice varieties from countries who had more different latitude and far geography position were clustered separately with lower genetic similarity indexes. The results indicated the genetic similarity indexes among improved japonica varieties had a close relationship with the geographical position, especially with the latitude. | SHU Ai-ping Kim Jong hwan ZHANG San-yuan CAO Gui-lan NAN Zhong-hao Lee Kyu seong LU Qin HAN Long-zhi | 2009 | Agricultural Sciences in China2009，8，5： | 4 |
| 19 | Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer显示文摘Neoantigens are considered to be ultimate target of tumor immunotherapy due to their high tumor specificity and immunogenicity.Dendritic cell(DCs)vaccines based on neoantigens have exciting effects in treatment of some malignant tumors and are a promising therapeutic modality.Lung cancer is a lethal disease with the highest morbidity and mortality rate in the world.Despite the rapid development of targeted therapy and immune checkpoint inhibitors for lung cancer in recent years,their efficacy is still unsatisfactory overall.Therefore,there is an urgent unmet clinical need for lung cancer treatment.Here,we attempted to treat lung cancer using a personalized neoantigen peptide-pulsed autologous DC vaccine and conducted a single-arm,2 medical centers,pilot study initiated by the investigator(ChiCTR-ONC 16009100,NCT02956551).The patients enrolled were patients with heavily treated metastatic lung cancer.Candidate neoantigens were derived from whole-exome sequencing and RNA sequencing of fresh biopsy tissues as well as bioinformatics analysis.A total of 12 patients were enrolled in this study.A total of 85 vaccine treatments were administered with a median value of 5 doses/person(range:3-14 doses/person).In total,12-30 peptide-based neoantigens were selected for each patient.AIl treatment-related adverse events were grade 1-2 and there were no delays in dosing due to toxic effects.The objective effectiveness rate was 25%;the disease control rate was 75%;the median progression-free survival was 5.5 months and the median overall survival was 7.9 months.This study provides new evidence for neoantigen vaccine therapy and new therapeutic opportunities for lung cancer treatment. | Zhenyu Ding Qing Li Rui Zhang Li Xie Yang shu Song Gao Peipei Wang Xiaoqing Su Yun Qin Yuelan Wang Juemin Fang Zhongzheng Zhu Xuyang Xia Guochao Wei Hui Wang Hong Qian Xianling Guo Zhibo Gao Yu Wang Yuquan Wei Qing Xu Heng Xu Li Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 3 |
| 20 | Pattern of No.12a lymph node metastasis in gastric cancer显示文摘Objective:The current standard D2 lymphadenectomy for gastric cancer(GC)includes dissection of lymph nodes(LNs)along the proper hepatic artery(No.12 a),however,the survival benefit remains controversial.The purpose of this study was to evaluate the pattern of No.12 a LN metastasis(LNM)in GC and explore the indications for No.12 a LN dissection.Methods:Medical records of 413 consecutive GC patients who underwent curative surgery in Zhongshan Hospital,Fudan University between January 2015 and December 2018 were enrolled and reviewed retrospectively.The correlation between No.12 a LNM and clinicopathologic characteristics of patients was analyzed.Results:The overall incidence of No.12 a LNM was 2.67%(11/413).Tumor location(P=0.012),depth of tumor infiltration(P<0.01)and N stage(P=0.018)were significant factors associated with No.12 a LNM.All the tumors with No.12 a LNM involved the lower third of the stomach and were in T3-4 stages.Patients with No.12 a LNM had extensive LNM than those without(20.91±4.25 vs.5.0±0.54,P<0.001).For advanced GC patients(stage III/IV)with tumors involving the lower third of the stomach,the incidence of No.12 a LNM increased to 10.7%(11/103).Patients with No.12 a LNM had a significantly poorer recurrence-free survival(RFS)(P=0.005)and overall survival(OS)(P=0.017).According to the result of multivariable Cox regression,No.12 a LNM was not an independent impact factor on RFS and OS.Conclusions:The overall incidence of No.12 a LNM was low but it was much higher in GC patients who had very advanced tumors involving the lower third of the stomach.No.12 a LN dissection should be considered for these patients to improve the survival outcomes. | Ping Shu Xiangfei Sun Fenglin Liu Yong Fang Kuntang Shen Yihong Sun Jing Qin Xinyu Qin | 2021 | Chinese Journal of Cancer Research2021，33，1： | 3 |
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